| Entry |
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| Symbol |
APPL1, APPL, DIP13alpha, MODY14
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| Name |
(RefSeq) adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
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| KO |
| K08733 | DCC-interacting protein 13 alpha |
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| Organism |
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| Pathway |
| hsa04920 | Adipocytokine signaling pathway |
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| Network |
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| Element |
| N00102 | Loss of DCC to DCC-apoptotic pathway |
| N01788 | ADIPOQ-ADIPOR signaling pathway |
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| Disease |
| H00410 | Maturity onset diabetes of the young (MODY) |
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| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
09133 Signaling molecules and interaction
04081 Hormone signaling
26060 (APPL1)
09150 Organismal Systems
09152 Endocrine system
04920 Adipocytokine signaling pathway
26060 (APPL1)
09149 Aging
04211 Longevity regulating pathway
26060 (APPL1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
26060 (APPL1)
09162 Cancer: specific types
05210 Colorectal cancer
26060 (APPL1)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:hsa04131]
26060 (APPL1)
Membrane trafficking [BR:hsa04131]
Endocytosis
Rab GTPases and associated proteins
Rab associated proteins
26060 (APPL1)
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| SSDB |
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| Motif |
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| Other DBs |
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| Structure |
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| LinkDB |
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| Position |
3:57227729..57273471
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| AA seq |
709 aa
MPGIDKLPIEETLEDSPQTRSLLGVFEEDATAISNYMNQLYQAMHRIYDAQNELSAATHL
TSKLLKEYEKQRFPLGGDDEVMSSTLQQFSKVIDELSSCHAVLSTQLADAMMFPITQFKE
RDLKEILTLKEVFQIASNDHDAAINRYSRLSKKRENDKVKYEVTEDVYTSRKKQHQTMMH
YFCALNTLQYKKKIALLEPLLGYMQAQISFFKMGSENLNEQLEEFLANIGTSVQNVRREM
DSDIETMQQTIEDLEVASDPLYVPDPDPTKFPVNRNLTRKAGYLNARNKTGLVSSTWDRQ
FYFTQGGNLMSQARGDVAGGLAMDIDNCSVMAVDCEDRRYCFQITSFDGKKSSILQAESK
KDHEEWICTINNISKQIYLSENPEETAARVNQSALEAVTPSPSFQQRHESLRPAAGQSRP
PTARTSSSGSLGSESTNLAALSLDSLVAPDTPIQFDIISPVCEDQPGQAKAFGQGGRRTN
PFGESGGSTKSETEDSILHQLFIVRFLGSMEVKSDDHPDVVYETMRQILAARAIHNIFRM
TESHLLVTCDCLKLIDPQTQVTRLTFPLPCVVLYATHQENKRLFGFVLRTSSGRSESNLS
SVCYIFESNNEGEKICDSVGLAKQIALHAELDRRASEKQKEIERVKEKQQKELNKQKQIE
KDLEEQSRLIAASSRPNQASSEGQFVVLSSSQSEESDLGEGGKKRESEA |
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| NT seq |
2130 nt +upstreamnt +downstreamnt
atgccggggatcgacaagctgcccatcgaggagacgctggaggacagcccgcagacaagg
tctttactaggtgtatttgaagaagatgccacagctatttccaactatatgaaccagttg
tatcaagctatgcatcggatttatgatgcacagaatgaattaagtgcagcaacacacctg
acctcaaaacttttaaaagaatatgaaaaacagcgttttccattgggaggtgatgatgaa
gttatgagctctacattgcaacagttttcaaaagttatagatgagcttagctcttgtcat
gcagtgctttcaactcaacttgctgatgccatgatgttccccattacccagtttaaagaa
agagatctgaaagaaatactaacattaaaggaagtatttcagattgcaagtaatgatcat
gatgctgcgattaatagatatagccgtttatcaaaaaaaagagaaaatgacaaggtgaag
tatgaagtaacagaagatgtgtacacatccagaaagaaacaacaccagaccatgatgcat
tatttttgtgcattaaatactcttcagtacaagaagaaaatagcattgttagaacctcta
cttgggtacatgcaagctcagataagtttctttaagatgggttctgaaaatcttaatgaa
caactggaagaatttttagctaatattggaacaagcgttcagaatgttcgcagggaaatg
gacagtgatatagagaccatgcaacagacaatagaggatttggaagtagccagtgatccc
ttatatgtgcctgacccagaccccaccaaatttcctgttaatcgaaatttaacccgaaag
gctggataccttaatgctaggaataaaacaggcttggtgtcatctacctgggacagacag
ttttacttcacgcagggtggaaatttaatgagtcaggcccgtggggatgtagcaggaggc
ctggccatggacatagacaactgttcagtgatggctgtggactgtgaagacagacgatat
tgttttcagatcacctctttcgatggaaaaaaatcttcaattttgcaagcagagagtaaa
aaagatcatgaagagtggatctgtacaataaacaacatatctaaacaaatatacttaagt
gaaaatccagaggaaactgctgcacgagtaaatcaatcagctctggaagctgtcactcct
tccccatctttccagcagaggcacgagagcctgcggccagcagcaggacaatctcggcca
ccgacagctcgaaccagcagttcaggatccttaggatctgagtctacaaatttggctgcc
ctctctctagattctcttgttgccccagacaccccaatacagtttgacataatttctcct
gtgtgtgaagatcagcctggccaggcaaaagcctttggccagggaggcaggcgtacaaat
ccatttggagaatctggaggaagtacaaaatctgaaactgaagattctattcttcatcag
ttatttattgtccgattccttggttcaatggaggtgaaatcagatgaccatccagatgtt
gtttatgaaactatgcgccaaatcttagctgcccgggccatccataacatctttcgtatg
acagaatcgcatttattagtcacttgtgactgtttaaagttaattgatccacagacacaa
gttacaaggctcacgtttccattaccttgtgtagttttgtatgctacacaccaggaaaat
aagcgcctttttggatttgttcttcggacatcaagcgggagaagtgaaagtaatctgtca
tcagtctgctatatatttgagtcaaacaatgagggggaaaagatatgtgattctgttgga
ctggcaaaacagatagctttgcatgctgaactggatcgtagggcatcagaaaaacaaaaa
gaaatagagagagtaaaagagaagcaacagaaagaactcaataaacaaaaacagattgaa
aaggacttggaagaacaaagtcggttgatagctgcttccagtagaccaaaccaagccagt
agtgaggggcagtttgttgtccttagcagtagccagtcagaagagagtgatttgggagaa
ggaggaaagaagagagaatcagaagcataa |
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