Homo sapiens (human): 25825
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Entry
25825 CDS
T01001
Symbol
BACE2, AEPLC, ALP56, ASP1, ASP21, BAE2, CDA13, CEAP1, DRAP
Name
(RefSeq) beta-secretase 2
KO
K07747
beta-site APP-cleaving enzyme 2 (memapsin 1) [EC:
3.4.23.45
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa05010
Alzheimer disease
Drug target
Elenbecestat:
D11509
Verubecestat:
D10739
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09160 Human Diseases
09164 Neurodegenerative disease
05010 Alzheimer disease
25825 (BACE2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01002 Peptidases and inhibitors [BR:
hsa01002
]
25825 (BACE2)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.4 Acting on peptide bonds (peptidases)
3.4.23 Aspartic endopeptidases
3.4.23.45 memapsin 1
25825 (BACE2)
Peptidases and inhibitors [BR:
hsa01002
]
Aspartic peptidases
Family A1: pepsin family
25825 (BACE2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Asp
TAXi_C
TAXi_N
Motif
Other DBs
NCBI-GeneID:
25825
NCBI-ProteinID:
NP_036237
OMIM:
605668
HGNC:
934
Ensembl:
ENSG00000182240
UniProt:
Q9Y5Z0
Structure
PDB
PDBj
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All DBs
Position
21:41168160..41282530
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AA seq
518 aa
AA seq
DB search
MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGL
ALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAG
TPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATI
FESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVA
GSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKA
IVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISI
YLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFD
RAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCG
AILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK
NT seq
1557 nt
NT seq
+upstream
nt +downstream
nt
atgggcgcactggcccgggcgctgctgctgcctctgctggcccagtggctcctgcgcgcc
gccccggagctggcccccgcgcccttcacgctgcccctccgggtggccgcggccacgaac
cgcgtagttgcgcccaccccgggacccgggacccctgccgagcgccacgccgacggcttg
gcgctcgccctggagcctgccctggcgtcccccgcgggcgccgccaacttcttggccatg
gtagacaacctgcagggggactctggccgcggctactacctggagatgctgatcgggacc
cccccgcagaagctacagattctcgttgacactggaagcagtaactttgccgtggcagga
accccgcactcctacatagacacgtactttgacacagagaggtctagcacataccgctcc
aagggctttgacgtcacagtgaagtacacacaaggaagctggacgggcttcgttggggaa
gacctcgtcaccatccccaaaggcttcaatacttcttttcttgtcaacattgccactatt
tttgaatcagagaatttctttttgcctgggattaaatggaatggaatacttggcctagct
tatgccacacttgccaagccatcaagttctctggagaccttcttcgactccctggtgaca
caagcaaacatccccaacgttttctccatgcagatgtgtggagccggcttgcccgttgct
ggatctgggaccaacggaggtagtcttgtcttgggtggaattgaaccaagtttgtataaa
ggagacatctggtatacccctattaaggaagagtggtactaccagatagaaattctgaaa
ttggaaattggaggccaaagccttaatctggactgcagagagtataacgcagacaaggcc
atcgtggacagtggcaccacgctgctgcgcctgccccagaaggtgtttgatgcggtggtg
gaagctgtggcccgcgcatctctgattccagaattctctgatggtttctggactgggtcc
cagctggcgtgctggacgaattcggaaacaccttggtcttacttccctaaaatctccatc
tacctgagagacgagaactccagcaggtcattccgtatcacaatcctgcctcagctttac
attcagcccatgatgggggccggcctgaattatgaatgttaccgattcggcatttcccca
tccacaaatgcgctggtgatcggtgccacggtgatggagggcttctacgtcatcttcgac
agagcccagaagagggtgggcttcgcagcgagcccctgtgcagaaattgcaggtgctgca
gtgtctgaaatttccgggcctttctcaacagaggatgtagccagcaactgtgtccccgct
cagtctttgagcgagcccattttgtggattgtgtcctatgcgctcatgagcgtctgtgga
gccatcctccttgtcttaatcgtcctgctgctgctgccgttccggtgtcagcgtcgcccc
cgtgaccctgaggtcgtcaatgatgagtcctctctggtcagacatcgctggaaatga
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