KEGG   Gorilla gorilla gorilla (western lowland gorilla): 101144878
Entry
101144878         CDS       T02442                                 
Symbol
AKR1C3
Name
(RefSeq) aldo-keto reductase family 1 member C3
  KO
K04119  aldo-keto reductase family 1 member C3 [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
Organism
ggo  Gorilla gorilla gorilla (western lowland gorilla)
Pathway
ggo00140  Steroid hormone biosynthesis
ggo00590  Arachidonic acid metabolism
ggo00790  Folate biosynthesis
ggo01100  Metabolic pathways
ggo04913  Ovarian steroidogenesis
ggo05208  Chemical carcinogenesis - reactive oxygen species
Module
ggo_M00976  C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
ggo_M00977  C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:ggo00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    101144878 (AKR1C3)
   00590 Arachidonic acid metabolism
    101144878 (AKR1C3)
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    101144878 (AKR1C3)
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    101144878 (AKR1C3)
 09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    101144878 (AKR1C3)
Enzymes [BR:ggo01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.51  3(or 17)beta-hydroxysteroid dehydrogenase
     101144878 (AKR1C3)
    1.1.1.188  prostaglandin-F synthase
     101144878 (AKR1C3)
    1.1.1.213  3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
     101144878 (AKR1C3)
    1.1.1.357  3alpha-hydroxysteroid 3-dehydrogenase
     101144878 (AKR1C3)
SSDB
Motif
Pfam: Aldo_ket_red
Other DBs
NCBI-GeneID: 101144878
NCBI-ProteinID: XP_055210033
Ensembl: ENSGGOG00000002965
LinkDB
Position
8:join(14064921..14065004,14066886..14067053,14067905..14068021,14069258..14069335,14069783..14069905,14072535..14072644,14072921..14073086,14076012..14076094,14077915..14077957)
AA seq 323 aa
MDSKHQCVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQ
VGLAIRSKIADGSVKREDIFYTSKLWSTFHRSELVRPALENSLKKAQLDYVDLYLIHSPV
SLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKP
GLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPV
LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRENVQVFEFQLTAEDMKAIDGLD
RNLHYFNSDSLASHPNYPYSDEY
NT seq 972 nt   +upstreamnt  +downstreamnt
atggattccaaacaccagtgtgtgaagctaaatgatggccacttcatgcctgtattggga
tttggcacctatgcacctccagaggttccgagaagtaaagctttggaggtcacaaaatta
gcaatagaagctgggttccgccatatagattctgctcatttatacaataatgaggagcag
gttggactggccatccgaagcaagattgcagatggcagtgtgaagagagaagacatattc
tacacttcaaagctttggtccacttttcatcgatcagagttggtccgaccagccttggaa
aactcgctgaaaaaagctcaattggactatgttgacctctatcttattcattctccagtg
tctctaaagccaggtgaggaactttcaccaacagatgaaaatggaaaagtaatatttgac
atagtggatctctgtaccacctgggaggccatggagaagtgtaaggatgcaggattggcc
aagtccattggggtgtcaaacttcaaccgcaggcagctggagatgatccttaacaagcca
ggactcaagtacaagcctgtctgcaaccaggtagaatgtcatccgtatttcaaccggagt
aaattgctagatttctgcaagtcaaaagatattgttctggttgcctatagtgctctggga
tctcaacgagacaaacgatgggtggacccgaactccccggttctcttggaggacccagtc
ctttgtgccttggcaaaaaagcacaagcgaaccccagccctgattgccctgcgctaccag
ctgcagcgtggggttgtggtcctggccaagagctacaatgagcagcgcatcagagagaat
gtccaggtttttgagttccagttgactgcagaggacatgaaagccatagatggcctagac
agaaatctccactattttaacagtgatagtcttgctagccaccctaattatccgtattca
gatgaatattaa

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