KEGG   NETWORK: N01640
Entry
N01640                      Network                                
Name
GPCR-PLCB-ITPR signaling pathway
Definition
GPCR -> GNAQ -> PLCB -> IP3 -> ITPR -> Ca2+(cyto)
  Expanded
(2149,623,624,1128,1129,1131,148,147,146,3269,3356,3357,3358,185,2925,886,887,7852,1909,1910,4923,6869,6865,6870,552,553,5021,3973,5731,5733,5737,6915,5724,7201,56413,10800,57105,2911,2915) -> (2776,2767,9630,2769) -> (23236,5330,5331,5332) -> C01245 -> (3708,3709,3710) -> C00076
Class
nt06528 Calcium signaling
Type
Reference
Pathway
hsa04020  Calcium signaling pathway
Gene
2149  F2R; coagulation factor II thrombin receptor
623  BDKRB1; bradykinin receptor B1
624  BDKRB2; bradykinin receptor B2
1128  CHRM1; cholinergic receptor muscarinic 1
1129  CHRM2; cholinergic receptor muscarinic 2
1131  CHRM3; cholinergic receptor muscarinic 3
148  ADRA1A; adrenoceptor alpha 1A
147  ADRA1B; adrenoceptor alpha 1B
146  ADRA1D; adrenoceptor alpha 1D
3269  HRH1; histamine receptor H1
3356  HTR2A; 5-hydroxytryptamine receptor 2A
3357  HTR2B; 5-hydroxytryptamine receptor 2B
3358  HTR2C; 5-hydroxytryptamine receptor 2C
185  AGTR1; angiotensin II receptor type 1
2925  GRPR; gastrin releasing peptide receptor
886  CCKAR; cholecystokinin A receptor
887  CCKBR; cholecystokinin B receptor
7852  CXCR4; C-X-C motif chemokine receptor 4
1909  EDNRA; endothelin receptor type A
1910  EDNRB; endothelin receptor type B
4923  NTSR1; neurotensin receptor 1
6869  TACR1; tachykinin receptor 1
6865  TACR2; tachykinin receptor 2
6870  TACR3; tachykinin receptor 3
552  AVPR1A; arginine vasopressin receptor 1A
553  AVPR1B; arginine vasopressin receptor 1B
5021  OXTR; oxytocin receptor
3973  LHCGR; luteinizing hormone/choriogonadotropin receptor
5731  PTGER1; prostaglandin E receptor 1
5733  PTGER3; prostaglandin E receptor 3
5737  PTGFR; prostaglandin F receptor
6915  TBXA2R; thromboxane A2 receptor
5724  PTAFR; platelet activating factor receptor
7201  TRHR; thyrotropin releasing hormone receptor
56413  LTB4R2; leukotriene B4 receptor 2
10800  CYSLTR1; cysteinyl leukotriene receptor 1
57105  CYSLTR2; cysteinyl leukotriene receptor 2
2911  GRM1; glutamate metabotropic receptor 1
2915  GRM5; glutamate metabotropic receptor 5
2776  GNAQ; G protein subunit alpha q
2767  GNA11; G protein subunit alpha 11
9630  GNA14; G protein subunit alpha 14
2769  GNA15; G protein subunit alpha 15
23236  PLCB1; phospholipase C beta 1
5330  PLCB2; phospholipase C beta 2
5331  PLCB3; phospholipase C beta 3
5332  PLCB4; phospholipase C beta 4
3708  ITPR1; inositol 1,4,5-trisphosphate receptor type 1
3709  ITPR2; inositol 1,4,5-trisphosphate receptor type 2
3710  ITPR3; inositol 1,4,5-trisphosphate receptor type 3
Metabolite
C01245  D-myo-Inositol 1,4,5-trisphosphate
C00076  Calcium cation
Reference
PMID:22435804
  Authors
Berridge MJ
  Title
Calcium signalling remodelling and disease.
  Journal
Biochem Soc Trans 40:297-309 (2012)
DOI:10.1042/BST20110766
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:29618985
  Authors
Avila-Medina J, Mayoral-Gonzalez I, Dominguez-Rodriguez A, Gallardo-Castillo I, Ribas J, Ordonez A, Rosado JA, Smani T
  Title
The Complex Role of Store Operated Calcium Entry Pathways and Related Proteins in the Function of Cardiac, Skeletal and Vascular Smooth Muscle Cells.
  Journal
Front Physiol 9:257 (2018)
DOI:10.3389/fphys.2018.00257
Reference
PMID:35203269
  Authors
Munzer P, Borst O
  Title
CRACking the Molecular Regulatory Mechanism of SOCE during Platelet Activation in Thrombo-Occlusive Diseases.
  Journal
Cells 11:cells11040619 (2022)
DOI:10.3390/cells11040619
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