 | | NETWORK: N00043 | |
| Entry |
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| Name |
HGF-MET-PI3K signaling pathway
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| Definition |
HGF -> MET -> GAB1 -> PI3K -> PIP3 -> AKT -| BAD |
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| Expanded |
3082 -> 4233 -> 2549 -> (5290,5291,5293) -> C05981 -> (207,208,10000) -| 572 |
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| Class |
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| Type |
Reference
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| Pathway |
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| Gene |
| 3082 | HGF; hepatocyte growth factor |
| 4233 | MET; MET proto-oncogene, receptor tyrosine kinase |
| 2549 | GAB1; GRB2 associated binding protein 1 |
| 5290 | PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha |
| 5291 | PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta |
| 5293 | PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta |
| 207 | AKT1; AKT serine/threonine kinase 1 |
| 208 | AKT2; AKT serine/threonine kinase 2 |
| 10000 | AKT3; AKT serine/threonine kinase 3 |
| 572 | BAD; BCL2 associated agonist of cell death |
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| Metabolite |
| C05981 | Phosphatidylinositol-3,4,5-trisphosphate |
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| Reference |
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| Authors |
Birchmeier C, Birchmeier W, Gherardi E, Vande Woude GF. |
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| Title |
Met, metastasis, motility and more. |
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| Journal |
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| Reference |
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| Authors |
Bradley CA, Salto-Tellez M, Laurent-Puig P, Bardelli A, Rolfo C, Tabernero J, Khawaja HA, Lawler M, Johnston PG, Van Schaeybroeck S |
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| Title |
Targeting c-MET in gastrointestinal tumours: rationale, opportunities and challenges. |
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| Journal |
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| Reference |
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| Authors |
Meyer R, D'Alessandro LA, Kar S, Kramer B, She B, Kaschek D, Hahn B, Wrangborg D, Karlsson J, Kvarnstrom M, Jirstrand M, Lehmann WD, Timmer J, Hofer T, Klingmuller U |
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| Title |
Heterogeneous kinetics of AKT signaling in individual cells are accounted for by variable protein concentration. |
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| Journal |
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| LinkDB |
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