Homo sapiens (human): 10411
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Entry
10411 CDS
T01001
Symbol
RAPGEF3, CAMP-GEFI, EPAC, EPAC1, HSU79275, bcm910
Name
(RefSeq) Rap guanine nucleotide exchange factor 3
KO
K08014
Rap guanine nucleotide exchange factor 3
Organism
hsa
Homo sapiens (human)
Pathway
hsa04015
Rap1 signaling pathway
hsa04024
cAMP signaling pathway
hsa04072
Phospholipase D signaling pathway
hsa04081
Hormone signaling
hsa04261
Adrenergic signaling in cardiomyocytes
hsa04670
Leukocyte transendothelial migration
hsa04720
Long-term potentiation
hsa04726
Serotonergic synapse
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04015 Rap1 signaling pathway
10411 (RAPGEF3)
04072 Phospholipase D signaling pathway
10411 (RAPGEF3)
04024 cAMP signaling pathway
10411 (RAPGEF3)
09133 Signaling molecules and interaction
04081 Hormone signaling
10411 (RAPGEF3)
09150 Organismal Systems
09151 Immune system
04670 Leukocyte transendothelial migration
10411 (RAPGEF3)
09156 Nervous system
04726 Serotonergic synapse
10411 (RAPGEF3)
04720 Long-term potentiation
10411 (RAPGEF3)
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Gene cluster
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Motif
Pfam:
RasGEF
cNMP_binding
RasGEF_N
DEP
Motif
Other DBs
NCBI-GeneID:
10411
NCBI-ProteinID:
NP_001092002
OMIM:
606057
HGNC:
16629
Ensembl:
ENSG00000079337
UniProt:
O95398
Q99777
Structure
PDB
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Position
12:complement(47734363..47758880)
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AA seq
881 aa
AA seq
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MVLRRMHRPRSCSYQLLLEHQRPSCIQGLRWTPLTNSEESLDFSESLEQASTERVLRAGR
QLHRHLLATCPNLIRDRKYHLRLYRQCCSGRELVDGILALGLGVHSRSQVVGICQVLLDE
GALCHVKHDWAFQDRDAQFYRFPGPEPEPVGTHEMEEELAEAVALLSQRGPDALLTVALR
KPPGQRTDEELDLIFEELLHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTS
WYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVNDAPRAATIILREDNCHFLRVDKQDF
NRIIKDVEAKTMRLEEHGKVVLVLERASQGAGPSRPPTPGRNRYTVMSGTPEKILELLLE
AMGPDSSAHDPTETFLSDFLLTHRVFMPSAQLCAALLHHFHVEPAGGSEQERSTYVCNKR
QQILRLVSQWVALYGSMLHTDPVATSFLQKLSDLVGRDTRLSNLLREQWPERRRCHRLEN
GCGNASPQMKARNLPVWLPNQDEPLPGSSCAIQVGDKVPYDICRPDHSVLTLQLPVTASV
REVMAALAQEDGWTKGQVLVKVNSAGDAIGLQPDARGVATSLGLNERLFVVNPQEVHELI
PHPDQLGPTVGSAEGLDLVSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTA
NLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLS
NSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDM
TFIHEGNHTLVENLINFEKMRMMARAARMLHHCRSHNPVPLSPLRSRVSHLHEDSQVARI
STCSEQSLSTRSPASTWAYVQQLKVIDNQRELSRLSRELEP
NT seq
2646 nt
NT seq
+upstream
nt +downstream
nt
atggtgttgagaaggatgcaccggccccgaagctgctcctaccagctgctgctggagcac
cagcgtccgagctgcatccaggggctgcgctggacaccactcaccaacagcgaggagtcc
ctggatttcagcgagagcctggagcaggcctccacagagcgggtgctcagggctgggagg
cagctgcatcggcatctgctggccacctgcccaaacctcatccgagaccggaagtaccac
cttaggctctatcggcagtgctgctctggccgggagctggtggatgggatcttggccctg
ggacttggggtccattcccggagccaagttgtgggaatctgccaggtgctgctggatgaa
ggtgccctctgccatgtgaaacacgactgggccttccaggaccgagatgcccaattctac
cggttccccgggcccgagcccgagcccgtgggaactcatgagatggaggaggagttggcc
gaagctgtggccctgctctcccagcgggggcctgacgccctgctcactgtggcacttcga
aagcccccaggtcagcgcacggatgaagagctggacctcatctttgaggagctgctgcac
atcaaggctgtggcccacctctccaactcggtgaagcgagaattagcggctgttctgctc
tttgaaccacacagcaaggcagggaccgtgttgttcagccagggggacaagggcacttcg
tggtacattatctggaagggatctgtcaacgtggtgacccatggcaaggggctggtgacc
accctgcatgagggagatgattttggacagctggctctggtgaatgatgcaccccgggca
gccaccatcatcctgcgagaagacaactgtcatttcctgcgtgtggacaagcaggacttc
aaccgtatcatcaaggatgtggaggcaaagaccatgcggctggaagaacatggcaaagtg
gtgctggtgctggagagagcctctcagggcgccggcccttcccgacccccaaccccaggc
aggaaccggtatacagtgatgtctggcaccccagagaagatcctagagcttctgttggag
gccatgggaccagattccagtgctcatgacccaacagagacattcctcagcgacttcctc
ctgacccacagggtcttcatgcccagcgcccaactctgcgctgcccttctgcaccacttc
catgtggagcctgcgggtggcagcgagcaggagcgcagcacctacgtctgcaacaagagg
cagcagatcttgcggctggtcagccagtgggtggccctgtatggctccatgctccacact
gaccctgtggccaccagcttcctccagaaactctcagacctggtgggcagggacacccga
ctcagcaacctgctgagggagcagtggccagagaggcggcgatgccacaggttggagaat
ggctgtgggaatgcatctcctcagatgaaggcccggaacttgcctgtttggctccccaac
caggacgagccccttcctggcagcagctgtgccatccaagttggggataaagtcccctat
gacatctgccggccagaccactcagtgttgaccctgcagctgcctgtgacagcctccgtg
agagaggtgatggcagcgttggcccaggaggatggctggaccaaggggcaggtgctggtg
aaggtcaattctgcaggtgatgccattggcctgcagccagatgcccgtggtgtggccaca
tctctggggctcaatgagcgtctctttgttgtcaacccacaggaagtgcatgagctgatc
ccacaccctgaccagctggggcccactgtgggctctgctgaggggctggacctggtgagt
gccaaggacctggcaggccagctgacggaccacgactggagcctcttcaacagtatccac
caggtggagctgatccactatgtgctgggcccccagcatctgcgggatgtcaccaccgcc
aacctggagcgcttcatgcgccgcttcaatgagctgcagtactgggtggccaccgagctg
tgtctctgccccgtgcccggcccccgggcccagctgctcaggaagttcattaagctggcg
gcccacctcaaggagcagaagaatctcaattccttctttgccgtcatgtttggcctcagc
aactcggccatcagccgcctagcccacacctgggagcggctgcctcacaaagtccggaag
ctgtactccgccctcgagaggctgctggatccctcatggaaccaccgggtataccgactg
gccctcgccaagctctcccctcctgtcatccccttcatgccccttcttctcaaagacatg
accttcattcatgagggaaaccacacactagtggagaatctcatcaactttgagaagatg
agaatgatggccagagccgcgcggatgctgcaccactgccgaagccacaaccctgtgcct
ctctcaccactcagaagccgagtttcccacctccacgaggacagccaggtggcgaggatt
tccacatgctcggagcagtccctgagcacccggagtccagccagcacctgggcttatgtc
cagcagctgaaggtcattgacaaccagcgggaactctcccgcctctcccgagagctggag
ccatga
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