Homo sapiens (human): 10606
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Entry
10606 CDS
T01001
Symbol
PAICS, ADE2, ADE2H1, AIRC, PAICSD, PAIS
Name
(RefSeq) phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
KO
K01587
phosphoribosylaminoimidazole carboxylase / phosphoribosylaminoimidazole-succinocarboxamide synthase [EC:
4.1.1.21
6.3.2.6
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00230
Purine metabolism
hsa01100
Metabolic pathways
Module
hsa_M00048
De novo purine biosynthesis, PRPP + glutamine => IMP
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
10606 (PAICS)
Enzymes [BR:
hsa01000
]
4. Lyases
4.1 Carbon-carbon lyases
4.1.1 Carboxy-lyases
4.1.1.21 phosphoribosylaminoimidazole carboxylase
10606 (PAICS)
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.6 phosphoribosylaminoimidazolesuccinocarboxamide synthase
10606 (PAICS)
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SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
SAICAR_synt
AIRC
VCD
Motif
Other DBs
NCBI-GeneID:
10606
NCBI-ProteinID:
NP_001072992
OMIM:
172439
HGNC:
8587
Ensembl:
ENSG00000128050
UniProt:
P22234
Structure
PDB
PDBj
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All DBs
Position
4:56410507..56464578
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AA seq
425 aa
AA seq
DB search
MATAEVLNIGKKLYEGKTKEVYELLDSPGKVLLQSKDQITAGNAARKNHLEGKAAISNKI
TSCIFQLLQEAGIKTAFTRKCGETAFIAPQCEMIPIEWVCRRIATGSFLKRNPGVKEGYK
FYPPKVELFFKDDANNDPQWSEEQLIAAKFCFAGLLIGQTEVDIMSHATQAIFEILEKSW
LPQNCTLVDMKIEFGVDVTTKEIVLADVIDNDSWRLWPSGDRSQQKDKQSYRDLKEVTPE
GLQMVKKNFEWVAERVELLLKSESQCRVVVLMGSTSDLGHCEKIKKACGNFGIPCELRVT
SAHKGPDETLRIKAEYEGDGIPTVFVAVAGRSNGLGPVMSGNTAYPVISCPPLTPDWGVQ
DVWSSLRLPSGLGCSTVLSPEGSAQFAAQIFGLSNHLVWSKLRASILNTWISLKQADKKI
RECNL
NT seq
1278 nt
NT seq
+upstream
nt +downstream
nt
atggcgacagctgaggtactgaacattggtaaaaaattatatgagggtaaaacaaaagaa
gtctacgaattgttagacagtccaggaaaagtcctcctgcagtccaaggaccagattaca
gcaggaaatgcagctagaaaaaaccacctggaaggaaaagctgcaatctcaaataaaatc
accagttgtatttttcagttattacaggaagcaggtattaaaactgccttcaccagaaaa
tgtggggagacagctttcattgcaccgcagtgtgaaatgattccaattgaatgggtttgc
agaagaatagcaactggttcttttctcaaaagaaatcctggtgtcaaggaaggatataag
ttttacccacctaaagtggagttgtttttcaaggatgatgccaataatgacccacagtgg
tctgaggaacagctgattgctgcaaaattttgctttgctggacttcttataggccagact
gaagtggatatcatgagtcatgctacacaggctatatttgaaatactggagaaatcctgg
ttgccccagaattgtacactggttgatatgaagattgaatttggtgttgatgtaaccacc
aaagaaattgttcttgctgatgttattgacaatgattcctggagactctggccatcagga
gatcgaagccaacagaaagacaaacagtcttatcgggacctcaaagaagtaactcctgaa
gggctccaaatggtaaagaaaaactttgagtgggttgcagagagagtagagttgcttttg
aaatcagaaagtcagtgcagggttgtagtgttgatgggctctacttctgatcttggtcac
tgtgaaaaaatcaagaaggcctgtggaaattttggcattccatgtgaacttcgagtaaca
tctgcgcataaaggaccagatgaaactctgaggattaaagctgagtatgaaggggatggc
attcctactgtatttgtggcagtggcaggcagaagtaatggtttgggaccagtgatgtct
gggaacactgcatatccagttatcagctgtcctcccctcacaccagactggggagttcag
gatgtgtggtcttctcttcgactacccagtggtcttggctgttcaaccgtactttctcca
gaaggatcagctcaatttgctgctcagatatttgggttaagcaaccatttggtatggagc
aaactgcgagcaagcattttgaacacatggatttccttgaagcaggctgacaagaaaatc
agagaatgtaatttataa
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