Heterocephalus glaber (naked mole-rat): 101721615 Help Entry 101721615         CDS       T02812                                  Symbol Th Name (RefSeq) tyrosine hydroxylase   KO K00501   tyrosine 3-monooxygenase [EC:1.14.16.2] Organism hgl  Heterocephalus glaber (naked mole-rat) Pathway hgl00350   Tyrosine metabolism hgl00790   Folate biosynthesis hgl01100   Metabolic pathways hgl04728   Dopaminergic synapse hgl04917   Prolactin signaling pathway hgl05012   Parkinson disease hgl05030   Cocaine addiction hgl05031   Amphetamine addiction hgl05034   Alcoholism Module hgl_M00042   Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline Brite KEGG Orthology (KO) [BR:hgl00001]  09100 Metabolism   09105 Amino acid metabolism    00350 Tyrosine metabolism     101721615 (Th)   09108 Metabolism of cofactors and vitamins    00790 Folate biosynthesis     101721615 (Th)  09150 Organismal Systems   09152 Endocrine system    04917 Prolactin signaling pathway     101721615 (Th)   09156 Nervous system    04728 Dopaminergic synapse     101721615 (Th)  09160 Human Diseases   09164 Neurodegenerative disease    05012 Parkinson disease     101721615 (Th)   09165 Substance dependence    05030 Cocaine addiction     101721615 (Th)    05031 Amphetamine addiction     101721615 (Th)    05034 Alcoholism     101721615 (Th) Enzymes [BR:hgl01000]  1. Oxidoreductases   1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen    1.14.16  With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor     1.14.16.2  tyrosine 3-monooxygenase      101721615 (Th) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Biopterin_H TH_ACT TOH_N LTP_2 Motif Other DBs NCBI-GeneID:  101721615 NCBI-ProteinID:  XP_004852155 UniProt:  A0AAX6PH44 LinkDB All DBs Position Un AA seq 498 aa AA seqDB search MPTPGAATPQPKGFRRAVSELDAKQAEAIMSPQFIGRRQSLIEDARKEREAAAAAAAAAV VSSEPGDPPEAVAFEEKEGKAVLNLLFSLRGSKPSPLSRAVKVFETFEAKIHHLETRPAS RQRAGGPYLEYFVRFEVPSGDLPALLSSLRRVSEDVRSAREEKVPWFPRKVSELDKCHHL VTKFDPDLDMDHPGFSDQVYRQRRKLIAEIAFQYKHGEPIPHVEYTAEEIATWKEVYTTL KGLYATHACREHLEGFQLLERFCGYREDSIPQLEDVSRFLKERTGFQLRPVAGLLSARDF LASLAFRVFQCTQYIRHASSPMHSPEPDCCHELLGHVPMLADRTFAQFSQDIGLASLGAS DEEIEKLSTVYWFTVEFGLCKQNGELKAYGAGLLSSYGELLHSLSEEPEIRAFDPDAAAV QPYQDQTYQPVYFVSESFSDAKDKLRGYASRIQRPFSVKFDPYAQAVDVLDSPHTIQRSL EGVQDQLHTLIHALSAIS NT seq 1497 nt NT seq  +upstreamnt  +downstreamnt atgcccacccccggcgccgccacaccgcagcccaagggctttcgaagggccgtctcagag ctggatgccaagcaggctgaggcaatcatgtccccacagttcatcgggcgtcggcagagc ctcattgaggatgctcgcaaggagcgggaggcagctgcggcggcagcagcagctgcagtg gtctcctcggagcctggggaccccccggaggcggtggcctttgaggaaaaggaggggaaa gctgtgctgaacctgctcttctcccttcggggctccaagccctctccgctgtcccgggca gtcaaggtgtttgagacatttgaagccaaaatccaccacctggagacccgtccagcctcg aggcaaagggccggtggcccctacctggaatactttgtgcgctttgaggtgcccagtggg gacctgcctgctctgcttagctctctgcgccgggtgtcggaggatgtgcgcagtgccagg gaggagaaggtcccatggttcccacgaaaggtgtccgagctggacaagtgtcaccacctg gtcaccaagtttgaccctgacctggacatggaccatccgggcttctcagaccaggtgtac cgccagcgccggaagttgattgccgagatcgccttccagtacaagcacggtgagccgatt ccccatgtggagtatacagctgaagagattgctacctggaaggaggtctacaccacgctg aagggcctctatgccacccatgcgtgccgggagcacctggagggcttccagctgctggag cgtttctgtggctaccgcgaggacagcattccacagctggaggacgtgtctcggttcctg aaggagcggaccggcttccagctgcggcccgtggctggcctgctgtctgcacgggacttc ctggccagcctggccttccgcgtgttccagtgcacccagtacatccgccatgcctcctcg cctatgcactcccctgagccggattgctgccacgagctgctgggacacgtgcccatgctg gccgatcgcacgtttgcccagttctcccaggacattggcctcgcgtccctgggagcctca gacgaggaaattgagaagttgtccacagtgtactggttcacagtggagtttgggctgtgc aaacagaatggagagctgaaggcctacggtgctgggttgctgtcctcctacggggagctc ctgcactccctctctgaggagcctgagatccgggccttcgaccccgatgctgccgctgtt cagccctaccaagaccagacctaccagccagtctacttcgtgtcagagagcttcagtgat gctaaggacaagctcaggggctatgcctctcgaatccagcgcccattctctgtgaagttc gacccctacgcacaggccgttgatgtgctggacagtccccacactatccaacgctcccta gagggtgtccaggaccagctgcataccctcatccacgcactgagtgccatcagctag

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