KEGG   Homo sapiens (human): 1743
Entry
1743              CDS       T01001                                 
Symbol
DLST, DLTS, KGD2, PGL7, PPGL7
Name
(RefSeq) dihydrolipoamide S-succinyltransferase
  KO
K00658  2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase) [EC:2.3.1.61]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00020  Citrate cycle (TCA cycle)
hsa00310  Lysine degradation
hsa00380  Tryptophan metabolism
hsa00785  Lipoic acid metabolism
hsa01100  Metabolic pathways
hsa01200  Carbon metabolism
hsa01210  2-Oxocarboxylic acid metabolism
Module
hsa_M00009  Citrate cycle (TCA cycle, Krebs cycle)
hsa_M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
hsa_M00032  Lysine degradation, lysine => saccharopine => acetoacetyl-CoA
Network
nt06031  Citrate cycle and pyruvate metabolism
nt06032  Lipoic acid metabolism
nt06036  Lysine degradation
  Element
N01609  Citrate cycle, second carbon oxidation 1
N01686  Lysine degradation 2
Disease
H02538  Paraganglioma
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00020 Citrate cycle (TCA cycle)
    1743 (DLST)
  09105 Amino acid metabolism
   00310 Lysine degradation
    1743 (DLST)
   00380 Tryptophan metabolism
    1743 (DLST)
  09108 Metabolism of cofactors and vitamins
   00785 Lipoic acid metabolism
    1743 (DLST)
Enzymes [BR:hsa01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.61  dihydrolipoyllysine-residue succinyltransferase
     1743 (DLST)
SSDB
Motif
Pfam: 2-oxoacid_dh Biotin_lipoyl Biotin_lipoyl_2
Other DBs
NCBI-GeneID: 1743
NCBI-ProteinID: NP_001924
OMIM: 126063
HGNC: 2911
Ensembl: ENSG00000119689
UniProt: P36957
Structure
LinkDB
Position
14:74881916..74903743
AA seq 453 aa
MLSRSRCVSRAFSRSLSAFQKGNCPLGRRSLPGVSLCQGPGYPNSRKVVINNSVFSVRFF
RTTAVCKDDLVTVKTPAFAESVTEGDVRWEKAVGDTVAEDEVVCEIETDKTSVQVPSPAN
GVIEALLVPDGGKVEGGTPLFTLRKTGAAPAKAKPAEAPAAAAPKAEPTAAAVPPPAAPI
PTQMPPVPSPSQPPSGKPVSAVKPTVAPPLAEPGAGKGLRSEHREKMNRMRQRIAQRLKE
AQNTCAMLTTFNEIDMSNIQEMRARHKEAFLKKHNLKLGFMSAFVKASAFALQEQPVVNA
VIDDTTKEVVYRDYIDISVAVATPRGLVVPVIRNVEAMNFADIERTITELGEKARKNELA
IEDMDGGTFTISNGGVFGSLFGTPIINPPQSAILGMHGIFDRPVAIGGKVEVRPMMYVAL
TYDHRLIDGREAVTFLRKIKAAVEDPRVLLLDL
NT seq 1362 nt   +upstreamnt  +downstreamnt
atgctgtcccgatcccgctgtgtgtctcgggcgttcagccgctcgctctccgccttccag
aaggggaactgccctctagggagacgttccctgcctggggtctccttatgccagggacca
ggttaccctaacagcaggaaggttgtcattaacaacagtgtcttcagtgttcgctttttc
agaactacagctgtatgcaaggatgacttggttacagtcaaaaccccagcgtttgcagaa
tctgtcacagagggagatgtcaggtgggagaaagctgttggagacacagttgcagaagat
gaagtggtttgtgagattgaaactgacaagacatctgtgcaggttccatcaccagcaaat
ggcgtgattgaagctcttttggtacctgatgggggaaaagtcgaaggaggcactccactt
ttcacactcaggaaaactggtgctgctcctgctaaggccaagccggctgaagctcctgct
gctgcagccccaaaagcagaacctacagcagcggcagttcctccccctgcagcacccata
cccactcagatgccaccggtgccctcgccctcacagcctccttctggcaaacctgtgtct
gcagtaaaacccactgttgccccaccactagctgagccaggagctggcaaaggtctgcgt
tcagaacatcgggagaaaatgaacaggatgcggcagcgcattgctcagcgtctgaaggag
gcccagaatacatgtgcaatgctgacaacttttaatgagattgacatgagtaacatccag
gagatgagggctcggcacaaagaggcttttttgaagaaacataacctcaaactaggcttc
atgtcggcatttgtgaaggcctcagcctttgccttgcaggaacagcctgttgtaaatgca
gtgattgacgacacaaccaaagaggtggtgtatagggattatattgacatcagtgttgca
gtggccaccccacggggtctggtggttccagtcatcaggaatgtggaagctatgaatttt
gcagatattgaacggaccatcactgaactgggagagaaggcccgaaagaatgaacttgcc
attgaagatatggatggcggtaccttcaccattagcaatggaggcgtttttggctcgctc
tttggaacacccattatcaacccccctcagtctgccatcctggggatgcatggcatcttt
gacaggccagtggctataggaggcaaggtagaggtgcggcccatgatgtacgtggcactg
acctatgatcaccggctgattgatggcagagaggctgtgactttcctccgcaaaatcaag
gcagcggtagaggatcccagagtcctcctcctggatctttag

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