KEGG   Globicephala melas (long-finned pilot whale): 115849424
Entry
115849424         CDS       T11080                                 
Symbol
CYP21A2
Name
(RefSeq) steroid 21-hydroxylase
  KO
K00513  steroid 21-monooxygenase [EC:1.14.14.16]
Organism
gmf  Globicephala melas (long-finned pilot whale)
Pathway
gmf00140  Steroid hormone biosynthesis
gmf01100  Metabolic pathways
gmf04925  Aldosterone synthesis and secretion
gmf04927  Cortisol synthesis and secretion
gmf04934  Cushing syndrome
Module
gmf_M00109  C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone
Brite
KEGG Orthology (KO) [BR:gmf00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    115849424 (CYP21A2)
 09150 Organismal Systems
  09152 Endocrine system
   04925 Aldosterone synthesis and secretion
    115849424 (CYP21A2)
   04927 Cortisol synthesis and secretion
    115849424 (CYP21A2)
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    115849424 (CYP21A2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450 [BR:gmf00199]
    115849424 (CYP21A2)
Enzymes [BR:gmf01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.16  steroid 21-monooxygenase
     115849424 (CYP21A2)
Cytochrome P450 [BR:gmf00199]
 Cytochrome P450, animal type
  CYP21 family
   115849424 (CYP21A2)
SSDB
Motif
Pfam: p450
Other DBs
NCBI-GeneID: 115849424
NCBI-ProteinID: XP_030706529
LinkDB
Position
11:complement(79148284..79151379)
AA seq 495 aa
MVLVGLLLLLLLPLLVGTRLLWGQWKLRSLHLPPLVPGFLHLLQPNLPVYLLGLTQKLGP
IYRLRLGLQDVVVLNSKRTIEEALIRKWVDFAGRPQIPSYQLVSQHCQDISLGDYSLLWK
AHKKLTRSALLLGVRSSMEPRVEQLTQEFCERMKARAGAPVTIQKEFSLLTCSIICYLTF
GHKEDTLVHAFHDCVQDLMKTWDHWSIQILDMVPFLRFFPNPGLRRLKQAMENRDHIVEK
QLRQHKKSMVAGQWRDMTDYMLQGMGKQRVEEGPGQLLEGHVHMSVVDLFIGGTETTANT
LSWAVAFLLHHPEIQRRLQEELDRELGPGASGSRVPYKDRARLPLLNATIAEVLRLRPVV
PLALPHRATRASSIFGYDIPEGMVVIPNLQGAHLDETVWERPHEFRPDRFLDAGANPSAL
AFGCGARVCLGEPLARLELFVVLGQLLQAFTLLSPAGALPSLQPHPYCGVNLKIQPFQVR
LQPRGGGGRGVREHQ
NT seq 1488 nt   +upstreamnt  +downstreamnt
atggtactcgtagggctgctgctgctgctgctgctgcccttgctagtcggcactcgcctg
ctgtggggccagtggaagctcaggagcctccacctcccacctcttgtccctggcttcctg
cacctgctgcagcccaacctccccgtctatctgcttggcctgactcagaaactcgggccc
atctacaggctccgcctcgggctgcaagatgtggtggtgctgaactccaagaggaccatt
gaggaggccctgatcaggaagtgggtggactttgccggcagaccccagataccatcctac
cagctggtatctcagcactgccaggacatctcactgggggactactccctgctctggaag
gcccacaagaaactcacgcgctcagccctgctgctgggcgtccgcagctccatggagccc
cgggtggagcagctgacccaggagttctgtgagcgcatgaaagcccgggcaggtgccccc
gtgaccatccagaaggaattctctctcctcacctgcagcatcatctgttacctcaccttt
ggacacaaggaggacaccttagtacatgcctttcacgactgtgtccaggacttgatgaaa
acctgggatcactggtccatccaaattttggacatggttccctttctcaggttcttcccc
aaccccgggctccggaggctgaagcaggccatggagaacagggaccacattgtagagaag
cagctgaggcagcacaagaagagcatggtggcgggccagtggagggacatgacggactac
atgcttcaggggatggggaagcaaagagtggaagagggccccgggcagctccttgaaggg
cacgtgcatatgtccgtggtggaccttttcatcggtggcactgagaccacagcaaacacc
ctttcctgggctgtggcgttcctgcttcaccaccctgagattcagcggcgactgcaggag
gagttggatcgcgagctgggccccggagcctcgggctcccgagtcccatacaaggaccgc
gctcggctgcccttgctcaacgccaccatcgctgaggtgctgcgcctgcggcccgtcgtg
cccctggccttgccgcaccgcgccacgcgggctagcagcatctttggctacgacatcccc
gagggcatggttgtcatccccaacctccaaggtgcccacctggacgagaccgtttgggag
cggccgcacgagttccggcccgaccgcttcctggacgcgggcgcgaaccccagcgcgctg
gccttcggctgcggggcgcgcgtgtgcctgggcgagccgctggcgcgcctcgagctcttc
gtggtgctggggcaactgctgcaggccttcacgctgctgtcgcccgcgggcgccctgccc
tcgctgcagccccatccctactgcggcgtcaacctcaagattcagcctttccaggtgcgg
ctgcagccccggggcggtggaggccggggcgtgcgcgagcaccaatga

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