KEGG   Homo sapiens (human): 1729
Entry
1729              CDS       T01001                                 
Symbol
DIAPH1, DFNA1, DIA1, DRF1, LFHL1, SCBMS, hDIA1, mDia1
Name
(RefSeq) diaphanous related formin 1
  KO
K05740  diaphanous 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04510  Focal adhesion
hsa04810  Regulation of actin cytoskeleton
hsa04933  AGE-RAGE signaling pathway in diabetic complications
hsa05131  Shigellosis
Disease
H00604  Deafness, autosomal dominant
H01740  Macrothrombocytopenia
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    1729 (DIAPH1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    1729 (DIAPH1)
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05131 Shigellosis
    1729 (DIAPH1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    1729 (DIAPH1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    1729 (DIAPH1)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Actin filaments / Microfilaments
   Actin-binding proteins
    Formins
     1729 (DIAPH1)
SSDB
Motif
Pfam: FH2 Drf_FH3 Drf_GBD Drf_FH1 Drf_DAD DUF3450 DUF948 Glucan_synthase
Other DBs
NCBI-GeneID: 1729
NCBI-ProteinID: NP_005210
OMIM: 602121
HGNC: 2876
Ensembl: ENSG00000131504
Vega: OTTHUMG00000149893
Pharos: O60610(Tbio)
UniProt: O60610 Q6URC4
LinkDB
Position
5:complement(141515021..141619000)
AA seq 1272 aa
MEPPGGSLGPGRGTRDKKKGRSPDELPSAGGDGGKSKKFTLKRLMADELERFTSMRIKKE
KEKPNSAHRNSSASYGDDPTAQSLQDVSDEQVLVLFEQMLLDMNLNEEKQQPLREKDIII
KREMVSQYLYTSKAGMSQKESSKSAMMYIQELRSGLRDMPLLSCLESLRVSLNNNPVSWV
QTFGAEGLASLLDILKRLHDEKEETAGSYDSRNKHEIIRCLKAFMNNKFGIKTMLETEEG
ILLLVRAMDPAVPNMMIDAAKLLSALCILPQPEDMNERVLEAMTERAEMDEVERFQPLLD
GLKSGTTIALKVGCLQLINALITPAEELDFRVHIRSELMRLGLHQVLQDLREIENEDMRV
QLNVFDEQGEEDSYDLKGRLDDIRMEMDDFNEVFQILLNTVKDSKAEPHFLSILQHLLLV
RNDYEARPQYYKLIEECISQIVLHKNGADPDFKCRHLQIEIEGLIDQMIDKTKVEKSEAK
AAELEKKLDSELTARHELQVEMKKMESDFEQKLQDLQGEKDALHSEKQQIATEKQDLEAE
VSQLTGEVAKLTKELEDAKKEMASLSAAAITVPPSVPSRAPVPPAPPLPGDSGTIIPPPP
APGDSTTPPPPPPPPPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEG
VGIPSPSSLPGGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPL
PGGPGIPPPPPFPGGPGIPPPPPGMGMPPPPPFGFGVPAAPVLPFGLTPKKLYKPEVQLR
RPNWSKLVAEDLSQDCFWTKVKEDRFENNELFAKLTLTFSAQTKTSKAKKDQEGGEEKKS
VQKKKVKELKVLDSKTAQNLSIFLGSFRMPYQEIKNVILEVNEAVLTESMIQNLIKQMPE
PEQLKMLSELKDEYDDLAESEQFGVVMGTVPRLRPRLNAILFKLQFSEQVENIKPEIVSV
TAACEELRKSESFSNLLEITLLVGNYMNAGSRNAGAFGFNISFLCKLRDTKSTDQKMTLL
HFLAELCENDYPDVLKFPDELAHVEKASRVSAENLQKNLDQMKKQISDVERDVQNFPAAT
DEKDKFVEKMTSFVKDAQEQYNKLRMMHSNMETLYKELGEYFLFDPKKLSVEEFFMDLHN
FRNMFLQAVKENQKRRETEEKMRRAKLAKEKAEKERLEKQQKREQLIDMNAEGDETGVMD
SLLEALQSGAAFRRKRGPRQANRKAGCAVTSLLASELTKDDAMAAVPAKVSKNSETFPTI
LEEAKELVGRAS
NT seq 3819 nt   +upstreamnt  +downstreamnt
atggagccgcccggcgggagcctggggcccggccgcgggacccgggacaagaagaagggc
cggagcccagatgagctgccctcggcgggcggcgacggcggcaaatctaagaaatttact
ctgaagcggctcatggcagatgagctggagagatttaccagcatgagaattaagaaggag
aaggaaaagcccaattctgctcatagaaattcttctgcatcatatggggatgatcccaca
gcacagtcattgcaagatgtttcagatgaacaagtgctggttctctttgaacagatgctg
ctggatatgaacctgaatgaggagaaacagcaacctttgagggagaaggacatcatcatc
aagagggagatggtgtcccaatacttgtacacctccaaggctggcatgagccagaaggag
agctctaagtctgccatgatgtatattcaggagttgaggtcaggcttgcgggatatgcct
ctgctcagctgcctggagtcccttcgtgtgtctctcaacaacaaccctgtcagttgggtg
caaacatttggtgctgaaggcttggcctccttattggacattcttaaacgacttcatgat
gagaaagaagagactgctgggagttacgatagccggaacaagcatgagatcattcgctgc
ttgaaagcttttatgaacaacaagtttggaatcaagaccatgttggagacagaagaagga
atcctactgctggtcagagccatggatcctgctgttcccaacatgatgattgatgcagct
aagctgctttctgctctttgtattctaccgcagccagaggacatgaatgaaagggttttg
gaggcaatgacagaaagagctgagatggatgaagtggaacgtttccagccgctgctggat
ggattaaaaagtggaaccactattgcactgaaggttggatgcctacagctgatcaatgct
ctcatcacaccagcggaggaacttgacttccgagttcacatcagaagtgaactgatgcgt
ttggggctacatcaggtgttgcaggaccttcgagagattgaaaatgaagatatgagagtg
caactaaatgtgtttgatgaacaaggggaagaggattcctatgacctgaagggacggctg
gatgacattcgcatggagatggatgactttaatgaagtctttcagattctcttaaacaca
gtgaaggattcaaaggcagagccacacttcctttccatcctgcagcacttactcttggtc
cgaaatgactatgaggccagacctcagtactataagttgattgaagaatgtatttcccag
atagttctgcacaagaacggggctgatcctgacttcaagtgccggcacctccagattgag
attgagggattaattgatcaaatgattgataagacaaaggtggagaaatctgaagccaaa
gctgcagagctggaaaagaagttggactcagagttaacagcccgacatgagctacaggtg
gaaatgaaaaagatggaaagtgactttgagcagaagcttcaagatcttcagggagaaaaa
gatgcactgcattctgaaaagcagcaaattgccacagagaaacaggacctggaagcagag
gtgtcccagctcacaggagaggttgccaagctgacaaaggaactggaagatgccaagaaa
gaaatggcttccctctctgcggcagctattactgtacctccttctgttcctagtcgtgct
cctgttccccctgcccctcctttacctggtgactctggcactattattccaccaccacct
gctcctggggatagtaccactcctcctcctcctcctcctcctcctcctcctccacctcct
ttgcctgggggtgtttgcatctcctcacccccttctttacctggaggtactgctatctct
ccaccccctcctttgtctggggatgctaccatccctccaccccctcctttgcctgagggt
gttggcatcccttcaccctcttctttgcctggaggtactgccatccccccacctcctcct
ttgcctgggagtgctagaatccccccaccaccacctcctttgcctgggagtgctggaatt
ccccccccacctcctcccttgcctggagaagcaggaatgccacctcctcctccccctctt
cctggtggtcctggaatccctccacctcctccatttcccggaggccctggcattcctcca
cctccacccggaatgggtatgcctccacctcccccatttggatttggagttcctgcagcc
ccagttctgccatttggattaacccccaaaaagctttataagccagaggtgcagctccgg
aggccaaactggtccaagcttgtggctgaggacctctcccaggactgcttctggacaaag
gtgaaggaggaccgctttgagaacaatgaacttttcgccaaacttacccttaccttctct
gcccagaccaagacttccaaagccaagaaggatcaagaaggtggagaagaaaagaaatct
gtgcaaaagaaaaaagtaaaagagttaaaggtgttggattcaaagacagcccagaatctc
tcaatctttttgggttccttccgcatgccctatcaagagattaagaatgtcatcctggag
gtgaatgaggctgttctgactgagtctatgatccagaacctcattaagcaaatgccagag
ccagagcagttaaaaatgctttctgaactgaaggatgaatatgatgacctggctgagtca
gagcagtttggcgtggtgatgggcactgtgccccgactgcggcctcgcctcaatgccatt
ctcttcaagctacaattcagcgagcaagtggagaatatcaagccagagattgtgtctgtc
actgctgcatgtgaggagttacgtaagagtgagagcttttccaatctcctagagattacc
ttgcttgttggaaattacatgaatgctggctccagaaatgctggtgcttttggcttcaat
atcagcttcctctgtaagcttcgagacaccaagtccacagatcagaagatgacgttgtta
cacttcttggctgagttgtgtgagaatgactatcccgatgtcctcaagtttccagacgag
cttgcccatgtggagaaagccagccgagtttctgctgaaaacttgcaaaagaacctagat
cagatgaagaaacaaatttctgatgtggaacgtgatgttcagaatttcccagctgccaca
gatgaaaaagacaagtttgttgaaaaaatgaccagctttgtgaaggatgcacaggaacag
tataacaagctgcggatgatgcattctaacatggagaccctctataaggagctgggcgag
tacttcctctttgaccccaagaagttgtctgttgaagaatttttcatggatcttcacaat
tttcggaatatgtttttgcaagcagtcaaggagaaccagaagcggcgggagacagaagaa
aagatgaggcgagcaaaactagccaaggagaaggcagagaaggagcggctagagaagcag
cagaagagagagcaactcatagacatgaatgcagagggcgatgagacaggtgtgatggac
agtcttctagaagccctgcagtcaggggcagcattccgacggaagagagggccccgtcaa
gccaacaggaaggccgggtgtgcagtcacatctctgctagcttcggagctgaccaaggat
gatgccatggctgctgttcctgccaaggtgtccaagaacagtgagacattccccacaatc
cttgaggaagccaaggagttggttggccgtgcaagctaa

KEGG   Homo sapiens (human): 1730
Entry
1730              CDS       T01001                                 
Symbol
DIAPH2, DIA, DIA2, DRF2, POF, POF2, POF2A
Name
(RefSeq) diaphanous related formin 2
  KO
K05741  diaphanous 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04810  Regulation of actin cytoskeleton
Disease
H00627  Premature ovarian failure
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    1730 (DIAPH2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    1730 (DIAPH2)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Actin filaments / Microfilaments
   Actin-binding proteins
    Formins
     1730 (DIAPH2)
SSDB
Motif
Pfam: FH2 Drf_FH3 Drf_GBD Drf_DAD DUF6779 Drf_FH1
Other DBs
NCBI-GeneID: 1730
NCBI-ProteinID: NP_006720
OMIM: 300108
HGNC: 2877
Ensembl: ENSG00000147202
Vega: OTTHUMG00000022689
Pharos: O60879(Tbio)
UniProt: O60879
LinkDB
Position
X:96684842..97604997
AA seq 1101 aa
MEQPGAAASGAGGGSEEPGGGRSNKRSAGNRAANEEETKNKPKLNIQIKTLADDVRDRIT
SFRKSTVKKEKPLIQHPIDSQVAMSEFPAAQPLYDERSLNLSEKEVLDLFEKMMEDMNLN
EEKKAPLRNKDFTTKREMVVQYISATAKSGGLKNSKHECTLSSQEYVHELRSGISDEKLL
NCLESLRVSLTSNPVSWVNNFGHEGLGLLLDELEKLLDKKQQENIDKKNQYKLIQCLKAF
MNNKFGLQRILGDERSLLLLARAIDPKQPNMMTEIVKILSAICIVGEENILDKLLGAITT
AAERNNRERFSPIVEGLENQEALQLQVACMQFINALVTSPYELDFRIHLRNEFLRSGLKT
MLPDLKEKENDELDIQLKVFDENKEDDLTELSHRLNDIRAEMDDMNEVYHLLYNMLKDTA
AENYFLSILQHFLLIRNDYYIRPQYYKIIEECVSQIVLHCSGMDPDFKYRQRLDIDLTHL
IDSCVNKAKVEESEQKAAEFSKKFDEEFTARQEAQAELQKRDEKIKELEAEIQQLRTQAQ
VLSSSSGIPGPPAAPPLPGVGPPPPPPAPPLPGGAPLPPPPPPLPGMMGIPPPPPPPLLF
GGPPPPPPLGGVPPPPGISLNLPYGMKQKKMYKPEVSMKRINWSKIEPTELSENCFWLRV
KEDKFENPDLFAKLALNFATQIKVQKNAEALEEKKTGPTKKKVKELRILDPKTAQNLSIF
LGSYRMPYEDIRNVILEVNEDMLSEALIQNLVKHLPEQKILNELAELKNEYDDLCEPEQF
GVVMSSVKMLQPRLSSILFKLTFEEHINNIKPSIIAVTLACEELKKSESFNRLLELVLLV
GNYMNSGSRNAQSLGFKINFLCKIRDTKSADQKTTLLHFIADICEEKYRDILKFPEELEH
VESASKVSAQILKSNLASMEQQIVHLERDIKKFPQAENQHDKFVEKMTSFTKTAREQYEK
LSTMHNNMMKLYENLGEYFIFDSKTVSIEEFFGDLNNFRTLFLEAVRENNKRREMEEKTR
RAKLAKEKAEQEKLERQKKKKQLIDINKEGDETGVMDNLLEALQSGAAFRDRRKRIPRNP
DNRRVPLERSRSRHNGAISSK
NT seq 3306 nt   +upstreamnt  +downstreamnt
atggagcagcccggggcggcggcgtcgggagcgggaggcggcagcgaggaacccggtggg
ggccggagcaacaagcggagcgcggggaaccgggccgccaatgaagaggaaacgaaaaac
aaacccaaattgaacattcaaataaaaactttggcagatgatgtgcgtgaccgaattaca
agttttagaaaatctactgtcaaaaaagaaaaacctcttattcaacatcctattgattct
caagtcgcgatgagtgagtttcctgcagctcagccattatatgatgaacgatctttgaat
ttgtcagaaaaggaagtattggatctctttgaaaaaatgatggaggacatgaaccttaac
gaagagaaaaaagctcctttacgaaacaaagactttaccaccaaacgtgagatggttgtc
cagtatatttctgccactgccaaatctggtgggctgaaaaacagcaaacatgaatgcacc
ctgtcttcacaagaatatgttcatgaattacgatcgggtatatcagatgagaaacttctt
aattgcctagaatccctcagggtttctttaaccagcaatccggtcagctgggttaacaac
tttggccatgaaggtcttggactcttattggatgagctggaaaagcttctggacaaaaaa
cagcaagaaaatattgacaagaagaatcagtataaacttattcaatgcctcaaagcattt
atgaataataagtttggattacaaaggattctaggagatgaaagaagtcttttactattg
gcaagagcaattgaccccaaacaacccaacatgatgactgaaatagtaaaaatactttct
gctatttgcattgttggagaagagaacattctagataaacttttaggggctataacaaca
gcagcagaaagaaataacagggaacgattttcaccaattgtggaaggtttagaaaatcag
gaagccttgcaattacaggtggcctgcatgcagtttataaatgcccttgtcacttctcct
tatgagcttgattttcgaatacatttaaggaatgaattcctccgttcaggactaaaaaca
atgttaccagatctaaaagaaaaagagaatgatgagcttgatattcagttgaaagtattt
gatgaaaacaaagaagatgacctaactgaattatcacaccgtctcaatgacattcgagca
gaaatggatgatatgaatgaagtctaccatcttctatataatatgctgaaggacactgct
gctgaaaattacttcttatctattctacaacattttttgcttatcagaaatgattattat
atcaggccacaatattataaaataattgaggaatgtgtttcacagatagtgctacactgc
agtggtatggatccagacttcaaatacaggcaaagattagacatcgatttaactcatctg
atagattcttgtgtgaacaaggcgaaagttgaagaaagtgaacaaaaagctgcagagttt
tcaaagaagttcgatgaagaattcacagctcgacaggaagctcaagcagagcttcaaaaa
agagatgagaaaatcaaagaacttgaagcagaaatccagcaacttcgaacccaggcacaa
gtactctcaagttcatcaggaattccaggtcctcctgcagcacctccattgccaggtgta
gggccgcctccaccaccacccgcgccacctctacccggaggagctcctcttcctcctcca
ccacctcctttacctggaatgatggggataccaccaccacccccaccaccacttttattt
gggggacctcctccaccaccaccccttggaggagttcctcctcccccaggaatatcactt
aatctaccttatggaatgaagcagaaaaaaatgtataaacctgaagtgtccatgaagaga
atcaattggtcaaagattgaacccacagaattatctgagaactgtttctggttaagagtc
aaagaagacaagtttgagaatccagatctctttgccaaattggcattgaattttgctact
cagataaaagttcaaaagaacgcagaagcattagaagaaaagaagactgggcctacaaag
aagaaagtgaaagaactgagaattttggatcccaaaacagctcagaatctgtccatcttt
ctgggatcatatcgcatgccatatgaagacataagaaacgttattctggaggttaatgaa
gacatgctgagtgaggctttaattcagaaccttgtgaaacatcttcctgagcagaagata
ctcaacgaattagcagagcttaagaatgaatatgatgacctctgtgagcctgaacaattt
ggagttgtgatgagctctgtgaaaatgttacagcctcgtctcagtagtatcctgttcaag
ctcacatttgaagaacacataaacaacatcaaaccaagcatcatagcagtaactcttgcc
tgtgaagaactgaagaaaagtgaaagctttaacagacttttagagttagttcttcttgtt
ggaaactacatgaactcaggctcaagaaatgcccagtctttgggatttaagatcaacttc
ctttgtaagatcagagatactaaatcagcggatcaaaaaacaacccttttgcattttatt
gccgacatttgtgaggaaaaatatcgagatatcctaaaatttcctgaagaactggaacac
gtagaaagtgcaagcaaagtttcagctcaaattctcaagagcaaccttgcatcaatggaa
caacaaattgttcatctggaacgtgacatcaagaaattcccccaagcagaaaatcaacac
gataagtttgtggaaaagatgaccagctttacaaagactgcccgagaacagtatgaaaaa
ctctccaccatgcacaacaacatgatgaagctctatgagaatcttggagaatacttcatt
tttgactcaaagacagtgagcatagaagagttctttggtgatctcaacaacttccgaact
ttgtttttggaagcagtgagagaaaacaataagagaagagaaatggaagagaagaccagg
agggcaaaacttgcaaaagagaaagctgaacaagaaaagttagaacgccagaagaaaaag
aaacaactcattgatataaacaaagagggtgatgagactggtgtgatggataatcttcta
gaagccctacaatcaggtgcagcattcagagaccgtcgaaagcggattccaaggaatcca
gataacagacgagtacctttggaaaggtcacgctctcgccacaatggagctatctcatct
aagtga

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