Homo sapiens (human): 140885
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Entry
140885 CDS
T01001
Symbol
SIRPA, BIT, CD172A, MFR, MYD-1, P84, PTPNS1, SHPS1, SIRP
Name
(RefSeq) signal regulatory protein alpha
KO
K06551
signal-regulatory protein alpha/beta1/gamma
Organism
hsa
Homo sapiens (human)
Pathway
hsa04148
Efferocytosis
hsa04380
Osteoclast differentiation
Network
nt06535
Efferocytosis
Element
N01785
Don't eat me signal (CD47)
Drug target
Anzurstobart:
D12342
Maplirpacept:
D12826
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09140 Cellular Processes
09141 Transport and catabolism
04148 Efferocytosis
140885 (SIRPA)
09150 Organismal Systems
09158 Development and regeneration
04380 Osteoclast differentiation
140885 (SIRPA)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04515 Cell adhesion molecules [BR:
hsa04515
]
140885 (SIRPA)
04090 CD molecules [BR:
hsa04090
]
140885 (SIRPA)
Cell adhesion molecules [BR:
hsa04515
]
Immunoglobulin superfamily
SIRP family
140885 (SIRPA)
CD molecules [BR:
hsa04090
]
Proteins
140885 (SIRPA)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
C1-set
C2-set_2
Ig_3
V-set
Ig_2
ig
I-set
SIT
C2-set_3
Psg1
CcmD_alt
TMEM132_C
Eryth_link_C
Orf78
TMEM154
Mid2
DUF4577
Syndecan
Motif
Other DBs
NCBI-GeneID:
140885
NCBI-ProteinID:
NP_001035111
OMIM:
602461
HGNC:
9662
Ensembl:
ENSG00000198053
UniProt:
P78324
Structure
PDB
PDBj
LinkDB
All DBs
Position
20:1894167..1940592
Genome browser
AA seq
504 aa
AA seq
DB search
MEPAGPAPGRLGPLLCLLLAASCAWSGVAGEEELQVIQPDKSVLVAAGETATLRCTATSL
IPVGPIQWFRGAGPGRELIYNQKEGHFPRVTTVSDLTKRNNMDFSIRIGNITPADAGTYY
CVKFRKGSPDDVEFKSGAGTELSVRAKPSAPVVSGPAARATPQHTVSFTCESHGFSPRDI
TLKWFKNGNELSDFQTNVDPVGESVSYSIHSTAKVVLTREDVHSQVICEVAHVTLQGDPL
RGTANLSETIRVPPTLEVTQQPVRAENQVNVTCQVRKFYPQRLQLTWLENGNVSRTETAS
TVTENKDGTYNWMSWLLVNVSAHRDDVKLTCQVEHDGQPAVSKSHDLKVSAHPKEQGSNT
AAENTGSNERNIYIVVGVVCTLLVALLMAALYLVRIRQKKAQGSTSSTRLHEPEKNAREI
TQDTNDITYADLNLPKGKKPAPQAAEPNNHTEYASIQTSPQPASEDTLTYADLDMVHLNR
TPKQPAPKPEPSFSEYASVQVPRK
NT seq
1515 nt
NT seq
+upstream
nt +downstream
nt
atggagcccgccggcccggcccccggccgcctcgggccgctgctctgcctgctgctcgcc
gcgtcctgcgcctggtcaggagtggcgggtgaggaggagctgcaggtgattcagcctgac
aagtccgtgttggttgcagctggagagacagccactctgcgctgcactgcgacctctctg
atccctgtggggcccatccagtggttcagaggagctggaccaggccgggaattaatctac
aatcaaaaagaaggccacttcccccgggtaacaactgtttcagacctcacaaagagaaac
aacatggacttttccatccgcatcggtaacatcaccccagcagatgccggcacctactac
tgtgtgaagttccggaaagggagccccgatgacgtggagtttaagtctggagcaggcact
gagctgtctgtgcgcgccaaaccctctgcccccgtggtatcgggccctgcggcgagggcc
acacctcagcacacagtgagcttcacctgcgagtcccacggcttctcacccagagacatc
accctgaaatggttcaaaaatgggaatgagctctcagacttccagaccaacgtggacccc
gtaggagagagcgtgtcctacagcatccacagcacagccaaggtggtgctgacccgcgag
gacgttcactctcaagtcatctgcgaggtggcccacgtcaccttgcagggggaccctctt
cgtgggactgccaacttgtctgagaccatccgagttccacccaccttggaggttactcaa
cagcccgtgagggcagagaaccaggtgaatgtcacctgccaggtgaggaagttctacccc
cagagactacagctgacctggttggagaatggaaacgtgtcccggacagaaacggcctca
accgttacagagaacaaggatggtacctacaactggatgagctggctcctggtgaatgta
tctgcccacagggatgatgtgaagctcacctgccaggtggagcatgacgggcagccagcg
gtcagcaaaagccatgacctgaaggtctcagcccacccgaaggagcagggctcaaatacc
gccgctgagaacactggatctaatgaacggaacatctatattgtggtgggtgtggtgtgc
accttgctggtggccctactgatggcggccctctacctcgtccgaatcagacagaagaaa
gcccagggctccacttcttctacaaggttgcatgagcccgagaagaatgccagagaaata
acacaggacacaaatgatatcacatatgcagacctgaacctgcccaaggggaagaagcct
gctccccaggctgcggagcccaacaaccacacggagtatgccagcattcagaccagcccg
cagcccgcgtcggaggacaccctcacctatgctgacctggacatggtccacctcaaccgg
acccccaagcagccggcccccaagcctgagccgtccttctcagagtacgccagcgtccag
gtcccgaggaagtga
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