Homo sapiens (human): 23043 Help Entry 23043             CDS       T01001                                  Symbol TNIK, MRT54 Name (RefSeq) TRAF2 and NCK interacting kinase   KO K08840   TRAF2 and NCK interacting kinase [EC:2.7.11.1] Organism hsa  Homo sapiens (human) Disease H00768   Autosomal recessive intellectual developmental disorder Drug target Rentosertib (DG03341):  D13106 D13107 Brite KEGG Orthology (KO) [BR:hsa00001]  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:hsa01001]     23043 (TNIK) Enzymes [BR:hsa01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.11  Protein-serine/threonine kinases     2.7.11.1  non-specific serine/threonine protein kinase      23043 (TNIK) Protein kinases [BR:hsa01001]  Serine/threonine kinases: STE group   STE20 family    23043 (TNIK) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Pkinase CNH PK_Tyr_Ser-Thr ABC1 Motif Other DBs NCBI-GeneID:  23043 NCBI-ProteinID:  NP_055843 OMIM:  610005 HGNC:  30765 Ensembl:  ENSG00000154310 UniProt:  Q9UKE5 Structure PDBPDBj LinkDB All DBs Position 3:complement(171058414..171460408) Genome browser AA seq 1360 aa AA seqDB search MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE REQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQL EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEER SRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKS QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS WLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILES PLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVK PEESRDITRPSRPASYKKAIDEDLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSE EEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISRE GTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSG TEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKI SVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVY NLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGD LEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVE EGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYED EGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKR AQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW NT seq 4083 nt NT seq  +upstreamnt  +downstreamnt atggcgagcgactccccggctcgaagcctggatgaaatagatctctcggctctgagggac cccgcagggatctttgaattggtggaacttgttggaaatggaacatacgggcaagtttat aagggtcgtcatgtcaaaacgggccagcttgcagccatcaaggttatggatgtcacaggg gatgaagaggaagaaatcaaacaagaaattaacatgttgaagaaatattctcatcaccgg aatattgctacatactatggtgcttttatcaaaaagaacccaccaggcatggatgaccaa ctttggttggtgatggagttttgtggtgctggctctgtcaccgacctgatcaagaacaca aaaggtaacacgttgaaagaggagtggattgcatacatctgcagggaaatcttacggggg ctgagtcacctgcaccagcataaagtgattcatcgagatattaaagggcaaaatgtcttg ctgactgaaaatgcagaagttaaactagtggactttggagtcagtgctcagcttgatcga acagtgggcaggaggaatactttcattggaactccctactggatggcaccagaagttatt gcctgtgatgaaaacccagatgccacatatgatttcaagagtgacttgtggtctttgggt atcaccgccattgaaatggcagaaggtgctccccctctctgtgacatgcaccccatgaga gctctcttcctcatcccccggaacccagcgcctcggctgaagtctaagaagtggtcaaaa aaattccagtcatttattgagagctgcttggtaaagaatcacagccagcgaccagcaaca gaacaattgatgaagcatccatttatacgagaccaacctaatgagcgacaggtccgcatt caactcaaggaccatattgatagaacaaagaagaagcgaggagaaaaagatgagacagag tatgagtacagtggaagtgaggaagaagaggaggagaatgactcaggagagcccagctcc atcctgaatctgccaggggagtcgacgctgcggagggactttctgaggctgcagctggcc aacaaggagcgttctgaggccctacggaggcagcagctggagcagcagcagcgggagaat gaggagcacaagcggcagctgctggccgagcgtcagaagcgcatcgaggagcagaaagag cagaggcggcggctggaggagcaacaaaggcgagagaaggagctgcggaagcagcaggag agggagcagcgccggcactatgaggagcagatgcgccgggaggaggagaggaggcgtgcg gagcatgaacaggaatacatcaggcgacagttagaggaggagcagagacagttagagatc ttgcagcagcagctactgcatgaacaagctctacttctggaatataagcgcaaacaattg gaagaacagagacaagcagaaagactgcagaggcagctaaagcaagaaagagactactta gtttcccttcagcatcagcggcaggagcagaggcctgtggagaagaagccactgtaccat tacaaagaaggaatgagtcctagtgagaagccagcatgggccaaggaggtagaagaacgg tcaaggctcaaccggcaaagttcccctgccatgcctcacaaggttgccaacaggatatct gaccccaacctgcccccaaggtcggagtccttcagcattagtggagttcagcctgctcga acaccccccatgctcagaccagtcgatccccagatcccacatctggtagctgtaaaatcc cagggacctgccttgaccgcctcccagtcagtgcacgagcagcccacaaagggcctctct gggtttcaggaggctctgaacgtgacctcccaccgcgtggagatgccacgccagaactca gatcccacctcggaaaatcctcctctccccactcgcattgaaaagtttgaccgaagctct tggttacgacaggaagaagacattccaccaaaggtgcctcaaagaacaacttctatatcc ccagcattagccagaaagaattctcctgggaatggtagtgctctgggacccagactagga tctcaacccatcagagcaagcaaccctgatctccggagaactgagcccatcttggagagc cccttgcagaggaccagcagtggcagttcctccagctccagcacccctagctcccagccc agctcccaaggaggctcccagcctggatcacaagcaggatccagtgaacgcaccagagtt cgagccaacagtaagtcagaaggatcacctgtgctcccccatgagcctgcgaaggtgaaa ccagaagaatccagggacattacccggcccagtcgaccagctagctacaaaaaagctata gatgaggatctgacggcattagccaaagaactaagagaactccggattgaagaaacaaac cgcccaatgaagaaggtgactgattactcctcctccagtgaggagtcagaaagtagcgag gaagaggaggaagatggagagagcgagacccatgatgggacagtggctgtcagcgacata cccagactgataccaacaggagctccaggcagcaacgagcagtacaatgtgggaatggtg gggacgcatgggctggagacctctcatgcggacagtttcagcggcagtatttcaagagaa ggaaccttgatgattagagagacgtctggagagaagaagcgatctggccacagtgacagc aatggctttgctggccacatcaacctccctgacctggtgcagcagagccattctccagct ggaaccccgactgagggactggggcgcgtctcaacccattcccaggagatggactctggg actgaatatggcatggggagcagcaccaaagcctccttcaccccctttgtggaccccaga gtataccagacgtctcccactgatgaagatgaagaggatgaggaatcatcagccgcagct ctgtttactagcgaacttcttaggcaagaacaggccaaactcaatgaagcaagaaagatt tcggtggtaaatgtaaacccaaccaacattcggcctcatagcgacacaccagaaatcaga aaatacaagaaacgattcaactcagaaatactttgtgcagctctgtggggtgtaaacctt ctggtggggactgaaaatggcctgatgcttttggaccgaagtgggcaaggcaaagtctat aatctgatcaaccggaggcgatttcagcagatggatgtgctagagggactgaatgtcctt gtgacaatttcaggaaagaagaataagctacgagtttactatctttcatggttaagaaac agaatactacataatgacccagaagtagaaaagaaacaaggctggatcactgttggggac ttggaaggctgtatacattataaagttgttaaatatgaaaggatcaaatttttggtgatt gccttaaagaatgctgtggaaatatatgcttgggctcctaaaccgtatcataaattcatg gcatttaagtcttttgcagatctccagcacaagcctctgctagttgatctcacggtagaa gaaggtcaaagattaaaggttatttttggttcacacactggtttccatgtaattgatgtt gattcaggaaactcttatgatatctacataccatctcatattcagggcaatatcactcct catgctattgtcatcttgcctaaaacagatggaatggaaatgcttgtttgctatgaggat gagggggtgtatgtaaacacctatggccggataactaaggatgtggtgctccaatgggga gaaatgcccacgtctgtggcctacattcattccaatcagataatgggctggggcgagaaa gctattgagatccggtcagtggaaacaggacatttggatggagtatttatgcataagcga gctcaaaggttaaagtttctatgtgaaagaaatgataaggtattttttgcatccgtgcga tctggaggaagtagccaagtgtttttcatgaccctcaacagaaattccatgatgaactgg taa

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