Homo sapiens (human): 23411 Help Entry 23411             CDS       T01001                                  Symbol SIRT1, SIR2, SIR2L1, SIR2alpha Name (RefSeq) sirtuin 1   KO K11411   NAD-dependent protein deacetylase sirtuin 1 [EC:2.3.1.286] Organism hsa  Homo sapiens (human) Pathway hsa00760   Nicotinate and nicotinamide metabolism hsa01100   Metabolic pathways hsa04068   FoxO signaling pathway hsa04148   Efferocytosis hsa04152   AMPK signaling pathway hsa04211   Longevity regulating pathway hsa04213   Longevity regulating pathway - multiple species hsa04218   Cellular senescence hsa04310   Wnt signaling pathway hsa04922   Glucagon signaling pathway hsa04936   Alcoholic liver disease hsa05031   Amphetamine addiction hsa05206   MicroRNAs in cancer Network nt06535  Efferocytosis   Element N01778   Production of IL10 via the Sirtuin1 signaling cascade Brite KEGG Orthology (KO) [BR:hsa00001]  09100 Metabolism   09108 Metabolism of cofactors and vitamins    00760 Nicotinate and nicotinamide metabolism     23411 (SIRT1)  09130 Environmental Information Processing   09132 Signal transduction    04310 Wnt signaling pathway     23411 (SIRT1)    04068 FoxO signaling pathway     23411 (SIRT1)    04152 AMPK signaling pathway     23411 (SIRT1)  09140 Cellular Processes   09141 Transport and catabolism    04148 Efferocytosis     23411 (SIRT1)  09150 Organismal Systems   09152 Endocrine system    04922 Glucagon signaling pathway     23411 (SIRT1)   09149 Aging    04211 Longevity regulating pathway     23411 (SIRT1)    04213 Longevity regulating pathway - multiple species     23411 (SIRT1)  09160 Human Diseases   09161 Cancer: overview    05206 MicroRNAs in cancer     23411 (SIRT1)   09165 Substance dependence    05031 Amphetamine addiction     23411 (SIRT1)   09167 Endocrine and metabolic disease    04936 Alcoholic liver disease     23411 (SIRT1)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03036 Chromosome and associated proteins [BR:hsa03036]     23411 (SIRT1)    03029 Mitochondrial biogenesis [BR:hsa03029]     23411 (SIRT1) Enzymes [BR:hsa01000]  2. Transferases   2.3  Acyltransferases    2.3.1  Transferring groups other than aminoacyl groups     2.3.1.286  protein acetyllysine N-acetyltransferase      23411 (SIRT1) Chromosome and associated proteins [BR:hsa03036]  Eukaryotic type   Histone modification proteins    HDACs (histone deacetylases)     SIRTs (sirtuins, class III HDACs)      23411 (SIRT1) Mitochondrial biogenesis [BR:hsa03029]  Mitochondrial quality control factors   Regulator of mitochondrial biogenesis    Other regulator of mitochondrial biogenesis     23411 (SIRT1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  SIR2 DUF592 Motif Other DBs NCBI-GeneID:  23411 NCBI-ProteinID:  NP_036370 OMIM:  604479 HGNC:  14929 Ensembl:  ENSG00000096717 UniProt:  Q96EB6 Structure PDBPDBj LinkDB All DBs Position 10:67884656..67918390 Genome browser AA seq 747 aa AA seqDB search MADEAALALQPGGSPSAAGADREAASSPAGEPLRKRPRRDGPGLERSPGEPGGAAPEREV PAAARGCPGAAAAALWREAEAEAAAAGGEQEAQATAAAGEGDNGPGLQGPSREPPLADNL YDEDDDDEGEEEEEAAAAAIGYRDNLLFGDEIITNGFHSCESDEEDRASHASSSDWTPRP RIGPYTFVQQHLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDI NTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIE YFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRII QCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPE QFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLG DCDVIINELCHRLGGEYAKLCCNPVKLSEITEKPPRTQKELAYLSELPPTPLHVSEDSSS PERTSPPDSSVIVTLLDQAAKSNDDLDVSESKGCMEEKPQEVQTSRNVESIAEQMENPDL KNVGSSTGEKNERTSVAGTVRKCWPNRVAKEQISRRLDGNQYLFLPPNRYIFHGAEVYSD SEDDVLSSSSCGSNSDSGTCQSPSLEEPMEDESEIEEFYNGLEDEPDVPERAGGAGFGTD GDDQEAINEAISVKQEVTDMNYPSNKS NT seq 2244 nt NT seq  +upstreamnt  +downstreamnt atggcggacgaggcggccctcgcccttcagcccggcggctccccctcggcggcgggggcc gacagggaggccgcgtcgtcccccgccggggagccgctccgcaagaggccgcggagagat ggtcccggcctcgagcggagcccgggcgagcccggtggggcggccccagagcgtgaggtg ccggcggcggccaggggctgcccgggtgcggcggcggcggcgctgtggcgggaggcggag gcagaggcggcggcggcaggcggggagcaagaggcccaggcgactgcggcggctggggaa ggagacaatgggccgggcctgcagggcccatctcgggagccaccgctggccgacaacttg tacgacgaagacgacgacgacgagggcgaggaggaggaagaggcggcggcggcggcgatt gggtaccgagataaccttctgttcggtgatgaaattatcactaatggttttcattcctgt gaaagtgatgaggaggatagagcctcacatgcaagctctagtgactggactccaaggcca cggataggtccatatacttttgttcagcaacatcttatgattggcacagatcctcgaaca attcttaaagatttattgccggaaacaatacctccacctgagttggatgatatgacactg tggcagattgttattaatatcctttcagaaccaccaaaaaggaaaaaaagaaaagatatt aatacaattgaagatgctgtgaaattactgcaagagtgcaaaaaaattatagttctaact ggagctggggtgtctgtttcatgtggaatacctgacttcaggtcaagggatggtatttat gctcgccttgctgtagacttcccagatcttccagatcctcaagcgatgtttgatattgaa tatttcagaaaagatccaagaccattcttcaagtttgcaaaggaaatatatcctggacaa ttccagccatctctctgtcacaaattcatagccttgtcagataaggaaggaaaactactt cgcaactatacccagaacatagacacgctggaacaggttgcgggaatccaaaggataatt cagtgtcatggttcctttgcaacagcatcttgcctgatttgtaaatacaaagttgactgt gaagctgtacgaggagatatttttaatcaggtagttcctcgatgtcctaggtgcccagct gatgaaccgcttgctatcatgaaaccagagattgtgttttttggtgaaaatttaccagaa cagtttcatagagccatgaagtatgacaaagatgaagttgacctcctcattgttattggg tcttccctcaaagtaagaccagtagcactaattccaagttccataccccatgaagtgcct cagatattaattaatagagaacctttgcctcatctgcattttgatgtagagcttcttgga gactgtgatgtcataattaatgaattgtgtcataggttaggtggtgaatatgccaaactt tgctgtaaccctgtaaagctttcagaaattactgaaaaacctccacgaacacaaaaagaa ttggcttatttgtcagagttgccacccacacctcttcatgtttcagaagactcaagttca ccagaaagaacttcaccaccagattcttcagtgattgtcacacttttagaccaagcagct aagagtaatgatgatttagatgtgtctgaatcaaaaggttgtatggaagaaaaaccacag gaagtacaaacttctaggaatgttgaaagtattgctgaacagatggaaaatccggatttg aagaatgttggttctagtactggggagaaaaatgaaagaacttcagtggctggaacagtg agaaaatgctggcctaatagagtggcaaaggagcagattagtaggcggcttgatggtaat cagtatctgtttttgccaccaaatcgttacattttccatggcgctgaggtatattcagac tctgaagatgacgtcttatcctctagttcttgtggcagtaacagtgatagtgggacatgc cagagtccaagtttagaagaacccatggaggatgaaagtgaaattgaagaattctacaat ggcttagaagatgagcctgatgttccagagagagctggaggagctggatttgggactgat ggagatgatcaagaggcaattaatgaagctatatctgtgaaacaggaagtaacagacatg aactatccatcaaacaaatcatag

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