KEGG   ENZYME: 1.14.11.27
Entry
EC 1.14.11.27               Enzyme                                 
Name
[histone H3]-dimethyl-L-lysine36 demethylase;
KDM2A (gene name);
KDM2B (gene name);
JHDM1A (gene name);
JHDM1B (gene name);
JmjC domain-containing histone demethylase 1A;
H3-K36-specific demethylase (ambiguous);
histone-lysine (H3-K36) demethylase (ambiguous);
histone demethylase (ambiguous);
protein-6-N,6-N-dimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase;
protein-N6,N6-dimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase;
[histone-H3]-lysine-36 demethylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
Sysname
[histone H3]-N6,N6-dimethyl-L-lysine36,2-oxoglutarate:oxygen oxidoreductase
Reaction(IUBMB)
a [histone H3]-N6,N6-dimethyl-L-lysine36 + 2 2-oxoglutarate + 2 O2 = a [histone H3]-L-lysine36 + 2 succinate + 2 formaldehyde + 2 CO2 (overall reaction) [RN:R10056];
(1a) a [histone H3]-N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2 = a [histone H3]-N6-methyl-L-lysine36 + succinate + formaldehyde + CO2 [RN:R09510];
(1b) a [histone H3]-N6-methyl-L-lysine36 + 2-oxoglutarate + O2 = a [histone H3]-L-lysine36 + succinate + formaldehyde + CO2 [RN:R09511]
Reaction(KEGG)
Substrate
[histone H3]-N6,N6-dimethyl-L-lysine36;
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007];
[histone H3]-N6-methyl-L-lysine36
Product
[histone H3]-L-lysine36;
succinate [CPD:C00042];
formaldehyde [CPD:C00067];
CO2 [CPD:C00011];
[histone H3]-N6-methyl-L-lysine36
Comment
Requires iron(II). Of the seven potential methylation sites in histones H3 (K4, K9, K27, K36, K79) and H4 (K20, R3) from HeLa cells, the enzyme is specific for Lys36. Lysine residues exist in three methylation states (mono-, di- and trimethylated). The enzyme preferentially demethylates the dimethyl form of Lys36 (K36me2), which is its natural substrate, to form the monomethylated and unmethylated forms of Lys36. It can also demethylate monomethylated (but not the trimethylated) Lys36. cf. EC 1.14.11.69, [histone H3]-trimethyl-L-lysine36 demethylase.
History
EC 1.14.11.27 created 2006, modified 2019
Orthology
K10276  F-box and leucine-rich repeat protein 10/11
K24444  [histone H3]-dimethyl/trimethyl-L-lysine36 demethylase
Genes
HSA22992(KDM2A) 84678(KDM2B)
PTR107967129(KDM2A) 465184(KDM2B)
PPS100983162(KDM2A) 100988129(KDM2B)
GGO101140212(KDM2A) 101154151(KDM2B)
PON100434567(KDM2A) 100462645(KDM2B)
NLE100579905(KDM2B) 100601545(KDM2A)
HMH116469069(KDM2A) 116477778(KDM2B)
MCC699938(KDM2B) 712907(KDM2A)
MCF102125851(KDM2B) 102142242(KDM2A)
MTHB126930598 126935329
MNI105469666(KDM2A) 105494556(KDM2B)
CSAB103219229(KDM2A) 103239283(KDM2B)
CATY105577615(KDM2A) 105590967(KDM2B)
PANU101017786(KDM2A) 101023070(KDM2B)
TGE112606108(KDM2A) 112634202(KDM2B)
MLEU105528004(KDM2B) 105544457(KDM2A)
RRO104664750(KDM2A) 104666275(KDM2B)
RBB108518607(KDM2A) 108529633(KDM2B)
TFN117080583(KDM2A) 117089271(KDM2B)
PTEH111522325(KDM2A) 113219552(KDM2B)
CANG105512099(KDM2A) 105516339(KDM2B)
CJC100397900(KDM2B) 100403232(KDM2A)
SBQ101044630(KDM2B) 101049444(KDM2A)
CIMI108310367(KDM2A) 108315130(KDM2B)
CSYR103258730(KDM2A) 103264052(KDM2B)
MMUR105867478(KDM2A) 105880908(KDM2B)
LCAT123626074(KDM2B) 123642866(KDM2A)
PCOQ105825615(KDM2B) 105827428(KDM2A)
OGA100940651(KDM2A) 100951584(KDM2B)
MMU225876(Kdm2a) 30841(Kdm2b)
MCAL110285231(Kdm2a) 110294179(Kdm2b)
MPAH110337427(Kdm2a) 110339091(Kdm2b)
RNO304495(Kdm2b) 361700(Kdm2a)
MCOC116103333(Kdm2a) 116104643(Kdm2b)
ANU117697917(Kdm2b) 117703820(Kdm2a)
MUN110545328(Kdm2b) 110560366(Kdm2a)
CGE100763039(Kdm2a) 100767158(Kdm2b)
MAUA101839594(Kdm2b) 101839946(Kdm2a)
PROB127216080(Kdm2b) 127228645(Kdm2a)
PLEU114683642 114686005(Kdm2a) 114686154 114704550(Kdm2b)
MORG121445909(Kdm2b) 121453852(Kdm2a) 121461952
MFOT126498203 126504216
AAMP119812921(Kdm2a) 119825697(Kdm2b)
NGI103725573(Kdm2a) 103739068(Kdm2b)
HGL101696346(Kdm2b) 101713712(Kdm2a)
CPOC100726076(Kdm2b) 100732285(Kdm2a)
CCAN109684942 109684944(Kdm2a) 109686393(Kdm2b)
DORD105989077(Kdm2a) 105990689(Kdm2b)
DSP122098481(Kdm2b) 122104659(Kdm2a)
PLOP125349146(Kdm2b) 125362359(Kdm2a)
NCAR124958238 124990785
MMMA107156416(Kdm2b) 107156994(Kdm2a)
OCU100349603 100352993 127482665
OPI101523726(KDM2A) 101536451(KDM2B)
TUP102482421(KDM2A) 102488934(KDM2B)
GVR103589971(KDM2A) 103602934(KDM2B)
CFA483702(KDM2A) 486262(KDM2B)
CLUD112659432(KDM2A) 112676510(KDM2B)
VVP112924192(KDM2A) 112935168(KDM2B)
VLG121471969(KDM2A) 121475384(KDM2B)
NPO129499962(KDM2A) 129508412(KDM2B)
AML100467038(KDM2B) 100469601(KDM2A)
UMR103661272(KDM2B) 103679509(KDM2A)
UAH113244041(KDM2A) 113266944(KDM2B)
UAR123778525(KDM2A) 123779338(KDM2B)
ELK111149677 111156340
LLV125080086 125082678
MPUF101686934(KDM2B) 101690280(KDM2A)
MNP132018016(KDM2A) 132023131(KDM2B)
MLK131811696(KDM2B) 131816234(KDM2A)
NVS122903453(KDM2B) 122913174(KDM2A)
ORO101368497(KDM2B) 101385046(KDM2A)
EJU114219056(KDM2B) 114220547(KDM2A)
ZCA113912625(KDM2B) 113913959(KDM2A)
MLX118016115(KDM2A) 118018441(KDM2B)
NSU110576380(KDM2A) 110588251(KDM2B)
LWW102738974 102740454(KDM2A)
FCA101090549(KDM2A) 101094455(KDM2B)
PYU121010451(KDM2B) 121023707(KDM2A)
PCOO112852035(KDM2A) 112870128(KDM2B)
PBG122470195(KDM2B) 122484041(KDM2A)
PVIV125146717(KDM2A) 125149533(KDM2B)
LRUF124505551 124518147
PTG102959050(KDM2A) 102971585(KDM2B)
PPAD109246832(KDM2A) 109277681(KDM2B)
PUC125911683 125914191
AJU106967547 106971187
HHV120231486(KDM2B) 120233876(KDM2A)
BTA540141(KDM2A) 614487(KDM2B)
BOM102274509(KDM2B) 102286032(KDM2A)
BIU109554334(KDM2A) 109571124(KDM2B)
BBUB102398958(KDM2B) 102407952(KDM2A)
BBIS104986975(KDM2A) 104989615(KDM2B)
CHX102180467(KDM2A) 102180525(KDM2B)
OAS101103759(KDM2B) 101108003(KDM2A)
BTAX128062002(KDM2B) 128068504(KDM2A)
ODA120856438 120871025(KDM2B) 120874763(KDM2A)
CCAD122423797(KDM2B) 122431484(KDM2A)
MBEZ129542713(KDM2B) 129548708(KDM2A)
SSC100294703(KDM2A) 100512074(KDM2B)
CFR102503719(KDM2B) 102523384(KDM2A)
CBAI105070323(KDM2A) 105080628(KDM2B)
CDK105102511(KDM2B) 105104438(KDM2A)
VPC102539900(KDM2B) 102543069(KDM2A)
BACU103004183(KDM2B) 103010328 103019182(KDM2A)
BMUS118898821(KDM2A) 118906887(KDM2B)
LVE103076521(KDM2A) 103088952(KDM2B)
OOR101280158(KDM2B) 101283255(KDM2A)
DLE111183686(KDM2A) 111186955(KDM2B)
PCAD102978197(KDM2B) 102995738(KDM2A)
PSIU116755922 116757832(KDM2A) 116765072(KDM2B)
NASI112402388(KDM2A) 112408848(KDM2B)
ECB100052955(KDM2A) 100059690(KDM2B)
EPZ103541690(KDM2B) 103559839(KDM2A)
EAI106833507(KDM2A) 106842217(KDM2B)
MYB102249116(KDM2A) 102253219(KDM2B)
MYD102751904(KDM2B) 102768553(KDM2A)
MMYO118665231(KDM2A) 118678173(KDM2B)
MLF102419266(KDM2B) 102433104(KDM2A) 102439028
PKL118706967(KDM2A) 118725299(KDM2B)
EFUS103287028(KDM2B) 103290935(KDM2A)
MNA107529559(KDM2B) 107533588(KDM2A)
DRO112310458(KDM2B) 112317322(KDM2A)
SHON118991072(KDM2B) 118991803(KDM2A)
AJM119041861(KDM2A) 119048704(KDM2B)
PDIC114499250(KDM2A) 114509357(KDM2B)
PHAS123823004(KDM2B) 123829280(KDM2A)
MMF118628053(KDM2A) 118639803(KDM2B)
PPAM129068540(KDM2A) 129087353(KDM2B)
HAI109384201(KDM2A) 109386110(KDM2B)
RFQ117017373(KDM2B) 117031282(KDM2A)
PALE102883377(KDM2B) 102893981(KDM2A)
PGIG120584774(KDM2A) 120616077(KDM2B)
PVP105289380(KDM2B) 105309915
RAY107503783(KDM2A) 107515252(KDM2B)
MJV108390401(KDM2B) 108393149(KDM2A)
TOD119245013(KDM2B) 119249920(KDM2A)
SARA101547993(KDM2A) 101556894(KDM2B)
SETR126018095(KDM2A) 126030682(KDM2B)
LAV100669609(KDM2B) 100672180(KDM2A)
TMU101346594 101348103 111821051
ETF101651408(KDM2A) 101654703
DNM101425403(KDM2A) 101447492(KDM2B)
MDO100015947(KDM2B) 100029240(KDM2A) 103104734
GAS123251245(KDM2A) 123255833 123256857
SHR100925042(KDM2A) 105749708(KDM2B)
AFZ127541047 127543158 127545444
PCW110195381(KDM2A) 110196804(KDM2B)
OAA100079482(KDM2B) 100084241(KDM2A)
GGA416844(KDM2B) 425999(KDM2A)
PCOC116228612(KDM2B) 116243004(KDM2A)
MGP100544042(KDM2B) 100551270(KDM2A)
CJO107314187(KDM2A) 107321115(KDM2B)
TPAI128084644(KDM2B) 128086777(KDM2A)
LMUT125694630(KDM2A) 125701583(KDM2B)
NMEL110400817(KDM2A) 110406580(KDM2B)
APLA101791557(KDM2B) 101795359(KDM2A)
ACYG106029324(KDM2A) 106031144(KDM2B)
CATA118244544(KDM2A) 118257198(KDM2B)
AFUL116490040(KDM2A) 116496229(KDM2B)
TGU100218907(KDM2B) 100230512(KDM2A)
LSR110471756(KDM2B) 110484936(KDM2A)
SCAN103818165(KDM2B) 103822131(KDM2A)
PMOA120499553(KDM2A) 120509578(KDM2B)
OTC121339022(KDM2B) 121339269(KDM2A)
PRUF121355161(KDM2A) 121364831(KDM2B)
GFR102033306(KDM2A) 102045075(KDM2B)
FAB101813982(KDM2B) 101818982(KDM2A)
OMA130253482(KDM2A) 130259853(KDM2B)
PHI102113870(KDM2B) 102114250(KDM2A)
PMAJ107206215(KDM2A) 107211564(KDM2B)
CCAE111930406(KDM2A) 111936391(KDM2B)
CCW104684132(KDM2A) 104688702(KDM2B)
CBRC103611832(KDM2A) 103615925(KDM2B)
ETL114054942(KDM2B) 114067858(KDM2A)
ZAB102061355(KDM2A) 102062662(KDM2B)
ZLE135448990(KDM2A) 135454818(KDM2B)
SVG106852378(KDM2B) 106854662(KDM2A)
MMEA130580086(KDM2A) 130580367(KDM2B)
HRT120753687(KDM2A) 120760380(KDM2B)
FPG101912390(KDM2B) 101914594(KDM2A)
FCH102050781(KDM2B) 102052310(KDM2A)
CLV102084883(KDM2B) 102096388(KDM2A)
EGZ104129653(KDM2A) 104130143(KDM2B)
NNI104009386(KDM2A) 104019494(KDM2B)
PCRI104035838(KDM2B)
PLET104618844(KDM2B)
EHS104512210(KDM2B)
PCAO104044861(KDM2B)
ACUN113486070(KDM2B) 113490447(KDM2A)
TALA104358065(KDM2A) 104364770(KDM2B)
PADL103914528(KDM2B) 103925836(KDM2A)
AFOR103902792(KDM2B) 103904967(KDM2A)
ACHC115345468(KDM2B) 115351840(KDM2A)
HALD104311639(KDM2B)
HLE104833295(KDM2A) 104840894(KDM2B)
AGEN126040988 126046879
GCL127016793 127023096
CCRI104159309(KDM2B)
CSTI104550525(KDM2B)
CMAC104476619(KDM2B)
BREG104637363(KDM2B)
FGA104075895(KDM2B)
GSTE104262199(KDM2B)
LDI104353399(KDM2B)
MNB103782204(KDM2B)
OHA104333334(KDM2A) 104339358(KDM2B)
NNT104402807(KDM2B) 104408937
SHAB115606128(KDM2A) 115614305(KDM2B)
DPUB104304458(KDM2A) 104308400(KDM2B)
PGUU104470336(KDM2B)
ACAR104530612(KDM2B)
CPEA104386422(KDM2A) 104389417(KDM2B)
AVIT104278052
CVF104282208(KDM2B) 104287547(KDM2A)
RTD128908456(KDM2A) 128916924(KDM2B)
CUCA104058827(KDM2B) 104063332(KDM2A)
TEO104373315(KDM2B)
BRHI104497580(KDM2B)
AAM106493402(KDM2A) 106495671(KDM2B)
AROW112962552(KDM2B) 112966994(KDM2A)
NPD112945877 112954257(KDM2A)
TGT104567197(KDM2B) 104576471(KDM2A)
DNE112988614(KDM2A) 112991810(KDM2B)
SCAM104138796(KDM2B) 104140371(KDM2A)
ASN102379559(KDM2B) 102388715(KDM2A)
AMJ102565389(KDM2A) 106736919(KDM2B)
CPOO109312625(KDM2B) 109324605(KDM2A)
GGN109290598(KDM2B)
PSS102446014(KDM2B) 102452607 102454325 102464032(KDM2A)
CMY102933550(KDM2B) 102946953(KDM2A)
CCAY125622716(KDM2B) 125637663(KDM2A)
DCC119843790(KDM2B) 119857032(KDM2A)
CPIC101941489(KDM2B) 101944320(KDM2A)
TST117876034(KDM2A) 117887903(KDM2B)
CABI116833413(KDM2A) 116836761(KDM2B)
MRV120386209(KDM2B) 120393433(KDM2A)
ACS100555582(kdm2a) 100557128(kdm2b)
ASAO132773142(KDM2A) 132781640(KDM2B)
PVT110083885(KDM2B) 110085628(KDM2A)
SUND121916509(KDM2B) 121926140(KDM2A)
PBI103055385(KDM2B) 103064363(KDM2A)
PMUR107286966(KDM2B) 107296660(KDM2A)
CTIG120306959(KDM2A) 120316722(KDM2B)
TSR106547428 106551961 106555402
PGUT117667174(KDM2A) 117672213(KDM2B)
APRI131185726(KDM2B)
PTEX113448661(KDM2B) 113448819(KDM2A)
NSS113424750(KDM2A) 113424924(KDM2B)
VKO123027328(KDM2A) 123028685(KDM2B)
PMUA114586201(KDM2B) 114601850(KDM2A)
PRAF128404489(KDM2B) 128419047(KDM2A)
ZVI118076389(KDM2B) 118090145(KDM2A)
HCG128338143(KDM2B) 128340997(KDM2A)
GJA107109113(KDM2A) 107115913
STOW125425844(KDM2A) 125442945(KDM2B)
EMC129323827(KDM2A) 129341712(KDM2B)
XLA108696323(kdm2a.L) 108697539 108707160(kdm2b.S) 444267(kdm2b.L)
XTR448624(kdm2b) 496596(kdm2a)
NPR108787819(KDM2B) 108801104(KDM2A)
RTEM120909275(KDM2A) 120933591(KDM2B)
BBUF120988579(KDM2B) 121003262(KDM2A)
BGAR122924538 122940172(KDM2A)
MUO115456603(KDM2A) 115479962(KDM2B)
GSH117348250(KDM2A) 117365291(KDM2B)
DRE100536129(kdm2bb) 571851(kdm2aa) 799441(kdm2ab)
SRX107712479 107742705 107746202 107746404 107753096 107754453 107758663(kdm2b)
SANH107658591 107661934 107665255 107674221 107679864 107687979 107689109 107703170
SGH107550974 107551394 107554421(kdm2b) 107556790 107557667 107558119 107588325 107602054
CCAR109052892 109063698 109063751 109065515 109080177 109091792 109094893 109097580
CAUA113054555 113069569 113070766 113073855 113078599 113107738 113110259 113113665
CGIB127949707 127963423 127966566 127971409 128017036 128018424 128020702 128027789
PTET122344856(kdm2aa) 122350853(kdm2ba) 122352490 122358018(kdm2ab)
LROH127166708(kdm2aa) 127169489(kdm2ba) 127172080 127175979(kdm2ab)
OMC131541458(kdm2aa) 131548076(kdm2bb) 131553084(kdm2ab)
PPRM120460615(kdm2ab) 120473577(kdm2ba) 120474221 120491886(kdm2aa)
RKG130076278(kdm2aa) 130078167 130081869(kdm2ba) 130084781(kdm2ab)
MAMB125258688(kdm2ab) 125262326 125272170(kdm2aa) 125280087(kdm2ba)
CIDE127494254 127517026 127517046 127520714
MASI127412896 127414795 127417926 127424117 127432981 127433405 127443372 127444561
TROS130545681 130552700(kdm2aa) 130563647(kdm2ab) 130568211(kdm2ba)
TDW130407068(kdm2ba) 130412050 130437647(kdm2ab) 130439808(kdm2aa)
MANU129415045(kdm2ba) 129422388(kdm2ab) 129444299(kdm2aa) 129446577
IPU108262769(kdm2aa) 108264901(kdm2ba) 108268705(kdm2ab)
IFU128605953(kdm2aa) 128611881(kdm2ab)
PHYP113539151 113542768(kdm2a)
SMEO124386061(kdm2ab) 124398976(kdm2aa) 124400426(kdm2ba)
TFD113638868(kdm2ba) 113642408(kdm2aa) 113647749(kdm2ab)
TVC132847541(kdm2aa) 132853899(kdm2ba) 132855535(kdm2ab)
TRN134315233(kdm2aa) 134318597(kdm2ba) 134319615(kdm2ab)
AMEX103024695 103030174 103034250(kdm2b) 103039345(kdm2a)
CMAO118807046(kdm2ab) 118810527(kdm2aa) 118813012(kdm2ba) 118824534
EEE113567668(kdm2b) 113570717(kdm2a) 113571493 113586912
CHAR105890028(kdm2ba) 105907592 105908476(kdm2aa) 105910963 122130524
TRU101063174 101067040(kdm2a) 101071235 101075964
TFS130517034 130525845(kdm2ba) 130526981(kdm2aa) 130530862(kdm2ab)
TNGGSTEN00004828G001 GSTEN00011934G001 GSTEN00017289G001 GSTEN00017290G001 GSTEN00024626G001
LCO104931175 104933677 104936293 104937673(kdm2a)
NCC104940908 104950965 104953326(kdm2b) 104958708(kdm2a)
TBEN117472506(kdm2ba) 117474884(kdm2aa) 117476548 117489646(kdm2ab)
CGOB115006789 115013687 115014563(kdm2a) 115016689
PGEO117453026(kdm2ba) 117453639(kdm2ab) 117455418(kdm2aa) 117456581 117456665
GACU117543868(kdm2ba) 117551559(kdm2aa) 117555872(kdm2ab) 117558156
EMAC134859784(kdm2ab) 134864883(kdm2aa) 134868205(kdm2bb) 134873863(kdm2ba)
ELY117252886(kdm2ba) 117255507(kdm2aa) 117261494(kdm2ab) 117269663
EFO125885061(kdm2aa) 125890451(kdm2ba) 125894995(kdm2ab) 125905721
PLEP121941507(kdm2aa) 121944340(kdm2ba) 121947896(kdm2ab) 121959647
SLUC116034958 116046932(kdm2aa) 116052404(kdm2ab) 116062323(kdm2ba)
ECRA117951958(kdm2ab) 117958690(kdm2aa) 117959062
ESP116696316(kdm2a) 116704051
PFLV114555585 114562811 114566068 114570709(kdm2b)
GAT120817446(kdm2ab) 120825039(kdm2aa) 120830320(kdm2ba) 120832110
PPUG119210553(kdm2ab) 119218122(kdm2aa) 119224524(kdm2ba) 119226294
AFB129090595(kdm2ab) 129095249(kdm2aa) 129101540(kdm2ba) 129102138
CLUM117735995(kdm2ba) 117737280(kdm2ab) 117740199 117744481(kdm2aa)
PSWI130189768(kdm2aa) 130196607(kdm2ba) 130205220 130209598(kdm2ab)
MSAM119888500(kdm2ab) 119891286(kdm2ba) 119914202(kdm2aa) 119914573
SCHU122865874 122870980(kdm2aa) 122876610(kdm2ba) 122880292(kdm2ab)
CUD121508395(kdm2aa) 121509709(kdm2ba) 121516335(kdm2ab) 121524960
ALAT119007052(kdm2ab) 119019750(kdm2ba) 119022277(kdm2aa) 119029524
MZE101465495 101468357(kdm2a) 101486102 101487519
ONL100691565 100692165 100695561(kdm2a) 100701413
OAU116322426 116323655(kdm2ba) 116326954(kdm2aa) 116331600(kdm2ab)
OLA101161646 101163098 101164160(kdm2a) 101171056
OML112137427(kdm2aa) 112148273(kdm2ba) 112152128 112153468(kdm2ab) 112163128
CSAI133446363(kdm2aa) 133447058(kdm2ab) 133451599(kdm2ba) 133455261(kdm2bb)
XMA102219164(kdm2a) 102224704 102228067 102237385
XCO114139543(kdm2a) 114145414 114149281 114154635
XHE116714885(kdm2a) 116720224 116724159 116729590
PRET103470449 103470607 103471745(kdm2a) 103473724
PFOR103146746 103147495(kdm2a) 103148830 103153626 103153631
PLAI106939770 106942325(kdm2a) 106953534 106954487 106961357
PMEI106907836 106920843 106921087 106924284 106924929
GAF122827808(kdm2ba) 122829166(kdm2aa) 122836685(kdm2ab) 122847192
PPRL129362965(kdm2ab) 129366369 129373042(kdm2ba)
CVG107085686(kdm2a) 107091301 107092765 107102329
CTUL119772942(kdm2aa) 119784952(kdm2ba) 119788321(kdm2ab) 119789003
GMU124859998(kdm2ab) 124868248(kdm2aa) 124872752 124878386(kdm2ba)
NFU107376672(kdm2a) 107382424 107389061 107393666 107395465
KMR108232715 108236516(kdm2ba) 108243031(kdm2ab) 108249790(kdm2aa)
ALIM106511523 106514481 106516297(kdm2a) 106516710 106533572 106536986
NWH119408440(kdm2ab) 119422629(kdm2aa) 119424379
AOCE111568501 111576508(kdm2a) 111581378 111581834
MCEP124996359 125004278(kdm2aa) 125008033(kdm2ab) 125011874(kdm2ba)
CSEM103384305 103390456 103390943(kdm2a) 103398071(kdm2b)
POV109626186 109626832(kdm2a) 109627364 109641108
SSEN122758210 122764768 122769343(kdm2ba) 122770914(kdm2aa) 122778912(kdm2ab)
HHIP117768461(kdm2ba) 117769016(kdm2ab) 117771518 117771754(kdm2aa)
HSP118112228(kdm2ab) 118114904(kdm2ba) 118120767(kdm2aa) 118125629
PPLT128424656 128436511(kdm2aa) 128437816(kdm2ba) 128445858(kdm2ab)
SMAU118285085 118312430(kdm2aa) 118314252(kdm2ba) 118320063(kdm2ab)
LCF108872906 108878302(kdm2ab) 108878436(kdm2ba) 108879821
SDU111226470 111230448 111232726 111234153
SLAL111644944 111646478 111647621 111655174 111662809(kdm2a)
XGL120785238(kdm2ab) 120799999(kdm2aa) 120805096(kdm2ba) 120805980
HCQ109511586 109512629 109521726 109524342(kdm2a)
SSCV125980026 125993514 125993693
SBIA133499766(kdm2ba) 133506764(kdm2aa) 133508266(kdm2ab) 133515246
PEE133399687(kdm2ba) 133403509(kdm2aa) 133407640(kdm2ab) 133413807
PTAO133465232 133475597(kdm2ba) 133477373(kdm2aa) 133484357(kdm2ab)
BPEC110160460 110163356(kdm2a) 110164352 110169850
MALB109951304 109954947 109955525(kdm2a) 109972565
BSPL114851203(kdm2aa) 114862268(kdm2ba) 114864035(kdm2ab) 114866505
SJO128362986(kdm2ab) 128365303(kdm2ba) 128369364(kdm2aa) 128380065
SASA106564592(kdm2b) 106568226 106579932 106585505 106602582 106604673 106609898(kdm2a) 106611679
STRU115149172 115159416 115164627 115171988 115191863 115200013 115202164 115205204
OTW112219441 112220949(kdm2ab) 112231599(kdm2aa) 112248375 112256247 112257585 112262401 112263010
OMY110488821(kdm2ab) 110497438 110505025 110522926 110525561 110534441(kdm2aa) 110535930 110537201
OGO123993412(kdm2ab) 124000176 124001532 124010402 124012101 124034392 124036216 124048818
ONE115105816 115111514 115124675 115129464 115130050 115137354 115139949 115145773
OKI109868395 109878626 109880676 109892531 109894138 109895810 109901150 109905197
OKE118358247 118362982 118363494 118370471 118375714 118387661 118393092 118395538
SALP111958253 111961481 111965740 111967492 111971338 111974223 111980664
SNH120025936 120034948(kdm2aa) 120045037 120048096(kdm2ab) 120052890 120062298 120063180 120063786
CCLU121533684 121535776(kdm2aa) 121542394 121550397 121573792 121582376 121584765
ELS105014887 105022887 105024850(kdm2b) 105028557(kdm2a)
SFM108921847 108925897 108935024 108935906
PKI111836283 111839265(kdm2b) 111842213 111861052
AANG118206992 118212759 118228247(kdm2aa) 118232420(kdm2ab)
LOC102691817(kdm2a) 102698511(kdm2b)
PSPA121296893 121299711 121302361 121307226 121307716
ARUT117426610 117428465
PSEX120538099 120540810
LCM102358334(KDM2A) 102363992(KDM2B)
CMK103180532 103184391
RTP109925258
CPLA122562672 122564136
HOC132827125 132830419 132834501
LERI129709402 129710720
PMRN116950061
LRJ133348819(KDM2B)
BFO118426751
BBEL109463838 109480680 109480681
CIN778852(zf(cxxc)-1)
SCLV120342191
SPU574799
LPIC129254727 129284257
APLC110976555
AJC117121939
SKO100371879
DMEDmel_CG11033(Kdm2)
DER6552450
DSE6607159
DSIDsimw501_GD18594(Dsim_GD18594)
DYADyak_GE25927
DAN6499376
DSR110186505
DPO6897677
DPE6591794
DMN108154942
DWI6647996
DGR6563071
DMODmoj_GI22556
DAZ108608577
DNV108653004
DHE111604808
DVI6629815
CCAT101462013
BOD106618051
BDR105225991
RZE108380816
AOQ129245780
TDA119679822
MDE101894252
SCAC106081790
LCQ111688372
LSQ119605789
GFS119639176
ECOE129942044
CLON129616227
HIS119659310
AGA1281229
ACOZ120951463
AARA120903074
AMER121589871
ASTE118506625
AFUN125760879
AAG110680236 5570227
AALB109407084 109426325 115268888
ASUA134221244
CQUCpipJ_CPIJ008371
CPII120414325
CNS116339439
BCOO119074472
AME410848
ACER108002708
ALAB122719543
ADR102675287
AFLR100866583
BIM100743608
BBIF117206763
BVK117236965
BVAN117157575
BTER100650431
BAFF126918952
BPYO122574496
BPAS132908363
FVI122537072
CCAL108623065
OBB114876411
OLG117600359
NMEA116427982
CGIG122397658
SOC105195163
MPHA105839651
AEC105148346
ACEP105626314
PBAR105432615
VEM105568858
HST105188521
DQU106740689
CFO105252240
FEX115233656
LHU105674731
PGC109852495
OBO105284273
PCF106787506
PFUC122524395
VPS122637277
VCRB124432535
VVE124957335
NVI100122421
CSOL105361242
TPRE106658971
LHT122510826
LBD127282048
MDL103569639
CGLO123261002
FAS105269920
DAM107041676
AGIF122848746
CINS118068740
VCAN122412617
CCIN107266661
AROA105692337
TCA659466
DPA109546828
SOY115881558
AGRG126733656
ATD109604615
CSET123319881
AGB108905622
LDC111505542
DVV114337792
NVL108566151
APLN108739321
PPYR116161098
OTU111415343
BMOR101739693
MSEX115441364
DPLKGM_206885
BANY112053444
MJU123871425
NIQ126775630
VCD124532738
MCIX123663226
PMAC106709104
PPOT106108319
PXU106117909
PRAP111002362
PBX123709568
PNAP125053814
ZCE119833100 119833109
CCRC123700468
LSIN126974044
AAGE121727660
HAW110370794
HZE124639460
TNL113502805
SLIU111359974
OFU114361897
ATRA106134191
PXY105381154
PGW126376172
LGLY125236382
CCRN123299883
API100169407
DNX107171100
AGS114125970
RMD113555479
ACOO126846693
DVT126894533
BTAB109042139
DCI103514594
CLEC106660819
HHAL106677496
NLU111046140 111047214
HVI124369113
MQU128995285 128998070
PHUPhum_PHUM316810
FOC113206778
TPAL117642172
ZNE110829331
CSEC111871260
BROR134534710 134534719
IEL124156145
FCD110850612
DPXDAPPUDRAFT_308697
DMK116922797
DPZ124340909
PVM113812052 113816225
PJA122261948
PCHN125035795
PMOO119594143
HAME121865035
CQD128688213
PTRU123517900
MNZ135218315
HAZT108665309
EAF111703939 111705001 111707473
LSM121122554 121124978
TCF131876865
PPOI119111631 119111633
ISC8053876
DSV119446592
RSAN119389762
RMP119161974
VDE111252269
VJA111271887
TUT107364877
DPTE113798945 113798953
DFR124497204 124497205
CSCU111622110 111640562
PTEP107451805
ABRU129971449
UDV129220186
SDM118197598
CELCELE_T26A5.5(jhdm-1)
CBRCBG_17150 CBG_19679
NAINECAME_11545
LOALOAG_01801
HROHELRODRAFT_104360
LGILOTGIDRAFT_52553
PVUL126825555
PCAN112563134
BGT106056201
GAE121367980
HRF124132061
HRJ124254173
CRG105328660
CVN111134660
CANU128189603
OED125650526
MYI110463070
PMAX117332570
MMER123534922
RPHI132742895
DPOL127842802
OBI106871161
OSN115222653
LJP135477213
LAK106162160
SMMSmp_127230
LLON135482829
NVE5512876
EPA110241366
ATEN116296360
ADF107332536
AMIL114952688
PDAM113676131
SPIS111322098
DGT114520394
XEN124435302
HMG100212991
HSY130623417
TADTRIADDRAFT_49824
AQU100632164
ATHAT3G20810(JMJD5)
ALY9321472
CRB17891861
CSAT104746496 104765969 104785791
EUSEUTSA_v10021129mg
BRP103869271(JMJ30)
BNA106401865 106451862 125603096
BOE106344094
RSZ108856700
THJ104816908
CPAP110811807
CIT102619679
CICCICLE_v10015488mg
PVY116141157
MINC123199410 123205616 123225021
TCC18589751
GRA105772548
GHI107889882 107962150
GAB108486474
HSYR120124365 120182532 120189381
DZI111286567 111302754
EGR104421557
GMX100779376 100813075
GSJ114374564 114379434
PVUPHAVU_011G056900g
VRA106755596
VAR108338976
VUN114169300
VUM124848830
CCAJ109798941
APRC113864360 113864393
MTR25492610
TPRA123913490
CAM101494684 101499299
PSAT127100340
VVO131602031 131635301
LJALj3g3v3271520.2(Lj3g3v3271520.2)
ADU107476784
AIP107629002
AHF112736762 112788856
LANG109325410 109353441
PCIN129313142 129315547
QSAO6P43_000107 O6P43_028126
FVE101301573
RCN112165779
PPER18774862
PMUM103341839
PAVI110770961
PDUL117631324
MDM103447103
MSYL126616129
PXB103963740
ZJU107412622
CSAV115721095
CSV101210592
CMO103492075
BHJ120070650
MCHA111021407
CMAX111467010
CMOS111434618
CPEP111792583
RCU8274402
HBR110639322 110648608
MESC110618015 110630769
POP7496047
PEU105134948
PALZ118061482
JRE108998746
CILL122291585
CAVE132163575
QSU112002893
QLO115976155 115980935
TWL120017196
VVI100267241
VRI117916444
SLY101251119(JMJ524)
SPEN107003102
SOT102591001
SSTN125867236
SDUL129887762
CANN107874851 124895353
LBB132625971
NTA107763337 107809124
NSY104226658
NTO104094942
NAU109220083
INI109152231 109159726
ITR116004326 116024574
SIND105163547
OEU111380176
EGT105951082
SSPL121792093 121792679
SMIL131013919
SHIS125221589
APAN127242921
HAN110927139
ECAD122596654
LSV111890249
CCAV112522168
DCR108227309
CSIN114265496
RVL131336116
AEW130761610 130791713
BVG104889940
SOE110801981
CQI110686607 110695983 110736170
ATRI130817407 130828738
MOF131147903
NNU104597503
MING122061548
TSS122642450
PSOM113320488
OSA4347435 9269734
DOSAOs08t0508500-00(Os08g0508500) Os09t0489200-00(Os09g0489200)
OBR102705376 102715783
OGL127782465 127783598
BDI100831374 100835429
ATS109731690 109755349
TDC119302039 119310833 119331051 119341255
TAES123104170 123112409 123120670 123151191 123157476 123165350
TUA125509852 125521519 125522092
LPER127302100 127316852
LRD124654394 124686518 124693484
SBI8055179 8064848
ZMA100272621 118477004
SITA101763987 101773425
SVS117845570 117861409
PVIR120661075 120678675 120712796
PHAI112880435 112897485
PDA103711389
EGU105050222
MUS103996261 103998486
ZOF121969911 121975016
DCT110098668
PEQ110029507
MSIN131220392
NCOL116256217
ATR18439881
SMOSELMODRAFT_147465 SELMODRAFT_75959
PPP112287109 112294064
MNGMNEG_6536
CSLCOCSUDRAFT_37936
CVRCHLNCDRAFT_36633
APROF751_1723
OLUOSTLU_39523
OTAOT_ostta01g04890
GSLGasu_02670
SCEYER051W(JHD1)
AGOAGOS_ADL088W
ERCEcym_4349
KLAKLLA0_F27643g
KMXKLMA_40344(JHD1)
LTHKLTH0A03960g
VPOKpol_1070p18
ZROZYRO0D16588g
CGRCAGL0J02860g
TPFTPHA_0C01220(TPHA0C01220)
TDLTDEL_0H02210(TDEL0H02210)
ZMKHG535_0F03570
PPAPAS_chr1-1_0295
DHADEHA2B02464g
PICPICST_53771
PGUPGUG_00053
SPAASPAPADRAFT_49589
LELPVL30_000511(JHD1)
CALCAALFM_CR00750CA(CaO19.3281)
CTPCTRG_01004
COTCORT_0A04120
CDUCD36_25830
YLIYALI0E30393g
CLUCLUG_04360
CLUSA9F13_04g01496
CAURCJI96_0003410
SLBAWJ20_3653(JHD1)
PKZC5L36_0A03250
BNNFOA43_004312
BBRXBRETT_002110
PPEIPpBr36_11321
ANIANIA_07455
AFMAFUA_2G05970
ACTACLA_068360
NFINFIA_082690
AORAO090001000714
ANGAn02g14310
AFVAFLA_012848
ALUCAKAW2_11201A(JHD1)
ACHEACHE_80271A(JHD1)
APUUAPUU_80592S(JHD1)
PCSN7525_005402
PDPPDIP_32210
POUPOX_h09503
TMFEYB26_001337
TRGTRUGW13939_06056
CIMCIMG_00992
CPWCPC735_053600
UREUREG_00939
PBLPAAG_01011
PBNPADG_03818
ABEARB_05068
TVETRV_06674
AJEHCAG_03655
BGHBDBG_05420
PNOSNOG_15868
PTEPTT_16007
BZECOCCADRAFT_23035
BSCCOCSADRAFT_84394
BORCOCMIDRAFT_1476
AALTCC77DRAFT_1025433
ARABEKO05_0000355
ZTRMYCGRDRAFT_43039
PFJMYCFIDRAFT_104451
FFUCLAFUR5_08842
CBETCB0940_10168
BCOMBAUCODRAFT_71174
NPAUCRNP2_7305
TMLGSTUM_00006749001
SPOSPCC622.16c(epe1)
SOMSOMG_04462(epe1)
CNECNG00620
CNBCNBG4160
CNGCNAG_03533
CGICGB_G6080W
CDEUCNBG_2082
TASAA1Q1_07436
CCACCcaHIS019_0502920(JHD1)
HIRHETIRDRAFT_407575
RSXRhiXN_01567
LBCLACBIDRAFT_316140(JMJ16203)
CCICC1G_05206
MOREE1B28_002655
CPUTCONPUDRAFT_118075
WSEWALSEDRAFT_37169
UMAUMAG_04522
PFPPFL1_01420
SGRAEX895_002091
MGLMGL_3466
MSYMMSY001_1659
PGRPGTG_15521
MLRMELLADRAFT_37912
MBRMONBRDRAFT_25364
ACANACA1_116850
PTIPHATRDRAFT_42595
FCYFRACYDRAFT_184520
AAFAURANDRAFT_27938
 » show all
Reference
1  [PMID:16362057]
  Authors
Tsukada Y, Fang J, Erdjument-Bromage H, Warren ME, Borchers CH, Tempst P, Zhang Y
  Title
Histone demethylation by a family of JmjC domain-containing proteins.
  Journal
Nature 439:811-6 (2006)
DOI:10.1038/nature04433
  Sequence
[hsa:22992 84678] [sce:YER051W]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.11.27
IUBMB Enzyme Nomenclature: 1.14.11.27
ExPASy - ENZYME nomenclature database: 1.14.11.27
BRENDA, the Enzyme Database: 1.14.11.27
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