KEGG   Homo sapiens (human): 200424
Entry
200424            CDS       T01001                                 
Symbol
TET3, BEFAHRS, hCG_40738
Name
(RefSeq) tet methylcytosine dioxygenase 3
  KO
K24309  methylcytosine dioxygenase TET2/3 [EC:1.14.11.80]
Organism
hsa  Homo sapiens (human)
Disease
H02633  Beck-Fahrner syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    200424 (TET3)
   03036 Chromosome and associated proteins [BR:hsa03036]
    200424 (TET3)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.11  With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
    1.14.11.80  methylcytosine dioxygenase
     200424 (TET3)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Zinc finger
   CXXC CpG-binding proteins
    200424 (TET3)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Histone modification proteins
   Histone demethylases
    200424 (TET3)
SSDB
Motif
Pfam: Tet_JBP zf-CXXC
Other DBs
NCBI-GeneID: 200424
NCBI-ProteinID: NP_001274420
OMIM: 613555
HGNC: 28313
Ensembl: ENSG00000187605
UniProt: O43151
Structure
LinkDB
Position
2:73983631..74135498
AA seq 1795 aa
MSQFQVPLAVQPDLPGLYDFPQRQVMVGSFPGSGLSMAGSESQLRGGGDGRKKRKRCGTC
EPCRRLENCGACTSCTNRRTHQICKLRKCEVLKKKVGLLKEVEIKAGEGAGPWGQGAAVK
TGSELSPVDGPVPGQMDSGPVYHGDSRQLSASGVPVNGAREPAGPSLLGTGGPWRVDQKP
DWEAAPGPAHTARLEDAHDLVAFSAVAEAVSSYGALSTRLYETFNREMSREAGNNSRGPR
PGPEGCSAGSEDLDTLQTALALARHGMKPPNCNCDGPECPDYLEWLEGKIKSVVMEGGEE
RPRLPGPLPPGEAGLPAPSTRPLLSSEVPQISPQEGLPLSQSALSIAKEKNISLQTAIAI
EALTQLSSALPQPSHSTPQASCPLPEALSPPAPFRSPQSYLRAPSWPVVPPEEHSSFAPD
SSAFPPATPRTEFPEAWGTDTPPATPRSSWPMPRPSPDPMAELEQLLGSASDYIQSVFKR
PEALPTKPKVKVEAPSSSPAPAPSPVLQREAPTPSSEPDTHQKAQTALQQHLHHKRSLFL
EQVHDTSFPAPSEPSAPGWWPPPSSPVPRLPDRPPKEKKKKLPTPAGGPVGTEKAAPGIK
PSVRKPIQIKKSRPREAQPLFPPVRQIVLEGLRSPASQEVQAHPPAPLPASQGSAVPLPP
EPSLALFAPSPSRDSLLPPTQEMRSPSPMTALQPGSTGPLPPADDKLEELIRQFEAEFGD
SFGLPGPPSVPIQDPENQQTCLPAPESPFATRSPKQIKIESSGAVTVLSTTCFHSEEGGQ
EATPTKAENPLTPTLSGFLESPLKYLDTPTKSLLDTPAKRAQAEFPTCDCVEQIVEKDEG
PYYTHLGSGPTVASIRELMEERYGEKGKAIRIEKVIYTGKEGKSSRGCPIAKWVIRRHTL
EEKLLCLVRHRAGHHCQNAVIVILILAWEGIPRSLGDTLYQELTDTLRKYGNPTSRRCGL
NDDRTCACQGKDPNTCGASFSFGCSWSMYFNGCKYARSKTPRKFRLAGDNPKEEEVLRKS
FQDLATEVAPLYKRLAPQAYQNQVTNEEIAIDCRLGLKEGRPFAGVTACMDFCAHAHKDQ
HNLYNGCTVVCTLTKEDNRCVGKIPEDEQLHVLPLYKMANTDEFGSEENQNAKVGSGAIQ
VLTAFPREVRRLPEPAKSCRQRQLEARKAAAEKKKIQKEKLSTPEKIKQEALELAGITSD
PGLSLKGGLSQQGLKPSLKVEPQNHFSSFKYSGNAVVESYSVLGNCRPSDPYSMNSVYSY
HSYYAQPSLTSVNGFHSKYALPSFSYYGFPSSNPVFPSQFLGPGAWGHSGSSGSFEKKPD
LHALHNSLSPAYGGAEFAELPSQAVPTDAHHPTPHHQQPAYPGPKEYLLPKAPLLHSVSR
DPSPFAQSSNCYNRSIKQEPVDPLTQAEPVPRDAGKMGKTPLSEVSQNGGPSHLWGQYSG
GPSMSPKRTNGVGGSWGVFSSGESPAIVPDKLSSFGASCLAPSHFTDGQWGLFPGEGQQA
ASHSGGRLRGKPWSPCKFGNSTSALAGPSLTEKPWALGAGDFNSALKGSPGFQDKLWNPM
KGEEGRIPAAGASQLDRAWQSFGLPLGSSEKLFGALKSEEKLWDPFSLEEGPAEEPPSKG
AVKEEKGGGGAEEEEEELWSDSEHNFLDENIGGVAVAPAHGSILIECARRELHATTPLKK
PNRCHPTRISLVFYQHKNLNQPNHGLALWEAKMKQLAERARARQEEAARLGLGQQEAKLY
GKKRKWGGTVVAEPQQKEKKGVVPTRQALAVPTDSAVTVSSYAYTKVTGPYSRWI
NT seq 5388 nt   +upstreamnt  +downstreamnt
atgagccagtttcaggtgcccctggccgtccagccggacctgccaggcctttatgacttc
cctcagcgccaggtgatggtagggagcttcccggggtctgggctctccatggctgggagt
gagtcccaactccgagggggtggagatggtcgaaagaaacggaaacggtgtggtacttgt
gagccctgccggcggctggaaaactgtggcgcttgcactagctgtaccaaccgccgcacg
caccagatctgcaaactgcgaaaatgtgaggtgctgaagaaaaaagtagggcttctcaag
gaggtggaaataaaggctggtgaaggagccgggccgtggggacaaggagcggctgtcaag
acaggctcagagctcagcccagttgatggacctgttccaggtcagatggactcagggcca
gtgtaccatggggactcacggcagctaagcgcctcaggggtgccggtcaatggtgctaga
gagcccgctggacccagtctgctggggactgggggtccttggcgggtagaccaaaagccc
gactgggaggctgccccaggcccagctcatactgctcgcctggaagatgcccacgatctg
gtggccttttcggctgtggccgaagctgtgtcctcttatggggcccttagcacccggctc
tatgaaaccttcaaccgtgagatgagtcgtgaggctgggaacaacagcaggggaccccgg
ccagggcctgagggctgctctgctggcagcgaagaccttgacacactgcagacggccctg
gccctcgcgcggcatggtatgaaaccacccaactgcaactgcgatggcccagaatgccct
gactacctcgagtggctggaggggaagatcaagtctgtggtcatggaaggaggggaggag
cggcccaggctcccagggcctctgcctcctggtgaggccggcctcccagcaccaagcacc
aggccactcctcagctcagaggtgccccagatctctccccaagagggcctgcccctgtcc
cagagtgccctgagcattgccaaggaaaaaaacatcagcttgcagaccgccattgccatt
gaggccctcacacagctctcctctgccctcccgcagccttctcattccaccccccaggct
tcttgcccccttcctgaggccttgtcacctcctgcccctttcagatctccccagtcttac
ctccgggctccctcatggcctgtggttcctcctgaagagcactcatcttttgctcctgat
agctctgccttccctccagcaactcctagaactgagttccctgaagcctggggcactgac
acccctccagcaacgccccggagctcctggcccatgcctcgcccaagccccgatcccatg
gctgaactggagcagttgttgggcagcgccagtgattacatccagtcagtattcaagcgg
cctgaggccctgcctaccaagcccaaggtcaaggtggaggcaccctcttcctccccggcc
ccggccccatcccctgtacttcagagggaggctcccacgccatcctcggagcccgacacc
caccagaaggcccagaccgccctgcagcagcacctccaccacaagcgcagcctcttccta
gaacaggtgcacgacacctccttccctgctccttcagagccttctgctcctggctggtgg
cccccaccaagttcacctgtcccacggcttccagacagaccacccaaggagaagaagaag
aagctcccaacaccagctggaggtcccgtgggaacggagaaagctgcccctgggatcaag
cccagtgtccgaaagcccattcagatcaagaagtccaggccccgggaagcacagcccctc
ttcccacctgtccgacagattgtcctggaagggcttaggtccccagcctcccaggaagtg
caggctcatccaccggcccctctgcctgcctcacagggctctgctgtgcccctgccccca
gaaccttctcttgcgctatttgcacctagtccctccagggacagcctgctgccccctact
caggaaatgaggtcccccagccccatgacagccttgcagccaggctccactggccctctt
ccccctgccgatgacaagctggaagagctcatccggcagtttgaggctgaatttggagat
agctttgggcttcccggccccccttctgtgcccattcaggaccccgagaaccagcaaaca
tgtctcccagcccctgagagcccctttgctacccgttcccccaagcaaatcaagattgag
tcttcgggggctgtgactgtgctctcaaccacctgcttccattcagaggagggaggacag
gaggccacacccaccaaggctgagaacccactcacacccaccctcagtggcttcttggag
tcacctcttaagtacctggacacacccaccaagagtctgctggacacacctgccaagaga
gcccaggccgagttccccacctgcgattgcgtcgaacaaatagtggagaaagatgaaggt
ccatattatactcacttgggatctggccccacggtcgcctctatccgggaactcatggag
gagcggtatggagagaaggggaaagccatccggatcgagaaggtcatctacacggggaag
gagggaaagagctcccgcggttgccccattgcaaagtgggtgatccgcaggcacacgctg
gaggagaagctactctgcctggtgcggcaccgggcaggccaccactgccagaacgctgtg
atcgtcatcctcatcctggcctgggagggcattccccgtagcctcggagacaccctctac
caggagctcaccgacaccctccggaagtatgggaaccccaccagccggagatgcggcctc
aacgatgaccggacctgcgcttgccaaggcaaagaccccaacacctgtggtgcctccttc
tcctttggttgttcctggagcatgtacttcaacggctgcaagtatgctcggagcaagaca
cctcgcaagttccgcctcgcaggggacaatcccaaagaggaagaagtgctccggaagagt
ttccaggacctggccaccgaagtcgctcccctgtacaagcgactggcccctcaggcctat
cagaaccaggtgaccaacgaggaaatagcgattgactgccgtctggggctgaaggaagga
cggcccttcgcgggggtcacggcctgcatggacttctgtgcccacgcccacaaggaccag
cataacctctacaatgggtgcaccgtggtctgcaccctgaccaaggaagacaatcgctgc
gtgggcaagattcccgaggatgagcagctgcatgttctccccctgtacaagatggccaac
acggatgagtttggtagcgaggagaaccagaatgcaaaggtgggcagcggagccatccag
gtgctcaccgccttcccccgcgaggtccgacgcctgcccgagcctgccaagtcctgccgc
cagcggcagctggaagccagaaaggcagcagccgagaagaagaagattcagaaggagaag
ctgagcactccggagaagatcaagcaggaggccctggagctggcgggcattacgtcggac
ccaggcctgtctctgaagggtggattgtcccagcaaggcctgaagccctccctcaaggtg
gagccgcagaaccacttcagctccttcaagtacagcggcaacgcggtggtggagagctac
tcggtgctgggcaactgccggccctccgacccttacagcatgaacagcgtgtactcctac
cactcctactatgcacagcccagcctgacctccgtcaatggcttccactccaagtacgct
ctcccgtcttttagctactatggctttccatccagcaaccccgtcttcccctctcagttc
ctgggtcctggtgcctgggggcacagtggcagcagtggcagttttgagaagaagccagac
ctccacgctctgcacaacagcctgagcccggcctacggtggtgctgagtttgccgagctg
cccagccaggctgttcccacagacgcccaccaccccactcctcaccaccagcagcctgcg
tacccaggccccaaggagtatctgcttcccaaggcccccctactccactcagtgtccagg
gacccctccccctttgcccagagctccaactgctacaacagatccatcaagcaagagcca
gtagacccgctgacccaggctgagcctgtgcccagagacgctggcaagatgggcaagaca
cctctgtccgaggtgtctcagaatggaggacccagtcacctttggggacagtactcagga
ggcccaagcatgtcccccaagaggactaacggtgtgggtggcagctggggtgtgttctcg
tctggggagagtcctgccatcgtccctgacaagctcagttcctttggggccagctgcctg
gccccttcccacttcacagatggccagtgggggctgttccccggtgaggggcagcaggca
gcttcccactctggaggacggctgcgaggcaaaccgtggagcccctgcaagtttgggaac
agcacctcggccttggctgggcccagcctgactgagaagccgtgggcgctgggggcaggg
gatttcaactcggccctgaaaggtagtcctgggttccaagacaagctgtggaaccccatg
aaaggagaggagggcaggattccagccgcaggggccagccagctggacagggcctggcag
tcctttggtctgcccctgggatccagcgagaagctgtttggggctctgaagtcagaggag
aagctgtgggaccccttcagcctggaggaggggccggctgaggagccccccagcaaggga
gcggtgaaggaggagaagggcggtggtggtgcggaggaggaagaggaggagctgtggtcg
gacagtgaacacaacttcctggacgagaacatcggcggcgtggccgtggccccagcccac
ggctccatcctcatcgagtgtgcccggcgggagctgcacgccaccacgccgcttaagaag
cccaaccgctgccaccccacccgcatctcgctggtcttctaccagcacaagaacctcaac
cagcccaaccacgggctggccctctgggaagccaagatgaagcagctggcggagagggca
cgggcacggcaggaggaggctgcccggctgggcctgggccagcaggaggccaagctctac
gggaagaagcgcaagtgggggggcactgtggttgctgagccccagcagaaagagaagaag
ggggtcgtccccacccggcaggcactggctgtgcccacagactcggcggtcaccgtgtcc
tcctatgcctacacgaaggtcactggcccctacagccgctggatctag

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