Homo sapiens (human): 1431 Help Entry 1431              CDS       T01001                                  Symbol CS Name (RefSeq) citrate synthase   KO K01647   citrate synthase [EC:2.3.3.1] Organism hsa  Homo sapiens (human) Pathway hsa00020   Citrate cycle (TCA cycle) hsa00630   Glyoxylate and dicarboxylate metabolism hsa01100   Metabolic pathways hsa01200   Carbon metabolism hsa01210   2-Oxocarboxylic acid metabolism hsa01230   Biosynthesis of amino acids Module hsa_M00009   Citrate cycle (TCA cycle, Krebs cycle) hsa_M00010   Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate Network nt06031  Citrate cycle and pyruvate metabolism   Element N01604   Citrate cycle, first carbon oxidation Brite KEGG Orthology (KO) [BR:hsa00001]  09100 Metabolism   09101 Carbohydrate metabolism    00020 Citrate cycle (TCA cycle)     1431 (CS)    00630 Glyoxylate and dicarboxylate metabolism     1431 (CS) Enzymes [BR:hsa01000]  2. Transferases   2.3  Acyltransferases    2.3.3  Acyl groups converted into alkyl groups on transfer     2.3.3.1  citrate (Si)-synthase      1431 (CS) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Citrate_synt PAS_3 Queuosine_synth Motif Other DBs NCBI-GeneID:  1431 NCBI-ProteinID:  NP_004068 OMIM:  118950 HGNC:  2422 Ensembl:  ENSG00000062485 UniProt:  O75390 Structure PDBPDBj LinkDB All DBs Position 12:complement(56271699..56300330) Genome browser AA seq 466 aa AA seqDB search MALLTAAARLLGTKNASCLVLAARHASASSTNLKDILADLIPKEQARIKTFRQQHGKTVV GQITVDMMYGGMRGMKGLVYETSVLDPDEGIRFRGFSIPECQKLLPKAKGGEEPLPEGLF WLLVTGHIPTEEQVSWLSKEWAKRAALPSHVVTMLDNFPTNLHPMSQLSAAVTALNSESN FARAYAQGISRTKYWELIYEDSMDLIAKLPCVAAKIYRNLYREGSGIGAIDSNLDWSHNF TNMLGYTDHQFTELTRLYLTIHSDHEGGNVSAHTSHLVGSALSDPYLSFAAAMNGLAGPL HGLANQEVLVWLTQLQKEVGKDVSDEKLRDYIWNTLNSGRVVPGYGHAVLRKTDPRYTCQ REFALKHLPNDPMFKLVAQLYKIVPNVLLEQGKAKNPWPNVDAHSGVLLQYYGMTEMNYY TVLFGVSRALGVLAQLIWSRALGFPLERPKSMSTEGLMKFVDSKSG NT seq 1401 nt NT seq  +upstreamnt  +downstreamnt atggctttacttactgcggccgcccggctcttgggaaccaagaatgcatcttgtcttgtt cttgcagcccggcatgccagtgcttcctccacgaatttgaaagacatattggctgacctg atacctaaggagcaggccagaattaagactttcaggcagcaacatggcaagacggtggtg ggccaaatcactgtggacatgatgtatggtggcatgagaggcatgaagggattggtctat gaaacatcagttcttgatcctgatgagggcatccgtttccgaggctttagtatccctgaa tgccagaaactgctacccaaggctaagggtggggaagaacccctgcctgagggcttattt tggctgctggtaactggacatatcccaacagaggaacaggtatcttggctctcaaaagag tgggcaaagagggcagctctgccttcccatgtggtcaccatgctggacaactttcccacc aatctacaccccatgtctcagctcagtgcagctgttacagccctcaacagtgaaagtaac tttgcccgagcatatgcacagggtatcagccgaaccaagtactgggagttgatttatgaa gactctatggatctaatcgcaaagctaccttgtgttgcagcaaagatctaccgaaatctc tacagagaaggcagcggtattggggccattgactctaacctggactggtctcacaatttc accaacatgttaggctatactgatcatcagttcactgagctcacgcgcctgtacctcacc atccacagtgaccatgagggtggcaatgtaagtgcccataccagccatttggtgggcagt gccctttccgacccttacctgtcctttgcagcagccatgaacgggctggcagggcctctc catggactggcaaatcaggaagtgcttgtctggctaacacagctgcagaaggaagttggc aaagatgtgtcagatgagaagttacgagactacatctggaacacactcaactcaggacgg gttgttccaggctatggccatgcagtactaaggaagactgatccgcgatatacctgtcag cgagagtttgctctgaaacacctgcctaatgaccccatgtttaagttggttgctcagctg tacaagattgtgcccaatgtcctcttagagcagggtaaagccaagaatccttggcccaat gtagatgctcacagtggggtgctgctccagtattatggcatgacggagatgaattactac acggtcctgtttggggtgtcacgagcattgggtgtactggcacagctcatctggagccga gccttaggcttccctctagaaaggcccaagtccatgagcacagagggtctgatgaagttt gtggactctaagtcagggtaa

Homo sapiens (human): 47 Help Entry 47                CDS       T01001                                  Symbol ACLY, ACL, ATPCL, CLATP Name (RefSeq) ATP citrate lyase   KO K01648   ATP citrate (pro-S)-lyase [EC:2.3.3.8] Organism hsa  Homo sapiens (human) Pathway hsa00020   Citrate cycle (TCA cycle) hsa01100   Metabolic pathways Network nt06031  Citrate cycle and pyruvate metabolism   Element N01604   Citrate cycle, first carbon oxidation Drug target Bempedoic acid:  D10691<US> Brite KEGG Orthology (KO) [BR:hsa00001]  09100 Metabolism   09101 Carbohydrate metabolism    00020 Citrate cycle (TCA cycle)     47 (ACLY)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:hsa04147]     47 (ACLY) Enzymes [BR:hsa01000]  2. Transferases   2.3  Acyltransferases    2.3.3  Acyl groups converted into alkyl groups on transfer     2.3.3.8  ATP citrate synthase      47 (ACLY) Exosome [BR:hsa04147]  Exosomal proteins   Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)    47 (ACLY)   Exosomal proteins of bladder cancer cells    47 (ACLY)   Exosomal proteins of melanoma cells    47 (ACLY) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Citrate_synth_N Citrate_bind Citrate_synt Ligase_CoA CoA_binding ATP-grasp_2 Succ_CoA_lig Motif Other DBs NCBI-GeneID:  47 NCBI-ProteinID:  NP_001087 OMIM:  108728 HGNC:  115 Ensembl:  ENSG00000131473 UniProt:  P53396 Structure PDBPDBj LinkDB All DBs Position 17:complement(41866917..41930545) Genome browser AA seq 1101 aa AA seqDB search MSAKAISEQTGKELLYKFICTTSAIQNRFKYARVTPDTDWARLLQDHPWLLSQNLVVKPD QLIKRRGKLGLVGVNLTLDGVKSWLKPRLGQEATVGKATGFLKNFLIEPFVPHSQAEEFY VCIYATREGDYVLFHHEGGVDVGDVDAKAQKLLVGVDEKLNPEDIKKHLLVHAPEDKKEI LASFISGLFNFYEDLYFTYLEINPLVVTKDGVYVLDLAAKVDATADYICKVKWGDIEFPP PFGREAYPEEAYIADLDAKSGASLKLTLLNPKGRIWTMVAGGGASVVYSDTICDLGGVNE LANYGEYSGAPSEQQTYDYAKTILSLMTREKHPDGKILIIGGSIANFTNVAATFKGIVRA IRDYQGPLKEHEVTIFVRRGGPNYQEGLRVMGEVGKTTGIPIHVFGTETHMTAIVGMALG HRPIPNQPPTAAHTANFLLNASGSTSTPAPSRTASFSESRADEVAPAKKAKPAMPQDSVP SPRSLQGKSTTLFSRHTKAIVWGMQTRAVQGMLDFDYVCSRDEPSVAAMVYPFTGDHKQK FYWGHKEILIPVFKNMADAMRKHPEVDVLINFASLRSAYDSTMETMNYAQIRTIAIIAEG IPEALTRKLIKKADQKGVTIIGPATVGGIKPGCFKIGNTGGMLDNILASKLYRPGSVAYV SRSGGMSNELNNIISRTTDGVYEGVAIGGDRYPGSTFMDHVLRYQDTPGVKMIVVLGEIG GTEEYKICRGIKEGRLTKPIVCWCIGTCATMFSSEVQFGHAGACANQASETAVAKNQALK EAGVFVPRSFDELGEIIQSVYEDLVANGVIVPAQEVPPPTVPMDYSWARELGLIRKPASF MTSICDERGQELIYAGMPITEVFKEEMGIGGVLGLLWFQKRLPKYSCQFIEMCLMVTADH GPAVSGAHNTIICARAGKDLVSSLTSGLLTIGDRFGGALDAAAKMFSKAFDSGIIPMEFV NKMKKEGKLIMGIGHRVKSINNPDMRVQILKDYVRQHFPATPLLDYALEVEKITTSKKPN LILNVDGLIGVAFVDMLRNCGSFTREEADEYIDIGALNGIFVLGRSMGFIGHYLDQKRLK QGLYRHPWDDISYVLPEHMSM NT seq 3306 nt NT seq  +upstreamnt  +downstreamnt atgtcggccaaggcaatttcagagcagacgggcaaagaactcctttacaagttcatctgt accacctcagccatccagaatcggttcaagtatgctcgggtcactcctgacacagactgg gcccgcttgctgcaggaccacccctggctgctcagccagaacttggtagtcaagccagac cagctgatcaaacgtcgtggaaaacttggtctcgttggggtcaacctcactctggatggg gtcaagtcctggctgaagccacggctgggacaggaagccacagttggcaaggccacaggc ttcctcaagaactttctgatcgagcccttcgtcccccacagtcaggctgaggagttctat gtctgcatctatgccacccgagaaggggactacgtcctgttccaccacgaggggggtgtg gacgtgggtgatgtggacgccaaggcccagaagctgcttgttggcgtggatgagaaactg aatcctgaggacatcaaaaaacacctgttggtccacgcccctgaagacaagaaagaaatt ctggccagttttatctccggcctcttcaatttctacgaggacttgtacttcacctacctc gagatcaatccccttgtagtgaccaaagatggagtctatgtccttgacttggcggccaag gtggacgccactgccgactacatctgcaaagtgaagtggggtgacatcgagttccctccc cccttcgggcgggaggcatatccagaggaagcctacattgcagacctcgatgccaaaagt ggggcaagcctgaagctgaccttgctgaaccccaaagggaggatctggaccatggtggcc gggggtggcgcctctgtcgtgtacagcgataccatctgtgatctagggggtgtcaacgag ctggcaaactatggggagtactcaggcgcccccagcgagcagcagacctatgactatgcc aagactatcctctccctcatgacccgagagaagcacccagatggcaagatcctcatcatt ggaggcagcatcgcaaacttcaccaacgtggctgccacgttcaagggcatcgtgagagca attcgagattaccagggccccctgaaggagcacgaagtcacaatctttgtccgaagaggt ggccccaactatcaggagggcttacgggtgatgggagaagtcgggaagaccactgggatc cccatccatgtctttggcacagagactcacatgacggccattgtgggcatggccctgggc caccggcccatccccaaccagccacccacagcggcccacactgcaaacttcctcctcaac gccagcgggagcacatcgacgccagcccccagcaggacagcatctttttctgagtccagg gccgatgaggtggcgcctgcaaagaaggccaagcctgccatgccacaagattcagtccca agtccaagatccctgcaaggaaagagcaccaccctcttcagccgccacaccaaggccatt gtgtggggcatgcagacccgggccgtgcaaggcatgctggactttgactatgtctgctcc cgagacgagccctcagtggctgccatggtctaccctttcactggggaccacaagcagaag ttttactgggggcacaaagagatcctgatccctgtcttcaagaacatggctgatgccatg aggaagcatccggaggtagatgtgctcatcaactttgcctctctccgctctgcctatgac agcaccatggagaccatgaactatgcccagatccggaccatcgccatcatagctgaaggc atccctgaggccctcacgagaaagctgatcaagaaggcggaccagaagggagtgaccatc atcggacctgccactgttggaggcatcaagcctgggtgctttaagattggcaacacaggt gggatgctggacaacatcctggcctccaaactgtaccgcccaggcagcgtggcctatgtc tcacgttccggaggcatgtccaacgagctcaacaatatcatctctcggaccacggatggc gtctatgagggcgtggccattggtggggacaggtacccgggctccacattcatggatcat gtgttacgctatcaggacactccaggagtcaaaatgattgtggttcttggagagattggg ggcactgaggaatataagatttgccggggcatcaaggagggccgcctcactaagcccatc gtctgctggtgcatcgggacgtgtgccaccatgttctcctctgaggtccagtttggccat gctggagcttgtgccaaccaggcttctgaaactgcagtagccaagaaccaggctttgaag gaagcaggagtgtttgtgccccggagctttgatgagcttggagagatcatccagtctgta tacgaagatctcgtggccaatggagtcattgtacctgcccaggaggtgccgcccccaacc gtgcccatggactactcctgggccagggagcttggtttgatccgcaaacctgcctcgttc atgaccagcatctgcgatgagcgaggacaggagctcatctacgcgggcatgcccatcact gaggtcttcaaggaagagatgggcattggcggggtcctcggcctcctctggttccagaaa aggttgcctaagtactcttgccagttcattgagatgtgtctgatggtgacagctgatcac gggccagccgtctctggagcccacaacaccatcatttgtgcgcgagctgggaaagacctg gtctccagcctcacctcggggctgctcaccatcggggatcggtttgggggtgccttggat gcagcagccaagatgttcagtaaagcctttgacagtggcattatccccatggagtttgtg aacaagatgaagaaggaagggaagctgatcatgggcattggtcaccgagtgaagtcgata aacaacccagacatgcgagtgcagatcctcaaagattacgtcaggcagcacttccctgcc actcctctgctcgattatgcactggaagtagagaagattaccacctcgaagaagccaaat cttatcctgaatgtagatggtctcatcggagtcgcatttgtagacatgcttagaaactgt gggtcctttactcgggaggaagctgatgaatatattgacattggagccctcaatggcatc tttgtgctgggaaggagtatggggttcattggacactatcttgatcagaagaggctgaag caggggctgtatcgtcatccgtgggatgatatttcatatgttcttccggaacacatgagc atgtaa

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