Entry |
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Symbol |
CFTR, ABC35, ABCC7, CF, CFTR/MRP, MRP7, TNR-CFTR, dJ760C5.1
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Name |
(RefSeq) CF transmembrane conductance regulator
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KO |
K05031 | cystic fibrosis transmembrane conductance regulator [EC:5.6.1.6] |
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Organism |
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Pathway |
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Disease |
H00933 | Hereditary pancreatitis |
H01033 | Congenital bilateral absence of vas deferens |
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Drug target |
Deutivacaftor, tezacaftor and vanzacaftor: | D13024<US> |
Ivacaftor and lumacaftor: | D10685<US> |
Ivacaftor and tezacaftor: | D11042<US> |
Ivacaftor, tezacaftor and elexacaftor: | D11700<US> |
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Brite |
KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
09131 Membrane transport
02010 ABC transporters
1080 (CFTR)
09132 Signal transduction
04024 cAMP signaling pathway
1080 (CFTR)
04152 AMPK signaling pathway
1080 (CFTR)
09150 Organismal Systems
09154 Digestive system
04971 Gastric acid secretion
1080 (CFTR)
04972 Pancreatic secretion
1080 (CFTR)
04976 Bile secretion
1080 (CFTR)
09160 Human Diseases
09171 Infectious disease: bacterial
05110 Vibrio cholerae infection
1080 (CFTR)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
02000 Transporters [BR:hsa02000]
1080 (CFTR)
Enzymes [BR:hsa01000]
5. Isomerases
5.6 Isomerases altering macromolecular conformation
5.6.1 Enzymes altering polypeptide conformation or assembly
5.6.1.6 channel-conductance-controlling ATPase
1080 (CFTR)
Transporters [BR:hsa02000]
ABC transporters, eukaryotic type
ABCC (CFTR/MRP) subfamily
ABCC7 subgroup
1080 (CFTR)
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SSDB |
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Motif |
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Other DBs |
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Structure |
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LinkDB |
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Position |
7:117480025..117668665
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AA seq |
1480 aa
MQRSPLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRE
LASKKNPKLINALRRCFFWRFMFYGIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIA
IYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQL
VSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGL
GRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAA
YVRYFNSSAFFFSGFFVVFLSVLPYALIKGIILRKIFTTISFCIVLRMAVTRQFPWAVQT
WYDSLGAINKIQDFLQKQEYKTLEYNLTTTEVVMENVTAFWEEGFGELFEKAKQNNNNRK
TSNGDDSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEG
KIKHSGRISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIV
LGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTR
ILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLMGCDSFDQFSAERRNS
ILTETLHRFSLEGDAPVSWTETKKQSFKQTGEFGEKRKNSILNPINSIRKFSIVQKTPLQ
MNGIEEDSDEPLERRLSLVPDSEQGEAILPRISVISTGPTLQARRRQSVLNLMTHSVNQG
QNIHRKTTASTRKVSLAPQANLTELDIYSRRLSQETGLEISEEINEEDLKECFFDDMESI
PAVTTWNTYLRYITVHKSLIFVLIWCLVIFLAEVAASLVVLWLLGNTPLQDKGNSTHSRN
NSYAVIITSTSSYYVFYIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAP
MSTLNTLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATV
PVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHK
ALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTTGEGEGRVGIILTLAMNIM
STLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLSKVMIIENSHVKK
DDIWPSGGQMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRL
LNTEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVAD
EVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVT
YQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQA
ISPSDRVKLFPHRNSSKCKSKPQIAALKEETEEEVQDTRL |
NT seq |
4443 nt +upstreamnt +downstreamnt
atgcagaggtcgcctctggaaaaggccagcgttgtctccaaactttttttcagctggacc
agaccaattttgaggaaaggatacagacagcgcctggaattgtcagacatataccaaatc
ccttctgttgattctgctgacaatctatctgaaaaattggaaagagaatgggatagagag
ctggcttcaaagaaaaatcctaaactcattaatgcccttcggcgatgttttttctggaga
tttatgttctatggaatctttttatatttaggggaagtcaccaaagcagtacagcctctc
ttactgggaagaatcatagcttcctatgacccggataacaaggaggaacgctctatcgcg
atttatctaggcataggcttatgccttctctttattgtgaggacactgctcctacaccca
gccatttttggccttcatcacattggaatgcagatgagaatagctatgtttagtttgatt
tataagaagactttaaagctgtcaagccgtgttctagataaaataagtattggacaactt
gttagtctcctttccaacaacctgaacaaatttgatgaaggacttgcattggcacatttc
gtgtggatcgctcctttgcaagtggcactcctcatggggctaatctgggagttgttacag
gcgtctgccttctgtggacttggtttcctgatagtccttgccctttttcaggctgggcta
gggagaatgatgatgaagtacagagatcagagagctgggaagatcagtgaaagacttgtg
attacctcagaaatgattgaaaatatccaatctgttaaggcatactgctgggaagaagca
atggaaaaaatgattgaaaacttaagacaaacagaactgaaactgactcggaaggcagcc
tatgtgagatacttcaatagctcagccttcttcttctcagggttctttgtggtgttttta
tctgtgcttccctatgcactaatcaaaggaatcatcctccggaaaatattcaccaccatc
tcattctgcattgttctgcgcatggcggtcactcggcaatttccctgggctgtacaaaca
tggtatgactctcttggagcaataaacaaaatacaggatttcttacaaaagcaagaatat
aagacattggaatataacttaacgactacagaagtagtgatggagaatgtaacagccttc
tgggaggagggatttggggaattatttgagaaagcaaaacaaaacaataacaatagaaaa
acttctaatggtgatgacagcctcttcttcagtaatttctcacttcttggtactcctgtc
ctgaaagatattaatttcaagatagaaagaggacagttgttggcggttgctggatccact
ggagcaggcaagacttcacttctaatggtgattatgggagaactggagccttcagagggt
aaaattaagcacagtggaagaatttcattctgttctcagttttcctggattatgcctggc
accattaaagaaaatatcatctttggtgtttcctatgatgaatatagatacagaagcgtc
atcaaagcatgccaactagaagaggacatctccaagtttgcagagaaagacaatatagtt
cttggagaaggtggaatcacactgagtggaggtcaacgagcaagaatttctttagcaaga
gcagtatacaaagatgctgatttgtatttattagactctccttttggatacctagatgtt
ttaacagaaaaagaaatatttgaaagctgtgtctgtaaactgatggctaacaaaactagg
attttggtcacttctaaaatggaacatttaaagaaagctgacaaaatattaattttgcat
gaaggtagcagctatttttatgggacattttcagaactccaaaatctacagccagacttt
agctcaaaactcatgggatgtgattctttcgaccaatttagtgcagaaagaagaaattca
atcctaactgagaccttacaccgtttctcattagaaggagatgctcctgtctcctggaca
gaaacaaaaaaacaatcttttaaacagactggagagtttggggaaaaaaggaagaattct
attctcaatccaatcaactctatacgaaaattttccattgtgcaaaagactcccttacaa
atgaatggcatcgaagaggattctgatgagcctttagagagaaggctgtccttagtacca
gattctgagcagggagaggcgatactgcctcgcatcagcgtgatcagcactggccccacg
cttcaggcacgaaggaggcagtctgtcctgaacctgatgacacactcagttaaccaaggt
cagaacattcaccgaaagacaacagcatccacacgaaaagtgtcactggcccctcaggca
aacttgactgaactggatatatattcaagaaggttatctcaagaaactggcttggaaata
agtgaagaaattaacgaagaagacttaaaggagtgcttttttgatgatatggagagcata
ccagcagtgactacatggaacacataccttcgatatattactgtccacaagagcttaatt
tttgtgctaatttggtgcttagtaatttttctggcagaggtggctgcttctttggttgtg
ctgtggctccttggaaacactcctcttcaagacaaagggaatagtactcatagtagaaat
aacagctatgcagtgattatcaccagcaccagttcgtattatgtgttttacatttacgtg
ggagtagccgacactttgcttgctatgggattcttcagaggtctaccactggtgcatact
ctaatcacagtgtcgaaaattttacaccacaaaatgttacattctgttcttcaagcacct
atgtcaaccctcaacacgttgaaagcaggtgggattcttaatagattctccaaagatata
gcaattttggatgaccttctgcctcttaccatatttgacttcatccagttgttattaatt
gtgattggagctatagcagttgtcgcagttttacaaccctacatctttgttgcaacagtg
ccagtgatagtggcttttattatgttgagagcatatttcctccaaacctcacagcaactc
aaacaactggaatctgaaggcaggagtccaattttcactcatcttgttacaagcttaaaa
ggactatggacacttcgtgccttcggacggcagccttactttgaaactctgttccacaaa
gctctgaatttacatactgccaactggttcttgtacctgtcaacactgcgctggttccaa
atgagaatagaaatgatttttgtcatcttcttcattgctgttaccttcatttccatttta
acaacaggagaaggagaaggaagagttggtattatcctgactttagccatgaatatcatg
agtacattgcagtgggctgtaaactccagcatagatgtggatagcttgatgcgatctgtg
agccgagtctttaagttcattgacatgccaacagaaggtaaacctaccaagtcaaccaaa
ccatacaagaatggccaactctcgaaagttatgattattgagaattcacacgtgaagaaa
gatgacatctggccctcagggggccaaatgactgtcaaagatctcacagcaaaatacaca
gaaggtggaaatgccatattagagaacatttccttctcaataagtcctggccagagggtg
ggcctcttgggaagaactggatcagggaagagtactttgttatcagcttttttgagacta
ctgaacactgaaggagaaatccagatcgatggtgtgtcttgggattcaataactttgcaa
cagtggaggaaagcctttggagtgataccacagaaagtatttattttttctggaacattt
agaaaaaacttggatccctatgaacagtggagtgatcaagaaatatggaaagttgcagat
gaggttgggctcagatctgtgatagaacagtttcctgggaagcttgactttgtccttgtg
gatgggggctgtgtcctaagccatggccacaagcagttgatgtgcttggctagatctgtt
ctcagtaaggcgaagatcttgctgcttgatgaacccagtgctcatttggatccagtaaca
taccaaataattagaagaactctaaaacaagcatttgctgattgcacagtaattctctgt
gaacacaggatagaagcaatgctggaatgccaacaatttttggtcatagaagagaacaaa
gtgcggcagtacgattccatccagaaactgctgaacgagaggagcctcttccggcaagcc
atcagcccctccgacagggtgaagctctttccccaccggaactcaagcaagtgcaagtct
aagccccagattgctgctctgaaagaggagacagaagaagaggtgcaagatacaaggctt
tag |