KEGG   DISEASE: 強直性脊椎炎
エントリ  
H01674                                                             
名称    
強直性脊椎炎;
ベヒテレフ病
概要    
Ankylosing spondylitis (AS), formerly also known as Bechterew's disease, is a rheumatic disease of the axial skeleton that mainly affects the spine and the sacroiliac joint in the pelvis. AS is one of a group of inflammatory diseases, called spondyloarthritides, which share features. This disease is characterized by erosion, sclerosis, and ossification, which may result in complete fusion and rigidity of the spine. Regarding extra-articular manifestations, the most frequent is anterior uveitis. The major functional losses occur during the first 10 years of disease. It usually begins in the second or third decade of life, preferentially in HLA-B27-positive Caucasian males. Its etiology and pathogenesis are not completely understood, but the most prevalent hypothesis involves immune mediation as its major mechanism, including several cytokines. To date, more than 40 genetic variants have been identified that influence the risk of developing AS, including HLA alleles such as HLA-B27.
カテゴリ  
免疫系疾患; 筋骨格疾患
階層分類  
ヒト疾患 [BR:jp08402]
 免疫系疾患
  アレルギーと自己免疫疾患
   H01674  強直性脊椎炎
 筋骨格疾患
  骨格疾患
   H01674  強直性脊椎炎
ICD-11 による疾患分類 [BR:jp08403]
 15 筋骨格系・結合組織の疾患
  脊椎に関連する病態
   脊椎の炎症
    FA92  炎症性脊椎関節炎
     H01674  強直性脊椎炎
特定疾患 (難病) [jp08407.html]
 H01674
関連パスウェイ
hsa04612  Antigen processing and presentation
病因遺伝子 
HLA-B [HSA:3106] [KO:K06751]
治療薬   
アスピリン [DR:D00109]
ナプロキセン [DR:D00118]
デキサメタゾン [DR:D00292]
デキサメタゾンリン酸エステルナトリウム [DR:D00975]
ベタメタゾンリン酸エステルナトリウム [DR:D00972]
トリアムシノロンアセトニド [DR:D00983]
インフリキシマブ [DR:D02598]
ヒドロコルチゾンコハク酸エステルナトリウム [DR:D00978]
トリアムシノロン [DR:D00385]
ベタメタゾン [DR:D00244]
プレドニゾロン [DR:D00472]
プレドニゾロンコハク酸エステルナトリウム [DR:D01239]
メチルプレドニゾロン酢酸エステル [DR:D00979]
アダリムマブ [DR:D02597]
セクキヌマブ [DR:D09967]
ブロダルマブ [DR:D10061]
イキセキズマブ [DR:D10071]
コメント  
See also H00630 Rheumatoid arthritis and H01656 Psoriasis.
リンク   
ICD-11: FA92
ICD-10: M45
MeSH: D013167
OMIM: 106300
文献    
  著者
Gouveia EB, Elmann D, Morales MS
  タイトル
Ankylosing spondylitis and uveitis: overview.
  雑誌
Rev Bras Reumatol 52:742-56 (2012)
DOI:10.1590/S0482-50042012000500009
文献    
PMID:27445458 (drug)
  著者
Koenders MI, van den Berg WB
  タイトル
Secukinumab for rheumatology: development and its potential place in therapy.
  雑誌
Drug Des Devel Ther 10:2069-80 (2016)
DOI:10.2147/DDDT.S105263
文献    
  著者
Brown MA, Kenna T, Wordsworth BP
  タイトル
Genetics of ankylosing spondylitis--insights into pathogenesis.
  雑誌
Nat Rev Rheumatol 12:81-91 (2016)
DOI:10.1038/nrrheum.2015.133
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