Homo sapiens (human): 1352
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Entry
1352 CDS
T01001
Symbol
COX10, MC4DN3
Name
(RefSeq) cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10
KO
K02257
heme o synthase [EC:
2.5.1.141
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00190
Oxidative phosphorylation
hsa00860
Porphyrin metabolism
hsa01100
Metabolic pathways
hsa01240
Biosynthesis of cofactors
hsa04714
Thermogenesis
Module
hsa_M00154
Cytochrome c oxidase
Network
nt06529
Thermogenesis
Element
N01691
mitochondrial complex - UCP1 in Thermogenesis
Disease
H01368
Cytochrome c oxidase (COX) deficiency
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09102 Energy metabolism
00190 Oxidative phosphorylation
1352 (COX10)
09108 Metabolism of cofactors and vitamins
00860 Porphyrin metabolism
1352 (COX10)
09150 Organismal Systems
09159 Environmental adaptation
04714 Thermogenesis
1352 (COX10)
09180 Brite Hierarchies
09181 Protein families: metabolism
01006 Prenyltransferases [BR:
hsa01006
]
1352 (COX10)
09182 Protein families: genetic information processing
03029 Mitochondrial biogenesis [BR:
hsa03029
]
1352 (COX10)
Enzymes [BR:
hsa01000
]
2. Transferases
2.5 Transferring alkyl or aryl groups, other than methyl groups
2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
2.5.1.141 heme o synthase
1352 (COX10)
Prenyltransferases [BR:
hsa01006
]
Compound prenylation
Protoheme farnesyltransferase
1352 (COX10)
Mitochondrial biogenesis [BR:
hsa03029
]
Mitochondrial quality control factors
Mitochondrial respiratory chain complex assembly factors
Complex-IV assembly factors
1352 (COX10)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
UbiA
Motif
Other DBs
NCBI-GeneID:
1352
NCBI-ProteinID:
NP_001294
OMIM:
602125
HGNC:
2260
Ensembl:
ENSG00000006695
Pharos:
Q12887
(Tbio)
UniProt:
Q12887
LinkDB
All DBs
Position
17:14069504..14208677
Genome browser
AA seq
443 aa
AA seq
DB search
MAASPHTLSSRLLTGCVGGSVWYLERRTIQDSPHKFLHLLRNVNKQWITFQHFSFLKRMY
VTQLNRSHNQQVRPKPEPVASPFLEKTSSGQAKAEIYEMRPLSPPSLSLSRKPNEKELIE
LEPDSVIEDSIDVGKETKEEKRWKEMKLQVYDLPGILARLSKIKLTALVVSTTAAGFALA
PGPFDWPCFLLTSVGTGLASCAANSINQFFEVPFDSNMNRTKNRPLVRGQISPLLAVSFA
TCCAVPGVAILTLGVNPLTGALGLFNIFLYTCCYTPLKRISIANTWVGAVVGAIPPVMGW
TAATGSLDAGAFLLGGILYSWQFPHFNALSWGLREDYSRGGYCMMSVTHPGLCRRVALRH
CLALLVLSAAAPVLDITTWTFPIMALPINAYISYLGFRFYVDADRRSSRRLFFCSLWHLP
LLLLLMLTCKRPSGGGDAGPPPS
NT seq
1332 nt
NT seq
+upstream
nt +downstream
nt
atggccgcatctccgcacactctctcctcacgcctcctgacaggttgcgtaggaggctct
gtctggtatcttgaaagaagaactatacaggactcccctcacaagttcttacatcttctc
aggaatgtcaataagcagtggattacatttcagcactttagcttcctcaaacgcatgtat
gtcacacagctgaacagaagccacaaccagcaagtaagacccaagccagaaccagtagca
tctcctttccttgaaaaaacatcttcaggtcaagccaaagcagaaatatatgagatgaga
cctctctcaccgcccagcctatctttgtccagaaagccaaatgaaaaggaattgatagaa
ctagagccagactcagtaattgaagactcaatagatgtagggaaagagacaaaagaggaa
aagcggtggaaagagatgaagctgcaagtgtatgatttgccaggaattttggctcgacta
tccaaaatcaaactcacagctctggttgtaagtaccactgcagctggatttgcattggct
ccgggcccttttgactggccctgtttcctgcttacttctgttgggacaggccttgcatcc
tgtgctgccaactccatcaatcagttttttgaggtgccatttgactcaaacatgaatagg
acaaagaacagaccgctggttcgtggacagatcagcccattgctagctgtgtcctttgcc
acttgttgtgctgttccgggagttgccattctgaccttgggggtgaatccactcacagga
gccctggggctcttcaacattttcctgtatacctgctgctacacaccactgaaaaggatc
agcattgccaacacatgggtcggagctgtggttggggccatcccgcctgtcatgggctgg
acagcggccacgggcagcctcgatgctggcgcatttctcctgggaggaatcctctactcc
tggcagtttcctcatttcaacgccctgagctggggcctccgtgaagactactcccggggc
ggctactgcatgatgtcggtcacccacccgggcctgtgccggcgcgtggcgctgcgccac
tgcctggccctgctcgtgctgtccgcagcagcccctgtgctggacatcaccacatggacc
ttccccatcatggcccttcccatcaatgcgtacatctcctacctcggcttccgcttctac
gtggacgcagaccgcaggagctcgcggagactgttcttctgcagcctgtggcacctgccg
ctgctgctgctgctcatgctcacctgcaagcggccgagcggaggcggggacgcagggccc
cctcccagctga
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