Homo sapiens (human): 197259
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Entry
197259 CDS
T01001
Symbol
MLKL, hMLKL
Name
(RefSeq) mixed lineage kinase domain like pseudokinase
KO
K08849
mixed lineage kinase domain-like [EC:
2.7.11.1
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04217
Necroptosis
hsa04623
Cytosolic DNA-sensing pathway
hsa04668
TNF signaling pathway
hsa05132
Salmonella infection
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04668 TNF signaling pathway
197259 (MLKL)
09140 Cellular Processes
09143 Cell growth and death
04217 Necroptosis
197259 (MLKL)
09150 Organismal Systems
09151 Immune system
04623 Cytosolic DNA-sensing pathway
197259 (MLKL)
09160 Human Diseases
09171 Infectious disease: bacterial
05132 Salmonella infection
197259 (MLKL)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hsa01001
]
197259 (MLKL)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
197259 (MLKL)
Protein kinases [BR:
hsa01001
]
Serine/threonine kinases: TKL group
Other
197259 (MLKL)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
MLKL_N
PK_Tyr_Ser-Thr
Pkinase
DUF7792
DUF5672
Motif
Other DBs
NCBI-GeneID:
197259
NCBI-ProteinID:
NP_689862
OMIM:
615153
HGNC:
26617
Ensembl:
ENSG00000168404
UniProt:
Q8NB16
Structure
PDB
PDBj
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All DBs
Position
16:complement(74671855..74700862)
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AA seq
471 aa
AA seq
DB search
MENLKHIITLGQVIHKRCEEMKYCKKQCRRLGHRVLGLIKPLEMLQDQGKRSVPSEKLTT
AMNRFKAALEEANGEIEKFSNRSNICRFLTASQDKILFKDVNRKLSDVWKELSLLLQVEQ
RMPVSPISQGASWAQEDQQDADEDRRAFQMLRRDNEKIEASLRRLEINMKEIKETLRQYL
PPKCMQEIPQEQIKEIKKEQLSGSPWILLRENEVSTLYKGEYHRAPVAIKVFKKLQAGSI
AIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLDREKD
LTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMS
LGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKI
RKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKKLSTFSK
NT seq
1416 nt
NT seq
+upstream
nt +downstream
nt
atggaaaatttgaagcatattatcacccttggccaggtcatccacaaacggtgtgaagag
atgaaatactgcaagaaacagtgccggcgcctgggccaccgcgtcctcggcctgatcaag
cctctggagatgctccaggaccaaggaaagaggagcgtgccctctgagaagttaaccaca
gccatgaaccgcttcaaggctgccctggaggaggctaatggggagatagaaaagttcagc
aatagatccaatatctgcaggtttctaacagcaagccaggacaaaatactcttcaaggac
gtgaacaggaagctgagtgatgtctggaaggagctctcgctgttacttcaggttgagcaa
cgcatgcctgtttcacccataagccaaggagcgtcctgggcacaggaagatcagcaggat
gcagacgaagacaggcgagctttccagatgctaagaagagataatgaaaaaatagaagct
tcactgagacgattagaaatcaacatgaaagaaatcaaggaaactttgaggcagtattta
ccaccaaaatgcatgcaggagatcccgcaagagcaaatcaaggagatcaagaaggagcag
ctttcaggatccccgtggattctgctaagggaaaatgaagtcagcacactttataaagga
gaataccacagagctccagtggccataaaagtattcaaaaaactccaggctggcagcatt
gcaatagtgaggcagactttcaataaggagatcaaaaccatgaagaaattcgaatctccc
aacatcctgcgtatatttgggatttgcattgatgaaacagtgactccgcctcaattctcc
attgtcatggagtactgtgaactcgggaccctgagggagctgttggatagggaaaaagac
ctcacacttggcaagcgcatggtcctagtcctgggggcagcccgaggcctataccggcta
caccattcagaagcacctgaactccacggaaaaatcagaagctcaaacttcctggtaact
caaggctaccaagtgaagcttgcaggatttgagttgaggaaaacacagacttccatgagt
ttgggaactacgagagaaaagacagacagagtcaaatctacagcatatctctcacctcag
gaactggaagatgtattttatcaatatgatgtaaagtctgaaatatacagctttggaatc
gtcctctgggaaatcgccactggagatatcccgtttcaaggctgtaattctgagaagatc
cgcaagctggtggctgtgaagcggcagcaggagccactgggtgaagactgcccttcagag
ctgcgggagatcattgatgagtgccgggcccatgatccctctgtgcggccctctgtggat
gaaatcttaaagaaactctccaccttttctaagtag
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