KEGG   NETWORK: N01778
Entry
N01778                      Network                                
Name
Production of IL10 via the Sirtuin1 signaling cascade
Definition
NAD -> SIRT1 -> PBX1 => IL10
  Expanded
C00003 -> 23411 -> 5087 => 3586
Class
nt06535 Efferocytosis
Type
Reference
Pathway
hsa04148 Efferocytosis   
Gene
23411  SIRT1; sirtuin 1
5087  PBX1; PBX homeobox 1
3586  IL10; interleukin 10
Metabolite
C00003  NAD+
Reference
PMID:30595481
  Authors
Zhang S, Weinberg S, DeBerge M, Gainullina A, Schipma M, Kinchen JM, Ben-Sahra I, Gius DR, Yvan-Charvet L, Chandel NS, Schumacker PT, Thorp EB
  Title
Efferocytosis Fuels Requirements of Fatty Acid Oxidation and the Electron Transport Chain to Polarize Macrophages for Tissue Repair.
  Journal
Cell Metab 29:443-456.e5 (2019)
DOI:10.1016/j.cmet.2018.12.004
Reference
PMID:31611251
  Authors
Saraiva M, Vieira P, O'Garra A
  Title
Biology and therapeutic potential of interleukin-10.
  Journal
J Exp Med 217:jem.20190418 (2020)
DOI:10.1084/jem.20190418
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