Homo sapiens (human): 23418
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Entry
23418 CDS
T01001
Symbol
CRB1, CRB1-A, CRB1-B, CRB1-C, LCA8, RP12
Name
(RefSeq) crumbs cell polarity complex component 1
KO
K16681
protein crumbs
Organism
hsa
Homo sapiens (human)
Pathway
hsa04390
Hippo signaling pathway
Disease
H00527
Retinitis pigmentosa
H00837
Leber congenital amaurosis
H01088
Pigmented paravenous chorioretinal atrophy
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04390 Hippo signaling pathway
23418 (CRB1)
BRITE hierarchy
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Gene cluster
GFIT
Motif
Pfam:
EGF
Laminin_G_2
hEGF
EGF_TEN
Laminin_G_1
EGF_CA
EGF_3
EGF_2
EGF_Teneurin
JAG1-like_EGF2
SH3_6
Motif
Other DBs
NCBI-GeneID:
23418
NCBI-ProteinID:
NP_957705
OMIM:
604210
HGNC:
2343
Ensembl:
ENSG00000134376
UniProt:
P82279
A0A7D6VM04
Structure
PDB
PDBj
LinkDB
All DBs
Position
1:197201504..197478455
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AA seq
1406 aa
AA seq
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MALKNINYLLIFYLSFSLLIYIKNSFCNKNNTRCLSNSCQNNSTCKDFSKDNDCSCSDTA
NNLDKDCDNMKDPCFSNPCQGSATCVNTPGERSFLCKCPPGYSGTICETTIGSCGKNSCQ
HGGICHQDPIYPVCICPAGYAGRFCEIDHDECASSPCQNGAVCQDGIDGYSCFCVPGYQG
RHCDLEVDECASDPCKNEATCLNEIGRYTCICPHNYSGVNCELEIDECWSQPCLNGATCQ
DALGAYFCDCAPGFLGDHCELNTDECASQPCLHGGLCVDGENRYSCNCTGSGFTGTHCET
LMPLCWSKPCHNNATCEDSVDNYTCHCWPGYTGAQCEIDLNECNSNPCQSNGECVELSSE
KQYGRITGLPSSFSYHEASGYVCICQPGFTGIHCEEDVNECSSNPCQNGGTCENLPGNYT
CHCPFDNLSRTFYGGRDCSDILLGCTHQQCLNNGTCIPHFQDGQHGFSCLCPSGYTGSLC
EIATTLSFEGDGFLWVKSGSVTTKGSVCNIALRFQTVQPMALLLFRSNRDVFVKLELLSG
YIHLSIQVNNQSKVLLFISHNTSDGEWHFVEVIFAEAVTLTLIDDSCKEKCIAKAPTPLE
SDQSICAFQNSFLGGLPVGMTSNGVALLNFYNMPSTPSFVGCLQDIKIDWNHITLENISS
GSSLNVKAGCVRKDWCESQPCQSRGRCINLWLSYQCDCHRPYEGPNCLREYVAGRFGQDD
STGYVIFTLDESYGDTISLSMFVRTLQPSGLLLALENSTYQYIRVWLERGRLAMLTPNSP
KLVVKFVLNDGNVHLISLKIKPYKIELYQSSQNLGFISASTWKIEKGDVIYIGGLPDKQE
TELNGGFFKGCIQDVRLNNQNLEFFPNPTNNASLNPVLVNVTQGCAGDNSCKSNPCHNGG
VCHSRWDDFSCSCPALTSGKACEEVQWCGFSPCPHGAQCQPVLQGFECIANAVFNGQSGQ
ILFRSNGNITRELTNITFGFRTRDANVIILHAEKEPEFLNISIQDSRLFFQLQSGNSFYM
LSLTSLQSVNDGTWHEVTLSMTDPLSQTSRWQMEVDNETPFVTSTIATGSLNFLKDNTDI
YVGDRAIDNIKGLQGCLSTIEIGGIYLSYFENVHGFINKPQEEQFLKISTNSVVTGCLQL
NVCNSNPCLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDECFSNPCIHGNCSDRVAAYHC
TCEPGYTGVNCEVDIDNCQSHQCANGATCISHTNGYSCLCFGNFTGKFCRQSRLPSTVCG
NEKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEKDIDECASDPCVNGGLCQDLLNKFQ
CLCDVAFAGERCEVDLADDLISDIFTTIGSVTVALLLILLLAIVASVVTSNKRATQGTYS
PSRQEKEGSRVEMWNLMPPPAMERLI
NT seq
4221 nt
NT seq
+upstream
nt +downstream
nt
atggcacttaagaacattaactaccttctcatcttctacctcagtttctcactgcttatc
tacataaaaaattccttttgcaataaaaacaacaccaggtgcctctcaaattcttgccaa
aacaattctacatgcaaagatttttcaaaagacaatgattgttcttgttcagacacagcc
aataatttggacaaagactgtgacaacatgaaagacccttgcttctccaatccctgtcaa
ggaagtgccacttgtgtgaacaccccaggagaaaggagctttctgtgcaaatgtcctcct
gggtacagtgggacaatctgtgaaactaccattggttcctgtggcaagaactcctgccaa
catggaggtatttgccatcaggaccctatttatcctgtctgcatctgccctgctggatat
gctggaagattctgtgagatagatcacgatgagtgtgcttccagcccttgccaaaatggg
gccgtgtgccaggatggaattgatggttactcctgcttctgtgtcccaggatatcaaggc
agacactgcgacttggaagtggatgaatgtgcttcagatccctgcaagaacgaggctaca
tgcctcaatgaaataggaagatatacttgtatctgtccccacaattattctggtgtaaac
tgtgaattggaaattgacgaatgttggtcccagccttgtttaaatggtgcaacttgtcag
gatgctctgggggcctatttctgcgactgtgcccctggattcctgggggatcactgtgaa
ctcaacactgatgagtgtgccagtcaaccttgtctccatggagggctgtgtgtggatgga
gaaaacagatatagctgtaactgcacgggtagtggattcacagggacacactgtgagacc
ttgatgcctctttgttggtcaaaaccttgtcacaataatgctacatgtgaggacagtgtt
gacaattacacttgtcactgctggcctggatacacaggtgcccagtgtgagatcgacctc
aatgaatgcaatagtaacccctgccagtccaatggggaatgtgtggagctgtcctcagag
aaacaatatggacgcatcactggactgccttcttctttcagctaccatgaagcctcaggt
tatgtctgtatctgtcagcctggattcacaggaatccactgcgaagaagacgtcaatgaa
tgttcttcaaacccttgccaaaatggtggtacttgtgagaacttgcctgggaattatact
tgccattgcccatttgataacctttctagaactttttatggaggaagggactgttctgat
attctcctgggctgtacccatcagcaatgtctaaataatggaacatgcatccctcacttc
caagatggccagcatggattcagctgcctatgtccatctggctacaccgggtccctgtgt
gaaatcgcaaccacactttcatttgagggcgatggcttcctgtgggtcaaaagtggctca
gtgacaaccaagggctcagtttgtaacatagccctcaggtttcagactgttcagccaatg
gctcttctacttttccgaagcaacagggatgtgtttgtgaagctggagctgctaagtggc
tacattcacttatcaattcaggtcaataatcagtcaaaggtgcttctgttcatttcccac
aacaccagcgatggagagtggcatttcgtggaggtaatatttgcagaggctgtgaccctt
accttaatcgacgactcctgtaaggagaaatgcatcgcgaaagctcctactccacttgaa
agtgatcaatcaatatgtgcttttcagaactcctttttgggtggtttaccagtgggaatg
accagcaatggtgttgctctgcttaacttctataatatgccatccacaccttcgtttgta
ggctgtctccaagacattaaaattgattggaatcacattaccctggagaacatctcgtct
ggctcatcattaaatgtcaaggcaggctgtgtgagaaaggattggtgtgaaagccaacct
tgtcaaagcagaggacgctgcatcaacttgtggctgagttaccagtgtgactgccacagg
ccctatgaaggccccaactgtctgagagagtatgtggcaggcagatttggccaggatgac
tccactggttatgtcatctttactcttgatgagagctatggagacaccatcagcctctcc
atgtttgtccgaacgcttcaaccatcaggcttacttctagctttggaaaacagcacttat
caatatatccgtgtctggctagagcgcggcagactagcaatgctgactccaaactctccc
aaattagtagtaaaatttgttcttaatgatggaaatgtccacttgatatctttgaaaatc
aagccatataaaattgaactgtatcagtcttcacaaaacctaggatttatttctgcttct
acgtggaaaatcgaaaagggagatgtcatctacattggtggcctacctgacaagcaagag
actgaacttaatggtggattcttcaaaggctgtatccaagatgtaagactaaacaaccaa
aatctggaattctttccaaatccaacaaacaatgcatctctcaatccagttcttgtcaat
gtaacccaaggctgtgctggagacaacagctgcaagtccaacccctgtcacaatggaggt
gtttgccattcccggtgggatgacttctcctgttcctgtcctgccctcacaagtgggaaa
gcctgtgaggaggttcagtggtgtggattcagcccgtgtcctcacggagcccagtgccag
ccggtgcttcaaggatttgaatgtattgcaaatgctgtttttaatggacaaagcggtcaa
atattattcagaagcaatgggaatattaccagagaactcaccaatatcacatttggtttc
agaacaagggatgcaaatgtaataatattgcatgcagaaaaagagcctgaatttcttaat
attagcattcaagattccagattattctttcaattgcaaagtggcaacagcttttatatg
ctaagtctgacaagtttgcagtcagtgaatgatggcacatggcacgaagtgaccctttcc
atgacagacccactgtcccagacctccaggtggcaaatggaagtggacaacgaaacacct
tttgtgaccagcacaattgctactggaagcctcaactttttgaaggataatacagatatt
tatgtgggagacagagctattgacaatataaagggcctgcaagggtgtctaagtacaata
gaaatcggaggcatttatctctcttactttgaaaatgttcatggtttcattaataaacct
caggaagagcaatttctcaaaatctctaccaattcagtggtcactggctgtttgcagtta
aatgtctgcaactccaacccctgtttgcatggaggaaactgtgaagacatctatagctct
tatcattgctcctgtcccttgggatggtcagggaaacactgtgaactcaacatcgatgaa
tgcttttcaaacccctgtatccatggcaactgctctgacagagttgcagcctaccactgc
acatgtgagcctggatacactggtgtgaactgtgaagtggatatagacaactgccagagt
caccagtgtgcaaatggagccacctgcattagtcatactaatggctattcttgcctctgt
tttggaaattttacaggaaaattttgcagacagagcagattaccctcaacagtctgtggg
aatgagaagacaaatctcacttgctacaatggaggcaactgcacagagttccagactgaa
ttaaaatgtatgtgccggccaggttttactggagaatggtgtgaaaaggacattgatgag
tgtgcctctgatccgtgtgtcaatggaggtctgtgccaggacttactcaacaaattccag
tgcctctgtgatgttgcctttgctggcgagcgctgcgaggtggacttggcagatgacttg
atctccgacattttcaccactattggctcagtgactgtcgccttgttactgatcctcttg
ctggccattgttgcttctgttgtcacctccaacaaaagggcaactcagggaacctacagc
cccagccgtcaggagaaggagggctcccgagtggaaatgtggaacttgatgccaccccct
gcaatggagagactgatttag
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