KEGG ORTHOLOGY: K07747

ORTHOLOGY: K07747

Entry

K07747                      KO

Symbol

BACE2

Name

beta-site APP-cleaving enzyme 2 (memapsin 1) [EC:3.4.23.45]

Pathway

map05010

Alzheimer disease

Brite

KEGG Orthology (KO) [BR:ko00001]
09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K07747  BACE2; beta-site APP-cleaving enzyme 2 (memapsin 1)
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K07747  BACE2; beta-site APP-cleaving enzyme 2 (memapsin 1)
Enzymes [BR:ko01000]
3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.23  Aspartic endopeptidases
    3.4.23.45  memapsin 1
     K07747  BACE2; beta-site APP-cleaving enzyme 2 (memapsin 1)
Peptidases and inhibitors [BR:ko01002]
Aspartic peptidases
  Family A1: pepsin family
   K07747  BACE2; beta-site APP-cleaving enzyme 2 (memapsin 1)

Genes

HSA:	25825(BACE2)

PTR:	747819(BACE2)

PPS:	100990201(BACE2)

GGO:	101131488(BACE2)

PON:	100442149(BACE2)

PPYG:

129022574(BACE2)

NLE:	100598433(BACE2)

HMH:	116481803(BACE2)

SSYN:

129483013(BACE2)

MCC:	715330(BACE2)

MCF:	102140609(BACE2)

MTHB:

126950688

MNI:	105472608(BACE2)

CSAB:

103219113(BACE2)

CATY:

105575468(BACE2)

PANU:

101022049(BACE2)

TGE:	112620298(BACE2)

MLEU:

105542583(BACE2)

RRO:	104655130(BACE2)

RBB:	108534721(BACE2)

TFN:	117095807(BACE2)

PTEH:

111526175(BACE2)

CANG:

105520372(BACE2)

CJC:	100406072(BACE2)

SBQ:	101041728(BACE2)

CIMI:

108311241(BACE2)

ANAN:

105712181(BACE2)

CSYR:

103269514(BACE2)

MMUR:

105868023(BACE2)

LCAT:

123630753(BACE2)

PCOQ:

105806870(BACE2)

OGA:	100960504(BACE2)

MMU:	56175(Bace2)

MCAL:

110311491(Bace2)

MPAH:

110329601(Bace2)

RNO:	288227(Bace2)

MCOC:

116086190(Bace2)

ANU:	117718073(Bace2)

ASYL:

127666227(Bace2)

MUN:	110553487(Bace2)

CGE:	100764950(Bace2)

MAUA:

101844196(Bace2)

PROB:

127227565(Bace2)

PLEU:

114700348(Bace2)

PMAV:

102913203(Bace2)

MORG:

121461779(Bace2)

MFOT:

126513584

AAMP:

119825049(Bace2)

NGI:	103748454(Bace2)

HGL:	101717943(Bace2)

CPOC:

100720853(Bace2)

DORD:

105993951(Bace2)

DSP:	122114277(Bace2)

DMER:

138832550(Bace2)

PLOP:

125351658(Bace2)

NCAR:

124992931

MMMA:

107136157(Bace2)

ITI:	101972083(Bace2)

OCU:	100342092 127486849

OPI:	101520126(BACE2)

OCZ:	121160667(BACE2)

TUP:	102498668(BACE2)

GVR:	103589278(BACE2)

CFA:	100684381 478418(BACE2)

CLUD:

112661680(BACE2)

VVP:	112908004(BACE2)

VLG:	121479488(BACE2) 121486528

NPO:	129502235(BACE2)

AML:	100477612(BACE2)

UMR:	103680727(BACE2)

UAR:	123802633(BACE2)

ELK:

111155713

LLV:

125093972

MPUF:

101670860(BACE2)

MNP:	132012411(BACE2)

MLK:	131825388(BACE2)

NVS:	122908281(BACE2)

ORO:	101382461(BACE2)

EJU:	114226403(BACE2)

ZCA:	113916393(BACE2)

MLX:	118026127(BACE2)

NSU:	110571122(BACE2)

LWW:	102735101(BACE2)

FCA:	101096756(BACE2)

PYU:	121036454(BACE2)

PCOO:

112849464(BACE2)

PBG:	122491153(BACE2)

PVIV:

125175018(BACE2)

LRUF:

124526676

LGF:	123610555(BACE2)

AJU:

106965624

PTG:	102955826(BACE2)

PPAD:

109249665(BACE2)

PUC:

125920716

PLEZ:

122229668(BACE2)

HHV:	120230328(BACE2)

BTA:	534774(BACE2)

BOM:	102272554(BACE2)

BIU:	109560497(BACE2)

BBUB:

102400736(BACE2)

BBIS:

104985026(BACE2)

CHX:	102187812(BACE2)

OAS:	101102027(BACE2)

BTAX:

128049008(BACE2)

CSUM:

138079863(BACE2)

ODA:	120856835(BACE2)

CCAD:

122445355(BACE2)

MREE:

136173790(BACE2)

OVR:	110141078(BACE2)

MBEZ:

129547972(BACE2)

SSC:	100517374(BACE2)

CFR:	102516803(BACE2)

CBAI:

105081120(BACE2)

CDK:	105099560(BACE2)

VPC:	102536824(BACE2)

BACU:

103014984(BACE2)

BMUS:

118894877(BACE2)

LVE:	103085141(BACE2)

OOR:	101276476(BACE2)

LALB:

132521348(BACE2)

GMF:	115841491(BACE2)

DDP:	132423942(BACE2)

DLE:	111163827(BACE2)

PCAD:

102989241(BACE2)

PSIU:

116753479(BACE2)

PPHC:

136122260(BACE2)

NASI:

112408587(BACE2)

ECB:	100058700(BACE2)

EPZ:	103563066(BACE2)

EAI:	106829946(BACE2)

MYB:	102254769(BACE2)

MYD:	102767911(BACE2)

MMYO:

118676055(BACE2)

MLF:	102427816(BACE2)

MDT:	132229892(BACE2)

MYUM:

139004279(BACE2)

PKL:	118723392(BACE2)

EFUS:

103289900(BACE2)

MNA:	107543580(BACE2)

DRO:	112305990(BACE2)

SHON:

118984839(BACE2)

AJM:	119048822(BACE2)

PDIC:

114490483(BACE2)

PHAS:

123827923(BACE2)

MMF:	118617504(BACE2)

PPAM:

129074632(BACE2)

HAI:	109372661(BACE2)

RFQ:	117034943(BACE2)

PALE:

102896199(BACE2)

PGIG:

120598839(BACE2)

PVP:	105300589(BACE2)

RAY:	107498533(BACE2)

MJV:	108397054(BACE2)

TOD:	119257185(BACE2)

SARA:

101541926(BACE2)

SFUM:

130028689(BACE2)

SETR:

126025640(BACE2)

LAV:	100653591(BACE2)

TMU:

101360622

ETF:	101653908(BACE2)

DNM:	101426319(BACE2)

MDO:	100016587(BACE2)

GAS:	123242508(BACE2)

SHR:	100932104(BACE2)

AFZ:

127553775

PCW:	110200869(BACE2)

TVP:	118838319(BACE2)

PBRV:

138151410(BACE2)

MLAO:

141506774(BACE2)

OAA:	100080196(BACE2)

TACU:

119940084(BACE2)

GGA:	418526(BACE2)

PCOC:

116242118(BACE2)

MGP:	100547969(BACE2)

CJO:	107323138(BACE2)

TPAI:

128076411(BACE2)

LMUT:

125702980(BACE2)

NMEL:

110403123(BACE2)

APLA:

101795939(BACE2)

ACYG:

106036113(BACE2)

CATA:

118247713(BACE2)

AFUL:

116485795(BACE2)

TGU:	100224177(BACE2)

LSR:	110475869(BACE2)

SCAN:

103815877(BACE2)

PMOA:

120511889(BACE2)

OTC:	121333463(BACE2)

PRUF:

121364492(BACE2)

ATRC:

139591521(BACE2)

GFR:	102039028(BACE2)

FAB:	101816221(BACE2)

OMA:	130257070(BACE2)

PHI:	102107969(BACE2)

PMAJ:

107212623(BACE2)

CCAE:

111929198(BACE2)

CCW:	104686367(BACE2)

CBRC:

103612881(BACE2)

ACOE:

138110615(BACE2)

ETL:	114059201(BACE2)

ZAB:	102065528(BACE2)

ZLE:	135444224(BACE2)

ACHL:

103802824(BACE2)

SVG:	106855723(BACE2)

MMEA:

130578109(BACE2)

HRT:	120749227(BACE2)

SATI:

136358202(BACE2)

CCIC:

134058123(BACE2)

FPG:	101919630(BACE2)

FCH:	102051138(BACE2)

CCRI:

104162065(BACE2)

NNT:	104412472(BACE2)

SHAB:

115604130(BACE2)

ACUN:

113478950(BACE2)

TALA:

104368265(BACE2)

ACHC:

115343812(BACE2)

HLE:	104839841(BACE2)

AGEN:

126053203

HHAR:

128144956(BACE2)

GCL:

127021081

CSTI:

104561523

LDI:	104340929(BACE2)

DPUB:

104305048(BACE2)

PPUS:

135180204(BACE2)

AVIT:

104280971(BACE2)

EGZ:	104128185(BACE2)

NNI:	104020195(BACE2)

PCRI:

104025588(BACE2)

PCAO:

104049091(BACE2)

PADL:

103920335(BACE2)

AFOR:

103902087(BACE2)

FGA:	104070289(BACE2)

CBOR:

142092649(BACE2)

GSTE:

104251217(BACE2)

CBOY:

140644245(BACE2)

MAME:

142417843(BACE2)

CLV:	102088959(BACE2)

CNIC:

135996737(BACE2)

MUI:	104539610(BACE2)

PGUU:

104458710(BACE2)

PLET:

104625785(BACE2)

EHS:	104503686(BACE2)

CMAC:

104483640(BACE2)

CUCA:

104059266(BACE2)

TEO:	104378622(BACE2)

BREG:

104629664(BACE2)

OHA:	104327756(BACE2)

ACAR:

104518840(BACE2)

CPEA:

104391212(BACE2)

CVF:	104292048(BACE2)

RTD:	128900512(BACE2)

CRID:

134520184(BACE2)

LMIC:

141749223(BACE2)

AAM:	106494905(BACE2)

AROW:

112971894(BACE2)

NPD:	112959094(BACE2)

TGT:	104572262(BACE2)

DNE:	112996158(BACE2)

SCAM:

104147147(BACE2)

ASN:	102386120(BACE2)

AMJ:	102561959(BACE2)

CPOO:

109305833(BACE2)

GGN:	109302738(BACE2)

PSS:	102447109(BACE2)

CIZ:	142006910(BACE2)

CMY:	102940897(BACE2)

CCAY:

125643525(BACE2)

DCC:	119846336(BACE2)

CPIC:

101938324(BACE2)

TST:	117867825(BACE2)

CABI:

116831583(BACE2)

MRV:	120376150(BACE2)

ACS:	100552914(bace2)

ASAO:

132771829(BACE2)

PVT:	110076824(BACE2)

SUND:

121925185(BACE2)

PBI:	103059516(BACE2)

PMUR:

107288321(BACE2)

CTIG:

120319913(BACE2)

TSR:	106556057(BACE2)

PGUT:

117669474(BACE2)

PCAE:

139317261(BACE2)

APRI:

131199707(BACE2)

PTEX:

113444798(BACE2)

NSS:	113416234(BACE2)

VKO:	123029376(BACE2)

PMUA:

114596101(BACE2)

PRAF:

128413034(BACE2)

ZVI:	118084833(BACE2)

HCG:	128350757(BACE2)

GJA:	107124625(BACE2)

STOW:

125431451(BACE2)

EMC:	129325997(BACE2)

XLA:	380307(bace2.L) 398806(bace2.S)

XTR:	100216145(bace2)

NPR:	108783971(BACE2)

RTEM:

120927954(BACE2)

ACAT:

141129285(BACE2)

PADS:

140337167(BACE2)

BBUF:

120994469(BACE2)

BGAR:

122932842(BACE2)

DTC:	141097490(BACE2)

PWL:	138248733(BACE2)

MUO:	115470564(BACE2)

GSH:	117359782(BACE2)

DRE:	449818(bace2)

SRX:	107726120 107747683

SANH:

107655814 107677045

SGH:	107562815 107598803

CCAR:

109086471(bace2) 109104250

CAUA:

113098361 113115343

CGIB:

127972543 128029401

PTET:

122358883(bace2)

LROH:

127177154(bace2)

GRF:	141284679(bace2)

OMC:	131520721(bace2)

PPRM:

120464687(bace2)

RKG:	130076526(bace2)

MAMB:

125248797(bace2)

CIDE:

127496264

CERY:

137004751(bace2)

MASI:

127422271 127429494

TROS:

130564722(bace2)

TDW:	130428371(bace2)

MANU:

129437457(bace2)

PDAB:

135771573(bace2)

IPU:	108280663(bace2)

IFU:	128624147(bace2)

PHYP:

113542974

SMEO:

124403299(bace2)

TFD:	113653734(bace2)

TVC:	132849819(bace2)

CGAR:

128513113(bace2)

NGRA:

132871523(bace2)

TRN:	134302799(bace2)

AMEX:

103044755(bace2)

CMAO:

118796789(bace2)

EEE:

113585008

CHAR:

105909666(bace2)

ASAD:

121683643(bace2)

TRU:	101078612(bace2)

TFS:	130535302(bace2)

TNG:	GSTEN00002182G001 GSTEN00005390G001

LCO:	104921140(bace2)

NCC:	104967128(bace2)

TBEN:

117470062(bace2)

CGOB:

115018082(bace2)

PGEO:

117457825(bace2)

GACU:

117551666(bace2)

EMAC:

134880380(bace2)

ELY:	117260034(bace2)

EFO:	125888885(bace2)

PLEP:

121943259(bace2)

SLUC:

116043868(bace2)

ECRA:

117942609(bace2)

ESP:	116672023(bace2)

PFLV:

114552799(bace2)

GAT:	120825547(bace2)

PPUG:

119218890(bace2)

AFB:	129104700(bace2)

CLUM:

117741883(bace2)

PSWI:

130211117(bace2)

CANA:

137790925(bace2)

CVE:	137870907(bace2)

MSAM:

119883029(bace2)

SCHU:

122879092(bace2)

CUD:	121526372(bace2)

SPUL:

138597305(bace2)

LMIX:

132980224(bace2)

HTC:	141798437(bace2)

ALAT:

119009934(bace2)

ASTR:

137597093(bace2)

MZE:	101466632 112435929

ONL:

100694039

OAU:	116330383(bace2)

OLA:

101167562

OML:	112149116(bace2)

CSAI:

133441619(bace2)

XMA:

XCO:

XHE:

PRET:

PFOR:

103153985(bace2)

PLAI:

106960258(bace2)

PMEI:

106928684(bace2)

GAF:	122832149(bace2)

PPRL:

129359359(bace2)

CVG:	107097200(bace2)

CTUL:

119783850(bace2)

GMU:	124883471(bace2)

NFU:	107380543(bace2)

KMR:	108238129(bace2)

ALIM:

106522153(bace2)

NWH:	119411200(bace2)

AOCE:

111588940(bace2)

EJA:	138197102(bace2)

BFRE:

138625269(bace2)

MCEP:

125013281(bace2)

CSEM:

103377589(bace2)

POV:

109634601

SSEN:

122765438 122773488(bace2)

SSOE:

131462895(bace2)

HHIP:

117772960(bace2)

HSP:	118106667(bace2)

PPLT:

128440837(bace2)

SMAU:

118299433(bace2)

LCF:

108873776

SDU:	111239096(bace2)

SLAL:

111654565(bace2)

XGL:	120792312(bace2)

HCQ:

109512909

SSCV:

125971838(bace2)

SBIA:

133504381(bace2)

PEE:	133405401(bace2)

PTAO:

133482293(bace2)

BPEC:

110171890(bace2)

ENY:	140374230(bace2)

MALB:

109960296(bace2)

BSPL:

114868019(bace2)

SJO:	128360095(bace2)

SSCO:

133980239(bace2)

TTY:	137185880(bace2)

GMH:	115561566(bace2)

SASA:

106581128 106612993

STRU:

115163493 115206407

OTW:	112265580 112267157

OMY:	110503995 110507827

OGO:	123992685 124006025

ONE:	115136688 115141881

OKI:	109905771 109909177

OKE:	118397489 118402585

OMM:	135546509 135552992

OCLA:

139382893 139386152

SALP:

111949503 111958149

SNH:	120018154 120029099

SFON:

129822147 129831925

CCLU:

121558993 121568016

ELS:	105021658(bace2)

OEP:	134029097(bace2)

SFM:

108932129

PKI:

111844859

AANG:

118210131(bace2)

AROT:

135235605(bace2)

CCOG:

133108566(bace2)

LOC:	102686808(bace2)

PSPA:

121302783(bace2)

ARUT:

117406200 117407070

PSEX:

120523296(bace2)

LCM:	102362842(BACE2)

CMK:	103187270(bace2)

CPLA:

122555395(bace2)

CPUN:

140486478(bace2)

HOC:	132821180(bace2)

SCAU:

119968767(bace2)

LERI:

129702993(bace2)

HAKA:

140727542(bace2)

DALB:

ATEN:

ADF:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

HSY:	130645718 130645826

RES:

135681979

PIF:	PITG_06900 PITG_08190

PSOJ:

PHYSODRAFT_348172 PHYSODRAFT_479874

SPAR:

SPRG_07185

» show all

Reference

PMID:11083922

Authors

Hussain I, Powell DJ, Howlett DR, Chapman GA, Gilmour L, Murdock PR, Tew DG, Meek TD, Chapman C, Schneider K, Ratcliffe SJ, Tattersall D, Testa TT, Southan C, Ryan DM, Simmons DL, Walsh FS, Dingwall C, Christie G

Title

ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site.

Journal

Mol Cell Neurosci 16:609-19 (2000)
DOI:10.1006/mcne.2000.0884

Sequence

[hsa:25825]

LinkDB

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