Homo sapiens (human): 2149
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Entry
2149 CDS
T01001
Symbol
F2R, CF2R, HTR, PAR-1, PAR1, TR
Name
(RefSeq) coagulation factor II thrombin receptor
KO
K03914
coagulation factor II (thrombin) receptor
Organism
hsa
Homo sapiens (human)
Pathway
hsa04015
Rap1 signaling pathway
hsa04020
Calcium signaling pathway
hsa04024
cAMP signaling pathway
hsa04072
Phospholipase D signaling pathway
hsa04080
Neuroactive ligand-receptor interaction
hsa04151
PI3K-Akt signaling pathway
hsa04610
Complement and coagulation cascades
hsa04611
Platelet activation
hsa04810
Regulation of actin cytoskeleton
hsa05130
Pathogenic Escherichia coli infection
hsa05200
Pathways in cancer
Network
nt06528
Calcium signaling
nt06530
PI3K signaling
Element
N01640
GPCR-PLCB-ITPR signaling pathway
N01657
GPCR-PI3K signaling pathway
Drug target
Atopaxar (
DG01348
):
D09866
D09867
Vorapaxar (
DG01349
):
D09765
D09766
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04015 Rap1 signaling pathway
2149 (F2R)
04020 Calcium signaling pathway
2149 (F2R)
04072 Phospholipase D signaling pathway
2149 (F2R)
04024 cAMP signaling pathway
2149 (F2R)
04151 PI3K-Akt signaling pathway
2149 (F2R)
09133 Signaling molecules and interaction
04080 Neuroactive ligand-receptor interaction
2149 (F2R)
09140 Cellular Processes
09142 Cell motility
04810 Regulation of actin cytoskeleton
2149 (F2R)
09150 Organismal Systems
09151 Immune system
04610 Complement and coagulation cascades
2149 (F2R)
04611 Platelet activation
2149 (F2R)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
2149 (F2R)
09171 Infectious disease: bacterial
05130 Pathogenic Escherichia coli infection
2149 (F2R)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04030 G protein-coupled receptors [BR:
hsa04030
]
2149 (F2R)
G protein-coupled receptors [BR:
hsa04030
]
Rhodopsin family
Peptide
Thrombin
2149 (F2R)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
7tm_1
Motif
Other DBs
NCBI-GeneID:
2149
NCBI-ProteinID:
NP_001983
OMIM:
187930
HGNC:
3537
Ensembl:
ENSG00000181104
Pharos:
P25116
(Tclin)
UniProt:
P25116
Structure
PDB
PDBj
LinkDB
All DBs
Position
5:76716126..76735770
Genome browser
AA seq
425 aa
AA seq
DB search
MGPRRLLLVAACFSLCGPLLSARTRARRPESKATNATLDPRSFLLRNPNDKYEPFWEDEE
KNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLN
IMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTA
AFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLK
EQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSS
AVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVS
SISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIY
KKLLT
NT seq
1278 nt
NT seq
+upstream
nt +downstream
nt
atggggccgcggcggctgctgctggtggccgcctgcttcagtctgtgcggcccgctgttg
tctgcccgcacccgggcccgcaggccagaatcaaaagcaacaaatgccaccttagatccc
cggtcatttcttctcaggaaccccaatgataaatatgaaccattttgggaggatgaggag
aaaaatgaaagtgggttaactgaatacagattagtctccatcaataaaagcagtcctctt
caaaaacaacttcctgcattcatctcagaagatgcctccggatatttgaccagctcctgg
ctgacactctttgtcccatctgtgtacaccggagtgtttgtagtcagcctcccactaaac
atcatggccatcgttgtgttcatcctgaaaatgaaggtcaagaagccggcggtggtgtac
atgctgcacctggccacggcagatgtgctgtttgtgtctgtgctcccctttaagatcagc
tattacttttccggcagtgattggcagtttgggtctgaattgtgtcgcttcgtcactgca
gcattttactgtaacatgtacgcctctatcttgctcatgacagtcataagcattgaccgg
tttctggctgtggtgtatcccatgcagtccctctcctggcgtactctgggaagggcttcc
ttcacttgtctggccatctgggctttggccatcgcaggggtagtgcctctgctcctcaag
gagcaaaccatccaggtgcccgggctcaacatcactacctgtcatgatgtgctcaatgaa
accctgctcgaaggctactatgcctactacttctcagccttctctgctgtcttctttttt
gtgccgctgatcatttccacggtctgttatgtgtctatcattcgatgtcttagctcttcc
gcagttgccaaccgcagcaagaagtcccgggctttgttcctgtcagctgctgttttctgc
atcttcatcatttgcttcggacccacaaacgtcctcctgattgcgcattactcattcctt
tctcacacttccaccacagaggctgcctactttgcctacctcctctgtgtctgtgtcagc
agcataagctgctgcatcgaccccctaatttactattacgcttcctctgagtgccagagg
tacgtctacagtatcttatgctgcaaagaaagttccgatcccagcagttataacagcagt
gggcagttgatggcaagtaaaatggatacctgctctagtaacctgaataacagcatatac
aaaaagctgttaacttag
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