Homo sapiens (human): 27034
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Entry
27034 CDS
T01001
Symbol
ACAD8, ACAD-8, ARC42, IBDH
Name
(RefSeq) acyl-CoA dehydrogenase family member 8
KO
K11538
isobutyryl-CoA dehydrogenase [EC:1.3.99.-]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00280
Valine, leucine and isoleucine degradation
hsa01100
Metabolic pathways
Network
nt06024
Valine, leucine and isoleucine degradation
Element
N00852
Valine degradation
N00853
ALDH6A1 deficiency in valine degradation
N00854
HIBCH deficiency in valine degradation
N00855
ACAD8 deficiency in valine degradation
Disease
H01279
Isobutyryl-CoA dehydrogenase deficiency
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09105 Amino acid metabolism
00280 Valine, leucine and isoleucine degradation
27034 (ACAD8)
Enzymes [BR:
hsa01000
]
1. Oxidoreductases
1.3 Acting on the CH-CH group of donors
1.3.99 With unknown physiological acceptors
1.3.99.-
27034 (ACAD8)
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SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Acyl-CoA_dh_1
Acyl-CoA_dh_N
Acyl-CoA_dh_M
Acyl-CoA_dh_2
Motif
Other DBs
NCBI-GeneID:
27034
NCBI-ProteinID:
NP_055199
OMIM:
604773
HGNC:
87
Ensembl:
ENSG00000151498
Vega:
OTTHUMG00000167177
Pharos:
Q9UKU7
(Tbio)
UniProt:
Q9UKU7
Structure
PDB
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All DBs
Position
11:134253568..134265855
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AA seq
415 aa
AA seq
DB search
MLWSGCRRFGARLGCLPGGLRVLVQTGHRSLTSCIDPSMGLNEEQKEFQKVAFDFAAREM
APNMAEWDQKELFPVDVMRKAAQLGFGGVYIQTDVGGSGLSRLDTSVIFEALATGCTSTT
AYISIHNMCAWMIDSFGNEEQRHKFCPPLCTMEKFASYCLTEPGSGSDAASLLTSAKKQG
DHYILNGSKAFISGAGESDIYVVMCRTGGPGPKGISCIVVEKGTPGLSFGKKEKKVGWNS
QPTRAVIFEDCAVPVANRIGSEGQGFLIAVRGLNGGRINIASCSLGAAHASVILTRDHLN
VRKQFGEPLASNQYLQFTLADMATRLVAARLMVRNAAVALQEERKDAVALCSMAKLFATD
ECFAICNQALQMHGGYGYLKDYAVQQYVRDSRVHQILEGSNEVMRILISRSLLQE
NT seq
1248 nt
NT seq
+upstream
nt +downstream
nt
atgctgtggagcggctgccggcgtttcggggcgcgcctcggctgcctgcccggcggtctc
cgggtcctcgtccagaccggccaccggagcttgacctcctgcatcgacccttccatggga
cttaatgaagagcagaaagaatttcaaaaagtggcctttgactttgctgcccgagagatg
gctccaaatatggcagagtgggaccagaaggagctgttcccagtggatgtgatgcggaag
gcagcccagctaggcttcggaggggtctacatacaaacagatgtgggcgggtctgggctg
tcacgtcttgatacctctgtcatttttgaagccttggctacaggctgcaccagcaccaca
gcctatataagcatccacaacatgtgtgcctggatgattgatagcttcggaaatgaggaa
cagaggcacaaattttgcccaccgctctgtaccatggagaagtttgcttcctactgcctc
actgaaccaggaagtgggagtgatgctgcctctcttctgacctccgctaagaaacaggga
gatcattacatcctcaatggctccaaggccttcatcagtggtgctggtgagtcagacatc
tatgtggtcatgtgccgaacaggaggaccaggccccaagggcatctcatgcatagttgtt
gagaaggggacccctggcctcagctttggcaagaaggagaaaaaggtggggtggaactcc
cagccaacacgagctgtgatcttcgaagactgtgctgtccctgtggccaacagaattggg
agcgaggggcagggcttcctcattgccgtgagaggactgaacggagggaggatcaatatt
gcttcctgctccctgggggctgcccacgcctctgtcatcctcacccgagaccacctcaat
gtccggaagcagtttggagagcctctggccagtaaccagtacttgcaattcacactggct
gatatggcaacaaggctggtggccgcgcggctgatggtccgcaatgcagcagtggctctg
caggaggagaggaaggatgcagtggccttgtgctccatggccaagctctttgctacagat
gaatgctttgccatctgcaaccaggccttgcagatgcacgggggctacggctacctgaag
gattacgctgttcagcagtacgtgcgggactccagggtccaccagattctagaaggtagc
aatgaagtgatgaggatactgatctctagaagcctgcttcaggagtag
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