Homo sapiens (human): 25759 Help Entry 25759             CDS       T01001                                  Symbol SHC2, SCK, SHCB, SLI Name (RefSeq) SHC adaptor protein 2   KO K17447   SHC-transforming protein 2 Organism hsa  Homo sapiens (human) Pathway hsa01521   EGFR tyrosine kinase inhibitor resistance hsa01522   Endocrine resistance hsa04012   ErbB signaling pathway hsa04014   Ras signaling pathway hsa04062   Chemokine signaling pathway hsa04072   Phospholipase D signaling pathway hsa04370   VEGF signaling pathway hsa04510   Focal adhesion hsa04650   Natural killer cell mediated cytotoxicity hsa04722   Neurotrophin signaling pathway hsa04910   Insulin signaling pathway hsa04915   Estrogen signaling pathway hsa04917   Prolactin signaling pathway hsa04926   Relaxin signaling pathway hsa04935   Growth hormone synthesis, secretion and action hsa05034   Alcoholism hsa05100   Bacterial invasion of epithelial cells hsa05214   Glioma hsa05220   Chronic myeloid leukemia hsa05224   Breast cancer hsa05225   Hepatocellular carcinoma hsa05226   Gastric cancer Network nt06526  MAPK signaling   Element N01595   Regulation of GF-RTK-RAS-ERK signaling pathway, adaptor proteins Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04012 ErbB signaling pathway     25759 (SHC2)    04014 Ras signaling pathway     25759 (SHC2)    04370 VEGF signaling pathway     25759 (SHC2)    04072 Phospholipase D signaling pathway     25759 (SHC2)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04510 Focal adhesion     25759 (SHC2)  09150 Organismal Systems   09151 Immune system    04650 Natural killer cell mediated cytotoxicity     25759 (SHC2)    04062 Chemokine signaling pathway     25759 (SHC2)   09152 Endocrine system    04910 Insulin signaling pathway     25759 (SHC2)    04915 Estrogen signaling pathway     25759 (SHC2)    04917 Prolactin signaling pathway     25759 (SHC2)    04926 Relaxin signaling pathway     25759 (SHC2)    04935 Growth hormone synthesis, secretion and action     25759 (SHC2)   09156 Nervous system    04722 Neurotrophin signaling pathway     25759 (SHC2)  09160 Human Diseases   09162 Cancer: specific types    05225 Hepatocellular carcinoma     25759 (SHC2)    05226 Gastric cancer     25759 (SHC2)    05214 Glioma     25759 (SHC2)    05220 Chronic myeloid leukemia     25759 (SHC2)    05224 Breast cancer     25759 (SHC2)   09171 Infectious disease: bacterial    05100 Bacterial invasion of epithelial cells     25759 (SHC2)   09165 Substance dependence    05034 Alcoholism     25759 (SHC2)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     25759 (SHC2)    01522 Endocrine resistance     25759 (SHC2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PID SH2 Motif Other DBs NCBI-GeneID:  25759 NCBI-ProteinID:  NP_036567 OMIM:  605217 HGNC:  29869 Ensembl:  ENSG00000129946 Pharos:  P98077(Tbio) UniProt:  P98077 LinkDB All DBs Position 19:complement(416589..461033) Genome browser AA seq 582 aa AA seqDB search MTQGPGGRAPPAPPAPPEPEAPTTFCALLPRMPQWKFAAPGGFLGRGPAAARAAGASGGA DPQPEPAGPGGVPALAAAVLGACEPRCAAPCPLPALSRCRGAGSRGSRGGRGAAGSGDAA AAAEWIRKGSFIHKPAHGWLHPDARVLGPGVSYVVRYMGCIEVLRSMRSLDFNTRTQVTR EAINRLHEAVPGVRGSWKKKAPNKALASVLGKSNLRFAGMSISIHISTDGLSLSVPATRQ VIANHHMPSISFASGGDTDMTDYVAYVAKDPINQRACHILECCEGLAQSIISTVGQAFEL RFKQYLHSPPKVALPPERLAGPEESAWGDEEDSLEHNYYNSIPGKEPPLGGLVDSRLALT QPCALTALDQGPSPSLRDACSLPWDVGSTGTAPPGDGYVQADARGPPDHEEHLYVNTQGL DAPEPEDSPKKDLFDMRPFEDALKLHECSVAAGVTAAPLPLEDQWPSPPTRRAPVAPTEE QLRQEPWYHGRMSRRAAERMLRADGDFLVRDSVTNPGQYVLTGMHAGQPKHLLLVDPEGV VRTKDVLFESISHLIDHHLQNGQPIVAAESELHLRGVVSREP NT seq 1749 nt NT seq  +upstreamnt  +downstreamnt atgacgcagggtccgggcgggcgcgcgcccccggcgccccccgcgccccccgagcccgag gcgcccaccaccttctgcgcgttgctgccccgaatgccgcagtggaagttcgcggccccg ggcggcttcctgggccgcggcccggcggcggcgcgggcggctggggcctcggggggcgcg gacccccaacccgagccggcgggcccggggggcgtcccggcgctggcggccgccgtcctg ggcgcctgcgagccccgctgcgccgcgccctgtcccctgcccgcgctcagccgctgtcgg ggcgcggggtcgcgggggtcgcggggcgggcggggggcggcggggtccggggacgccgcc gccgccgccgagtggatccggaagggcagcttcatccacaaacccgcgcacggctggcta caccccgacgccagggtcctggggcccggggtctcctacgtcgtgcggtacatgggctgc atcgaggttctccgctctatgcgctccctggactttaacacgcgcacgcaggtgaccagg gaagccatcaaccggctccatgaggccgtgcctggcgtccggggatcctggaagaaaaag gcccccaacaaggccctggcgtccgtcctgggcaagagcaaccttcgctttgccggcatg agcatctccatccacatctccactgatggcctcagcctctccgtgcctgccacgcgccag gtcatcgccaaccaccacatgccgtccatctccttcgcgtcaggcggagacacggacatg acggattacgtggcctacgtcgccaaggaccccatcaaccagagagcctgccacatcctg gagtgctgtgagggcctggcacagagcatcatcagcaccgtgggccaagctttcgagctg cgcttcaagcagtacctgcacagcccgcccaaggtggcgctgcccccagaaaggctggca gggccggaggagtcggcctggggggacgaggaggactctttggagcacaattactacaac agcatcccggggaaggagccgccgctgggcgggctagtggactccaggctggccctgaca cagccctgcgccctcacggccctcgaccagggcccatctccttctctaagagatgcctgc agcctgccatgggacgtggggtccaccggtacagctccaccgggggacggctacgtgcag gcggacgcccggggccccccggaccacgaggagcacctgtatgtcaacacccagggtctg gacgcccccgagccggaggacagccccaaaaaggatctgtttgacatgcgaccctttgag gatgccctgaagttgcatgagtgctcagtggcggcaggcgtgacagcagcccctcttccc ttggaggaccagtggcccagcccccctacccgccgggcccctgtggcccccacggaggaa cagctgcgtcaggagccctggtaccacggccggatgagccgccgggcggcagagaggatg cttcgagctgacggggacttccttgtgcgagacagcgtcaccaaccccgggcagtatgtc ctcaccggcatgcacgccgggcagcccaagcacctgctgctcgtggaccccgagggcgtg gtacggacgaaggacgtgctgtttgagagcatcagccacctgatcgaccaccacctgcag aacgggcagcccatcgtggccgccgagagtgagctgcacctgcgtggcgtggtctcacgg gagccctga

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