Homo sapiens (human): 2145
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Entry
2145 CDS
T01001
Symbol
EZH1, KMT6B
Name
(RefSeq) enhancer of zeste 1 polycomb repressive complex 2 subunit
KO
K17451
[histone H3]-lysine27 N-trimethyltransferase EZH1 [EC:
2.1.1.356
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00310
Lysine degradation
hsa01100
Metabolic pathways
hsa03083
Polycomb repressive complex
Network
nt06523
Epigenetic regulation by Polycomb complexes
Element
N01577
Gene silencing by methylation of H3K27 and ubiquitination of H2AK119
N01586
Activation of PRC2.2 by ubiquitination of H2AK119
N01614
Activation of PRC2.2 by ubiquitination of H2AK119 in germline genes
Drug target
Valemetostat (
DG03075
):
D11551
D11662
<JP>
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09105 Amino acid metabolism
00310 Lysine degradation
2145 (EZH1)
09120 Genetic Information Processing
09126 Chromosome
03083 Polycomb repressive complex
2145 (EZH1)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:
hsa03036
]
2145 (EZH1)
Enzymes [BR:
hsa01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.356 [histone H3]-lysine27 N-trimethyltransferase
2145 (EZH1)
Chromosome and associated proteins [BR:
hsa03036
]
Eukaryotic type
Histone modification proteins
HMTs (histone methyltransferases)
HKMTs (histone lysine methyltransferases)
2145 (EZH1)
Polycomb repressive complex (PRC) and associated proteins
PRC2.1
2145 (EZH1)
PRC2.2
2145 (EZH1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Ezh2_MCSS
PRC2_HTH_1
SET
EZH2_WD-Binding
preSET_CXC
Myb_DNA-binding
Motif
Other DBs
NCBI-GeneID:
2145
NCBI-ProteinID:
NP_001982
OMIM:
601674
HGNC:
3526
Ensembl:
ENSG00000108799
UniProt:
Q92800
Structure
PDB
PDBj
LinkDB
All DBs
Position
17:complement(42700275..42745040)
Genome browser
AA seq
747 aa
AA seq
DB search
MEIPNPPTSKCITYWKRKVKSEYMRLRQLKRLQANMGAKALYVANFAKVQEKTQILNEEW
KKLRVQPVQSMKPVSGHPFLKKCTIESIFPGFASQHMLMRSLNTVALVPIMYSWSPLQQN
FMVEDETVLCNIPYMGDEVKEEDETFIEELINNYDGKVHGEEEMIPGSVLISDAVFLELV
DALNQYSDEEEEGHNDTSDGKQDDSKEDLPVTRKRKRHAIEGNKKSSKKQFPNDMIFSAI
ASMFPENGVPDDMKERYRELTEMSDPNALPPQCTPNIDGPNAKSVQREQSLHSFHTLFCR
RCFKYDCFLHPFHATPNVYKRKNKEIKIEPEPCGTDCFLLLEGAKEYAMLHNPRSKCSGR
RRRRHHIVSASCSNASASAVAETKEGDSDRDTGNDWASSSSEANSRCQTPTKQKASPAPP
QLCVVEAPSEPVEWTGAEESLFRVFHGTYFNNFCSIARLLGTKTCKQVFQFAVKESLILK
LPTDELMNPSQKKKRKHRLWAAHCRKIQLKKDNSSTQVYNYQPCDHPDRPCDSTCPCIMT
QNFCEKFCQCNPDCQNRFPGCRCKTQCNTKQCPCYLAVRECDPDLCLTCGASEHWDCKVV
SCKNCSIQRGLKKHLLLAPSDVAGWGTFIKESVQKNEFISEYCGELISQDEADRRGKVYD
KYMSSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVVMVNGDHRIGIFAKRAIQAG
EELFFDYRYSQADALKYVGIERETDVL
NT seq
2244 nt
NT seq
+upstream
nt +downstream
nt
atggaaataccaaatccccctacctccaaatgtatcacttactggaaaagaaaagtgaaa
tctgaatacatgcgacttcgacaacttaaacggcttcaggcaaatatgggtgcaaaggct
ttgtatgtggcaaattttgcaaaggttcaagaaaaaacccagatcctcaatgaagaatgg
aagaagcttcgtgtccaacctgttcagtcaatgaagcctgtgagtggacacccttttctc
aaaaagtgtaccatagagagcattttcccgggatttgcaagccaacatatgttaatgagg
tcactgaacacagttgcattggttcccatcatgtattcctggtcccctctccaacagaac
tttatggtagaagatgagacggttttgtgcaatattccctacatgggagatgaagtgaaa
gaagaagatgagacttttattgaggagctgatcaataactatgatgggaaagtccatggt
gaagaagagatgatccctggatccgttctgattagtgatgctgtttttctggagttggtc
gatgccctgaatcagtactcagatgaggaggaggaagggcacaatgacacctcagatgga
aagcaggatgacagcaaagaagatctgccagtaacaagaaagagaaagcgacatgctatt
gaaggcaacaaaaagagttccaagaaacagttcccaaatgacatgatcttcagtgcaatt
gcctcaatgttccctgagaatggtgtcccagatgacatgaaggagaggtatcgagaacta
acagagatgtcagaccccaatgcacttccccctcagtgcacacccaacatcgatggcccc
aatgccaagtctgtgcagcgggagcaatctctgcactccttccacacacttttttgccgg
cgctgctttaaatacgactgcttccttcacccttttcatgccacccctaatgtatataaa
cgcaagaataaagaaatcaagattgaaccagaaccatgtggcacagactgcttccttttg
ctggaaggagcaaaggagtatgccatgctccacaacccccgctccaagtgctctggtcgt
cgccggagaaggcaccacatagtcagtgcttcctgctccaatgcctcagcctctgctgtg
gctgagactaaagaaggagacagtgacagggacacaggcaatgactgggcctccagttct
tcagaggctaactctcgctgtcagactcccacaaaacagaaggctagtccagccccacct
caactctgcgtagtggaagcaccctcggagcctgtggaatggactggggctgaagaatct
ctttttcgagtcttccatggcacctacttcaacaacttctgttcaatagccaggcttctg
gggaccaagacgtgcaagcaggtctttcagtttgcagtcaaagaatcacttatcctgaag
ctgccaacagatgagctcatgaacccctcacagaagaagaaaagaaagcacagattgtgg
gctgcacactgcaggaagattcagctgaagaaagataactcttccacacaagtgtacaac
taccaaccctgcgaccacccagaccgcccctgtgacagcacctgcccctgcatcatgact
cagaatttctgtgagaagttctgccagtgcaacccagactgtcagaatcgtttccctggc
tgtcgctgtaagacccagtgcaataccaagcaatgtccttgctatctggcagtgcgagaa
tgtgaccctgacctgtgtctcacctgtggggcctcagagcactgggactgcaaggtggtt
tcctgtaaaaactgcagcatccagcgtggacttaagaagcacctgctgctggccccctct
gatgtggccggatggggcaccttcataaaggagtctgtgcagaagaacgaattcatttct
gaatactgtggtgagctcatctctcaggatgaggctgatcgacgcggaaaggtctatgac
aaatacatgtccagcttcctcttcaacctcaataatgattttgtagtggatgctactcgg
aaaggaaacaaaattcgatttgcaaatcattcagtgaatcccaactgttatgccaaagtg
gtcatggtgaatggagaccatcggattgggatctttgccaagagggcaattcaagctggc
gaagagctcttctttgattacaggtacagccaagctgatgctctcaagtacgtggggatc
gagagggagaccgacgtcctttag
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