KEGG   NETWORK: N01691
Entry
N01691                      Network                                
Name
mitochondrial complex - UCP1 in Thermogenesis
Definition
CxI == CxII == CxIII == CxIV == ATPase -> UCP1
  Expanded
(4719,4720,4722,4724,4726,374291,4728,4723,4729,4694,4695,4700,4702,4704,4705,126328,55967,51079,4709,4714,4715,4716,54539,4718,51103,91942,25915,29078,79133,137682,284184,4713) == (6389,6390,6391,6392) == (7386,1537,7385,7381,27089) == (1327,9377,1339,1340,1351,1352,84987,1355,51241,116228,28958,493753,388753,4697,1353) == (514,498,513,539,4508) -> 7350
Class
nt06529 Thermogenesis
Type
Reference
Pathway
hsa04714  Thermogenesis
Gene
4719  NDUFS1; NADH:ubiquinone oxidoreductase core subunit S1
4720  NDUFS2; NADH:ubiquinone oxidoreductase core subunit S2
4722  NDUFS3; NADH:ubiquinone oxidoreductase core subunit S3
4724  NDUFS4; NADH:ubiquinone oxidoreductase subunit S4
4726  NDUFS6; NADH:ubiquinone oxidoreductase subunit S6
374291  NDUFS7; NADH:ubiquinone oxidoreductase core subunit S7
4728  NDUFS8; NADH:ubiquinone oxidoreductase core subunit S8
4723  NDUFV1; NADH:ubiquinone oxidoreductase core subunit V1
4729  NDUFV2; NADH:ubiquinone oxidoreductase core subunit V2
4694  NDUFA1; NADH:ubiquinone oxidoreductase subunit A1
4695  NDUFA2; NADH:ubiquinone oxidoreductase subunit A2
4700  NDUFA6; NADH:ubiquinone oxidoreductase subunit A6
4702  NDUFA8; NADH:ubiquinone oxidoreductase subunit A8
4704  NDUFA9; NADH:ubiquinone oxidoreductase subunit A9
4705  NDUFA10; NADH:ubiquinone oxidoreductase subunit A10
126328  NDUFA11; NADH:ubiquinone oxidoreductase subunit A11
55967  NDUFA12; NADH:ubiquinone oxidoreductase subunit A12
51079  NDUFA13; NADH:ubiquinone oxidoreductase subunit A13
4709  NDUFB3; NADH:ubiquinone oxidoreductase subunit B3
4714  NDUFB8; NADH:ubiquinone oxidoreductase subunit B8
4715  NDUFB9; NADH:ubiquinone oxidoreductase subunit B9
4716  NDUFB10; NADH:ubiquinone oxidoreductase subunit B10
54539  NDUFB11; NADH:ubiquinone oxidoreductase subunit B11
4718  NDUFC2; NADH:ubiquinone oxidoreductase subunit C2
51103  NDUFAF1; NADH:ubiquinone oxidoreductase complex assembly factor 1
91942  NDUFAF2; NADH:ubiquinone oxidoreductase complex assembly factor 2
25915  NDUFAF3; NADH:ubiquinone oxidoreductase complex assembly factor 3
29078  NDUFAF4; NADH:ubiquinone oxidoreductase complex assembly factor 4
79133  NDUFAF5; NADH:ubiquinone oxidoreductase complex assembly factor 5
137682  NDUFAF6; NADH:ubiquinone oxidoreductase complex assembly factor 6
284184  NDUFAF8; NADH:ubiquinone oxidoreductase complex assembly factor 8
4713  NDUFB7; NADH:ubiquinone oxidoreductase subunit B7
6389  SDHA; succinate dehydrogenase complex flavoprotein subunit A
6390  SDHB; succinate dehydrogenase complex iron sulfur subunit B
6391  SDHC; succinate dehydrogenase complex subunit C
6392  SDHD; succinate dehydrogenase complex subunit D
7386  UQCRFS1; ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
1537  CYC1; cytochrome c1
7385  UQCRC2; ubiquinol-cytochrome c reductase core protein 2
7381  UQCRB; ubiquinol-cytochrome c reductase binding protein
27089  UQCRQ; ubiquinol-cytochrome c reductase complex III subunit VII
1327  COX4I1; cytochrome c oxidase subunit 4I1
9377  COX5A; cytochrome c oxidase subunit 5A
1339  COX6A2; cytochrome c oxidase subunit 6A2
1340  COX6B1; cytochrome c oxidase subunit 6B1
1351  COX8A; cytochrome c oxidase subunit 8A
1352  COX10; cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10
84987  COX14; cytochrome c oxidase assembly factor COX14
1355  COX15; cytochrome c oxidase assembly homolog COX15
51241  COX16; cytochrome c oxidase assembly factor COX16
116228  COX20; cytochrome c oxidase assembly factor COX20
28958  COA3; cytochrome c oxidase assembly factor 3
493753  COA5; cytochrome c oxidase assembly factor 5
388753  COA6; cytochrome c oxidase assembly factor 6
4697  NDUFA4; NDUFA4 mitochondrial complex associated
1353  COX11; cytochrome c oxidase copper chaperone COX11
514  ATP5F1E; ATP synthase F1 subunit epsilon
498  ATP5F1A; ATP synthase F1 subunit alpha
513  ATP5F1D; ATP synthase F1 subunit delta
539  ATP5PO; ATP synthase peripheral stalk subunit OSCP
4508  ATP6; ATP synthase F0 subunit 6
7350  UCP1; uncoupling protein 1
Reference
PMID:36674862
  Authors
Takeda Y, Harada Y, Yoshikawa T, Dai P
  Title
Mitochondrial Energy Metabolism in the Regulation of Thermogenic Brown Fats and Human Metabolic Diseases.
  Journal
Int J Mol Sci 24:ijms24021352 (2023)
DOI:10.3390/ijms24021352
Reference
PMID:33758402
  Authors
Cohen P, Kajimura S
  Title
The cellular and functional complexity of thermogenic fat.
  Journal
Nat Rev Mol Cell Biol 22:393-409 (2021)
DOI:10.1038/s41580-021-00350-0
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