KEGG   Homo sapiens (human): 22992
Entry
22992             CDS       T01001                                 
Symbol
KDM2A, CXXC8, FBL11, FBL7, FBXL11, JHDM1A, LILINA
Name
(RefSeq) lysine demethylase 2A
  KO
K10276  F-box and leucine-rich repeat protein 10/11 [EC:1.14.11.27]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03083  Polycomb repressive complex
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09126 Chromosome
   03083 Polycomb repressive complex
    22992 (KDM2A)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    22992 (KDM2A)
   04121 Ubiquitin system [BR:hsa04121]
    22992 (KDM2A)
   03036 Chromosome and associated proteins [BR:hsa03036]
    22992 (KDM2A)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.11  With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
    1.14.11.27  [histone H3]-dimethyl-L-lysine36 demethylase
     22992 (KDM2A)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Zinc finger
   CXXC CpG-binding proteins
    22992 (KDM2A)
Ubiquitin system [BR:hsa04121]
 Ubiquitin ligases (E3)
  Multi subunit type E3
   SCF complex
    Target recognizing subunit (F-box)
     22992 (KDM2A)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Histone modification proteins
   Histone demethylases
    22992 (KDM2A)
   Polycomb repressive complex (PRC) and associated proteins
    Noncanonical PRC1 (PRC1.1)
     22992 (KDM2A)
SSDB
Motif
Pfam: PHD_4 zf-CXXC F-box-like JHD F-box JmjC Cupin_8 LRR_4 Cupin_1
Other DBs
NCBI-GeneID: 22992
NCBI-ProteinID: NP_036440
OMIM: 605657
HGNC: 13606
Ensembl: ENSG00000173120
UniProt: Q9Y2K7 I3VM53
Structure
LinkDB
Position
11:67119263..67258082
AA seq 1162 aa
MEPEEERIRYSQRLRGTMRRRYEDDGISDDEIEGKRTFDLEEKLHTNKYNANFVTFMEGK
DFNVEYIQRGGLRDPLIFKNSDGLGIKMPDPDFTVNDVKMCVGSRRMVDVMDVNTQKGIE
MTMAQWTRYYETPEEEREKLYNVISLEFSHTRLENMVQRPSTVDFIDWVDNMWPRHLKES
QTESTNAILEMQYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHIHQGGKVFWLIPPTAHN
LELYENWLLSGKQGDIFLGDRVSDCQRIELKQGYTFVIPSGWIHAVYTPTDTLVFGGNFL
HSFNIPMQLKIYNIEDRTRVPNKFRYPFYYEMCWYVLERYVYCITNRSHLTKEFQKESLS
MDLELNGLESGNGDEEAVDREPRRLSSRRSVLTSPVANGVNLDYDGLGKTCRSLPSLKKT
LAGDSSSDCSRGSHNGQVWDPQCAPRKDRQVHLTHFELEGLRCLVDKLESLPLHKKCVPT
GIEDEDALIADVKILLEELANSDPKLALTGVPIVQWPKRDKLKFPTRPKVRVPTIPITKP
HTMKPAPRLTPVRPAAASPIVSGARRRRVRCRKCKACVQGECGVCHYCRDMKKFGGPGRM
KQSCVLRQCLAPRLPHSVTCSLCGEVDQNEETQDFEKKLMECCICNEIVHPGCLQMDGEG
LLNEELPNCWECPKCYQEDSSEKAQKRKMEESDEEAVQAKVLRPLRSCDEPLTPPPHSPT
SMLQLIHDPVSPRGMVTRSSPGAGPSDHHSASRDERFKRRQLLRLQATERTMVREKENNP
SGKKELSEVEKAKIRGSYLTVTLQRPTKELHGTSIVPKLQAITASSANLRHSPRVLVQHC
PARTPQRGDEEGLGGEEEEEEEEEEEDDSAEEGGAARLNGRGSWAQDGDESWMQREVWMS
VFRYLSRRELCECMRVCKTWYKWCCDKRLWTKIDLSRCKAIVPQALSGIIKRQPVSLDLS
WTNISKKQLTWLVNRLPGLKDLLLAGCSWSAVSALSTSSCPLLRTLDLRWAVGIKDPQIR
DLLTPPADKPGQDNRSKLRNMTDFRLAGLDITDATLRLIIRHMPLLSRLDLSHCSHLTDQ
SSNLLTAVGSSTRYSLTELNMAGCNKLTDQTLIYLRRIANVTLIDLRGCKQITRKACEHF
ISDLSINSLYCLSDEKLIQKIS
NT seq 3489 nt   +upstreamnt  +downstreamnt
atggaacccgaagaagaaaggattcgttacagccagagattgcgtggtaccatgcgacga
cgctatgaagatgatggcatttcagatgatgaaattgaaggaaaaagaacttttgacttg
gaagagaaactgcacaccaacaaatataatgccaattttgttacttttatggaaggaaaa
gattttaatgtagagtatattcagcggggtggcttgagagatcctctgattttcaagaat
tctgatggactcggaataaaaatgccggatccagacttcactgtgaatgatgtcaaaatg
tgtgtggggagtcgtcgcatggtggatgtcatggacgtgaacacacagaaaggcattgaa
atgaccatggctcagtggacacgctactatgagaccccagaggaggagcgagagaaactc
tataatgtcatcagcctcgagtttagccacaccaggctggagaatatggtgcagaggccc
tccacggtggatttcattgactgggtagacaacatgtggccaaggcacttgaaggaaagc
cagactgaatcaacaaatgccatcttggagatgcagtaccctaaagtgcagaagtactgt
ctaatgagtgttcgaggctgctatactgacttccatgtggactttggtggtacctctgtt
tggtatcacatccatcaagggggaaaggtcttctggctcatcccccctacagcccacaac
ctggagctgtacgagaattggctgctgtcagggaaacagggagacatctttctgggtgac
cgggtatcagattgtcagcgcattgagctcaagcagggctataccttcgtcattccctca
ggctggattcatgctgtgtatactcctacagacacattagtgtttgggggcaattttttg
catagcttcaacatccctatgcagttaaaaatatacaacattgaagatcggacacgggtt
ccaaataagtttcgctatccattctactatgagatgtgttggtatgtgttggagcgctat
gtgtactgcataaccaaccgttcccacctaactaaggaatttcagaaagagtccctcagc
atggatttggagttaaatgggttggagtctgggaatggggatgaggaagcagtggatcga
gaaccccgacgcttgagcagcaggcgttctgtcctcactagccctgtagcgaatggagtc
aacctggattatgatggactgggcaaaacctgccgaagtcttccaagtctgaagaaaact
ttggctggggactcatcttctgactgtagccggggctcccacaatggacaagtgtgggat
ccccagtgtgctccccgaaaggacaggcaagtgcatctgacccattttgagcttgaaggc
cttcgctgccttgtagataagttggagtctctgccactgcacaagaaatgtgtccccaca
gggatagaagatgaagatgctctcattgctgatgtaaagattttgctggaggagcttgcc
aacagcgatcccaagttagccctcactggagttcctatagtacagtggccaaaaagggat
aagcttaaattccccactcggccaaaggtgcgggttcctaccatccccattacgaagcct
cacactatgaaaccagctccacggttaacacctgtgaggccagctgctgcctccccgatt
gtgtcaggagccagacggagacgagtgcgatgtcgaaaatgcaaagcctgtgtgcaagga
gagtgtggtgtttgccactactgcagagacatgaagaagtttggggggcctggacgcatg
aagcagtcctgtgtcctccgacagtgcttggcacccagactgcctcactcagtcacatgt
tccctctgtggagaggtggatcagaatgaagagacacaagactttgagaagaaactcatg
gaatgctgtatctgcaatgagattgttcatcctggctgcctccagatggacggagagggg
ttgcttaacgaagaattgccaaattgctgggaatgtccaaagtgctaccaggaggacagc
tcggagaaagcccagaagcggaaaatggaagagagtgacgaagaagctgtgcaagccaaa
gtcctgcggcccctgcggagctgcgatgagcctctcacgcccccgcctcattcacccact
tccatgctgcagctcatccatgacccggtttccccccggggtatggtgactcggtcatcc
cctggggctggccccagcgaccaccacagtgccagccgcgatgagcgcttcaaacggcgg
cagttgctgcggctgcaggccacagagcgcaccatggtacgggaaaaggagaacaatccc
agcggcaaaaaggagctgtctgaagttgagaaagccaagatccggggatcgtacctcact
gtcacgctacagaggcccaccaaagagctccacgggacatccattgtgcccaagctgcag
gccatcacggcctcctctgccaaccttcgccattccccccgtgtgctagtgcagcactgc
ccagcccgaaccccccagcgtggggatgaggaggggctggggggagaggaggaggaagag
gaggaggaggaggaggaagatgacagtgcagaggaggggggtgcagccaggctgaatggc
cggggcagttgggctcaggatggagacgaaagctggatgcagcgggaggtctggatgtct
gtcttccgctacctcagccgcagagaactttgtgaatgtatgcgagtgtgcaagacgtgg
tataaatggtgctgcgacaagagactttggacaaaaattgacttgagtaggtgtaaggcc
attgtgccccaggccctcagtggcatcatcaagaggcagccagtcagccttgacctcagt
tggaccaacatctctaaaaagcaactgacatggctcgtcaataggctgccaggactgaaa
gacctcctcctagcaggctgctcctggtctgcagtctctgccctcagcacctccagctgc
ccccttctcaggacccttgatcttcggtgggcagtaggaatcaaggaccctcaaattcgg
gacttgcttactccaccggctgataaaccaggtcaggacaatcgcagcaagctccggaac
atgaccgacttccggctggcaggccttgacatcacagatgccacgcttcgcctcataatt
cgccacatgcccctcctgtctcgactcgacctcagtcactgcagccaccttacagatcag
tcctccaatctactcactgctgtcgggtcttccactcgctactctctcacagagctcaat
atggcaggttgcaataaattgacagaccagaccctgatctacctacggcgcattgccaac
gtcaccttgatcgaccttcgaggatgcaagcagatcactcgaaaagcctgcgagcacttc
atctcagacttgtccatcaacagcctctactgcctgtctgacgagaagctgatacagaag
atcagctaa

KEGG   Homo sapiens (human): 84678
Entry
84678             CDS       T01001                                 
Symbol
KDM2B, CXXC2, FBXL10, Fbl10, JHDM1B, PCCX2
Name
(RefSeq) lysine demethylase 2B
  KO
K10276  F-box and leucine-rich repeat protein 10/11 [EC:1.14.11.27]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03083  Polycomb repressive complex
Network
nt06523  Epigenetic regulation by Polycomb complexes
  Element
N01586  Activation of PRC2.2 by ubiquitination of H2AK119
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09126 Chromosome
   03083 Polycomb repressive complex
    84678 (KDM2B)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    84678 (KDM2B)
   04121 Ubiquitin system [BR:hsa04121]
    84678 (KDM2B)
   03036 Chromosome and associated proteins [BR:hsa03036]
    84678 (KDM2B)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.11  With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
    1.14.11.27  [histone H3]-dimethyl-L-lysine36 demethylase
     84678 (KDM2B)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Zinc finger
   CXXC CpG-binding proteins
    84678 (KDM2B)
Ubiquitin system [BR:hsa04121]
 Ubiquitin ligases (E3)
  Multi subunit type E3
   SCF complex
    Target recognizing subunit (F-box)
     84678 (KDM2B)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Histone modification proteins
   Histone demethylases
    84678 (KDM2B)
   Polycomb repressive complex (PRC) and associated proteins
    Noncanonical PRC1 (PRC1.1)
     84678 (KDM2B)
SSDB
Motif
Pfam: PHD_4 zf-CXXC F-box-like JHD F-box Cupin_8 JmjC AppA_SCHIC
Other DBs
NCBI-GeneID: 84678
NCBI-ProteinID: NP_115979
OMIM: 609078
HGNC: 13610
Ensembl: ENSG00000089094
UniProt: Q8NHM5
Structure
LinkDB
Position
12:complement(121408461..121582279)
AA seq 1336 aa
MAGPQMGGSAEDHPPRKRHAAEKQKKKTVIYTKCFEFESATQRPIDRQRYDENEDLSDVE
EIVSVRGFSLEEKLRSQLYQGDFVHAMEGKDFNYEYVQREALRVPLIFREKDGLGIKMPD
PDFTVRDVKLLVGSRRLVDVMDVNTQKGTEMSMSQFVRYYETPEAQRDKLYNVISLEFSH
TKLEHLVKRPTVVDLVDWVDNMWPQHLKEKQTEATNAIAEMKYPKVKKYCLMSVKGCFTD
FHIDFGGTSVWYHVFRGGKIFWLIPPTLHNLALYEEWVLSGKQSDIFLGDRVERCQRIEL
KQGYTFFIPSGWIHAVYTPVDSLVFGGNILHSFNVPMQLRIYEIEDRTRVQPKFRYPFYY
EMCWYVLERYVYCVTQRSHLTQEYQRESMLIDAPRKPSIDGFSSDSWLEMEEEACDQQPQ
EEEEKDEEGEGRDRAPKPPTDGSTSPTSTPSEDQEALGKKPKAPALRFLKRTLSNESEES
VKSTTLAVDYPKTPTGSPATEVSAKWTHLTEFELKGLKALVEKLESLPENKKCVPEGIED
PQALLEGVKNVLKEHADDDPSLAITGVPVVTWPKKTPKNRAVGRPKGKLGPASAVKLAAN
RTTAGARRRRTRCRKCEACLRTECGECHFCKDMKKFGGPGRMKQSCIMRQCIAPVLPHTA
VCLVCGEAGKEDTVEEEEGKFNLMLMECSICNEIIHPGCLKIKESEGVVNDELPNCWECP
KCNHAGKTGKQKRGPGFKYASNLPGSLLKEQKMNRDNKEGQEPAKRRSECEEAPRRRSDE
HSKKVPPDGLLRRKSDDVHLRKKRKYEKPQELSGRKRASSLQTSPGSSSHLSPRPPLGSS
LSPWWRSSLTYFQQQLKPGKEDKLFRKKRRSWKNAEDRMALANKPLRRFKQEPEDELPEA
PPKTRESDHSRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLPNKELSRELSKELNHEIQR
TENSLANENQQPIKSEPESEGEEPKRPPGICERPHRFSKGLNGTPRELRHQLGPSLRSPP
RVISRPPPSVSPPKCIQMERHVIRPPPISPPPDSLPLDDGAAHVMHREVWMAVFSYLSHQ
DLCVCMRVCRTWNRWCCDKRLWTRIDLNHCKSITPLMLSGIIRRQPVSLDLSWTNISKKQ
LSWLINRLPGLRDLVLSGCSWIAVSALCSSSCPLLRTLDVQWVEGLKDAQMRDLLSPPTD
NRPGQMDNRSKLRNIVELRLAGLDITDASLRLIIRHMPLLSKLHLSYCNHVTDQSINLLT
AVGTTTRDSLTEINLSDCNKVTDQCLSFFKRCGNICHIDLRYCKQVTKEGCEQFIAEMSV
SVQFGQVEEKLLQKLS
NT seq 4011 nt   +upstreamnt  +downstreamnt
atggcgggtccgcaaatggggggatctgcagaggatcaccccccacgaaaaagacatgca
gcagaaaagcaaaaaaagaaaacagttatatatacaaaatgctttgaatttgagtcggcc
acacagcgcccgattgaccgccagcgatacgacgagaacgaggacttgtcggacgtggag
gagatcgtcagcgtccgcggcttcagcctggaggagaagcttcgcagccagctgtaccag
ggggacttcgtgcacgccatggagggcaaagatttcaactatgagtacgtacagagagaa
gctctcagggttcccctgatatttcgagaaaaggatggactgggaattaagatgcctgac
cctgatttcacagtccgagacgtcaaactcctagtggggagccggcggcttgtggacgtg
atggatgtgaacacccagaagggcacggagatgagcatgtcccagtttgtgcgttactac
gagacgcccgaggcccagcgggacaagctgtacaacgtcatcagcctagagttcagccac
accaagctggagcacttggtcaagcgtccgactgtggtagacctggtggactgggtggac
aacatgtggccccagcatctgaaggagaagcagacagaagccacgaacgccattgcagag
atgaagtacccgaaagtgaaaaagtactgtctgatgagcgtgaaaggttgtttcaccgac
ttccacatcgactttggaggcacttccgtttggtaccatgttttccggggtgggaagatt
ttttggctgattcctccaacgctgcacaatttggcgctgtacgaggagtgggtgctgtca
ggcaaacagagtgacatctttctgggagaccgtgtggaacgatgccaaagaattgagctg
aagcagggctacacatttttcatcccttccggttggatccatgccgtctacacccctgta
gactctttggtgttcggcggaaacatcctgcacagctttaacgtgcccatgcagctgcgg
atctacgagatcgaggacaggacgcgggtgcagcccaaattccgttaccccttctactat
gagatgtgctggtatgtcctggagagatacgtgtactgtgtgacccagcgctcccacctc
actcaggaataccagagggagtcgatgcttattgatgccccgaggaagcccagcatagac
ggcttctcttcggattcctggctggagatggaggaggaggcctgtgatcagcagcctcag
gaggaggaggagaaggacgaggagggcgagggcagggacagggcacccaaaccgcccacc
gatggctccacttcacccaccagcacgccctctgaggaccaggaggccctcgggaagaag
cccaaagcacctgccctgcgattcctcaaaaggactttgtctaatgagtcggaggaaagt
gtgaagtccaccacattggccgtagactaccccaagacccccaccggctctcccgccacg
gaggtctctgccaaatggacccatctcactgagtttgaactgaagggcctgaaagctctg
gtggagaaactggaatccctcccggagaacaagaagtgtgtccccgagggcatcgaggac
ccccaggcactcctggagggtgtgaagaacgtcctgaaggagcacgcagatgatgaccct
agtctggccatcactggggtccctgtggtgacttggccaaagaagactccaaagaaccgg
gctgtgggtcggcccaaggggaagctgggcccggcctccgcggtgaagttggccgccaac
cggacaacggcaggagctcggcggcgccggacgcgatgccgcaagtgcgaggcctgcctg
cggaccgagtgcggagagtgccacttctgcaaggacatgaagaagttcgggggccccggg
cgcatgaagcagagctgcatcatgcggcagtgcatcgcgccagtgctgccccacaccgcc
gtgtgccttgtgtgtggcgaggcggggaaggaagacacggtggaagaggaggaaggcaag
tttaacctcatgctcatggagtgctccatctgcaatgaaatcatccaccctggatgcctt
aagattaaggagtcagagggtgtggtcaacgacgagcttccaaactgctgggagtgtccg
aagtgtaaccacgccggcaagaccgggaaacaaaagcgtggccctggctttaagtacgcc
tccaacctgcccggctccctgctcaaggagcagaagatgaaccgggacaacaaggaaggg
caggaacctgccaagcggaggagtgagtgtgaggaggcgccccggcgcaggtcggatgag
cactcgaagaaggtgccgccggacggccttctgcgcagaaagtctgacgacgtgcacctg
aggaagaagcggaaatacgagaagccccaggagctgagtggacgcaagcgggcctcatcg
cttcaaacgtcccccggttcctcctctcacctctcgccgaggccccctctaggcagcagc
ctcagcccctggtggagatccagtctcacttacttccagcagcagctcaaacctggcaaa
gaagataagcttttcaggaaaaagcggcggtcctggaagaacgccgaggaccgcatggcg
ctggccaacaagcccctccggcgcttcaagcaggaacccgaggacgaactgcccgaggcg
ccccccaagaccagggagagcgaccactcccgctccagctcccccaccgcgggacccagc
accgaaggggccgagggcccggaggagaagaagaaggtgaagatgcgccggaagcggcgg
cttcccaacaaggagctgagcagggagctgagcaaggagctcaaccacgagatccagagg
acggagaacagcctggccaacgagaaccagcagcccatcaagtcggagcctgagagcgag
ggcgaggagcccaagcggcccccgggcatctgcgagcgtccccaccgcttcagcaagggg
ctcaacggcaccccccgggagctgcggcaccagctggggcccagcctgcgcagcccgccc
cgtgtcatctcccggcccccaccctccgtgtccccgcccaagtgtatccagatggagcgc
catgtgatccggccaccccccatcagccccccgcctgactcgctacccctggacgatggg
gcagcccacgtcatgcacagggaggtgtggatggccgtcttcagctacctcagccaccaa
gacctgtgtgtgtgcatgcgggtctgcaggacctggaaccgctggtgctgcgataagcgg
ttgtggacccgcattgacctgaaccactgcaagtctatcacacccctgatgctgagtggc
atcatccggcgacagcccgtctccctcgacctcagctggaccaatatctccaagaagcag
ctgagctggctcatcaaccggctgcctgggctccgggacttggtgctgtcaggctgctca
tggatcgcggtctcggccctttgcagctccagttgtccgctgctccggaccctggatgtc
cagtgggtggagggactaaaggatgcccagatgcgggatctcctgtccccgcccacagac
aacaggccaggtcagatggacaatcggagcaagctccggaacatcgtggagctgcgcctg
gcaggcctggacatcacagatgcctccctgcggctcatcatccgccacatgcccctgctc
tccaagctccacctcagttactgtaaccacgtcaccgaccagtctatcaacctgctcact
gctgttggcaccaccacccgagactccttaaccgagatcaacctgtctgactgcaataag
gtcactgatcagtgcctgtccttcttcaaacgctgtggaaacatctgtcatattgacctg
aggtactgcaagcaagtcaccaaggaaggctgtgagcagttcatagccgagatgtctgtg
agtgtccagtttgggcaagtagaagaaaaactcctgcaaaaactgagttag

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