Glycine max (soybean): 547833
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Entry
547833 CDS
T01710
Symbol
DHFR-TS
Name
(RefSeq) bifunctional dihydrofolate reductase-thymidylate synthase
KO
K13998
dihydrofolate reductase / thymidylate synthase [EC:
1.5.1.3
2.1.1.45
]
Organism
gmx
Glycine max (soybean)
Pathway
gmx00240
Pyrimidine metabolism
gmx00670
One carbon pool by folate
gmx00790
Folate biosynthesis
gmx01100
Metabolic pathways
gmx01232
Nucleotide metabolism
gmx01240
Biosynthesis of cofactors
Module
gmx_M00126
Tetrahydrofolate biosynthesis, GTP => THF
gmx_M00938
Pyrimidine deoxyribonucleotide biosynthesis, UDP => dTTP
Brite
KEGG Orthology (KO) [BR:
gmx00001
]
09100 Metabolism
09104 Nucleotide metabolism
00240 Pyrimidine metabolism
547833 (DHFR-TS)
09108 Metabolism of cofactors and vitamins
00790 Folate biosynthesis
547833 (DHFR-TS)
00670 One carbon pool by folate
547833 (DHFR-TS)
Enzymes [BR:
gmx01000
]
1. Oxidoreductases
1.5 Acting on the CH-NH group of donors
1.5.1 With NAD+ or NADP+ as acceptor
1.5.1.3 dihydrofolate reductase
547833 (DHFR-TS)
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.45 thymidylate synthase
547833 (DHFR-TS)
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Motif
Pfam:
Thymidylat_synt
DHFR_1
AAA_lid_TANC1
Motif
Other DBs
NCBI-GeneID:
547833
NCBI-ProteinID:
NP_001238644
UniProt:
P51820
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Position
6:814506..819714
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AA seq
530 aa
AA seq
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MPSDSSVISNGHSNGSVNPLPNLQRTYQVVVAATQDWGIGKDGKLPWRLPTDLKFFKEIT
MKTSDPGKKNAIVMGRKTWESIPLEYRPLSGRLNVVLTRSGSFDIATAENVVICGSMSSA
LELLAASPYSLSIEKVFVIGGGQIFREALNVPGCEAIHLTEIQSSIECDTFMPPVDFTIF
RPWYSSFPKVENNIRYSFTTYVRVRSSAAESAGQNIDPLLDNNSESMKFEVKDFSFLPKM
ISERHEEYLYLKLVQDIIAEGTTKGDRTGTGTLSKFGCQMRFNLRGNFPLLTTKKVFWRG
VVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDGVGLTEREEGDLGPVYGFQWRHFG
ARYTDMHHDYSGQGFDQLLDVINKIKRNPDDRRIILSAWNPVDLKLMALPPCHMFAQFYV
AHGELSCQMYQRSADMGLGIPFNIASYALLTCMIAHVCDLIPGDFIHVIGDAHIYRNHVR
PLQEQLHNQPKPFPTLKINPKKKDIDSFVAADFKLIGYDPHQKIDMKLSV
NT seq
1593 nt
NT seq
+upstream
nt +downstream
nt
atgcccagtgattcttctgtaatctccaatggacacagcaatggcagtgtcaatccacta
cctaacctgcaaaggacttaccaagtggtagtggctgccactcaagattggggcatcggt
aaggatgggaaattaccctggagattgcctactgatctcaagttttttaaggagatcact
atgaaaacatctgatcctgggaagaagaatgccattgtaatgggaaggaaaacatgggag
agcatccctcttgagtacaggcctctttctggtcgccttaatgttgttcttactcgctca
ggaagttttgatattgcaacagcagagaatgttgttatatgtggaagcatgtcttctgca
ttggaactgttagctgcttctccttactctctgtcaattgagaaagtttttgttataggg
ggtggtcagatatttagagaggctctcaatgtgcctggatgtgaagctatccacttaacg
gaaattcagtcaagcattgagtgtgacacttttatgcctccagttgatttcactatattt
cggccatggtactcatcctttcctaaagtggaaaacaacatccgctattctttcaccact
tatgtgcgtgtacggagttctgctgcagagtccgcgggtcagaacattgatccacttctt
gataataattctgagtccatgaaatttgaggtcaaggatttttcttttcttcctaaaatg
atttctgagagacatgaggagtatctgtatcttaagctggttcaggacatcattgctgaa
ggtacaactaagggtgataggacagggactggtaccttgtcaaaatttggttgccagatg
aggttcaatctgcgtggaaactttcctcttctaacaactaagaaagtattttggcgaggg
gttgttgaagagcttctttggtttatcagtggctcaacaaatgccaaggtgctacaggaa
aaaggcattcatatttgggatggcaatgcatccagagaataccttgatggtgttggtttg
acagagcgggaggagggtgacttgggacctgtttatgggtttcaatggaggcactttggt
gccagatatactgacatgcatcatgactactccggccaagggtttgatcaacttttagat
gttattaacaagataaagcgtaatcctgatgatcggcgaatcattctctctgcatggaat
ccagtggatcttaaattaatggcacttccaccctgccacatgtttgcacagttttatgta
gcacacggggagttatcatgtcaaatgtatcagcgatctgctgatatgggcctgggcatt
ccatttaatattgcatcttatgcccttttgacatgcatgattgctcatgtttgtgatctc
attcctggtgattttattcatgttattggggatgctcatatttaccgcaatcacgtgagg
cctttgcaggagcagctccataaccagccaaagccttttccaactttgaagataaatcca
aagaagaaagatatagattcttttgtggctgctgatttcaagctcataggctatgatcct
caccagaagattgatatgaagctgtctgtctaa
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