KEGG T02442: 101134157

Gorilla gorilla gorilla (western lowland gorilla): 101134157

Entry

101134157         CDS       T02442

Symbol

MTHFR

Name

(RefSeq) methylenetetrahydrofolate reductase (NADPH) isoform X1

K25004

methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.53]

Organism

ggo Gorilla gorilla gorilla (western lowland gorilla)

Pathway

ggo00670

One carbon pool by folate

ggo01100

Metabolic pathways

ggo01523

Antifolate resistance

ggo04981

Folate transport and metabolism

Brite

KEGG Orthology (KO) [BR:ggo00001]
09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    101134157 (MTHFR)
09150 Organismal Systems
  09154 Digestive system
   04981 Folate transport and metabolism
    101134157 (MTHFR)
09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    101134157 (MTHFR)
Enzymes [BR:ggo01000]
1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.53  methylenetetrahydrofolate reductase (NADPH)
     101134157 (MTHFR)

SSDB

Motif

Pfam:

MTHFR_C MTHFR DUF6919

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

Ensembl:

UniProt:

LinkDB

Position

1:join(228794507..228794616,228794892..228795140,228796610..228796848,228797687..228797797,228801605..228801798,228802657..228802907,228803141..228803275,228803465..228803645,228803922..228804104,228805625..228805726,228806649..228806768,228807087..228807305)

AA seq 697 aa
MDHRKARVFPAGHYCPSLGIWASQVGSVRSSVPPSISRNPAMVNEARGNSSLNPCLEGSA
SSGSESSKDSSRCSTPGLDPERHERLREKMRRRLESGDKWFSLEFFPPRTAEGAVNLISR
FDRMAAGGPLYIDVTWHPAGDPGSDKETSSMMIASTAVNYCGLETILHMTCCRQRLEEIT
GHLHKAKQLGLKNIMALRGDPIGDQWEEEEGGFNYAVDLVKHIRSEFGDYFDICVAGYPK
GHPEAGSFEADLKHLKEKVSAGADFIITQLFFEADTFFRFVKACTDMGITCPIVPGIFPI
QGYHSLRQLVKLSKLEVPQEIKDVIEPIKDNDAAIRNYGIELAVSLCQELLASGLVPGLH
FYTLNREMATTEVLKRLGMWTEDPRRPLPWALSAHPKRREEDVRPIFWASRPKSYIYRTQ
EWDEFPNGRWGNSSSPAFGELKDYYLFYLKSKSPKEELLKMWGEELTSEESVFEVFVLYL
SGEPNRNGHKVTCLPWNDEPLAAETSLLKEELLRVNRQGILTINSQPNINGKPSSDPIVG
WGPSGGYVFQKAYLEFFTSRETAEALLQVLKKYELRVNYHLVNVKGENITNAPELQPNAV
TWGIFPGREIIQPTVVDPVSFMFWKDEAFALWIERWGKLYEEESPSRTIIQYIHDNYFLV
NLVDNDFPLDNCLWQVVEDTLELLNRPTQNARETEAP

NT seq 2094 nt +upstreamnt +downstreamnt
atggaccatcgaaaagccagggtcttcccagctgggcactactgcccctcgctaggaata
tgggcctcgcaggtcggcagcgtgaggtcctctgtgccaccttccatcagcaggaaccca
gccatggtgaacgaagccagaggaaacagcagcctcaacccctgcttggagggcagtgcc
agtagtggcagtgagagctccaaagatagttcgagatgttccaccccgggcctggacccc
gagcggcatgagagactccgggagaagatgaggcggcgattggaatctggtgacaagtgg
ttctccctggaattcttccctcctcgaactgctgagggagctgtcaatctcatctcaagg
tttgaccggatggcagcaggcggccccctctacatagacgtgacctggcacccagcaggt
gaccctggctcagacaaggagacctcctccatgatgatcgccagcaccgccgtgaactac
tgtggcctggagaccatcctgcacatgacctgctgccgtcagcgcctggaggagatcacg
ggccatctgcacaaagctaagcagctgggcctgaagaacatcatggcgctgcggggagac
cccataggtgaccagtgggaagaggaggagggaggcttcaactacgcagtggacctggtg
aagcacatccgaagtgagtttggtgactactttgacatctgtgtggcaggttaccccaaa
ggccaccccgaagcagggagctttgaggctgacctgaagcacttgaaggagaaggtgtct
gcgggagccgatttcatcatcacgcagcttttctttgaggctgacacattcttccgcttt
gtgaaggcatgcaccgacatgggcatcacttgccccatcgtccccgggatctttcccatc
cagggctaccactcccttcggcagcttgtgaagctgtccaagctggaggtgccacaggag
atcaaggacgtgattgagcccatcaaagacaacgatgctgccatccgcaactatggcatc
gagctggccgtgagcctgtgccaggagcttctggccagtggcttggtgccaggcctccac
ttctacaccctcaaccgcgagatggctaccacagaggtgctgaagcgcctggggatgtgg
actgaggaccccaggcgtcccctaccctgggctctcagcgcccaccccaagcgccgagag
gaagatgtacgtcccatcttctgggcctccagaccaaagagttacatctaccgtacccag
gagtgggatgagttccctaacggccgctggggcaattcctcttcccctgcctttggggag
ctgaaggactactacctcttctacctgaagagcaagtcccccaaggaggagctgctgaag
atgtggggagaggagctgaccagtgaagaaagtgtctttgaagtctttgttctttacctc
tcgggagagccaaaccggaatggtcacaaagtgacttgcctgccctggaatgatgagccc
ctggcggccgagaccagcctgctgaaggaggagctgctgcgggtgaaccgccagggcatc
ctcaccatcaactcacagcccaacatcaacgggaagccatcctccgaccccatcgtgggc
tggggccccagcgggggctatgtcttccagaaggcctacttagagtttttcacttcccgt
gagacagcagaagcgcttctgcaagtgctgaagaagtacgagctccgggttaattaccac
cttgtcaatgtgaagggtgaaaacatcaccaatgcccctgaactgcagccgaatgctgtc
acttggggcatcttccctgggcgagagatcatccagcccaccgtagtggatcccgtcagc
ttcatgttctggaaggacgaggcctttgccctgtggattgagcggtggggaaagctgtat
gaggaggagtccccgtcccgcaccatcatccagtacatccacgacaactacttcctggtc
aacctggtggacaatgacttcccactggacaactgcctctggcaggtggtggaagacaca
ttggagcttctcaacaggcccacccagaatgcgagagagacggaggctccatga

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