Homo sapiens (human): 23439 Help Entry 23439             CDS       T01001                                  Symbol ATP1B4 Name (RefSeq) ATPase Na+/K+ transporting family member beta 4   KO K01540   sodium/potassium-transporting ATPase subunit beta Organism hsa  Homo sapiens (human) Pathway hsa04022   cGMP-PKG signaling pathway hsa04024   cAMP signaling pathway hsa04260   Cardiac muscle contraction hsa04261   Adrenergic signaling in cardiomyocytes hsa04820   Cytoskeleton in muscle cells hsa04911   Insulin secretion hsa04918   Thyroid hormone synthesis hsa04919   Thyroid hormone signaling pathway hsa04925   Aldosterone synthesis and secretion hsa04960   Aldosterone-regulated sodium reabsorption hsa04961   Endocrine and other factor-regulated calcium reabsorption hsa04964   Proximal tubule bicarbonate reclamation hsa04970   Salivary secretion hsa04971   Gastric acid secretion hsa04972   Pancreatic secretion hsa04973   Carbohydrate digestion and absorption hsa04974   Protein digestion and absorption hsa04976   Bile secretion hsa04978   Mineral absorption Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04024 cAMP signaling pathway     23439 (ATP1B4)    04022 cGMP-PKG signaling pathway     23439 (ATP1B4)  09140 Cellular Processes   09142 Cell motility    04820 Cytoskeleton in muscle cells     23439 (ATP1B4)  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     23439 (ATP1B4)    04918 Thyroid hormone synthesis     23439 (ATP1B4)    04919 Thyroid hormone signaling pathway     23439 (ATP1B4)    04925 Aldosterone synthesis and secretion     23439 (ATP1B4)   09153 Circulatory system    04260 Cardiac muscle contraction     23439 (ATP1B4)    04261 Adrenergic signaling in cardiomyocytes     23439 (ATP1B4)   09154 Digestive system    04970 Salivary secretion     23439 (ATP1B4)    04971 Gastric acid secretion     23439 (ATP1B4)    04972 Pancreatic secretion     23439 (ATP1B4)    04976 Bile secretion     23439 (ATP1B4)    04973 Carbohydrate digestion and absorption     23439 (ATP1B4)    04974 Protein digestion and absorption     23439 (ATP1B4)    04978 Mineral absorption     23439 (ATP1B4)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     23439 (ATP1B4)    04961 Endocrine and other factor-regulated calcium reabsorption     23439 (ATP1B4)    04964 Proximal tubule bicarbonate reclamation     23439 (ATP1B4)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04090 CD molecules [BR:hsa04090]     23439 (ATP1B4) CD molecules [BR:hsa04090]  Proteins   23439 (ATP1B4) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Na_K-ATPase DUF5427 Motif Other DBs NCBI-GeneID:  23439 NCBI-ProteinID:  NP_001135919 OMIM:  301073 HGNC:  808 Ensembl:  ENSG00000101892 UniProt:  Q9UN42 LinkDB All DBs Position X:120362089..120383237 Genome browser AA seq 357 aa AA seqDB search MRRQLRSRRAPSFPYSYRYRLDDPDEANQNYLADEEEEAEEEARVTVVPKSEEEEEEEEK EEEEEEEKEEEEGQGQPTGNAWWQKLQIMSEYLWDPERRMFLARTGQSWSLILLIYFFFY ASLAAVITLCMYTLFLTISPYIPTFTERVKPPGVMIRPFAHSLNFNFNVSEPDTWQHYVI SLNGFLQGYNDSLQEEMNVDCPPGQYFIQDGNEDEDKKACQFKRSFLKNCSGLEDPTFGY STGQPCILLKMNRIVGFRPELGDPVKVSCKVQRGDENDIRSISYYPESASFDLRYYPYYG KLTHVNYTSPLVAMHFTDVVKNQAVPVQCQLKGKGVINDVINDRFVGRVIFTLNIET NT seq 1074 nt NT seq  +upstreamnt  +downstreamnt atgagaaggcaactccggtccagaagggctccatcctttccttacagttatcgctacaga ctcgatgatccggatgaagcgaaccagaactacttagcagatgaagaggaggaagcagaa gaagaggctcgggtgacggtggtgcccaaatcggaggaggaggaagaagaggaggagaaa gaagaggaggaagaggaggaaaaggaggaggaagagggtcaaggtcagccaacaggcaat gcctggtggcagaaattgcagatcatgagtgaatacctgtgggatccagagagaaggatg tttctggcccgaacaggtcagagttggagcctgatcttactcatttacttcttcttctat gcctccttggctgctgtgatcaccctctgcatgtacacactatttctgaccatcagtccc tatataccaaccttcacggagcgggtaaagcctcctggagttatgatcagacccttcgcc catagccttaacttcaacttcaacgtttctgaacccgacacttggcagcattatgtgatt agcctaaatggctttctccagggttataatgacagtcttcaagaggaaatgaatgtagat tgtcccccggggcagtacttcatccaagatggcaatgaggatgaggacaagaaggcctgc caatttaagcgctccttcctaaagaactgctctggtctggaggacccaacttttggatac tctactggacagccctgcatccttctaaagatgaaccggattgtaggctttcgtcctgag cttggagatcctgtgaaggtttcctgcaaagttcagagaggtgatgaaaatgacatccga tccatcagttactacccagagtcggcttcttttgacctccgctactacccttactacggc aaactgactcacgttaactacacatcccccttggtggcaatgcactttacagacgtggtg aagaaccaagcagtgcctgtgcagtgccaactgaagggcaaaggcgtcataaatgatgtc atcaatgatcgttttgtgggcagggtaatctttaccctgaacatagaaacttaa

Homo sapiens (human): 476 Help Entry 476               CDS       T01001                                  Symbol ATP1A1, CMT2DD, HOMGSMR2 Name (RefSeq) ATPase Na+/K+ transporting subunit alpha 1   KO K01539   sodium/potassium-transporting ATPase subunit alpha [EC:7.2.2.13] Organism hsa  Homo sapiens (human) Pathway hsa04022   cGMP-PKG signaling pathway hsa04024   cAMP signaling pathway hsa04260   Cardiac muscle contraction hsa04261   Adrenergic signaling in cardiomyocytes hsa04820   Cytoskeleton in muscle cells hsa04911   Insulin secretion hsa04918   Thyroid hormone synthesis hsa04919   Thyroid hormone signaling pathway hsa04925   Aldosterone synthesis and secretion hsa04960   Aldosterone-regulated sodium reabsorption hsa04961   Endocrine and other factor-regulated calcium reabsorption hsa04964   Proximal tubule bicarbonate reclamation hsa04970   Salivary secretion hsa04971   Gastric acid secretion hsa04972   Pancreatic secretion hsa04973   Carbohydrate digestion and absorption hsa04974   Protein digestion and absorption hsa04976   Bile secretion hsa04978   Mineral absorption Network nt06316  Renin-angiotensin-aldosterone signaling   Element N00304   Mutation-inactivated ATP1A1 to angiotensin-aldosterone signaling pathway Disease H00264   Charcot-Marie-Tooth disease H01210   Hypomagnesemia H01603   Primary aldosteronism Drug target Acetyldigitoxin:  D06881 Acetyldigoxin:  D07555 Bepridil (DG00333):  D00631<JP> D07520 Bretylium tosilate:  D00645 Deslanoside:  D01240<JP> Digitoxin:  D00297 Digoxin:  D00298<JP/US> G-strophanthin:  D00112 Gitoformate:  D07147 Lanatoside C:  D01972 Metildigoxin (DG00191):  D02587<JP> D09847 Proscillaridin:  D01379 beta-Acetyldigoxin:  D07556 Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04024 cAMP signaling pathway     476 (ATP1A1)    04022 cGMP-PKG signaling pathway     476 (ATP1A1)  09140 Cellular Processes   09142 Cell motility    04820 Cytoskeleton in muscle cells     476 (ATP1A1)  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     476 (ATP1A1)    04918 Thyroid hormone synthesis     476 (ATP1A1)    04919 Thyroid hormone signaling pathway     476 (ATP1A1)    04925 Aldosterone synthesis and secretion     476 (ATP1A1)   09153 Circulatory system    04260 Cardiac muscle contraction     476 (ATP1A1)    04261 Adrenergic signaling in cardiomyocytes     476 (ATP1A1)   09154 Digestive system    04970 Salivary secretion     476 (ATP1A1)    04971 Gastric acid secretion     476 (ATP1A1)    04972 Pancreatic secretion     476 (ATP1A1)    04976 Bile secretion     476 (ATP1A1)    04973 Carbohydrate digestion and absorption     476 (ATP1A1)    04974 Protein digestion and absorption     476 (ATP1A1)    04978 Mineral absorption     476 (ATP1A1)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     476 (ATP1A1)    04961 Endocrine and other factor-regulated calcium reabsorption     476 (ATP1A1)    04964 Proximal tubule bicarbonate reclamation     476 (ATP1A1)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:hsa04147]     476 (ATP1A1) Enzymes [BR:hsa01000]  7. Translocases   7.2  Catalysing the translocation of inorganic cations    7.2.2  Linked to the hydrolysis of a nucleoside triphosphate     7.2.2.13  Na+/K+-exchanging ATPase      476 (ATP1A1) Exosome [BR:hsa04147]  Exosomal proteins   Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)    476 (ATP1A1)   Exosomal proteins of other body fluids (saliva and urine)    476 (ATP1A1)   Exosomal proteins of colorectal cancer cells    476 (ATP1A1)   Exosomal proteins of bladder cancer cells    476 (ATP1A1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  E1-E2_ATPase Cation_ATPase_C Cation_ATPase Cation_ATPase_N Hydrolase Hydrolase_3 HAD DUF1290 Motif Other DBs NCBI-GeneID:  476 NCBI-ProteinID:  NP_000692 OMIM:  182310 HGNC:  799 Ensembl:  ENSG00000163399 UniProt:  P05023 Structure PDB LinkDB All DBs Position 1:116373244..116404774 Genome browser AA seq 1023 aa AA seqDB search MGKGVGRDKYEPAAVSEQGDKKGKKGKKDRDMDELKKEVSMDDHKLSLDELHRKYGTDLS RGLTSARAAEILARDGPNALTPPPTTPEWIKFCRQLFGGFSMLLWIGAILCFLAYSIQAA TEEEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNGEKMSI NAEEVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENPLETR NIAFFSTNCVEGTARGIVVYTGDRTVMGRIATLASGLEGGQTPIAAEIEHFIHIITGVAV FLGVSFFILSLILEYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKN LEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGVSFDKTSATWLA LSRIAGLCNRAVFQANQENLPILKRAVAGDASESALLKCIELCCGSVKEMRERYAKIVEI PFNSTNKYQLSIHKNPNTSEPQHLLVMKGAPERILDRCSSILLHGKEQPLDEELKDAFQN AYLELGGLGERVLGFCHLFLPDEQFPEGFQFDTDDVNFPIDNLCFVGLISMIDPPRAAVP DAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDA KACVVHGSDLKDMTSEQLDDILKYHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVN DSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTL TSNIPEITPFLIFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEQAESDIMKRQPRNPK TDKLVNERLISMAYGQIGMIQALGGFFTYFVILAENGFLPIHLLGLRVDWDDRWINDVED SYGQQWTYEQRKIVEFTCHTAFFVSIVVVQWADLVICKTRRNSVFQQGMKNKILIFGLFE ETALAAFLSYCPGMGVALRMYPLKPTWWFCAFPYSLLIFVYDEVRKLIIRRRPGGWVEKE TYY NT seq 3072 nt NT seq  +upstreamnt  +downstreamnt atggggaagggggttggacgtgataagtatgagcctgcagctgtttcagaacaaggtgat aaaaagggcaaaaagggcaaaaaagacagggacatggatgaactgaagaaagaagtttct atggatgatcataaacttagccttgatgaacttcatcgtaaatatggaacagacttgagc cggggattaacatctgctcgtgcagctgagatcctggcgcgagatggtcccaacgccctc actccccctcccactactcctgaatggatcaagttttgtcggcagctctttggggggttc tcaatgttactgtggattggagcgattctttgtttcttggcttatagcatccaagctgct acagaagaggaacctcaaaacgataatctgtacctgggtgtggtgctatcagccgttgta atcataactggttgcttctcctactatcaagaagctaaaagttcaaagatcatggaatcc ttcaaaaacatggtccctcagcaagcccttgtgattcgaaatggtgagaaaatgagcata aatgcggaggaagttgtggttggggatctggtggaagtaaaaggaggagaccgaattcct gctgacctcagaatcatatctgcaaatggctgcaaggtggataactcctcgctcactggt gaatcagaaccccagactaggtctccagatttcacaaatgaaaaccccctggagacgagg aacattgccttcttttcaaccaattgtgttgaaggcaccgcacgtggtattgttgtctac actggggatcgcactgtgatgggaagaattgccacacttgcttctgggctggaaggaggc cagacccccattgctgcagaaattgaacattttatccacatcatcacgggtgtggctgtg ttcctgggtgtgtctttcttcatcctttctctcatccttgagtacacctggcttgaggct gtcatcttcctcatcggtatcatcgtagccaatgtgccggaaggtttgctggccactgtc acggtctgtctgacacttactgccaaacgcatggcaaggaaaaactgcttagtgaagaac ttagaagctgtggagaccttggggtccacgtccaccatctgctctgataaaactggaact ctgactcagaaccggatgacagtggcccacatgtggtttgacaatcaaatccatgaagct gatacgacagagaatcagagtggtgtctcttttgacaagacttcagctacctggcttgct ctgtccagaattgcaggtctttgtaacagggcagtgtttcaggctaaccaggaaaaccta cctattcttaagcgggcagttgcaggagatgcctctgagtcagcactcttaaagtgcata gagctgtgctgtggttccgtgaaggagatgagagaaagatacgccaaaatcgtcgagata cccttcaactccaccaacaagtaccagttgtctattcataagaaccccaacacatcggag ccccaacacctgttggtgatgaagggcgccccagaaaggatcctagaccgttgcagctct atcctcctccacggcaaggagcagcccctggatgaggagctgaaagacgcctttcagaac gcctatttggagctggggggcctcggagaacgagtcctaggtttctgccacctctttctg ccagatgaacagtttcctgaagggttccagtttgacactgacgatgtgaatttccctatc gataatctgtgctttgttgggctcatctccatgattgaccctccacgggcggccgttcct gatgccgtgggcaaatgtcgaagtgctggaattaaggtcatcatggtcacaggagaccat ccaatcacagctaaagctattgccaaaggtgtgggcatcatctcagaaggcaatgagacc gtggaagacattgctgcccgcctcaacatcccagtcagccaggtgaaccccagggatgcc aaggcctgcgtagtacacggcagtgatctaaaggacatgacctccgagcagctggatgac attttgaagtaccacactgagatagtgtttgccaggacctcccctcagcagaagctcatc attgtggaaggctgccaaagacagggtgctatcgtggctgtgactggtgacggtgtgaat gactctccagctttgaagaaagcagacattggggttgctatggggattgctggctcagat gtgtccaagcaagctgctgacatgattcttctggatgacaactttgcctcaattgtgact ggagtagaggaaggtcgtctgatctttgataacttgaagaaatccattgcttatacctta accagtaacattcccgagatcaccccgttcctgatatttattattgcaaacattccacta ccactggggactgtcaccatcctctgcattgacttgggcactgacatggttcctgccatc tccctggcttatgagcaggctgagagtgacatcatgaagagacagcccagaaatcccaaa acagacaaacttgtgaatgagcggctgatcagcatggcctatgggcagattggaatgatc caggccctgggaggcttctttacttactttgtgattctggctgagaacggcttcctccca attcacctgttgggcctccgagtggactgggatgaccgctggatcaacgatgtggaagac agctacgggcagcagtggacctatgagcagaggaaaatcgtggagttcacctgccacaca gccttcttcgtcagtatcgtggtggtgcagtgggccgacttggtcatctgtaagaccagg aggaattcggtcttccagcaggggatgaagaacaagatcttgatatttggcctctttgaa gagacagccctggctgctttcctttcctactgccctggaatgggtgttgctcttaggatg tatcccctcaaacctacctggtggttctgtgccttcccctactctcttctcatcttcgta tatgacgaagtcagaaaactcatcatcaggcgacgccctggcggctgggtggagaaggaa acctactattag

Homo sapiens (human): 477 Help Entry 477               CDS       T01001                                  Symbol ATP1A2, DEE98, FARIMPD, FHM2, MHP2 Name (RefSeq) ATPase Na+/K+ transporting subunit alpha 2   KO K01539   sodium/potassium-transporting ATPase subunit alpha [EC:7.2.2.13] Organism hsa  Homo sapiens (human) Pathway hsa04022   cGMP-PKG signaling pathway hsa04024   cAMP signaling pathway hsa04260   Cardiac muscle contraction hsa04261   Adrenergic signaling in cardiomyocytes hsa04820   Cytoskeleton in muscle cells hsa04911   Insulin secretion hsa04918   Thyroid hormone synthesis hsa04919   Thyroid hormone signaling pathway hsa04925   Aldosterone synthesis and secretion hsa04960   Aldosterone-regulated sodium reabsorption hsa04961   Endocrine and other factor-regulated calcium reabsorption hsa04964   Proximal tubule bicarbonate reclamation hsa04970   Salivary secretion hsa04971   Gastric acid secretion hsa04972   Pancreatic secretion hsa04973   Carbohydrate digestion and absorption hsa04974   Protein digestion and absorption hsa04976   Bile secretion hsa04978   Mineral absorption Disease H00606   Early infantile epileptic encephalopathy H00775   Hemiplegic migraine H00998   Alternating hemiplegia of childhood Drug target Acetyldigitoxin:  D06881 Acetyldigoxin:  D07555 Bepridil (DG00333):  D00631<JP> D07520 Bretylium tosilate:  D00645 Deslanoside:  D01240<JP> Digitoxin:  D00297 Digoxin:  D00298<JP/US> G-strophanthin:  D00112 Gitoformate:  D07147 Lanatoside C:  D01972 Metildigoxin (DG00191):  D02587<JP> D09847 Proscillaridin:  D01379 beta-Acetyldigoxin:  D07556 Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04024 cAMP signaling pathway     477 (ATP1A2)    04022 cGMP-PKG signaling pathway     477 (ATP1A2)  09140 Cellular Processes   09142 Cell motility    04820 Cytoskeleton in muscle cells     477 (ATP1A2)  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     477 (ATP1A2)    04918 Thyroid hormone synthesis     477 (ATP1A2)    04919 Thyroid hormone signaling pathway     477 (ATP1A2)    04925 Aldosterone synthesis and secretion     477 (ATP1A2)   09153 Circulatory system    04260 Cardiac muscle contraction     477 (ATP1A2)    04261 Adrenergic signaling in cardiomyocytes     477 (ATP1A2)   09154 Digestive system    04970 Salivary secretion     477 (ATP1A2)    04971 Gastric acid secretion     477 (ATP1A2)    04972 Pancreatic secretion     477 (ATP1A2)    04976 Bile secretion     477 (ATP1A2)    04973 Carbohydrate digestion and absorption     477 (ATP1A2)    04974 Protein digestion and absorption     477 (ATP1A2)    04978 Mineral absorption     477 (ATP1A2)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     477 (ATP1A2)    04961 Endocrine and other factor-regulated calcium reabsorption     477 (ATP1A2)    04964 Proximal tubule bicarbonate reclamation     477 (ATP1A2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:hsa04147]     477 (ATP1A2) Enzymes [BR:hsa01000]  7. Translocases   7.2  Catalysing the translocation of inorganic cations    7.2.2  Linked to the hydrolysis of a nucleoside triphosphate     7.2.2.13  Na+/K+-exchanging ATPase      477 (ATP1A2) Exosome [BR:hsa04147]  Exosomal proteins   Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)    477 (ATP1A2)   Exosomal proteins of other body fluids (saliva and urine)    477 (ATP1A2)   Exosomal proteins of colorectal cancer cells    477 (ATP1A2)   Exosomal proteins of bladder cancer cells    477 (ATP1A2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  E1-E2_ATPase Cation_ATPase_C Cation_ATPase Cation_ATPase_N Hydrolase Hydrolase_3 HAD Motif Other DBs NCBI-GeneID:  477 NCBI-ProteinID:  NP_000693 OMIM:  182340 HGNC:  800 Ensembl:  ENSG00000018625 UniProt:  P50993 A0A0S2Z3W6 LinkDB All DBs Position 1:160115759..160143591 Genome browser AA seq 1020 aa AA seqDB search MGRGAGREYSPAATTAENGGGKKKQKEKELDELKKEVAMDDHKLSLDELGRKYQVDLSKG LTNQRAQDVLARDGPNALTPPPTTPEWVKFCRQLFGGFSILLWIGAILCFLAYGIQAAME DEPSNDNLYLGVVLAAVVIVTGCFSYYQEAKSSKIMDSFKNMVPQQALVIREGEKMQINA EEVVVGDLVEVKGGDRVPADLRIISSHGCKVDNSSLTGESEPQTRSPEFTHENPLETRNI CFFSTNCVEGTARGIVIATGDRTVMGRIATLASGLEVGRTPIAMEIEHFIQLITGVAVFL GVSFFVLSLILGYSWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLE AVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTEDQSGATFDKRSPTWTALS RIAGLCNRAVFKAGQENISVSKRDTAGDASESALLKCIELSCGSVRKMRDRNPKVAEIPF NSTNKYQLSIHEREDSPQSHVLVMKGAPERILDRCSTILVQGKEIPLDKEMQDAFQNAYM ELGGLGERVLGFCQLNLPSGKFPRGFKFDTDELNFPTEKLCFVGLMSMIDPPRAAVPDAV GKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPMSQVNPREAKAC VVHGSDLKDMTSEQLDEILKNHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSP ALKKADIGIAMGISGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSN IPEITPFLLFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEAAESDIMKRQPRNSQTDK LVNERLISMAYGQIGMIQALGGFFTYFVILAENGFLPSRLLGIRLDWDDRTMNDLEDSYG QEWTYEQRKVVEFTCHTAFFASIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLLEETA LAAFLSYCPGMGVALRMYPLKVTWWFCAFPYSLLIFIYDEVRKLILRRYPGGWVEKETYY NT seq 3063 nt NT seq  +upstreamnt  +downstreamnt atgggccgtggggctggccgtgagtactcacctgccgccaccacggcagagaatgggggc ggcaagaagaaacagaaggagaaggaactggatgagctgaagaaggaggtggcaatggat gaccacaagctgtccttggatgagctgggccgcaaataccaagtggacctgtccaagggc ctcaccaaccagcgggctcaggacgttctggctcgagatgggcccaacgccctcacacca cctcccacaacccctgagtgggtcaagttctgccgtcagcttttcggggggttctccatc ctgctgtggattggggctatcctctgcttcctggcctacggcatccaggctgccatggag gatgaaccatccaacgacaatctatatctgggtgtggtgctggcagctgtggtcattgtc actggctgcttctcctactaccaggaggccaagagctccaagatcatggattccttcaag aacatggtacctcagcaagcccttgtgatccgggagggagagaagatgcagatcaacgca gaggaagtggtggtgggagacctggtggaggtgaagggtggagaccgcgtccctgctgac ctccggatcatctcttctcatggctgtaaggtggataactcatccttaacaggagagtcg gagccccagacccgctcccccgagttcacccatgagaaccccctggagacccgcaatatc tgtttcttctccaccaactgtgttgaaggcactgccaggggcattgtgattgccacagga gaccggacggtgatgggccgcatagctactctcgcctcaggcctggaggttgggcggaca cccatagcaatggagattgaacacttcatccagctgatcacaggggtcgctgtattcctg ggggtctccttcttcgtgctctccctcatcctgggctacagctggctggaggcagtcatc ttcctcatcggcatcatagtggccaacgtgcctgaggggcttctggccactgtcactgtg tgcctgaccctgacagccaagcgcatggcacggaagaactgcctggtgaagaacctggag gcggtggagacgctgggctccacgtccaccatctgctcggacaagacgggcaccctcacc cagaaccgcatgaccgtcgcccacatgtggttcgacaaccaaatccatgaggctgacacc accgaagatcagtctggggccacttttgacaaacgatcccctacgtggacggccctgtct cgaattgctggtctctgcaaccgcgccgtcttcaaggcaggacaggagaacatctccgtg tctaagcgggacacagctggtgatgcctctgagtcagctctgctcaagtgcattgagctc tcctgtggctcagtgaggaaaatgagagacagaaaccccaaggtggcagagattcctttc aactctaccaacaagtaccagctgtctatccacgagcgagaagacagcccccagagccac gtgctggtgatgaagggggccccagagcgcattctggaccggtgctccaccatcctggtg cagggcaaggagatcccgctcgacaaggagatgcaagatgcctttcaaaatgcctacatg gagctggggggacttggggagcgtgtgctgggattctgtcaactgaatctgccatctgga aagtttcctcggggcttcaaattcgacacggatgagctgaactttcccacggagaagctt tgctttgtggggctcatgtctatgattgaccctccccgggctgctgtgccagatgctgtg ggcaagtgccgaagcgcaggcatcaaggtgatcatggtaaccggggatcaccctatcaca gccaaggccattgccaaaggcgtgggcatcatatcagagggtaacgagactgtggaggac attgcagcccggctcaacattcccatgagtcaagtcaaccccagagaagccaaggcatgc gtggtgcacggctctgacctgaaggacatgacatcggagcagctcgatgagatcctcaag aaccacacagagatcgtctttgctcgaacgtctccccagcagaagctcatcattgtggag ggatgtcagaggcagggagccattgtggccgtgacgggtgacggggtgaacgactcccct gcattgaagaaggctgacattggcattgccatgggcatctctggctctgacgtctctaag caggcagccgacatgatcctgctggatgacaactttgcctccatcgtcacgggggtggag gagggccgcctgatctttgacaacttgaagaaatccatcgcctacaccctgaccagcaac atccccgagatcacccccttcctgctgttcatcattgccaacatccccctacctctgggc actgtgaccatcctttgcattgacctgggcacagatatggtccctgccatctccttggcc tatgaggcagctgagagtgatatcatgaagcggcagccacgaaactcccagacggacaag ctggtgaatgagaggctcatcagcatggcctacggacagatcgggatgatccaggcactg ggtggcttcttcacctactttgtgatcctggcagagaacggtttcctgccatcacggcta ctgggaatccgcctcgactgggatgaccggaccatgaatgatctggaggacagctatgga caggagtggacctatgagcagcggaaggtggtggagttcacgtgccacacggcattcttt gccagcatcgtggtggtgcagtgggctgacctcatcatctgcaagacccgccgcaactca gtcttccagcagggcatgaagaacaagatcctgatttttgggctcctggaggagacggcg ttggctgcctttctctcttactgcccaggcatgggtgtagccctccgcatgtacccgctc aaagtcacctggtggttctgcgccttcccctacagcctcctcatcttcatctatgatgag gtccgaaagctcatcctgcggcggtatcctggtggctgggtggagaaggagacatactac tga

Homo sapiens (human): 478 Help Entry 478               CDS       T01001                                  Symbol ATP1A3, AHC2, ATP1A1, CAPOS, DEE99, DYT12, RDP Name (RefSeq) ATPase Na+/K+ transporting subunit alpha 3   KO K01539   sodium/potassium-transporting ATPase subunit alpha [EC:7.2.2.13] Organism hsa  Homo sapiens (human) Pathway hsa04022   cGMP-PKG signaling pathway hsa04024   cAMP signaling pathway hsa04260   Cardiac muscle contraction hsa04261   Adrenergic signaling in cardiomyocytes hsa04820   Cytoskeleton in muscle cells hsa04911   Insulin secretion hsa04918   Thyroid hormone synthesis hsa04919   Thyroid hormone signaling pathway hsa04925   Aldosterone synthesis and secretion hsa04960   Aldosterone-regulated sodium reabsorption hsa04961   Endocrine and other factor-regulated calcium reabsorption hsa04964   Proximal tubule bicarbonate reclamation hsa04970   Salivary secretion hsa04971   Gastric acid secretion hsa04972   Pancreatic secretion hsa04973   Carbohydrate digestion and absorption hsa04974   Protein digestion and absorption hsa04976   Bile secretion hsa04978   Mineral absorption Disease H00606   Early infantile epileptic encephalopathy H00831   Primary dystonia H00998   Alternating hemiplegia of childhood H02272   CAPOS syndrome Drug target Acetyldigitoxin:  D06881 Acetyldigoxin:  D07555 Bepridil (DG00333):  D00631<JP> D07520 Bretylium tosilate:  D00645 Deslanoside:  D01240<JP> Digitoxin:  D00297 Digoxin:  D00298<JP/US> G-strophanthin:  D00112 Gitoformate:  D07147 Lanatoside C:  D01972 Metildigoxin (DG00191):  D02587<JP> D09847 Proscillaridin:  D01379 beta-Acetyldigoxin:  D07556 Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04024 cAMP signaling pathway     478 (ATP1A3)    04022 cGMP-PKG signaling pathway     478 (ATP1A3)  09140 Cellular Processes   09142 Cell motility    04820 Cytoskeleton in muscle cells     478 (ATP1A3)  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     478 (ATP1A3)    04918 Thyroid hormone synthesis     478 (ATP1A3)    04919 Thyroid hormone signaling pathway     478 (ATP1A3)    04925 Aldosterone synthesis and secretion     478 (ATP1A3)   09153 Circulatory system    04260 Cardiac muscle contraction     478 (ATP1A3)    04261 Adrenergic signaling in cardiomyocytes     478 (ATP1A3)   09154 Digestive system    04970 Salivary secretion     478 (ATP1A3)    04971 Gastric acid secretion     478 (ATP1A3)    04972 Pancreatic secretion     478 (ATP1A3)    04976 Bile secretion     478 (ATP1A3)    04973 Carbohydrate digestion and absorption     478 (ATP1A3)    04974 Protein digestion and absorption     478 (ATP1A3)    04978 Mineral absorption     478 (ATP1A3)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     478 (ATP1A3)    04961 Endocrine and other factor-regulated calcium reabsorption     478 (ATP1A3)    04964 Proximal tubule bicarbonate reclamation     478 (ATP1A3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:hsa04147]     478 (ATP1A3) Enzymes [BR:hsa01000]  7. Translocases   7.2  Catalysing the translocation of inorganic cations    7.2.2  Linked to the hydrolysis of a nucleoside triphosphate     7.2.2.13  Na+/K+-exchanging ATPase      478 (ATP1A3) Exosome [BR:hsa04147]  Exosomal proteins   Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)    478 (ATP1A3)   Exosomal proteins of other body fluids (saliva and urine)    478 (ATP1A3)   Exosomal proteins of colorectal cancer cells    478 (ATP1A3)   Exosomal proteins of bladder cancer cells    478 (ATP1A3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  E1-E2_ATPase Cation_ATPase_C Cation_ATPase Cation_ATPase_N Hydrolase Hydrolase_3 HAD Motif Other DBs NCBI-GeneID:  478 NCBI-ProteinID:  NP_689509 OMIM:  182350 HGNC:  801 Ensembl:  ENSG00000105409 UniProt:  P13637 Q53ES0 Structure PDB LinkDB All DBs Position 19:complement(41966582..41994230) Genome browser AA seq 1013 aa AA seqDB search MGDKKDDKDSPKKNKGKERRDLDDLKKEVAMTEHKMSVEEVCRKYNTDCVQGLTHSKAQE ILARDGPNALTPPPTTPEWVKFCRQLFGGFSILLWIGAILCFLAYGIQAGTEDDPSGDNL YLGIVLAAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIREGEKMQVNAEEVVVGDL VEIKGGDRVPADLRIISAHGCKVDNSSLTGESEPQTRSPDCTHDNPLETRNITFFSTNCV EGTARGVVVATGDRTVMGRIATLASGLEVGKTPIAIEIEHFIQLITGVAVFLGVSFFILS LILGYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGST STICSDKTGTLTQNRMTVAHMWFDNQIHEADTTEDQSGTSFDKSSHTWVALSHIAGLCNR AVFKGGQDNIPVLKRDVAGDASESALLKCIELSSGSVKLMRERNKKVAEIPFNSTNKYQL SIHETEDPNDNRYLLVMKGAPERILDRCSTILLQGKEQPLDEEMKEAFQNAYLELGGLGE RVLGFCHYYLPEEQFPKGFAFDCDDVNFTTDNLCFVGLMSMIDPPRAAVPDAVGKCRSAG IKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACVIHGTDL KDFTSEQIDEILQNHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADI GVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPF LLFIMANIPLPLGTITILCIDLGTDMVPAISLAYEAAESDIMKRQPRNPRTDKLVNERLI SMAYGQIGMIQALGGFFSYFVILAENGFLPGNLVGIRLNWDDRTVNDLEDSYGQQWTYEQ RKVVEFTCHTAFFVSIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSY CPGMDVALRMYPLKPSWWFCAFPYSFLIFVYDEIRKLILRRNPGGWVEKETYY NT seq 3042 nt NT seq  +upstreamnt  +downstreamnt atgggggacaagaaagatgacaaggactcacccaagaagaacaagggcaaggagcgccgg gacctggatgacctcaagaaggaggtggctatgacagagcacaagatgtcagtggaagag gtctgccggaaatacaacacagactgtgtgcagggtttgacccacagcaaagcccaggag atcctggcccgggatgggcctaacgcactcacgccaccgcctaccaccccagagtgggtc aagttttgccggcagctcttcgggggcttctccatcctgctgtggatcggggctatcctc tgcttcctggcctacggtatccaggcgggcaccgaggacgacccctctggtgacaacctg tacctgggcatcgtgctggcggccgtggtgatcatcactggctgcttctcctactaccag gaggccaagagctccaagatcatggagtccttcaagaacatggtgccccagcaagccctg gtgatccgggaaggtgagaagatgcaggtgaacgctgaggaggtggtggtcggggacctg gtggagatcaagggtggagaccgagtgccagctgacctgcggatcatctcagcccacggc tgcaaggtggacaactcctccctgactggcgaatccgagccccagactcgctctcccgac tgcactcacgacaaccccttggagactcggaacatcaccttcttttccaccaactgtgtg gaaggcacggctcggggcgtggtggtggccacgggcgaccgcactgtcatgggccgtatc gccaccctggcatcagggctggaggtgggcaagacgcccatcgccatcgagattgagcac ttcatccagctcatcaccggcgtggctgtcttcctgggtgtctccttcttcatcctctcc ctcattctcggatacacctggcttgaggctgtcatcttcctcatcggcatcatcgtggcc aatgtcccagagggtctgctggccactgtcactgtgtgtctgacgctgaccgccaagcgc atggcccggaagaactgcctggtgaagaacctggaggctgtagaaaccctgggctccacg tccaccatctgctcagataagacagggaccctcactcagaaccgcatgacagtcgcccac atgtggtttgacaaccagatccacgaggctgacaccactgaggaccagtcagggacctca tttgacaagagttcgcacacctgggtggccctgtctcacatcgctgggctctgcaatcgc gctgtcttcaagggtggtcaggacaacatccctgtgctcaagagggatgtggctggggat gcgtctgagtctgccctgctcaagtgcatcgagctgtcctctggctccgtgaagctgatg cgtgaacgcaacaagaaagtggctgagattcccttcaattccaccaacaaataccagctc tccatccatgagaccgaggaccccaacgacaaccgatacctgctggtgatgaagggtgcc cccgagcgcatcctggaccgctgctccaccatcctgctacagggcaaggagcagcctctg gacgaggaaatgaaggaggccttccagaatgcctaccttgagctcggtggcctgggcgag cgcgtgcttggtttctgccattattacctgcccgaggagcagttccccaagggctttgcc ttcgactgtgatgacgtgaacttcaccacggacaacctctgctttgtgggcctcatgtcc atgatcgacccaccccgggcagccgtccctgacgcggtgggcaagtgtcgcagcgcaggc atcaaggtcatcatggtcaccggcgatcaccccatcacggccaaggccattgccaagggt gtgggcatcatctctgagggcaacgagactgtggaggacatcgccgcccggctcaacatt cccgtcagccaggttaacccccgggatgccaaggcctgcgtgatccacggcaccgacctc aaggacttcacctccgagcaaatcgacgagatcctgcagaatcacaccgagatcgtcttc gcccgcacatccccccagcagaagctcatcattgtggagggctgtcagagacagggtgca attgtggctgtgaccggggatggtgtgaacgactcccccgctctgaagaaggccgacatt ggggtggccatgggcatcgctggctctgacgtctccaagcaggcagctgacatgatcctg ctggacgacaactttgcctccatcgtcacaggggtggaggagggccgcctgatcttcgac aacctaaagaagtccattgcctacaccctgaccagcaatatcccggagatcacgcccttc ctgctgttcatcatggccaacatcccgctgcccctgggcaccatcaccatcctctgcatc gatctgggcactgacatggtccctgccatctcactggcgtacgaggctgccgaaagcgac atcatgaagagacagcccaggaacccgcggacggacaaattggtcaatgagagactcatc agcatggcctacgggcagattggaatgatccaggctctcggtggcttcttctcttacttt gtgatcctggcagaaaatggcttcttgcccggcaacctggtgggcatccggctgaactgg gatgaccgcaccgtcaatgacctggaagacagttacgggcagcagtggacatacgagcag aggaaggtggtggagttcacctgccacacggccttctttgtgagcatcgttgtcgtccag tgggccgatctgatcatctgcaagacccggaggaactcggtcttccagcagggcatgaag aacaagatcctgatcttcgggctgtttgaggagacggccctggctgccttcctgtcctac tgccccggcatggacgtggccctgcgcatgtaccctctcaagcccagctggtggttctgt gccttcccctacagtttcctcatcttcgtctacgacgaaatccgcaaactcatcctgcgc aggaacccagggggttgggtggagaaggaaacctactactga

Homo sapiens (human): 480 Help Entry 480               CDS       T01001                                  Symbol ATP1A4, ATP1A1, ATP1AL2 Name (RefSeq) ATPase Na+/K+ transporting subunit alpha 4   KO K01539   sodium/potassium-transporting ATPase subunit alpha [EC:7.2.2.13] Organism hsa  Homo sapiens (human) Pathway hsa04022   cGMP-PKG signaling pathway hsa04024   cAMP signaling pathway hsa04260   Cardiac muscle contraction hsa04261   Adrenergic signaling in cardiomyocytes hsa04820   Cytoskeleton in muscle cells hsa04911   Insulin secretion hsa04918   Thyroid hormone synthesis hsa04919   Thyroid hormone signaling pathway hsa04925   Aldosterone synthesis and secretion hsa04960   Aldosterone-regulated sodium reabsorption hsa04961   Endocrine and other factor-regulated calcium reabsorption hsa04964   Proximal tubule bicarbonate reclamation hsa04970   Salivary secretion hsa04971   Gastric acid secretion hsa04972   Pancreatic secretion hsa04973   Carbohydrate digestion and absorption hsa04974   Protein digestion and absorption hsa04976   Bile secretion hsa04978   Mineral absorption Drug target Acetyldigitoxin:  D06881 Acetyldigoxin:  D07555 Bepridil (DG00333):  D00631<JP> D07520 Bretylium tosilate:  D00645 Deslanoside:  D01240<JP> Digitoxin:  D00297 Digoxin:  D00298<JP/US> G-strophanthin:  D00112 Gitoformate:  D07147 Lanatoside C:  D01972 Metildigoxin (DG00191):  D02587<JP> D09847 Proscillaridin:  D01379 beta-Acetyldigoxin:  D07556 Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04024 cAMP signaling pathway     480 (ATP1A4)    04022 cGMP-PKG signaling pathway     480 (ATP1A4)  09140 Cellular Processes   09142 Cell motility    04820 Cytoskeleton in muscle cells     480 (ATP1A4)  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     480 (ATP1A4)    04918 Thyroid hormone synthesis     480 (ATP1A4)    04919 Thyroid hormone signaling pathway     480 (ATP1A4)    04925 Aldosterone synthesis and secretion     480 (ATP1A4)   09153 Circulatory system    04260 Cardiac muscle contraction     480 (ATP1A4)    04261 Adrenergic signaling in cardiomyocytes     480 (ATP1A4)   09154 Digestive system    04970 Salivary secretion     480 (ATP1A4)    04971 Gastric acid secretion     480 (ATP1A4)    04972 Pancreatic secretion     480 (ATP1A4)    04976 Bile secretion     480 (ATP1A4)    04973 Carbohydrate digestion and absorption     480 (ATP1A4)    04974 Protein digestion and absorption     480 (ATP1A4)    04978 Mineral absorption     480 (ATP1A4)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     480 (ATP1A4)    04961 Endocrine and other factor-regulated calcium reabsorption     480 (ATP1A4)    04964 Proximal tubule bicarbonate reclamation     480 (ATP1A4)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:hsa04147]     480 (ATP1A4) Enzymes [BR:hsa01000]  7. Translocases   7.2  Catalysing the translocation of inorganic cations    7.2.2  Linked to the hydrolysis of a nucleoside triphosphate     7.2.2.13  Na+/K+-exchanging ATPase      480 (ATP1A4) Exosome [BR:hsa04147]  Exosomal proteins   Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)    480 (ATP1A4)   Exosomal proteins of other body fluids (saliva and urine)    480 (ATP1A4)   Exosomal proteins of colorectal cancer cells    480 (ATP1A4)   Exosomal proteins of bladder cancer cells    480 (ATP1A4) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  E1-E2_ATPase Cation_ATPase_C Cation_ATPase Hydrolase Cation_ATPase_N Hydrolase_3 HAD DUF3213 Motif Other DBs NCBI-GeneID:  480 NCBI-ProteinID:  NP_653300 OMIM:  607321 HGNC:  14073 Ensembl:  ENSG00000132681 UniProt:  Q13733 LinkDB All DBs Position 1:160151603..160186980 Genome browser AA seq 1029 aa AA seqDB search MGLWGKKGTVAPHDQSPRRRPKKGLIKKKMVKREKQKRNMEELKKEVVMDDHKLTLEELS TKYSVDLTKGHSHQRAKEILTRGGPNTVTPPPTTPEWVKFCKQLFGGFSLLLWTGAILCF VAYSIQIYFNEEPTKDNLYLSIVLSVVVIVTGCFSYYQEAKSSKIMESFKNMVPQQALVI RGGEKMQINVQEVVLGDLVEIKGGDRVPADLRLISAQGCKVDNSSLTGESEPQSRSPDFT HENPLETRNICFFSTNCVEGTARGIVIATGDSTVMGRIASLTSGLAVGQTPIAAEIEHFI HLITVVAVFLGVTFFALSLLLGYGWLEAIIFLIGIIVANVPEGLLATVTVCLTLTAKRMA RKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDMTVYEADTTEEQTGKTFT KSSDTWFMLARIAGLCNRADFKANQEILPIAKRATTGDASESALLKFIEQSYSSVAEMRE KNPKVAEIPFNSTNKYQMSIHLREDSSQTHVLMMKGAPERILEFCSTFLLNGQEYSMNDE MKEAFQNAYLELGGLGERVLGFCFLNLPSSFSKGFPFNTDEINFPMDNLCFVGLISMIDP PRAAVPDAVSKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGTETAEEVAARLKIPISK VDASAAKAIVVHGAELKDIQSKQLDQILQNHPEIVFARTSPQQKLIIVEGCQRLGAVVAV TGDGVNDSPALKKADIGIAMGISGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKK SIMYTLTSNIPEITPFLMFIILGIPLPLGTITILCIDLGTDMVPAISLAYESAESDIMKR LPRNPKTDNLVNHRLIGMAYGQIGMIQALAGFFTYFVILAENGFRPVDLLGIRLHWEDKY LNDLEDSYGQQWTYEQRKVVEFTCQTAFFVTIVVVQWADLIISKTRRNSLFQQGMRNKVL IFGILEETLLAAFLSYTPGMDVALRMYPLKITWWLCAIPYSILIFVYDEIRKLLIRQHPD GWVERETYY NT seq 3090 nt NT seq  +upstreamnt  +downstreamnt atggggctttgggggaagaaagggacagtggctccccatgaccagagtccaagacgaaga cctaaaaaagggcttatcaagaaaaaaatggtgaagagggaaaaacagaagcgcaatatg gaggaactgaagaaggaagtggtcatggatgatcacaaattaaccttggaagagctgagc accaagtactccgtggacctgacaaagggccatagccaccaaagggcaaaggaaatcctg actcgaggtggacccaatactgttaccccaccccccaccactccagaatgggtcaaattc tgtaagcaactgttcggaggcttctccctcctactatggactggggccattctctgcttt gtggcctacagcatccagatatatttcaatgaggagcctaccaaagacaacctctacctg agcatcgtactgtccgtcgtggtcatcgtcactggctgcttctcctattatcaggaggcc aagagctccaagatcatggagtcttttaagaacatggtgcctcagcaagctctggtaatt cgaggaggagagaagatgcaaattaatgtacaagaggtggtgttgggagacctggtggaa atcaagggtggagaccgagtccctgctgacctccggcttatctctgcacaaggatgtaag gtggacaactcatccttgactggggagtcagaaccccagagccgctcccctgacttcacc catgagaaccctctggagacccgaaacatctgcttcttttccaccaactgtgtggaagga accgcccggggtattgtgattgctacgggagactccacagtgatgggcagaattgcctcc ctgacgtcaggcctggcggttggccagacacctatcgctgctgagatcgaacacttcatc catctgatcactgtggtggccgtcttccttggtgtcactttttttgcgctctcacttctc ttgggctatggttggctggaggctatcatttttctcattggcatcattgtggccaatgtg cctgaggggctgttggccacagtcactgtgtgcctgaccctcacagccaagcgcatggcg cggaagaactgcctggtgaagaacctggaggcggtggagacgctgggctccacgtccacc atctgctcagacaagacgggcaccctcacccagaaccgcatgaccgtcgcccacatgtgg tttgatatgaccgtgtatgaggccgacaccactgaagaacagactggaaaaacatttacc aagagctctgatacctggtttatgctggcccgaatcgctggcctctgcaaccgggctgac tttaaggctaatcaggagatcctgcccattgctaagagggccacaacaggtgatgcttcc gagtcagccctcctcaagttcatcgagcagtcttacagctctgtggcggagatgagagag aaaaaccccaaggtggcagagattccctttaattctaccaacaagtaccagatgtccatc caccttcgggaggacagctcccagacccacgtactgatgatgaagggtgctccggagagg atcttggagttttgttctacctttcttctgaatgggcaggagtactcaatgaacgatgaa atgaaggaagccttccaaaatgcctacttagaactgggaggtctgggggaacgtgtgcta ggcttctgcttcttgaatctgcctagcagcttctccaagggattcccatttaatacagat gaaataaatttccccatggacaacctttgttttgtgggcctcatatccatgattgaccct ccccgagctgcagtgcctgatgctgtgagcaagtgtcgcagtgcaggaattaaggtgatc atggtaacaggagatcatcccattacagctaaggccattgccaagggtgtgggcatcatc tcagaaggcactgagacggcagaggaagtcgctgcccggcttaagatccctatcagcaag gtcgatgccagtgctgccaaagccattgtggtgcatggtgcagaactgaaggacatacag tccaagcagcttgatcagatcctccagaaccaccctgagatcgtgtttgctcggacctcc cctcagcagaagctcatcattgtcgagggatgtcagaggctgggagccgttgtggccgtg acaggtgacggggtgaacgactcccctgcgctgaagaaggctgacattggcattgccatg ggcatctctggctctgacgtctctaagcaggcagccgacatgatcctgctggatgacaac tttgcctccatcgtcacgggggtggaggagggccgcctgatctttgacaacctgaagaaa tccatcatgtacaccctgaccagcaacatccccgagatcacgcccttcctgatgttcatc atcctcggtatacccctgcctctgggaaccataaccatcctctgcattgatctcggcact gacatggtccctgccatctccttggcttatgagtcagctgaaagcgacatcatgaagagg cttccaaggaacccaaagacggataatctggtgaaccaccgtctcattggcatggcctat ggacagattgggatgatccaggctctggctggattctttacctactttgtaatcctggct gagaatggttttaggcctgttgatctgctgggcatccgcctccactgggaagataaatac ttgaatgacctggaggacagctacggacagcagtggacctatgagcaacgaaaagttgtg gagttcacatgccaaacggccttttttgtcaccatcgtggttgtgcagtgggcggatctc atcatctccaagactcgccgcaactcacttttccagcagggcatgagaaacaaagtctta atatttgggatcctggaggagacactcttggctgcatttctgtcctacactccaggcatg gacgtggccctgcgaatgtacccactcaagataacctggtggctctgtgccattccctac agtattctcatcttcgtctatgatgaaatcagaaaactcctcatccgtcagcacccggat ggctgggtggaaagggagacgtactactaa

Homo sapiens (human): 481 Help Entry 481               CDS       T01001                                  Symbol ATP1B1, ATP1B Name (RefSeq) ATPase Na+/K+ transporting subunit beta 1   KO K01540   sodium/potassium-transporting ATPase subunit beta Organism hsa  Homo sapiens (human) Pathway hsa04022   cGMP-PKG signaling pathway hsa04024   cAMP signaling pathway hsa04260   Cardiac muscle contraction hsa04261   Adrenergic signaling in cardiomyocytes hsa04820   Cytoskeleton in muscle cells hsa04911   Insulin secretion hsa04918   Thyroid hormone synthesis hsa04919   Thyroid hormone signaling pathway hsa04925   Aldosterone synthesis and secretion hsa04960   Aldosterone-regulated sodium reabsorption hsa04961   Endocrine and other factor-regulated calcium reabsorption hsa04964   Proximal tubule bicarbonate reclamation hsa04970   Salivary secretion hsa04971   Gastric acid secretion hsa04972   Pancreatic secretion hsa04973   Carbohydrate digestion and absorption hsa04974   Protein digestion and absorption hsa04976   Bile secretion hsa04978   Mineral absorption Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04024 cAMP signaling pathway     481 (ATP1B1)    04022 cGMP-PKG signaling pathway     481 (ATP1B1)  09140 Cellular Processes   09142 Cell motility    04820 Cytoskeleton in muscle cells     481 (ATP1B1)  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     481 (ATP1B1)    04918 Thyroid hormone synthesis     481 (ATP1B1)    04919 Thyroid hormone signaling pathway     481 (ATP1B1)    04925 Aldosterone synthesis and secretion     481 (ATP1B1)   09153 Circulatory system    04260 Cardiac muscle contraction     481 (ATP1B1)    04261 Adrenergic signaling in cardiomyocytes     481 (ATP1B1)   09154 Digestive system    04970 Salivary secretion     481 (ATP1B1)    04971 Gastric acid secretion     481 (ATP1B1)    04972 Pancreatic secretion     481 (ATP1B1)    04976 Bile secretion     481 (ATP1B1)    04973 Carbohydrate digestion and absorption     481 (ATP1B1)    04974 Protein digestion and absorption     481 (ATP1B1)    04978 Mineral absorption     481 (ATP1B1)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     481 (ATP1B1)    04961 Endocrine and other factor-regulated calcium reabsorption     481 (ATP1B1)    04964 Proximal tubule bicarbonate reclamation     481 (ATP1B1)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04090 CD molecules [BR:hsa04090]     481 (ATP1B1) CD molecules [BR:hsa04090]  Proteins   481 (ATP1B1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Na_K-ATPase Motif Other DBs NCBI-GeneID:  481 NCBI-ProteinID:  NP_001668 OMIM:  182330 HGNC:  804 Ensembl:  ENSG00000143153 UniProt:  P05026 A3KLL5 Structure PDB LinkDB All DBs Position 1:169106690..169132719 Genome browser AA seq 303 aa AA seqDB search MARGKAKEEGSWKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIFIGTIQVMLLT ISEFKPTYQDRVAPPGLTQIPQIQKTEISFRPNDPKSYEAYVLNIVRFLEKYKDSAQRDD MIFEDCGDVPSEPKERGDFNHERGERKVCRFKLEWLGNCSGLNDETYGYKEGKPCIIIKL NRVLGFKPKPPKNESLETYPVMKYNPNVLPVQCTGKRDEDKDKVGNVEYFGLGNSPGFPL QYYPYYGKLLQPKYLQPLLAVQFTNLTMDTEIRIECKAYGENIGYSEKDRFQGRFDVKIE VKS NT seq 912 nt NT seq  +upstreamnt  +downstreamnt atggcccgcgggaaagccaaggaggagggcagctggaagaaattcatctggaactcagag aagaaggagtttctgggcaggaccggtggcagttggtttaagatccttctattctacgta atattttatggctgcctggctggcatcttcatcggaaccatccaagtgatgctgctcacc atcagtgaatttaagcccacatatcaggaccgagtggccccgccaggattaacacagatt cctcagatccagaagactgaaatttcctttcgtcctaatgatcccaagagctatgaggca tatgtactgaacatagttaggttcctggaaaagtacaaagattcagcccagagggatgac atgatttttgaagattgtggcgatgtgcccagtgaaccgaaagaacgaggagactttaat catgaacgaggagagcgaaaggtctgcagattcaagcttgaatggctgggaaattgctct ggattaaatgatgaaacttatggctacaaagagggcaaaccgtgcattattataaagctc aaccgagttctaggcttcaaacctaagcctcccaagaatgagtccttggagacttaccca gtgatgaagtataacccaaatgtccttcccgttcagtgcactggcaagcgagatgaagat aaggataaagttggaaatgtggagtattttggactgggcaactcccctggttttcctctg cagtattatccgtactatggcaaactcctgcagcccaaatacctgcagcccctgctggcc gtacagttcaccaatcttaccatggacactgaaattcgcatagagtgtaaggcgtacggt gagaacattgggtacagtgagaaagaccgttttcagggacgttttgatgtaaaaattgaa gttaagagctga

Homo sapiens (human): 482 Help Entry 482               CDS       T01001                                  Symbol ATP1B2, AMOG Name (RefSeq) ATPase Na+/K+ transporting subunit beta 2   KO K01540   sodium/potassium-transporting ATPase subunit beta Organism hsa  Homo sapiens (human) Pathway hsa04022   cGMP-PKG signaling pathway hsa04024   cAMP signaling pathway hsa04260   Cardiac muscle contraction hsa04261   Adrenergic signaling in cardiomyocytes hsa04820   Cytoskeleton in muscle cells hsa04911   Insulin secretion hsa04918   Thyroid hormone synthesis hsa04919   Thyroid hormone signaling pathway hsa04925   Aldosterone synthesis and secretion hsa04960   Aldosterone-regulated sodium reabsorption hsa04961   Endocrine and other factor-regulated calcium reabsorption hsa04964   Proximal tubule bicarbonate reclamation hsa04970   Salivary secretion hsa04971   Gastric acid secretion hsa04972   Pancreatic secretion hsa04973   Carbohydrate digestion and absorption hsa04974   Protein digestion and absorption hsa04976   Bile secretion hsa04978   Mineral absorption Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04024 cAMP signaling pathway     482 (ATP1B2)    04022 cGMP-PKG signaling pathway     482 (ATP1B2)  09140 Cellular Processes   09142 Cell motility    04820 Cytoskeleton in muscle cells     482 (ATP1B2)  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     482 (ATP1B2)    04918 Thyroid hormone synthesis     482 (ATP1B2)    04919 Thyroid hormone signaling pathway     482 (ATP1B2)    04925 Aldosterone synthesis and secretion     482 (ATP1B2)   09153 Circulatory system    04260 Cardiac muscle contraction     482 (ATP1B2)    04261 Adrenergic signaling in cardiomyocytes     482 (ATP1B2)   09154 Digestive system    04970 Salivary secretion     482 (ATP1B2)    04971 Gastric acid secretion     482 (ATP1B2)    04972 Pancreatic secretion     482 (ATP1B2)    04976 Bile secretion     482 (ATP1B2)    04973 Carbohydrate digestion and absorption     482 (ATP1B2)    04974 Protein digestion and absorption     482 (ATP1B2)    04978 Mineral absorption     482 (ATP1B2)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     482 (ATP1B2)    04961 Endocrine and other factor-regulated calcium reabsorption     482 (ATP1B2)    04964 Proximal tubule bicarbonate reclamation     482 (ATP1B2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04090 CD molecules [BR:hsa04090]     482 (ATP1B2) CD molecules [BR:hsa04090]  Proteins   482 (ATP1B2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Na_K-ATPase Motif Other DBs NCBI-GeneID:  482 NCBI-ProteinID:  NP_001669 OMIM:  182331 HGNC:  805 Ensembl:  ENSG00000129244 UniProt:  P14415 LinkDB All DBs Position 17:7646627..7657770 Genome browser AA seq 290 aa AA seqDB search MVIQKEKKSCGQVVEEWKEFVWNPRTHQFMGRTGTSWAFILLFYLVFYGFLTAMFTLTMW VMLQTVSDHTPKYQDRLATPGLMIRPKTENLDVIVNVSDTESWDQHVQKLNKFLEPYNDS IQAQKNDVCRPGRYYEQPDNGVLNYPKRACQFNRTQLGNCSGIGDSTHYGYSTGQPCVFI KMNRVINFYAGANQSMNVTCAGKRDEDAENLGNFVMFPANGNIDLMYFPYYGKKFHVNYT QPLVAVKFLNVTPNVEVNVECRINAANIATDDERDKFAGRVAFKLRINKT NT seq 873 nt NT seq  +upstreamnt  +downstreamnt atggtcatccagaaagagaagaagagctgcgggcaggtggttgaggagtggaaggagttc gtgtggaacccgaggacgcaccagtttatgggccgcaccgggaccagctgggcctttatc ctcctcttctacctcgttttttatgggttcctcaccgccatgttcaccctcaccatgtgg gtgatgctgcagactgtctccgaccatacccccaagtaccaggaccgactggccacaccg ggcttgatgattcgccccaagactgagaaccttgatgtcattgtcaatgtcagtgacact gaaagctgggaccagcatgttcagaagctcaacaagttcttggagccttacaacgactct atccaagcccaaaagaatgatgtctgccgccctggacgctattacgaacagccagataat ggagtcctcaactaccccaaacgtgcctgccaattcaaccggacccagctgggcaactgc tccggcattggggactccacccactatggttacagcactgggcagccctgtgtcttcatc aagatgaaccgggtcatcaacttctatgcaggagcaaaccagagcatgaatgttacctgt gctgggaagcgagatgaagatgctgagaatctcggcaacttcgtcatgttccccgccaac ggcaacatcgacctcatgtacttcccctactatggcaaaaagttccacgtgaactacaca cagcccctggtggctgtgaagttcctgaatgtgacccccaacgtggaggtgaatgtagaa tgtcgcatcaacgccgccaacatcgccacagacgatgagcgagacaagttcgccggccgc gtggccttcaaactccgcatcaacaaaacctga

Homo sapiens (human): 483 Help Entry 483               CDS       T01001                                  Symbol ATP1B3, ATPB-3, CD298 Name (RefSeq) ATPase Na+/K+ transporting subunit beta 3   KO K01540   sodium/potassium-transporting ATPase subunit beta Organism hsa  Homo sapiens (human) Pathway hsa04022   cGMP-PKG signaling pathway hsa04024   cAMP signaling pathway hsa04260   Cardiac muscle contraction hsa04261   Adrenergic signaling in cardiomyocytes hsa04820   Cytoskeleton in muscle cells hsa04911   Insulin secretion hsa04918   Thyroid hormone synthesis hsa04919   Thyroid hormone signaling pathway hsa04925   Aldosterone synthesis and secretion hsa04960   Aldosterone-regulated sodium reabsorption hsa04961   Endocrine and other factor-regulated calcium reabsorption hsa04964   Proximal tubule bicarbonate reclamation hsa04970   Salivary secretion hsa04971   Gastric acid secretion hsa04972   Pancreatic secretion hsa04973   Carbohydrate digestion and absorption hsa04974   Protein digestion and absorption hsa04976   Bile secretion hsa04978   Mineral absorption Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04024 cAMP signaling pathway     483 (ATP1B3)    04022 cGMP-PKG signaling pathway     483 (ATP1B3)  09140 Cellular Processes   09142 Cell motility    04820 Cytoskeleton in muscle cells     483 (ATP1B3)  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     483 (ATP1B3)    04918 Thyroid hormone synthesis     483 (ATP1B3)    04919 Thyroid hormone signaling pathway     483 (ATP1B3)    04925 Aldosterone synthesis and secretion     483 (ATP1B3)   09153 Circulatory system    04260 Cardiac muscle contraction     483 (ATP1B3)    04261 Adrenergic signaling in cardiomyocytes     483 (ATP1B3)   09154 Digestive system    04970 Salivary secretion     483 (ATP1B3)    04971 Gastric acid secretion     483 (ATP1B3)    04972 Pancreatic secretion     483 (ATP1B3)    04976 Bile secretion     483 (ATP1B3)    04973 Carbohydrate digestion and absorption     483 (ATP1B3)    04974 Protein digestion and absorption     483 (ATP1B3)    04978 Mineral absorption     483 (ATP1B3)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     483 (ATP1B3)    04961 Endocrine and other factor-regulated calcium reabsorption     483 (ATP1B3)    04964 Proximal tubule bicarbonate reclamation     483 (ATP1B3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04090 CD molecules [BR:hsa04090]     483 (ATP1B3) CD molecules [BR:hsa04090]  Proteins   483 (ATP1B3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Na_K-ATPase Motif Other DBs NCBI-GeneID:  483 NCBI-ProteinID:  NP_001670 OMIM:  601867 HGNC:  806 Ensembl:  ENSG00000069849 UniProt:  P54709 LinkDB All DBs Position 3:141876643..141926549 Genome browser AA seq 279 aa AA seqDB search MTKNEKKSLNQSLAEWKLFIYNPTTGEFLGRTAKSWGLILLFYLVFYGFLAALFSFTMWV MLQTLNDEVPKYRDQIPSPGLMVFPKPVTALEYTFSRSDPTSYAGYIEDLKKFLKPYTLE EQKNLTVCPDGALFEQKGPVYVACQFPISLLQACSGMNDPDFGYSQGNPCILVKMNRIIG LKPEGVPRIDCVSKNEDIPNVAVYPHNGMIDLKYFPYYGKKLHVGYLQPLVAVQVSFAPN NTGKEVTVECKIDGSANLKSQDDRDKFLGRVMFKITARA NT seq 840 nt NT seq  +upstreamnt  +downstreamnt atgacgaagaacgagaagaagtccctcaaccagagcctggccgagtggaagctcttcatc tacaacccgaccaccggagaattcctggggcgcaccgccaagagctggggtttgatcttg ctcttctacctagttttttatgggttcctggctgcactcttctcattcacgatgtgggtt atgcttcagactctcaacgatgaggttccaaaataccgtgaccagattcctagcccagga ctcatggtttttccaaaaccagtgaccgcattggaatatacattcagtaggtctgatcca acttcgtatgcagggtacattgaagaccttaagaagtttctaaaaccatatactttagaa gaacagaagaacctcacagtctgtcctgatggagcactttttgaacagaagggtccagtt tatgttgcatgtcagtttcctatttcattacttcaagcatgcagtggtatgaatgatcct gattttggctattctcaaggaaacccttgtattcttgtgaaaatgaacagaataattgga ttaaagcctgaaggagtgccaaggatagattgtgtttcaaagaatgaagatataccaaat gtagcagtttatcctcataatggaatgatagacttaaaatatttcccatattatgggaaa aaactgcatgttgggtatctacagccattggttgctgttcaggtcagctttgctcctaac aacactgggaaagaagtaacagttgagtgcaagattgatggatcagccaacctaaaaagt caggatgatcgtgacaagtttttgggacgagttatgttcaaaatcacagcacgtgcatag

Homo sapiens (human): 486 Help Entry 486               CDS       T01001                                  Symbol FXYD2, ATP1G1, HOMG2 Name (RefSeq) FXYD domain containing ion transport regulator 2   KO K01538   sodium/potassium-transporting ATPase subunit gamma (FXYD domain-containing ion transport regulator 2) Organism hsa  Homo sapiens (human) Pathway hsa04022   cGMP-PKG signaling pathway hsa04024   cAMP signaling pathway hsa04260   Cardiac muscle contraction hsa04261   Adrenergic signaling in cardiomyocytes hsa04911   Insulin secretion hsa04918   Thyroid hormone synthesis hsa04919   Thyroid hormone signaling pathway hsa04960   Aldosterone-regulated sodium reabsorption hsa04961   Endocrine and other factor-regulated calcium reabsorption hsa04964   Proximal tubule bicarbonate reclamation hsa04970   Salivary secretion hsa04972   Pancreatic secretion hsa04973   Carbohydrate digestion and absorption hsa04974   Protein digestion and absorption hsa04976   Bile secretion hsa04978   Mineral absorption Disease H01210   Hypomagnesemia Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04024 cAMP signaling pathway     486 (FXYD2)    04022 cGMP-PKG signaling pathway     486 (FXYD2)  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     486 (FXYD2)    04918 Thyroid hormone synthesis     486 (FXYD2)    04919 Thyroid hormone signaling pathway     486 (FXYD2)   09153 Circulatory system    04260 Cardiac muscle contraction     486 (FXYD2)    04261 Adrenergic signaling in cardiomyocytes     486 (FXYD2)   09154 Digestive system    04970 Salivary secretion     486 (FXYD2)    04972 Pancreatic secretion     486 (FXYD2)    04976 Bile secretion     486 (FXYD2)    04973 Carbohydrate digestion and absorption     486 (FXYD2)    04974 Protein digestion and absorption     486 (FXYD2)    04978 Mineral absorption     486 (FXYD2)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     486 (FXYD2)    04961 Endocrine and other factor-regulated calcium reabsorption     486 (FXYD2)    04964 Proximal tubule bicarbonate reclamation     486 (FXYD2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    02000 Transporters [BR:hsa02000]     486 (FXYD2)    04147 Exosome [BR:hsa04147]     486 (FXYD2) Transporters [BR:hsa02000]  Other transporters   Pores ion channels [TC:1]    486 (FXYD2) Exosome [BR:hsa04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    486 (FXYD2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  ATP1G1_PLM_MAT8 EphA2_TM Motif Other DBs NCBI-GeneID:  486 NCBI-ProteinID:  NP_001671 OMIM:  601814 HGNC:  4026 Ensembl:  ENSG00000137731 UniProt:  P54710 Structure PDB LinkDB All DBs Position 11:complement(117820057..117828089) Genome browser AA seq 66 aa AA seqDB search MTGLSMDGGGSPKGDVDPFYYDYETVRNGGLIFAGLAFIVGLLILLSRRFRCGGNKKRRQ INEDEP NT seq 201 nt NT seq  +upstreamnt  +downstreamnt atgactgggttgtcgatggacggtggcggcagccccaagggggacgtggacccgttctac tatgactatgagaccgttcgcaatgggggcctgatcttcgctggactggccttcatcgtg gggctcctcatcctcctcagcagaagattccgctgtgggggcaataagaagcgcaggcaa atcaatgaagatgagccgtaa

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