Homo sapiens (human): 2549
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Entry
2549 CDS
T01001
Symbol
GAB1, DFNB26
Name
(RefSeq) GRB2 associated binding protein 1
KO
K09593
GRB2-associated-binding protein 1
Organism
hsa
Homo sapiens (human)
Pathway
hsa01521
EGFR tyrosine kinase inhibitor resistance
hsa04012
ErbB signaling pathway
hsa04014
Ras signaling pathway
hsa04072
Phospholipase D signaling pathway
hsa04722
Neurotrophin signaling pathway
hsa05100
Bacterial invasion of epithelial cells
hsa05205
Proteoglycans in cancer
hsa05211
Renal cell carcinoma
hsa05225
Hepatocellular carcinoma
hsa05226
Gastric cancer
Network
nt06214
PI3K signaling (cancer)
nt06261
Gastric cancer
nt06263
Hepatocellular carcinoma
nt06264
Renal cell carcinoma
nt06266
Non-small cell lung cancer
nt06526
MAPK signaling
Element
N00043
HGF-MET-PI3K signaling pathway
N00044
Mutation-activated MET to PI3K signaling pathway
N00247
HGF-overexpression to PI3K signaling pathway
N00249
MET-overexpression to PI3K signaling pathway
N00260
Amplified MET to PI3K signaling pathway
N01063
Mutation-activated MET to PI3K signaling pathway
N01595
Regulation of GF-RTK-RAS-ERK signaling pathway, adaptor proteins
Disease
H00605
Deafness, autosomal recessive
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04014 Ras signaling pathway
2549 (GAB1)
04072 Phospholipase D signaling pathway
2549 (GAB1)
09150 Organismal Systems
09156 Nervous system
04722 Neurotrophin signaling pathway
2549 (GAB1)
09160 Human Diseases
09161 Cancer: overview
05205 Proteoglycans in cancer
2549 (GAB1)
09162 Cancer: specific types
05225 Hepatocellular carcinoma
2549 (GAB1)
05226 Gastric cancer
2549 (GAB1)
05211 Renal cell carcinoma
2549 (GAB1)
09171 Infectious disease: bacterial
05100 Bacterial invasion of epithelial cells
2549 (GAB1)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
2549 (GAB1)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04990 Domain-containing proteins not elsewhere classified [BR:
hsa04990
]
2549 (GAB1)
Domain-containing proteins not elsewhere classified [BR:
hsa04990
]
Pleckstrin homology (PH) domain-containing proteins
Grb-2 associated binder (Gab) family proteins
2549 (GAB1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PH
PH_11
PH_8
PH_2
Motif
Other DBs
NCBI-GeneID:
2549
NCBI-ProteinID:
NP_002030
OMIM:
604439
HGNC:
4066
Ensembl:
ENSG00000109458
UniProt:
Q13480
Q9HA84
Structure
PDB
PDBj
LinkDB
All DBs
Position
4:143336876..143474565
Genome browser
AA seq
694 aa
AA seq
DB search
MSGGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRII
DLNLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPT
EEDPVKPPGSSLQAPADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDP
QDYLLLINCQSKKPEPTRTHADSAKSTSSETDCNDNVPSHKNPASSQSKHGMNGFFQQQM
IYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYVFNTPSGTSSVETQM
RHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSKLDTIPDIPPPRPPKPHPAHDRSPVETC
SIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKDASSQDCYDIPRAFPSDRSSSL
EGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEPIQEANYVPMTPGTF
DFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPDRKVKPAPLEIKPLP
EWEELQAPVRSPITRSFARDSSRFPMSPRPDSVHSTTSSSDSHDSEENYVPMNPNLSSED
PNLFGSNSLDGGSSPMIKPKGDKQVEYLDLDLDSGKSTPPRKQKSSGSGSSVADERVDYV
VVDQQKTLALKSTREAWTDGRQSTESETPAKSVK
NT seq
2085 nt
NT seq
+upstream
nt +downstream
nt
atgagcggtggtgaagtggtctgctccggatggctccgcaagtcccccccggagaaaaag
ttgaagcgttatgcatggaagaggagatggttcgtgttacgcagtggccgtttaactgga
gatccagatgttttggaatattacaaaaatgatcatgccaagaagcctattcgtattatt
gatttaaatttatgtcaacaagtagatgctggattgacatttaacaaaaaagagtttgaa
aacagctacatttttgatatcaacactattgaccggattttctacttggtagcagacagc
gaggaggagatgaataagtgggttcgttgtatttgtgacatctgtgggtttaatccaaca
gaagaagatcctgtgaagccacctggcagctctttacaagcaccagctgatttaccttta
gctataaatacagcaccaccatccacccaggcagattcatcctctgctactctacctcct
ccatatcagctaatcaatgttccaccacacctggaaactcttggcattcaggaggatcct
caagactacctgttgctcatcaactgtcaaagcaagaagcccgaacccaccagaacgcat
gctgattctgcaaaatccacctcttctgaaacagactgcaatgataacgtcccttctcat
aaaaatcctgcttcctcccagagcaaacatggaatgaatggcttttttcagcagcaaatg
atatacgactctccaccttcacgtgccccatctgcttcagttgactccagcctttataac
ctgcccaggagttattcccatgatgttttaccaaaggtgtctccatcaagtactgaagca
gatggagaactctatgtttttaataccccatctgggacatcgagtgtagagactcaaatg
aggcatgtatctattagttatgacattcctccaacacctggtaatacttatcagattcca
cgaacatttccagaaggaaccttgggacagacatcaaagctagacactattccagatatt
cctccacctcggccaccgaaaccacatccagctcatgaccgatctcctgtggaaacgtgt
agtatcccacgcaccgcctcagacactgacagtagttactgtatccctacagcagggatg
tcgccttcacgtagtaataccatttccactgtggatttaaacaaattgcgaaaagatgct
agttctcaagactgctatgatattccacgagcatttccaagtgatagatctagttcactt
gaaggcttccataaccactttaaagtcaaaaatgtgttgacagtgggaagtgtttcaagt
gaagaactggatgaaaattacgtcccaatgaatcccaattcaccaccacgacaacattcc
agcagttttacagaaccaattcaggaagcaaattatgtgccaatgactccaggaacattt
gatttttcctcatttggaatgcaagttcctcctcctgctcatatgggcttcaggtccagc
ccaaaaacccctcccagaaggccagttcctgttgcagactgtgaaccaccccccgtggat
aggaacctcaagccagacagaaaagtcaagccagcgcctttagaaataaaacctttgcca
gaatgggaagaattacaagccccagttagatctcccatcactaggagttttgctcgagac
tcttccaggtttcccatgtccccccgaccagattcagtgcatagcacaacttcaagcagt
gactcacacgacagtgaagagaattatgttcccatgaacccaaacctgtccagtgaagac
ccaaatctctttggcagtaacagtcttgatggaggaagcagccctatgatcaagcccaaa
ggagacaaacaggtggaatacttagatctcgacttagattctgggaaatccacaccacca
cgtaagcaaaagagcagtggctcaggcagcagtgtagcagatgagagagtggattatgtt
gttgttgaccaacagaagaccttggctctaaagagtacccgggaagcctggacagatggg
agacagtccacagaatcagaaacgccagcgaagagtgtgaaatga
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