Homo sapiens (human): 197322
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Entry
197322 CDS
T01001
Symbol
ACSF3
Name
(RefSeq) acyl-CoA synthetase family member 3
KO
K18660
malonyl-CoA/methylmalonyl-CoA synthetase [EC:
6.2.1.76
6.2.1.-]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00061
Fatty acid biosynthesis
hsa00280
Valine, leucine and isoleucine degradation
hsa01100
Metabolic pathways
hsa01212
Fatty acid metabolism
Module
hsa_M00873
Fatty acid biosynthesis in mitochondria, animals
Disease
H02109
Combined malonic and methylmalonic aciduria
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09103 Lipid metabolism
00061 Fatty acid biosynthesis
197322 (ACSF3)
09105 Amino acid metabolism
00280 Valine, leucine and isoleucine degradation
197322 (ACSF3)
Enzymes [BR:
hsa01000
]
6. Ligases
6.2 Forming carbon-sulfur bonds
6.2.1 Acid-thiol ligases
6.2.1.76 malonate---CoA ligase
197322 (ACSF3)
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GFIT
Motif
Pfam:
AMP-binding
AMP-binding_C
Motif
Other DBs
NCBI-GeneID:
197322
NCBI-ProteinID:
NP_001120686
OMIM:
614245
HGNC:
27288
Ensembl:
ENSG00000176715
Pharos:
Q4G176
(Tbio)
UniProt:
Q4G176
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Position
16:89093852..89156233
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AA seq
576 aa
AA seq
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MLPHVVLTFRRLGCALASCRLAPARHRGSGLLHTAPVARSDRSAPVFTRALAFGDRIALV
DQHGRHTYRELYSRSLRLSQEICRLCGCVGGDLREERVSFLCANDASYVVAQWASWMSGG
VAVPLYRKHPAAQLEYVICDSQSSVVLASQEYLELLSPVVRKLGVPLLPLTPAIYTGAVE
EPAEVPVPEQGWRNKGAMIIYTSGTTGRPKGVLSTHQNIRAVVTGLVHKWAWTKDDVILH
VLPLHHVHGVVNALLCPLWVGATCVMMPEFSPQQVWEKFLSSETPRINVFMAVPTIYTKL
MEYYDRHFTQPHAQDFLRAVCEEKIRLMVSGSAALPLPVLEKWKNITGHTLLERYGMTEI
GMALSGPLTTAVRLPGSVGTPLPGVQVRIVSENPQREACSYTIHAEGDERGTKVTPGFEE
KEGELLVRGPSVFREYWNKPEETKSAFTLDGWFKTGDTVVFKDGQYWIRGRTSVDIIKTG
GYKVSALEVEWHLLAHPSITDVAVIGVPDMTWGQRVTAVVTLREGHSLSHRELKEWARNV
LAPYAVPSELVLVEEIPRNQMGKIDKKALIRHFHPS
NT seq
1731 nt
NT seq
+upstream
nt +downstream
nt
atgctgccccatgtggtgctcaccttccggcgcctgggctgcgccttggcgtcctgccgg
ctggcgcctgcgagacacagaggaagtggtcttctgcacacagccccagtggcccgctcg
gacaggagcgccccggtgttcacccgtgccctggcctttggggacagaatcgccctggtt
gaccagcacggccgccacacgtacagggagctttattcccgcagccttcgcctgtcccag
gagatctgcaggctctgcgggtgtgtcggcggggacctccgggaggagagggtctccttc
ctatgcgctaacgatgcctcctacgtcgtggcccagtgggcgtcatggatgagtggcggt
gtggcagtccccctctacaggaagcatcccgcggcccagctggagtatgtcatctgcgac
tcccagagctctgtggtccttgccagccaggagtacctggagctcctgagcccggtggtc
aggaagctgggggtcccgctgctgccgctcacaccagccatctacactggagcagtagag
gaaccggcagaggtcccggtcccagagcagggatggaggaacaagggcgccatgatcatc
tacaccagtgggaccacggggaggcccaagggcgtgctgagcacgcaccaaaacatcagg
gctgtggtgaccgggctggtccacaagtgggcatggaccaaagacgacgtgatcctccac
gtgctcccgctgcaccacgtccatggtgtggtcaacgcgctgctctgtcctctctgggtg
ggagccacctgtgtgatgatgcctgagttcagccctcagcaggtttgggaaaagttctta
agttctgaaacgccgcggatcaatgtctttatggcagtgcctacaatatacaccaagctg
atggagtactacgacaggcattttacccagccgcacgcccaggatttcttgcgtgcagtt
tgtgaagaaaaaattaggctgatggtctcaggctcagctgccctgcccctcccagtgctg
gagaagtggaagaacatcacgggccacaccctgctggagcggtatggcatgaccgagatc
ggcatggctctgtccgggcccctgaccactgccgtgcgcctgccaggttccgtggggacc
ccactgcctggagtacaggtgcgcattgtctcagaaaacccacagagggaagcctgctcc
tacaccatccacgcagagggagacgagagggggaccaaggtgaccccagggtttgaagaa
aaggagggggagctgctggtgaggggaccctccgtgtttcgagaatactggaataaacca
gaagaaactaagagtgcattcaccctggatggctggtttaagacaggggacaccgtggtg
tttaaggatggccagtactggatccgaggccggacctcagtggacatcatcaagactgga
ggctacaaggtcagcgccctggaggtggagtggcacctgctggcccaccccagcatcaca
gatgtggctgtgattggagttccggatatgacatggggccagcgggtcactgctgtggtg
accctccgagaaggacactcactgtcccacagggagctcaaagagtgggccagaaatgtc
ctggccccgtacgcggtgccctcggagctggtgctggtggaggagatcccgcggaaccag
atgggcaagattgacaagaaggcgctcatcaggcacttccacccctcatga
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