KEGG   ORTHOLOGY: K08014
Entry
K08014                      KO                                     
Symbol
RAPGEF3, EPAC1
Name
Rap guanine nucleotide exchange factor 3
Pathway
map04015  Rap1 signaling pathway
map04024  cAMP signaling pathway
map04072  Phospholipase D signaling pathway
map04261  Adrenergic signaling in cardiomyocytes
map04670  Leukocyte transendothelial migration
map04720  Long-term potentiation
map04726  Serotonergic synapse
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K08014  RAPGEF3, EPAC1; Rap guanine nucleotide exchange factor 3
   04072 Phospholipase D signaling pathway
    K08014  RAPGEF3, EPAC1; Rap guanine nucleotide exchange factor 3
   04024 cAMP signaling pathway
    K08014  RAPGEF3, EPAC1; Rap guanine nucleotide exchange factor 3
 09150 Organismal Systems
  09151 Immune system
   04670 Leukocyte transendothelial migration
    K08014  RAPGEF3, EPAC1; Rap guanine nucleotide exchange factor 3
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K08014  RAPGEF3, EPAC1; Rap guanine nucleotide exchange factor 3
  09156 Nervous system
   04726 Serotonergic synapse
    K08014  RAPGEF3, EPAC1; Rap guanine nucleotide exchange factor 3
   04720 Long-term potentiation
    K08014  RAPGEF3, EPAC1; Rap guanine nucleotide exchange factor 3
Genes
HSA: 10411(RAPGEF3)
PTR: 467198(RAPGEF3)
PPS: 100979763(RAPGEF3)
GGO: 101153785(RAPGEF3)
PON: 100174087(RAPGEF3)
NLE: 100592347(RAPGEF3)
MCC: 703967(RAPGEF3)
MCF: 101865707(RAPGEF3)
CSAB: 103238211(RAPGEF3)
CATY: 105580438(RAPGEF3)
PANU: 101025773 116268864(RAPGEF3) 116273061
TGE: 112635556(RAPGEF3)
RRO: 104654834(RAPGEF3)
RBB: 108515949(RAPGEF3)
TFN: 117090223(RAPGEF3)
PTEH: 111555300(RAPGEF3)
CJC: 100399583(RAPGEF3)
SBQ: 101043933(RAPGEF3)
CSYR: 103255783(RAPGEF3)
MMUR: 105864995(RAPGEF3)
LCAT: 123640470(RAPGEF3)
OGA: 100962179(RAPGEF3)
MMU: 223864(Rapgef3)
MCAL: 110310170(Rapgef3)
MPAH: 110334708(Rapgef3)
RNO: 59326(Rapgef3)
MCOC: 116078746(Rapgef3)
MUN: 110546167(Rapgef3)
CGE: 100767619(Rapgef3)
MAUA: 101828520(Rapgef3)
PLEU: 114708554(Rapgef3)
MORG: 121441440(Rapgef3)
AAMP: 119823360(Rapgef3)
NGI: 103740631(Rapgef3)
HGL: 101711127(Rapgef3)
CPOC: 100723672(Rapgef3)
CCAN: 109691611(Rapgef3)
DORD: 105987528(Rapgef3)
DSP: 122106262(Rapgef3)
NCAR: 124982354
OCU: 100356363(RAPGEF3)
OPI: 101523807(RAPGEF3)
TUP: 102502265(RAPGEF3)
CFA: 486591(RAPGEF3)
CLUD: 112678240(RAPGEF3)
VVP: 112921075(RAPGEF3)
VLG: 121479984(RAPGEF3)
AML: 100473947(RAPGEF3)
UMR: 103675595(RAPGEF3)
UAH: 113257686(RAPGEF3)
UAR: 123794811(RAPGEF3)
ELK: 111157928
LLV: 125107069
MPUF: 101682435(RAPGEF3)
ORO: 101371953(RAPGEF3)
EJU: 114224104(RAPGEF3)
ZCA: 113922250(RAPGEF3)
MLX: 118008918(RAPGEF3)
FCA: 101085387(RAPGEF3)
PYU: 121038668(RAPGEF3)
PBG: 122473326(RAPGEF3)
PTG: 102966186(RAPGEF3)
PPAD: 109249020(RAPGEF3)
AJU: 106969310(RAPGEF3)
HHV: 120239023(RAPGEF3)
BTA: 535383(RAPGEF3)
BOM: 102282215(RAPGEF3)
BIU: 109559177(RAPGEF3)
BBUB: 102407658(RAPGEF3)
CHX: 102178145(RAPGEF3)
OAS: 101109786(RAPGEF3)
CCAD: 122427721(RAPGEF3)
SSC: 100620989(RAPGEF3)
CFR: 102524040(RAPGEF3)
CBAI: 105076166(RAPGEF3)
CDK: 105103807(RAPGEF3)
VPC: 102527378(RAPGEF3)
BACU: 103005728(RAPGEF3)
LVE: 103080613(RAPGEF3)
OOR: 101278657(RAPGEF3)
DLE: 111174075(RAPGEF3)
PCAD: 102987186
PSIU: 116761070(RAPGEF3)
ECB: 100050541(RAPGEF3)
EPZ: 103546793(RAPGEF3)
EAI: 106836844(RAPGEF3)
MYB: 102257237(RAPGEF3)
MYD: 102768579(RAPGEF3)
MMYO: 118651234(RAPGEF3)
MLF: 102423490(RAPGEF3)
MNA: 107528219(RAPGEF3)
PKL: 118729444(RAPGEF3)
HAI: 109372517
DRO: 112318292(RAPGEF3)
SHON: 118997444(RAPGEF3)
AJM: 119041969(RAPGEF3)
PDIC: 114513019(RAPGEF3)
PHAS: 123812417(RAPGEF3)
MMF: 118623856(RAPGEF3)
RFQ: 117028527(RAPGEF3)
PALE: 102895678(RAPGEF3)
PVP: 105297498(RAPGEF3)
RAY: 107499884(RAPGEF3)
MJV: 108392459(RAPGEF3)
TOD: 119247598(RAPGEF3)
SARA: 101540127(RAPGEF3)
LAV: 100655802(RAPGEF3)
TMU: 101344659
DNM: 101417819(RAPGEF3)
GAS: 123249342(RAPGEF3)
SHR: 100925807(RAPGEF3)
PCW: 110201486(RAPGEF3)
OAA: 100680839(RAPGEF3)
GGA: 426888(RAPGEF3)
PCOC: 116239648(RAPGEF3)
MGP: 100539538(RAPGEF3)
CJO: 107325717(RAPGEF3)
NMEL: 110389221(RAPGEF3)
APLA: 101791788
ACYG: 106047705(RAPGEF3)
AFUL: 116499913(RAPGEF3)
TGU: 115491504(RAPGEF3)
LSR: 110481646(RAPGEF3)
SCAN: 115483875
PMOA: 120500674(RAPGEF3)
OTC: 121333700(RAPGEF3)
PRUF: 121353961(RAPGEF3)
GFR: 102039560(RAPGEF3)
FAB: 101814980(RAPGEF3)
PHI: 102110109(RAPGEF3)
PMAJ: 107198895
CBRC: 103613210
FPG: 101924930(RAPGEF3)
FCH: 102048878(RAPGEF3)
CLV: 102094087(RAPGEF3)
EGZ: 104132693(RAPGEF3)
NNI: 104011982(RAPGEF3)
ACUN: 113491036(RAPGEF3)
TALA: 116964163(RAPGEF3)
PADL: 103914893(RAPGEF3)
ACHC: 115351213(RAPGEF3)
OHA: 104336076
AAM: 106485098(RAPGEF3)
AROW: 112975385(RAPGEF3)
NPD: 112950330(RAPGEF3)
DNE: 112991008(RAPGEF3)
ASN: 102381678(RAPGEF3)
AMJ: 102574517(RAPGEF3)
CPOO: 109324408(RAPGEF3)
GGN: 109293213(RAPGEF3)
PSS: 102443863(RAPGEF3)
CMY: 102939607(RAPGEF3)
CPIC: 101931835(RAPGEF3)
TST: 117889092(RAPGEF3)
CABI: 116826941(RAPGEF3)
MRV: 120391129(RAPGEF3)
ACS: 100560594(rapgef3)
PVT: 110071318(RAPGEF3)
SUND: 121920804(RAPGEF3)
PBI: 103063904(RAPGEF3)
PMUR: 107288970(RAPGEF3)
TSR: 106556124
PGUT: 117666559(RAPGEF3)
VKO: 123024026(RAPGEF3)
PMUA: 114592897(RAPGEF3)
ZVI: 118077695(RAPGEF3)
GJA: 107109551(RAPGEF3)
STOW: 125429966(RAPGEF3)
XLA: 108708626(rapgef3.L) 108709885
XTR: 100491495(rapgef3)
NPR: 108800976(RAPGEF3)
RTEM: 120929384(RAPGEF3)
BGAR: 122930866(RAPGEF3)
DRE: 101886094(rapgef3)
PPRM: 120462943(rapgef3) 120463796
MAMB: 125259848(rapgef3)
IPU: 108275659(rapgef3)
PHYP: 113530617
SMEO: 124398619(rapgef3)
TFD: 113641742(rapgef3)
AMEX: 103025506
EEE: 113576412(rapgef3)
TRU: 101068679
LCO: 104919939
CGOB: 115004794
ELY: 117257965(rapgef3)
EFO: 125891149(rapgef3)
PLEP: 121946557(rapgef3)
SLUC: 116043746(rapgef3)
ECRA: 117946996(rapgef3)
PFLV: 114558191
GAT: 120828846(rapgef3)
PPUG: 119221891(rapgef3)
MSAM: 119905182(rapgef3)
CUD: 121517284(rapgef3)
ALAT: 119022621(rapgef3)
MZE: 101480994
ONL: 100711715
OAU: 116322009(rapgef3)
OLA: 101158525
OML: 112158872(rapgef3)
XMA: 102222768
XCO: 114140440
XHE: 116716747
PRET: 103467797
PFOR: 103139154
PLAI: 106955063
PMEI: 106904967
GAF: 122829278(rapgef3)
CVG: 107091899
CTUL: 119799402(rapgef3)
GMU: 124866665(rapgef3)
NFU: 107390402
KMR: 108237632(rapgef3)
ALIM: 106522985
NWH: 119416619(rapgef3)
AOCE: 111581117
MCEP: 125005434(rapgef3)
CSEM: 103385263
POV: 109643141
SSEN: 122777200(rapgef3)
HHIP: 117764433(rapgef3)
HSP: 118111533(rapgef3)
LCF: 108886373
SDU: 111235101
SLAL: 111661896
XGL: 120803283(rapgef3)
HCQ: 109513787(rapgef3)
BPEC: 110164588
MALB: 109970308
BSPL: 114858485(rapgef3)
OMY: 110492097(rapgef3) 110532567
OGO: 124032166 124045982(rapgef3)
ELS: 105022286
SFM: 108939388
PKI: 111840326(rapgef3)
AANG: 118208262(rapgef3)
LOC: 102696564(rapgef3)
PSPA: 121308884(rapgef3)
 » show all
Reference
  Authors
Gloerich M, Bos JL
  Title
Epac: defining a new mechanism for cAMP action.
  Journal
Annu Rev Pharmacol Toxicol 50:355-75 (2010)
DOI:10.1146/annurev.pharmtox.010909.105714
Reference
PMID:9856955
  Authors
Kawasaki H, Springett GM, Mochizuki N, Toki S, Nakaya M, Matsuda M, Housman DE, Graybiel AM
  Title
A family of cAMP-binding proteins that directly activate Rap1.
  Journal
Science 282:2275-9 (1998)
DOI:10.1126/science.282.5397.2275
  Sequence
[hsa:10411]
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