KEGG   ORTHOLOGY: K17447
Entry
K17447                      KO                                     
Symbol
SHC2
Name
SHC-transforming protein 2
Pathway
map01521  EGFR tyrosine kinase inhibitor resistance
map01522  Endocrine resistance
map04012  ErbB signaling pathway
map04014  Ras signaling pathway
map04062  Chemokine signaling pathway
map04072  Phospholipase D signaling pathway
map04370  VEGF signaling pathway
map04510  Focal adhesion
map04650  Natural killer cell mediated cytotoxicity
map04722  Neurotrophin signaling pathway
map04910  Insulin signaling pathway
map04915  Estrogen signaling pathway
map04917  Prolactin signaling pathway
map04926  Relaxin signaling pathway
map04935  Growth hormone synthesis, secretion and action
map05034  Alcoholism
map05100  Bacterial invasion of epithelial cells
map05214  Glioma
map05220  Chronic myeloid leukemia
map05224  Breast cancer
map05225  Hepatocellular carcinoma
map05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    K17447  SHC2; SHC-transforming protein 2
   04014 Ras signaling pathway
    K17447  SHC2; SHC-transforming protein 2
   04370 VEGF signaling pathway
    K17447  SHC2; SHC-transforming protein 2
   04072 Phospholipase D signaling pathway
    K17447  SHC2; SHC-transforming protein 2
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K17447  SHC2; SHC-transforming protein 2
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    K17447  SHC2; SHC-transforming protein 2
   04062 Chemokine signaling pathway
    K17447  SHC2; SHC-transforming protein 2
  09152 Endocrine system
   04910 Insulin signaling pathway
    K17447  SHC2; SHC-transforming protein 2
   04915 Estrogen signaling pathway
    K17447  SHC2; SHC-transforming protein 2
   04917 Prolactin signaling pathway
    K17447  SHC2; SHC-transforming protein 2
   04926 Relaxin signaling pathway
    K17447  SHC2; SHC-transforming protein 2
   04935 Growth hormone synthesis, secretion and action
    K17447  SHC2; SHC-transforming protein 2
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K17447  SHC2; SHC-transforming protein 2
 09160 Human Diseases
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    K17447  SHC2; SHC-transforming protein 2
   05226 Gastric cancer
    K17447  SHC2; SHC-transforming protein 2
   05214 Glioma
    K17447  SHC2; SHC-transforming protein 2
   05220 Chronic myeloid leukemia
    K17447  SHC2; SHC-transforming protein 2
   05224 Breast cancer
    K17447  SHC2; SHC-transforming protein 2
  09171 Infectious disease: bacterial
   05100 Bacterial invasion of epithelial cells
    K17447  SHC2; SHC-transforming protein 2
  09165 Substance dependence
   05034 Alcoholism
    K17447  SHC2; SHC-transforming protein 2
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K17447  SHC2; SHC-transforming protein 2
   01522 Endocrine resistance
    K17447  SHC2; SHC-transforming protein 2
Genes
HSA: 25759(SHC2)
PTR: 749831(SHC2)
PPS: 100974798(SHC2)
GGO: 101129046(SHC2)
PON: 100445042(SHC2)
PPYG: 129026077(SHC2)
NLE: 100591489(SHC2)
HMH: 116464630
SSYN: 129465500(SHC2)
MCC: 721021(SHC2)
MCF: 102125325(SHC2)
MTHB: 126942949
MNI: 105486618(SHC2)
CSAB: 103233559(SHC2)
CATY: 105591876(SHC2)
PANU: 101006054
TGE: 112612298(SHC2)
MLEU: 105548833(SHC2)
RBB: 108531776(SHC2) 108533994
TFN: 117074894(SHC2)
PTEH: 111528883(SHC2)
CANG: 105527663(SHC2)
CJC: 100415083(SHC2)
SBQ: 101048523(SHC2)
CIMI: 108297501(SHC2)
ANAN: 105706187(SHC2)
MMUR: 105860825(SHC2)
LCAT: 123632067(SHC2)
PCOQ: 105811228(SHC2)
OGA: 100957623(SHC2)
MMU: 216148(Shc2)
MCAL: 110303444(Shc2)
MPAH: 110326457(Shc2)
RNO: 314612(Shc2)
MCOC: 116076241(Shc2)
ANU: 117696653(Shc2)
ASYL: 127671027(Shc2)
MUN: 110551355(Shc2)
CGE: 100761269(Shc2)
MAUA: 101843435(Shc2)
PROB: 127216670(Shc2)
PLEU: 114684102(Shc2)
MORG: 121459499(Shc2)
MFOT: 126489227
AAMP: 119825434(Shc2)
NGI: 103737407(Shc2)
HGL: 101723930(Shc2)
CPOC: 100723025
CCAN: 109686083(Shc2)
DORD: 105990314(Shc2)
DSP: 122122823(Shc2)
PLOP: 125347922(Shc2)
NCAR: 124975378
MMMA: 107157391(Shc2)
ITI: 101960401(Shc2)
OPI: 101522080(SHC2)
TUP: 102481863(SHC2)
GVR: 103600233(SHC2)
CFA: 611955(SHC2)
CLUD: 112666141(SHC2)
VVP: 112935467(SHC2)
VLG: 121494261(SHC2)
NPO: 129522289(SHC2)
AML: 100480694(SHC2)
UMR: 103681753(SHC2)
UAH: 113242690(SHC2)
UAR: 123794070
ELK: 111161808
LLV: 125087478
MPUF: 101692343(SHC2)
MNP: 132010667(SHC2)
MLK: 131823143(SHC2)
NVS: 122909991(SHC2)
ORO: 101384118(SHC2)
EJU: 114226321(SHC2)
ZCA: 113917867(SHC2)
MLX: 118004996(SHC2)
NSU: 110594105(SHC2)
LWW: 102727078(SHC2)
FCA: 101083489(SHC2)
PYU: 121021890(SHC2)
PCOO: 112852752(SHC2)
PBG: 122486600(SHC2)
PVIV: 125159758(SHC2)
LRUF: 124527699
LGF: 123604940(SHC2)
AJU: 106978092
PTG: 102954336(SHC2)
PPAD: 109257730(SHC2)
PUC: 125928763
PLEZ: 122213645(SHC2)
HHV: 120242345(SHC2)
BTA: 533455(SHC2)
BOM: 102281047(SHC2)
BIU: 109561056(SHC2)
BBUB: 102389953(SHC2)
BBIS: 104991966(SHC2)
CHX: 102169956(SHC2)
OAS: 101113847(SHC2)
BTAX: 128051196(SHC2)
CSUM: 138085991(SHC2)
ODA: 120864498(SHC2)
MREE: 136167630(SHC2)
OVR: 110142284(SHC2)
MBEZ: 129558379(SHC2)
SSC: 110259382(SHC2)
CFR: 102506382(SHC2)
CBAI: 105078342(SHC2)
CDK: 105093416(SHC2)
VPC: 102526634(SHC2)
BACU: 103006868(SHC2)
BMUS: 118893410(SHC2)
LVE: 103088833(SHC2)
OOR: 101275665(SHC2)
LALB: 132517863(SHC2)
DLE: 111170483(SHC2)
PCAD: 102974315(SHC2)
PSIU: 116751918(SHC2)
NASI: 112396342(SHC2)
ECB: 100146209(SHC2)
EPZ: 103542441(SHC2)
EAI: 106834253(SHC2)
MYB: 102251506(SHC2)
MYD: 102752087(SHC2)
MMYO: 118659254(SHC2)
MDT: 132235316(SHC2)
MYUM: 139010728(SHC2)
PKL: 118711420(SHC2)
EFUS: 103294446(SHC2)
MNA: 107538554(SHC2)
DRO: 112312297(SHC2)
SHON: 118984370(SHC2)
AJM: 119044619(SHC2)
PDIC: 114504166(SHC2)
PHAS: 123813838(SHC2)
MMF: 118615745(SHC2)
PPAM: 129072430(SHC2)
HAI: 109390676(SHC2)
RFQ: 117037962(SHC2)
PALE: 102885958(SHC2)
PGIG: 120589513(SHC2)
PVP: 105302278(SHC2)
RAY: 107500961(SHC2)
MJV: 108391745(SHC2)
TOD: 119240463(SHC2)
SARA: 101550526(SHC2)
SFUM: 130022114(SHC2)
SETR: 126030826(SHC2)
TMU: 101359726
ETF: 101644867(SHC2)
DNM: 101447321(SHC2)
GAS: 123256803(SHC2)
SHR: 100917745(SHC2)
AFZ: 127545256
PCW: 110223483(SHC2)
TVP: 118858308(SHC2)
PBRV: 138172978(SHC2)
OAA: 100081397(SHC2)
TACU: 119950507(SHC2)
GGA: 770341(SHC2)
PCOC: 116235831(SHC2)
MGP: 100538500(SHC2)
CJO: 107325668(SHC2)
TPAI: 128090392(SHC2)
LMUT: 125684893(SHC2)
NMEL: 110389019(SHC2)
APLA: 101803969(SHC2)
ACYG: 106049094(SHC2)
CATA: 118260038(SHC2)
AFUL: 116499186(SHC2)
TGU: 100217581(SHC2)
LSR: 110475781(SHC2)
SCAN: 103822026(SHC2)
PMOA: 120496007(SHC2)
OTC: 121341581(SHC2)
PRUF: 121361768(SHC2)
ATRC: 139602105(SHC2)
GFR: 102034643(SHC2)
FAB: 101815242(SHC2)
OMA: 130264447(SHC2)
PHI: 102100749(SHC2)
PMAJ: 107215430(SHC2)
CCAE: 111940286(SHC2)
CCW: 104697005(SHC2)
CBRC: 103622163(SHC2)
ACOE: 138099795(SHC2)
ETL: 114066416(SHC2)
ZAB: 102072622
ZLE: 135458912(SHC2)
SVG: 106857053(SHC2)
MMEA: 130580224(SHC2)
HRT: 120763362(SHC2)
SATI: 136371857(SHC2)
CCIC: 134054323(SHC2)
FPG: 101924524(SHC2)
FCH: 102049085(SHC2)
SHAB: 115618057(SHC2)
TALA: 116961635(SHC2)
ACHC: 115349526(SHC2)
HLE: 104829150(SHC2)
AGEN: 126041747
HHAR: 128148409(SHC2)
GCL: 127025457
CSTI: 104553408(SHC2)
MNB: 103767954(SHC2)
DPUB: 104300737(SHC2)
PPUS: 135192066(SHC2)
EGZ: 104124436(SHC2)
NNI: 104016320(SHC2)
PADL: 103923470(SHC2)
AFOR: 103899434(SHC2)
CLV: 102088882(SHC2)
CUCA: 104067731(SHC2)
TEO: 104376503(SHC2)
CPEA: 104392436(SHC2)
CVF: 104294391(SHC2)
RTD: 128900700(SHC2)
CRID: 134526442(SHC2)
AAM: 106486386(SHC2)
AROW: 112973886(SHC2)
NPD: 112946874(SHC2)
DNE: 112988087(SHC2)
ASN: 102383911(SHC2)
AMJ: 102565747(SHC2)
GGN: 109294913(SHC2)
CMY: 102933759(SHC2)
CCAY: 125627065(SHC2)
DCC: 119848306(SHC2)
CPIC: 101944228(SHC2)
TST: 117868957(SHC2)
CABI: 116814882(SHC2)
MRV: 120391919(SHC2)
ACS: 100553545(shc2)
ASAO: 132781147(SHC2)
PVT: 110079278(SHC2)
SUND: 121937364(SHC2)
PBI: 103061599(SHC2)
PMUR: 107298759
CTIG: 120297060(SHC2)
PGUT: 117668639(SHC2)
APRI: 131188198(SHC2)
PTEX: 113434988(SHC2)
NSS: 113425094(SHC2)
VKO: 123036581(SHC2)
PMUA: 114588608(SHC2)
PRAF: 128405810(SHC2)
ZVI: 118087871(SHC2)
HCG: 128347884(SHC2)
GJA: 107110440(SHC2)
STOW: 125433261(SHC2)
EMC: 129329904(SHC2)
XLA: 108706896(shc2.S) 108713169(shc2.L)
XTR: 100487416(shc2)
NPR: 108790334(SHC2)
RTEM: 120910109(SHC2)
BBUF: 120991599(SHC2)
BGAR: 122930875(SHC2)
PWL: 138268117(SHC2)
MUO: 115479981(SHC2)
GSH: 117365739(SHC2)
DRE: 562011(shc2)
SANH: 107676975(shc2) 107699410
CCAR: 109096032(shc2)
PTET: 122327715(shc2)
LROH: 127153208(shc2)
OMC: 131530701(shc2)
PPRM: 120495450(shc2)
RKG: 130089176(shc2)
MAMB: 125263808(shc2)
CIDE: 127519729
CERY: 137027760(shc2)
TROS: 130548718(shc2)
TDW: 130429330(shc2)
MANU: 129452610(shc2)
PDAB: 135729144(shc2)
IPU: 108270761
IFU: 128613975(shc2)
PHYP: 113547084(shc2)
SMEO: 124391651(shc2)
TFD: 113646129(shc2)
TVC: 132841736(shc2)
CGAR: 128543113(shc2)
NGRA: 132898956(shc2)
TRN: 134331377(shc2)
AMEX: 103026451(shc2)
CMAO: 118819383(shc2)
EEE: 113587209(shc2)
CHAR: 105910744(shc2)
SPIL: 134102391(shc2)
TRU: 101071160(shc2)
TFS: 130528532(shc2)
LCO: 104918475(shc2)
NCC: 104958981(shc2)
TBEN: 117495196(shc2)
CGOB: 115007109(shc2)
PGEO: 117445506(shc2)
GACU: 117550979(shc2)
EMAC: 134869118(shc2)
ELY: 117254016(shc2)
EFO: 125895735(shc2)
PLEP: 121938139(shc2)
SLUC: 116055201(shc2)
ECRA: 117950057(shc2)
ESP: 116696202
PFLV: 114561987(shc2)
GAT: 120823634(shc2)
PPUG: 119216728(shc2)
AFB: 129094479(shc2)
CLUM: 117729725(shc2)
CANA: 137794719(shc2)
CVE: 137870208(shc2)
MSAM: 119900775(shc2)
SCHU: 122877343(shc2)
CUD: 121512814(shc2)
SPUL: 138607304(shc2)
LMIX: 132960033(shc2)
ALAT: 119028931(shc2)
ASTR: 137598846(shc2)
MZE: 101463941
ONL: 100696779
OAU: 116317325(shc2)
OLA: 101156242(shc2)
OML: 112150934(shc2)
CSAI: 133457791(shc2)
XMA: 102216631
XCO: 114150293
XHE: 116726316
PRET: 103463557(shc2)
PFOR: 103142600(shc2)
PLAI: 106947864(shc2)
PMEI: 106918340(shc2)
GAF: 122838868(shc2)
PPRL: 129372280(shc2)
CVG: 107085719(shc2)
CTUL: 119794273(shc2)
GMU: 124874121(shc2)
NFU: 107393200(shc2)
KMR: 108230757(shc2)
ALIM: 106530194(shc2)
NWH: 119407858(shc2)
AOCE: 111573492(shc2)
EJA: 138198758(shc2)
BFRE: 138618961(shc2)
MCEP: 125009776(shc2)
CSEM: 103398231
POV: 109625730(shc2)
SSEN: 122780993(shc2)
SSOE: 131465448(shc2)
HHIP: 117760743(shc2)
HSP: 118120944(shc2)
PPLT: 128447815(shc2)
SMAU: 118318508(shc2)
LCF: 108881424
SDU: 111232138
SLAL: 111654285
XGL: 120790651(shc2)
HCQ: 109532226
SSCV: 125971263(shc2)
SBIA: 133503653(shc2)
PEE: 133406408(shc2)
PTAO: 133481173(shc2)
BPEC: 110167820(shc2)
ENY: 140353680(shc2)
MALB: 109964050
BSPL: 114854040(shc2)
SJO: 128361370(shc2)
SSCO: 133984854(shc2)
GMH: 115555187(shc2)
OMY: 110521457 110524319(shc2)
SNH: 120052448(shc2) 120054467
ELS: 105011583(shc2)
OEP: 134013016(shc2)
SFM: 108919768(shc2)
PKI: 111860152(shc2)
AANG: 118226180(shc2)
AROT: 135252364(shc2)
CCOG: 133127316(shc2)
LOC: 102690296
PSPA: 121301327(shc2)
PSEX: 120537706(shc2)
LCM: 102355047(SHC2)
CMK: 103182043
RTP: 109937865(shc2)
CPLA: 122565507(shc2)
HOC: 132828827(shc2)
LERI: 129711036(shc2)
ARUN: 117295791
AAMU: 139941800
IEL: 124165265
MCAF: 127733302
ATEN: 116299283
 » show all
Reference
PMID:9507002
  Authors
Nakamura T, Muraoka S, Sanokawa R, Mori N
  Title
N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling.
  Journal
J Biol Chem 273:6960-7 (1998)
DOI:10.1074/jbc.273.12.6960
  Sequence
[hsa:25759]
Reference
  Authors
Sasaki H, Emi M, Iijima H, Ito N, Sato H, Yabe I, Kato T, Utsumi J, Matsubara K
  Title
Copy number loss of (src homology 2 domain containing)-transforming protein 2 (SHC2) gene: discordant loss in monozygotic twins and frequent loss in patients with multiple system atrophy.
  Journal
Mol Brain 4:24 (2011)
DOI:10.1186/1756-6606-4-24
  Sequence
[hsa:25759]
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