Galeopterus variegatus (Sunda flying lemur): 103595280
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Entry
103595280 CDS
T08727
Symbol
TH
Name
(RefSeq) tyrosine 3-monooxygenase isoform X1
KO
K00501
tyrosine 3-monooxygenase [EC:
1.14.16.2
]
Organism
gvr
Galeopterus variegatus (Sunda flying lemur)
Pathway
gvr00350
Tyrosine metabolism
gvr00790
Folate biosynthesis
gvr01100
Metabolic pathways
gvr04728
Dopaminergic synapse
gvr04917
Prolactin signaling pathway
gvr05012
Parkinson disease
gvr05030
Cocaine addiction
gvr05031
Amphetamine addiction
gvr05034
Alcoholism
Module
gvr_M00042
Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline
Brite
KEGG Orthology (KO) [BR:
gvr00001
]
09100 Metabolism
09105 Amino acid metabolism
00350 Tyrosine metabolism
103595280 (TH)
09108 Metabolism of cofactors and vitamins
00790 Folate biosynthesis
103595280 (TH)
09150 Organismal Systems
09152 Endocrine system
04917 Prolactin signaling pathway
103595280 (TH)
09156 Nervous system
04728 Dopaminergic synapse
103595280 (TH)
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
103595280 (TH)
09165 Substance dependence
05030 Cocaine addiction
103595280 (TH)
05031 Amphetamine addiction
103595280 (TH)
05034 Alcoholism
103595280 (TH)
Enzymes [BR:
gvr01000
]
1. Oxidoreductases
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.16 With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
1.14.16.2 tyrosine 3-monooxygenase
103595280 (TH)
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Paralog
GFIT
Motif
Pfam:
Biopterin_H
TH_ACT
TOH_N
LTP_2
Motif
Other DBs
NCBI-GeneID:
103595280
NCBI-ProteinID:
XP_008576863
LinkDB
All DBs
Position
Unknown
AA seq
536 aa
AA seq
DB search
MPTPSAATPQAKGFRRAVSELDAKQAEAIMQAHSRCSIMRPGPGLALSPLDGGQGGSAME
EAWWPLSLQSPRFVGRRQSLIEDARKEREAAVAAAAAAASAEPGDPLEAVAFEERDGKAV
VNLLFSLRGTRPSSLSRAVKVFETFEAQIQHLETRPAQRPRAGGPSLEYFVRCEVPSGDL
AALLSSVRRVSEDVRSAGEDKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQAYRQ
RRKQIAEIAFQYKHGDPIPRVEYTAEEIATWKEVYTTLKGLYATHACREHLEAFGLLERF
SGYREDNIPQLEDVSRFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPM
HSPEPDCCHELLGHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTLYWFTVEFGLCKQ
DGEVKAYGAGLLSSYGELLHSLSEEPEIRAFDPEAAALQPYQDQTYQSVYFVSESFSDAK
DKLRSYAARIQRPFSVKFDPYTLAIDVLDGPHAIRRSLEGVQDELHTLTHALSAIG
NT seq
1611 nt
NT seq
+upstream
nt +downstream
nt
atgcccacccccagcgctgccacgccgcaggccaagggcttccgcagggccgtctccgag
ctggacgccaagcaggccgaggccatcatgcaggcacacagtaggtgctcaataatgcga
cctgggccagggctggcgctctcacctctggatgggggtcaagggggctcggcaatggag
gaggcatggtggcccctgtccctgcagtccccacggttcgtcgggcggcggcagagcctc
atcgaggatgcccgcaaggagcgggaggcagcggtggctgcggcggctgcggcggcctct
gcggagcccggggaccccctggaggcggtggcgttcgaggagagggacgggaaggccgtg
gtgaacctgctcttctctctgcggggcaccaggccctcctcgctgtcccgggccgtgaag
gtgtttgagacatttgaagcccaaatccagcacctggagacgcggcccgcccagaggccg
cgggcggggggcccctccctggagtacttcgtgcgctgtgaggtgcccagcggggacctg
gccgccctgctcagctctgtgcgccgcgtgtctgaggacgtgcgcagcgcaggggaggac
aaggtcccctggttcccaagaaaagtgtcagagctggacaagtgtcaccacctggtcact
aagtttgaccctgacctggatttggaccacccgggcttctcagaccaggcgtaccgccag
cgcaggaagcagatcgctgaaatagccttccagtacaagcacggtgacccgattccccgt
gtggagtacaccgccgaggagattgccacctggaaggaggtctacaccacgctgaagggc
ctctatgccacccacgcctgccgggagcacctggaggcttttgggctgctggagcgcttc
agcggctaccgggaggacaacatcccgcagctggaggacgtctcccgcttcctgaaggag
cggacaggcttccagctgcggcccgtggccggcctgctgtctgcccgggacttcctggcc
agcctggccttccgcgtgttccagtgcacccagtacatccgccatgcgtcctcgcccatg
cactcgcccgagccggactgctgtcacgagctgctggggcacgtgcccatgctggctgac
cgcaccttcgcccagttctcccaggacatcggtcttgcatctctgggggcctcagacgag
gaaattgagaagctgtccacactgtactggttcacggtggagttcgggctgtgcaagcag
gacggggaggtgaaggcatatggcgctgggctcctgtcctcctacggggagctcctgcac
tccctgtcagaggagcccgagatccgggccttcgaccccgaggctgcggctctgcagccc
taccaagaccagacctaccagtccgtctacttcgtgtccgagagcttcagcgatgccaag
gacaagctcaggagctacgctgcgcgcatccaacgccccttctccgtgaagttcgacccg
tacacgctggctatcgacgtgttggacggtccccacgccatccggcgctccctggagggc
gtacaggacgagttgcacaccctgacccatgctctgagtgctattggctag
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