Homo sapiens (human): 2660
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Entry
2660 CDS
T01001
Symbol
MSTN, GDF8, MSLHP
Name
(RefSeq) myostatin
KO
K05497
growth differentiation factor 8
Organism
hsa
Homo sapiens (human)
Pathway
hsa04060
Cytokine-cytokine receptor interaction
Network
nt06507
TGFB signaling
Element
N01457
Myostatin signaling pathway
Disease
H02452
Muscle hypertrophy
Drug target
Apitegromab:
D11797
Domagrozumab:
D11047
Landogrozumab:
D11235
Ramatercept:
D10347
Stamulumab:
D05917
Taldefgrobep alfa:
D11265
Trevogrumab:
D11242
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09133 Signaling molecules and interaction
04060 Cytokine-cytokine receptor interaction
2660 (MSTN)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04052 Cytokines and neuropeptides [BR:
hsa04052
]
2660 (MSTN)
Cytokines and neuropeptides [BR:
hsa04052
]
Cytokines
Transforming growth factors (RSTK binding)
2660 (MSTN)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
TGF_beta
TGFb_propeptide
Motif
Other DBs
NCBI-GeneID:
2660
NCBI-ProteinID:
NP_005250
OMIM:
601788
HGNC:
4223
Ensembl:
ENSG00000138379
UniProt:
O14793
Q53S46
Structure
PDB
PDBj
LinkDB
All DBs
Position
2:complement(190055700..190062729)
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AA seq
375 aa
AA seq
DB search
MQKLQLCVYIYLFMLIVAGPVDLNENSEQKENVEKEGLCNACTWRQNTKSSRIEAIKIQI
LSKLRLETAPNISKDVIRQLLPKAPPLRELIDQYDVQRDDSSDGSLEDDDYHATTETIIT
MPTESDFLMQVDGKPKCCFFKFSSKIQYNKVVKAQLWIYLRPVETPTTVFVQILRLIKPM
KDGTRYTGIRSLKLDMNPGTGIWQSIDVKTVLQNWLKQPESNLGIEIKALDENGHDLAVT
FPGPGEDGLNPFLEVKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIA
PKRYKANYCSGECEFVFLQKYPHTHLVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQII
YGKIPAMVVDRCGCS
NT seq
1128 nt
NT seq
+upstream
nt +downstream
nt
atgcaaaaactgcaactctgtgtttatatttacctgtttatgctgattgttgctggtcca
gtggatctaaatgagaacagtgagcaaaaagaaaatgtggaaaaagaggggctgtgtaat
gcatgtacttggagacaaaacactaaatcttcaagaatagaagccattaagatacaaatc
ctcagtaaacttcgtctggaaacagctcctaacatcagcaaagatgttataagacaactt
ttacccaaagctcctccactccgggaactgattgatcagtatgatgtccagagggatgac
agcagcgatggctctttggaagatgacgattatcacgctacaacggaaacaatcattacc
atgcctacagagtctgattttctaatgcaagtggatggaaaacccaaatgttgcttcttt
aaatttagctctaaaatacaatacaataaagtagtaaaggcccaactatggatatatttg
agacccgtcgagactcctacaacagtgtttgtgcaaatcctgagactcatcaaacctatg
aaagacggtacaaggtatactggaatccgatctctgaaacttgacatgaacccaggcact
ggtatttggcagagcattgatgtgaagacagtgttgcaaaattggctcaaacaacctgaa
tccaacttaggcattgaaataaaagctttagatgagaatggtcatgatcttgctgtaacc
ttcccaggaccaggagaagatgggctgaatccgtttttagaggtcaaggtaacagacaca
ccaaaaagatccagaagggattttggtcttgactgtgatgagcactcaacagaatcacga
tgctgtcgttaccctctaactgtggattttgaagcttttggatgggattggattatcgct
cctaaaagatataaggccaattactgctctggagagtgtgaatttgtatttttacaaaaa
tatcctcatactcatctggtacaccaagcaaaccccagaggttcagcaggcccttgctgt
actcccacaaagatgtctccaattaatatgctatattttaatggcaaagaacaaataata
tatgggaaaattccagcgatggtagtagaccgctgtgggtgctcatga
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