KEGG   ORTHOLOGY: K06751
Entry
K06751                      KO                                     
Symbol
MHC1
Name
MHC class I antigen
Pathway
map04144  Endocytosis
map04145  Phagosome
map04218  Cellular senescence
map04514  Cell adhesion molecules
map04612  Antigen processing and presentation
map04940  Type I diabetes mellitus
map05163  Human cytomegalovirus infection
map05165  Human papillomavirus infection
map05166  Human T-cell leukemia virus 1 infection
map05167  Kaposi sarcoma-associated herpesvirus infection
map05168  Herpes simplex virus 1 infection
map05169  Epstein-Barr virus infection
map05170  Human immunodeficiency virus 1 infection
map05203  Viral carcinogenesis
map05320  Autoimmune thyroid disease
map05330  Allograft rejection
map05332  Graft-versus-host disease
map05416  Viral myocarditis
Disease
H00079  Asthma
H01507  Seronegative arthritis
H01563  HIV infection
H01656  Psoriasis
H01674  Ankylosing spondylitis
H01694  Stevens-Johnson syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04514 Cell adhesion molecules
    K06751  MHC1; MHC class I antigen
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K06751  MHC1; MHC class I antigen
   04145 Phagosome
    K06751  MHC1; MHC class I antigen
  09143 Cell growth and death
   04218 Cellular senescence
    K06751  MHC1; MHC class I antigen
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    K06751  MHC1; MHC class I antigen
   04612 Antigen processing and presentation
    K06751  MHC1; MHC class I antigen
 09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    K06751  MHC1; MHC class I antigen
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K06751  MHC1; MHC class I antigen
   05170 Human immunodeficiency virus 1 infection
    K06751  MHC1; MHC class I antigen
   05168 Herpes simplex virus 1 infection
    K06751  MHC1; MHC class I antigen
   05163 Human cytomegalovirus infection
    K06751  MHC1; MHC class I antigen
   05167 Kaposi sarcoma-associated herpesvirus infection
    K06751  MHC1; MHC class I antigen
   05169 Epstein-Barr virus infection
    K06751  MHC1; MHC class I antigen
   05165 Human papillomavirus infection
    K06751  MHC1; MHC class I antigen
  09163 Immune disease
   05320 Autoimmune thyroid disease
    K06751  MHC1; MHC class I antigen
   05330 Allograft rejection
    K06751  MHC1; MHC class I antigen
   05332 Graft-versus-host disease
    K06751  MHC1; MHC class I antigen
  09166 Cardiovascular disease
   05416 Viral myocarditis
    K06751  MHC1; MHC class I antigen
  09167 Endocrine and metabolic disease
   04940 Type I diabetes mellitus
    K06751  MHC1; MHC class I antigen
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K06751  MHC1; MHC class I antigen
   00537 Glycosylphosphatidylinositol (GPI)-anchored proteins
    K06751  MHC1; MHC class I antigen
Exosome [BR:ko04147]
 Exosomal proteins
  Proteins found in most exosomes
   K06751  MHC1; MHC class I antigen
Glycosylphosphatidylinositol (GPI)-anchored proteins [BR:ko00537]
 Antigens
  K06751  MHC1; MHC class I antigen
Genes
HSA: 3105(HLA-A) 3106(HLA-B) 3107(HLA-C) 3133(HLA-E) 3134(HLA-F) 3135(HLA-G)
PTR: 100169977(PATR-F) 100608458 450202(PATR-B) 462540(PATR-E) 463178(PATR-AL) 471948 471962(PATR-C) 494187(PATR-G) 750725(PATR-A)
PPS: 100977055 100978112(Papa-A) 100978457 100978774 100979338 100982294(PAPA-C) 100982859 100993452
GGO: 101141279 101142134 101142998 101143843(MHC-G) 101144465 101153360 115930068 115934970
PON: 100173719(DKFZP469M1914) 100189734 100432875 100435133 100435866 100438533 100440558 100449631 100450716 100452132 100456603
NLE: 100579523 100587765 100588639 100591000 100592911 100602874 115830427
HMH: 116459773 116460053 116460055 116460058 116460103
MCC: 100187576(MAMU-AG) 100424348 100426197 106995452 106996627 106996676 106997893 114676051 114677644 694372 699243(MAMU-A3) 709076(MAMU-F) 711532(MAMU-E) 711832(MAMU-A) 714964 719250 719702 720132 723473
MCF: 102116527 102117143 102120132 102122138(MAFA-F) 102123548 102138874 102138883(MAFA-B) 102140002 102141835
MTHB: 126947251 126947252 126953081 126953085 126953093 126953095 126953097 126953098 126953131 126953169
MMU: 100529082(H2-T27) 110557(H2-Q6) 110558(H2-Q9) 110696(H2-M10.3) 14963(H2-Bl) 14964(H2-D1) 14972(H2-K1) 14980(H2-L) 14985(H2-M10.1) 14990(H2-M2) 14991(H2-M3) 14997(H2-M9) 15006(H2-Q1) 15007(H2-Q10) 15013(H2-Q2) 15015(H2-Q4) 15018(H2-Q7) 15024(H2-T10) 15039(H2-T22) 15040(H2-T23) 15042(H2-T24) 15043(H2-T3) 224753(H2-M10.4) 224754(H2-M11) 224756(H2-M1) 224761(H2-M10.5) 240095(H2-M5) 333715(H2-M10.2) 399549(H2-M10.6) 547349(H2-K1) 630294(H2-T25) 667977(H2-T26) 69717(Gm10499)
RNO: 102546590(H2-M10.6l) 24747(RT1-M3-1) 24750(RT1-N3) 24751(RT1-O1) 24973(RT1-A1) 24974(RT1-A2) 24988(RT1-M2) 294213(RT1-M1-4) 294228(RT1-S3) 309584(RT1-M4) 309600(RT1-CE12) 309603(RT1-CE1) 309607(RT1-CE5) 309627(RT1-A3) 360323(RT1-N2) 361787(RT1-T24-1) 365527(RT1-M6-2) 368153(RT1-CE7) 406194(RT1-T18) 414779(RT1-CE2) 414783(RT1-CE4) 414784(RT1-T24-4) 414785(RT1-M6-1) 414786(RT1-M1-2) 414788(RT1-T24-3) 414789(RT1-CE15) 414790(RT1-CE13) 414791(RT1-CE11) 414792(RT1-CE10) 414793(RT1-CE3) 414819(RT1-CE16) 499400(RT1-M5) 680842(RT1-M1-5)
HGL: 101721592
CFA: 100685196 474836(DLA88) 474838(DLA-64) 483594(DLA-79) 541592(DLA-12)
AML: 100465524 100466374 100470568(AIME-128) 100476691(AIME-152) 100483904(AIME-1906) 105241843 109488766
BTA: 407173(JSP.1) 507917 510417(BOLA-NC1) 512672 515712(BOLA) 533050(BoLA) 616942 767904(MGC126945)
SSC: 100037288(SLA-3) 100037293(SLA-1) 100135029(SLA-5) 100135031(SLA-2) 100135036(SLA-8) 100135037(SLA-6) 396650(SLA-7)
MDO: 100009719(MHC-I) 100024719(Mhc-1) 100026156(MODO-UM) 100026178(MODO-UE) 100026665(MODO-UJ) 100026781(MODO-UI) 100026802(Modo-UA) 100026822(MODO-UK) 103092123(Modo-UT5) 103092429(Modo-UT6) 103093835 103093918(Modo-UT9) 103094094(Modo-UT10) 103094634 103095253 103096009(Modo-UT15) 103103471 103106169 103106351(Modo-UT3) 107651120 107651418 751097(MHC-1) 780946(MODO-UG) 790902(MODO-UB) 790903(MODO-UC)
GGA: 100859134(HLA-F10AL4) 100859374(MHCIA2) 107049124 107050538 417057(MHCIA6) 417067(MICA) 425389(BF2) 427746(YF5) 430600(MHCIA7) 693260(BF1)
CJO: 107321563
CATA: 118260299
TGU: 100231469
LSR: 110483779
OTC: 121343095
PRUF: 121359110
GFR: 102034923(FCGRT) 102039800
CCW: 120412176
CBRC: 103617075
FPG: 101924893
CLV: 102084942
NNI: 104009142
PCRI: 104025148
ACUN: 113490617
PADL: 103914226
AGEN: 126034962
MUI: 104535842
NNT: 104406923
CPEA: 104385235
CVF: 104292679
TEO: 104372145
BRHI: 104490707
NPD: 112954975
SCAM: 104152267
DRE: 393377(mhc1uja) 393557(mhc1uxa2) 64885(mhc1uea) 767703(mhc1uha) 791453(mhc1zba)
PTET: 122335310
CSEM: 103393860
SASA: 106569843 106569935 106569936(Sasa-ZCA) 106569938(Sasa-ZBA) 106569947(Sasa-UGA) 106582436(Sasa-UHA) 106588377(HA1L) 106588378 106588380(Sasa-ZE) 106588381(Sasa-ZAA) 106588401(Sasa-UBA) 106588402(Sasa-UBA) 106592784 106597015 106597513 106599071
LCM: 102345098(Lach-UX-02) 102345904(Lach-UB-05) 102348044 102348567(Lach-UC-01) 102351815(Lach-UB-02) 102354307 102356466 102356482 102360930 102365553(Lach-UD-01) 102365812 102365873 106706643(Lach-UB-05)
CMK: 103189724
 » show all
Reference
  Authors
Belicha-Villanueva A, Blickwedehl J, McEvoy S, Golding M, Gollnick SO, Bangia N
  Title
What is the role of alternate splicing in antigen presentation by major histocompatibility complex class I molecules?
  Journal
Immunol Res 46:32-44 (2010)
DOI:10.1007/s12026-009-8123-8
Reference
  Authors
Sleiman M, Brons NH, Kaoma T, Dogu F, Villa-Forte A, Lenoble P, Hentges F, Kotsch K, Gadola SD, Vilches C, Zimmer J
  Title
NK cell killer Ig-like receptor repertoire acquisition and maturation are strongly modulated by HLA class I molecules.
  Journal
J Immunol 192:2602-10 (2014)
DOI:10.4049/jimmunol.1302843
  Sequence
[hsa:3105 3106 3107]
Reference
PMID:2715640
  Authors
Parham P, Lawlor DA, Lomen CE, Ennis PD
  Title
Diversity and diversification of HLA-A,B,C alleles.
  Journal
J Immunol 142:3937-50 (1989)
  Sequence
[hsa:3105 3106 3107]
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