KEGG ORTHOLOGY: K08849

ORTHOLOGY: K08849

Entry

K08849                      KO

Symbol

MLKL

Name

mixed lineage kinase domain-like [EC:2.7.11.1]

Pathway

map04217

Necroptosis

map04623

Cytosolic DNA-sensing pathway

map04668

TNF signaling pathway

map05132

Salmonella infection

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04668 TNF signaling pathway
    K08849  MLKL; mixed lineage kinase domain-like
09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    K08849  MLKL; mixed lineage kinase domain-like
09150 Organismal Systems
  09151 Immune system
   04623 Cytosolic DNA-sensing pathway
    K08849  MLKL; mixed lineage kinase domain-like
09160 Human Diseases
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    K08849  MLKL; mixed lineage kinase domain-like
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K08849  MLKL; mixed lineage kinase domain-like
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K08849  MLKL; mixed lineage kinase domain-like
Protein kinases [BR:ko01001]
Serine/threonine kinases: TKL group
  Other
   K08849  MLKL; mixed lineage kinase domain-like

Genes

HSA:	197259(MLKL)

PTR:	736069(MLKL)

PPS:	100976874(MLKL)

GGO:	101131212(MLKL)

PON:	100431964(MLKL)

PPYG:

129016059(MLKL)

NLE:	100593775(MLKL)

HMH:	116471496(MLKL)

SSYN:

129492731(MLKL)

MCC:	710316(MLKL)

MCF:	102140765(MLKL)

MTHB:

126943732

MNI:	105491539(MLKL)

CSAB:

103233145(MLKL)

CATY:

105574056(MLKL)

PANU:

101009086(MLKL)

TGE:	112614830(MLKL)

MLEU:

105537232(MLKL)

RRO:	104677830(MLKL)

RBB:	108527430(MLKL)

TFN:	117088046(MLKL)

PTEH:

111536157(MLKL)

CJC:	100400130(MLKL)

SBQ:	101045007(MLKL)

CIMI:

108305786(MLKL)

ANAN:

105706878(MLKL)

CSYR:

103270191(MLKL)

MMUR:

105875442(MLKL)

PCOQ:

105807976(MLKL)

OGA:	100966577(MLKL)

MMU:	74568(Mlkl)

MCAL:

110300641(Mlkl)

MPAH:

110337670(Mlkl)

RNO:	690743(Mlkl)

MCOC:

116070196(Mlkl)

ANU:	117723256(Mlkl)

ASYL:

127671939(Mlkl)

MUN:	110546008(Mlkl)

CGE:	100772478(Mlkl)

MAUA:

101837152(Mlkl)

PROB:

127234674(Mlkl)

PLEU:

114708095 114709118

MORG:

121447301(Mlkl)

MFOT:

126502975

AAMP:

119801989(Mlkl)

NGI:	103725675(Mlkl)

CPOC:

100715708(Mlkl)

CCAN:

109696571(Mlkl)

DORD:

105982965(Mlkl)

DSP:	122126264(Mlkl)

NCAR:

124967542

MMMA:

107150905(Mlkl)

ITI:	101962444(Mlkl)

OPI:	101521310(MLKL)

TUP:	102471426(MLKL)

GVR:	103590534(MLKL)

BTA:	790225(MLKL)

BOM:	102269257(MLKL)

BIU:	109573003(MLKL)

BBUB:

102415271(MLKL)

BBIS:

104996472(MLKL)

CHX:	102172181(MLKL)

OAS:	101115147(MLKL)

BTAX:

128063711(MLKL)

CSUM:

138096570(MLKL)

ODA:	120872869(MLKL)

CCAD:

122421006(MLKL)

MREE:

136160841(MLKL)

OVR:	110134587(MLKL)

MBEZ:

129547267(MLKL)

SSC:	100736836(MLKL)

CFR:	102523997(MLKL)

CBAI:

105078560(MLKL)

CDK:	105094684(MLKL)

VPC:	102525045(MLKL)

BACU:

103000454(MLKL)

BMUS:

118885795(MLKL)

LVE:	103071674(MLKL)

OOR:	101282908(MLKL)

LALB:

132509177(MLKL)

DLE:	111179706(MLKL)

PCAD:

102989423(MLKL)

PSIU:

116744759(MLKL)

NASI:

112393458(MLKL)

ECB:	100068748(MLKL)

EPZ:	103560158(MLKL)

EAI:	106836788(MLKL)

MYB:	102249398(MLKL)

MYD:	102754116(MLKL)

MMYO:

118674555(MLKL)

MLF:	102433583(MLKL)

MDT:	132217356(MLKL)

MYUM:

138996661(MLKL)

PKL:	118720750(MLKL)

EFUS:

103284722(MLKL)

MNA:	107525577(MLKL)

DRO:	112300647(MLKL)

SHON:

118999222(MLKL)

AJM:	119048932(MLKL)

PDIC:

114488245(MLKL)

PHAS:

123805911(MLKL)

MMF:	118639478(MLKL)

PPAM:

129075056(MLKL)

HAI:	109384777(MLKL)

RFQ:	117035303(MLKL)

PALE:

102898915(MLKL)

PGIG:

120617378(MLKL)

PVP:	105305348(MLKL)

RAY:	107510414(MLKL)

MJV:	108409625(MLKL)

SARA:

101537340(MLKL)

SFUM:

130044146(MLKL)

SETR:

126028458(MLKL)

TMU:

101351635

ETF:	101651769(MLKL)

DNM:	101434205(MLKL)

OAA:	100081728(MLKL)

TACU:

119935064(MLKL)

GGA:	415686(MLKL)

PCOC:

116243726(MLKL)

MGP:	100545440(MLKL)

CJO:	107319074(MLKL)

TPAI:

128081738(MLKL)

LMUT:

125699072(MLKL)

NMEL:

110404531(MLKL)

APLA:

101790564(MLKL)

CATA:

118246405(MLKL)

AFUL:

116494060(MLKL)

TGU:	100223797(MLKL)

LSR:	110476371(MLKL)

SCAN:

103816664(MLKL)

PMOA:

120508118(MLKL)

OTC:	121333946(MLKL)

PRUF:

121348951(MLKL)

ATRC:

139596329(MLKL)

GFR:	102041913(MLKL)

FAB:	101809477(MLKL)

OMA:	130257894(MLKL)

PHI:	102104292(MLKL)

PMAJ:

107209967(MLKL)

CCAE:

111934765(MLKL)

CCW:	104687510(MLKL)

CBRC:

103620286(MLKL)

ACOE:

138116977(MLKL)

ETL:	114063430(MLKL)

ZAB:	102066257(MLKL)

ZLE:	135452854(MLKL)

ACHL:

103801257(MLKL)

SVG:	106855872(MLKL)

MMEA:

130579547(MLKL)

HRT:	120757873(MLKL)

SATI:

136366589(MLKL)

CCIC:

134048413(MLKL)

FPG:	101919582(MLKL)

FCH:	102045724(MLKL)

CCRI:

104155205(MLKL)

NNT:	104401394(MLKL)

SHAB:

115601097(MLKL)

ACUN:

113484312(MLKL)

TALA:

104363374(MLKL)

ACHC:

115346122(MLKL)

HALD:

104320718(MLKL)

HLE:	104842122(MLKL)

AGEN:

126040849

HHAR:

128145860(MLKL)

GCL:

127021269

CSTI:

104561958(MLKL)

LDI:	104346790(MLKL)

MNB:	103781693(MLKL)

DPUB:

104305080(MLKL)

PPUS:

135184594(MLKL)

AVIT:

104275553(MLKL)

BRHI:

104497223(MLKL)

NNI:	104017499(MLKL)

PCRI:

104027574(MLKL)

PCAO:

104043948(MLKL)

PADL:

103918117(MLKL)

AFOR:

103908473(MLKL)

FGA:	104082163(MLKL)

GSTE:

104264171(MLKL)

CLV:	102091554(MLKL)

MUI:	104546189(MLKL)

PGUU:

104458439(MLKL)

PLET:

104614328(MLKL)

EHS:	104503321(MLKL)

CMAC:

104484102(MLKL)

CUCA:

104067261(MLKL)

TEO:	104382275(MLKL)

BREG:

104633306(MLKL)

OHA:	104333462(MLKL)

ACAR:

104525816(MLKL)

CPEA:

104389343(MLKL)

CVF:	104284787(MLKL)

RTD:	128909506(MLKL)

CRID:

134514506(MLKL)

AAM:	106492728(MLKL)

AROW:

112976875(MLKL)

NPD:	112943201(MLKL)

TGT:	104564354(MLKL)

DNE:	112987449(MLKL)

SCAM:

104147218(MLKL)

ASN:	102387916(MLKL)

AMJ:	102566438(MLKL)

CPOO:

109310460(MLKL)

GGN:	109289663(MLKL)

PSS:	102452795(MLKL)

CMY:	102931050(MLKL)

CCAY:

125620871(MLKL)

DCC:	119841218(MLKL)

CPIC:

101953736(MLKL)

TST:	117886659(MLKL)

CABI:

116831664(MLKL) 116833177

MRV:	120384303(MLKL)

ACS:	100565272(mlkl)

ASAO:

132782997(MLKL)

PVT:	110081310(MLKL)

SUND:

121914776

PBI:	103064224(MLKL)

PMUR:

107287365(MLKL)

CTIG:

120312664(MLKL)

PGUT:

117670343(MLKL)

APRI:

131184353(MLKL)

PTEX:

113445285(MLKL)

NSS:	113420277(MLKL)

VKO:	123025516(MLKL)

PMUA:

114601806(MLKL)

PRAF:

128419028(MLKL)

ZVI:	118086364(MLKL)

HCG:	128334492(MLKL)

GJA:	107126191(MLKL)

STOW:

125443600(MLKL)

EMC:	129344165(MLKL)

XLA:	108714143(mlkl.L) 108714144

XTR:	100379899(mlkl) 100497621

NPR:	108801508(MLKL)

RTEM:

120917803 120917804 120917805

BBUF:

120980326 120980327

BGAR:

122920452(MLKL)

PWL:	138268198(MLKL)

MUO:	115470442(MLKL)

SRX:	107707539(mlkl)

SANH:

107698231(mlkl)

SGH:	107562827(mlkl)

CCAR:

109081407 109084374

CAUA:

113043614 113067127

CGIB:

127946815 128013742

PTET:

122330316 122330427 122330875

LROH:

OMC:

PPRM:

RKG:

MAMB:

CIDE:

CERY:

MASI:

TROS:

MANU:

PDAB:

IPU:

IFU:

PHYP:

113528812(mlkl)

SMEO:

TFD:

TVC:

CGAR:

NGRA:

TRN:

AMEX:

CMAO:

EEE:	113585312(mlkl)

CHAR:

105900762

SPIL:

134093954

TNG:	GSTEN00019714G001

LCO:	104934603(mlkl)

NCC:	104942669(mlkl)

TBEN:

117479793 117479794 117479817 117479839

CGOB:

115010231(mlkl)

PGEO:

GACU:

EMAC:

ELY:

EFO:

PLEP:

SLUC:

ECRA:

ESP:	116693755(mlkl)

PFLV:

114559620 114560114(mlkl)

GAT:

PPUG:

AFB:

CLUM:

PSWI:

CANA:

CVE:

MSAM:

SCHU:

CUD:

SPUL:

LMIX:

ALAT:

ASTR:

MZE:	101466611 101483735 101486616

ONL:	100694305 100702331(mlkl) 102082348

OAU:	116315093 116325245

OLA:	101160750 101166152

OML:	112163185 112163186

CSAI:

133444804

XMA:	102220812 102222390 102229646

XCO:	114152157 114152159 114160059

XHE:	116709076 116726763 116726764

PRET:

PFOR:

PLAI:

PMEI:

GAF:

PPRL:

CVG:	107099717(mlkl)

CTUL:

119776442

GMU:

124877696

NFU:	107372999(mlkl)

KMR:

108229493

ALIM:

106534269(mlkl)

NWH:

AOCE:

EJA:

BFRE:

MCEP:

CSEM:

103379890(mlkl)

POV:	109624097(mlkl)

SSEN:

SSOE:

HHIP:

HSP:

PPLT:

SMAU:

LCF:	108872681 108872682

SDU:	111235989(mlkl)

SLAL:

111665393(mlkl)

XGL:

120793742

BPEC:

110166853(mlkl)

ENY:

140348839

MALB:

109952780

BSPL:

114857529 114857530 114857531

SJO:

128359164

GMH:	115551033(mlkl)

SASA:

100195264(mlkl) 106561002 106584536

STRU:

115192697 115196991 115196992

OTW:	112218188 112219177 112225121

OMY:	110493186 110493207 110521374

OGO:	124037622 124038672

ONE:	115134444 115144820

OKI:	109867150 109897805

OKE:	118359278 118396505

OMM:	135508846 135509549 135556589

OCLA:

139369960 139369982 139406482

SALP:

111962204 111962205 111972013

SNH:	120051767 120066142

CCLU:

121531710

ELS:	105031149(mlkl)

OEP:

134020757

SFM:	108940805(mlkl)

PKI:	111861185(mlkl)

AANG:

118214717

AROT:

135241541

CCOG:

133111582 133111813

LOC:	102687595(mlkl)

PSPA:

121295971 121326275

ARUT:

117424416 117425429

PSEX:

120535651

LCM:	102365452(MLKL)

CMK:

RTP:

CPLA:

LERI:

PMRN:

116945914(MLKL)

LRJ:	133340485(MLKL)

BFO:	118417918 118417962 118418092 118418427

BBEL:

CIN:

SCLV:

SPU:

LPIC:

APLC:

ARUN:

117294320 117294650 117294848 117295184

AAMU:

139941032 139941165 139941176 139941178

AFIL:

140135979 140135980 140164172 140164176 140164198 140164202 140164253

SKO:	100368192 102806569

PFLL:

139148384

» show all

Reference

PMID:22265413

Authors

Sun L, Wang H, Wang Z, He S, Chen S, Liao D, Wang L, Yan J, Liu W, Lei X, Wang X

Title

Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase.

Journal

Cell 148:213-27 (2012)
DOI:10.1016/j.cell.2011.11.031

Sequence

[hsa:197259]

LinkDB

DBGET integrated database retrieval system