KEGG   NETWORK: N00101
Entry
N00101                      Network                                
Name
DCC-apoptotic pathway
Definition
CASP3 -> DCC -> (CASP9+APPL1) -> CASP3
  Expanded
836 -> 1630 -> (842+26060) -> 836
Class
nt06260 Colorectal cancer
nt06231 Apoptosis (cancer)
Type
Reference
Gene
836  CASP3; caspase 3
1630  DCC; DCC netrin 1 receptor
842  CASP9; caspase 9
26060  APPL1; adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
Reference
PMID:17356579
  Authors
Cirulli V, Yebra M
  Title
Netrins: beyond the brain.
  Journal
Nat Rev Mol Cell Biol 8:296-306 (2007)
DOI:10.1038/nrm2142
Reference
PMID:22920895
  Authors
Ko SY, Dass CR, Nurgali K
  Title
Netrin-1 in the developing enteric nervous system and colorectal cancer.
  Journal
Trends Mol Med 18:544-54 (2012)
DOI:10.1016/j.molmed.2012.07.001
Reference
PMID:15573119
  Authors
Arakawa H.
  Title
Netrin-1 and its receptors in tumorigenesis.
  Journal
Nat Rev Cancer 4:978-87 (2004)
DOI:10.1038/nrc1504
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