Homo sapiens (human): 1733
Help
Entry
1733 CDS
T01001
Symbol
DIO1, 5DI, THMA2, TXDI1
Name
(RefSeq) iodothyronine deiodinase 1
KO
K01562
type I thyroxine 5'-deiodinase [EC:
1.21.99.4
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04919
Thyroid hormone signaling pathway
Disease
H01186
Abnormal thyroid hormone metabolism
Drug target
Propylthiouracil:
D00562
<JP/US>
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09150 Organismal Systems
09152 Endocrine system
04919 Thyroid hormone signaling pathway
1733 (DIO1)
Enzymes [BR:
hsa01000
]
1. Oxidoreductases
1.21 Catalysing the reaction X-H + Y-H = X-Y
1.21.99 With unknown physiological acceptors
1.21.99.4 thyroxine 5'-deiodinase
1733 (DIO1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
T4_deiodinase
DUF2019
SCIMP
CoV_NSP4_N
Motif
Other DBs
NCBI-GeneID:
1733
NCBI-ProteinID:
NP_000783
OMIM:
147892
HGNC:
2883
Ensembl:
ENSG00000211452
UniProt:
P49895
A8K415
LinkDB
All DBs
Position
1:53894187..53911086
Genome browser
AA seq
249 aa
AA seq
DB search
MGLPQPGLWLKRLWVLLEVAVHVVVGKVLLILFPDRVKRNILAMGEKTGMTRNPHFSHDN
WIPTFFSTQYFWFVLKVRWQRLEDTTELGGLAPNCPVVRLSGQRCNIWEFMQGNRPLVLN
FGSCTUPSFMFKFDQFKRLIEDFSSIADFLVIYIEEAHASDGWAFKNNMDIRNHQNLQDR
LQAAHLLLARSPQCPVVVDTMQNQSSQLYAALPERLYIIQEGRILYKGKSGPWNYNPEEV
RAVLEKLHS
NT seq
750 nt
NT seq
+upstream
nt +downstream
nt
atggggctgccccagccagggctgtggctgaagaggctctgggtgctcttggaggtggct
gtgcatgtggtcgtgggtaaagtgcttctgatattgtttccagacagagtcaagcggaac
atcctggccatgggcgagaagacgggtatgaccaggaacccccatttcagccacgacaac
tggataccaacctttttcagcacccagtatttctggttcgtcttgaaggtccgttggcag
cgactagaggacacgactgagctagggggtctggccccaaactgcccggtggtccgcctc
tcaggacagaggtgcaacatttgggagtttatgcaaggtaataggccactggtgctgaat
tttggaagttgtacctgaccttcatttatgttcaaatttgaccagttcaagaggcttatt
gaagactttagttccatagcagattttcttgtcatttacattgaagaagcacatgcatca
gatggctgggcttttaagaacaacatggacatcagaaatcaccagaaccttcaggatcgc
ctgcaggcagcccatctactgctggccaggagcccccagtgccctgtggtggtggacacc
atgcagaaccagagcagccagctctacgcagcactgcctgagaggctctacataatccag
gagggcaggatcctctacaagggtaaatctggcccttggaactacaacccagaggaagtt
cgtgctgttctggaaaagctccacagttaa
Homo sapiens (human): 1734
Help
Entry
1734 CDS
T01001
Symbol
DIO2, 5DII, D2, DIOII, SELENOY, SelY, TXDI2
Name
(RefSeq) iodothyronine deiodinase 2
KO
K17904
type II thyroxine 5'-deiodinase [EC:
1.21.99.4
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04919
Thyroid hormone signaling pathway
Drug target
Propylthiouracil:
D00562
<JP/US>
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09150 Organismal Systems
09152 Endocrine system
04919 Thyroid hormone signaling pathway
1734 (DIO2)
Enzymes [BR:
hsa01000
]
1. Oxidoreductases
1.21 Catalysing the reaction X-H + Y-H = X-Y
1.21.99 With unknown physiological acceptors
1.21.99.4 thyroxine 5'-deiodinase
1734 (DIO2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
T4_deiodinase
AhpC-TSA
Redoxin
Motif
Other DBs
NCBI-GeneID:
1734
NCBI-ProteinID:
NP_054644
OMIM:
601413
HGNC:
2884
Ensembl:
ENSG00000211448
UniProt:
Q92813
LinkDB
All DBs
Position
14:complement(80197526..80231057)
Genome browser
AA seq
273 aa
AA seq
DB search
MGILSVDLLITLQILPVFFSNCLFLALYDSVILLKHVVLLLSRSKSTRGEWRRMLTSEGL
RCVWKSFLLDAYKQVKLGEDAPNSSVVHVSSTEGGDNSGNGTQEKIAEGATCHLLDFASP
ERPLVVNFGSATUPPFTSQLPAFRKLVEEFSSVADFLLVYIDEAHPSDGWAIPGDSSLSF
EVKKHQNQEDRCAAAQQLLERFSLPPQCRVVADRMDNNANIAYGVAFERVCIVQRQKIAY
LGGKGPFSYNLQEVRHWLEKNFSKRUKKTRLAG
NT seq
822 nt
NT seq
+upstream
nt +downstream
nt
atgggcatcctcagcgtagacttgctgatcacactgcaaattctgccagtttttttctcc
aactgcctcttcctggctctctatgactcggtcattctgctcaagcacgtggtgctgctg
ttgagccgctccaagtccactcgcggagagtggcggcgcatgctgacctcagagggactg
cgctgcgtctggaagagcttcctcctcgatgcctacaaacaggtgaaattgggtgaggat
gcccccaattccagtgtggtgcatgtctccagtacagaaggaggtgacaacagtggcaat
ggtacccaggagaagatagctgagggagccacatgccaccttcttgactttgccagccct
gagcgcccactagtggtcaactttggctcagccacttgacctcctttcacgagccagctg
ccagccttccgcaaactggtggaagagttctcctcagtggctgacttcctgctggtctac
attgatgaggctcatccatcagatggctgggcgataccgggggactcctctttgtctttt
gaggtgaagaagcaccagaaccaggaagatcgatgtgcagcagcccagcagcttctggag
cgtttctccttgccgccccagtgccgagttgtggctgaccgcatggacaataacgccaac
atagcttacggggtagcctttgaacgtgtgtgcattgtgcagagacagaaaattgcttat
ctgggaggaaagggccccttctcctacaaccttcaagaagtccggcattggctggagaag
aatttcagcaagagatgaaagaaaactagattagctggttaa
DBGET
integrated database retrieval system
