KEGG   Homo sapiens (human): 2731
Entry
2731              CDS       T01001                                 
Symbol
GLDC, GCE, GCE1, GCSP, HYGN1
Name
(RefSeq) glycine decarboxylase
  KO
K00281  glycine cleavage system P protein (glycine dehydrogenase) [EC:1.4.4.2]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00260  Glycine, serine and threonine metabolism
hsa00630  Glyoxylate and dicarboxylate metabolism
hsa00670  One carbon pool by folate
hsa00785  Lipoic acid metabolism
hsa01100  Metabolic pathways
hsa01200  Carbon metabolism
Module
hsa_M00621  Glycine cleavage system
Network
nt06032  Lipoic acid metabolism
nt06033  Glycine, serine and arginine metabolism
  Element
N01611  Glycine cleavage system
N01613  Glycine cleavage system, Gly to MTHF
Disease
H00191  Nonketotic hyperglycinemia
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00630 Glyoxylate and dicarboxylate metabolism
    2731 (GLDC)
  09105 Amino acid metabolism
   00260 Glycine, serine and threonine metabolism
    2731 (GLDC)
  09108 Metabolism of cofactors and vitamins
   00785 Lipoic acid metabolism
    2731 (GLDC)
   00670 One carbon pool by folate
    2731 (GLDC)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.4  Acting on the CH-NH2 group of donors
   1.4.4  With a disulfide as acceptor
    1.4.4.2  glycine dehydrogenase (aminomethyl-transferring)
     2731 (GLDC)
SSDB
Motif
Pfam: GDC-P GcvP2_C Beta_elim_lyase Aminotran_5 Aminotran_1_2
Other DBs
NCBI-GeneID: 2731
NCBI-ProteinID: NP_000161
OMIM: 238300
HGNC: 4313
Ensembl: ENSG00000178445
UniProt: P23378
Structure
LinkDB
Position
9:complement(6532467..6645729)
AA seq 1020 aa
MQSCARAWGLRLGRGVGGGRRLAGGSGPCWAPRSRDSSSGGGDSAAAGASRLLERLLPRH
DDFARRHIGPGDKDQREMLQTLGLASIDELIEKTVPANIRLKRPLKMEDPVCENEILATL
HAISSKNQIWRSYIGMGYYNCSVPQTILRNLLENSGWITQYTPYQPEVSQGRLESLLNYQ
TMVCDITGLDMANASLLDEGTAAAEALQLCYRHNKRRKFLVDPRCHPQTIAVVQTRAKYT
GVLTELKLPCEMDFSGKDVSGVLFQYPDTEGKVEDFTELVERAHQSGSLACCATDLLALC
ILRPPGEFGVDIALGSSQRFGVPLGYGGPHAAFFAVRESLVRMMPGRMVGVTRDATGKEV
YRLALQTREQHIRRDKATSNICTAQALLANMAAMFAIYHGSHGLEHIARRVHNATLILSE
GLKRAGHQLQHDLFFDTLKIQCGCSVKEVLGRAAQRQINFRLFEDGTLGISLDETVNEKD
LDDLLWIFGCESSAELVAESMGEECRGIPGSVFKRTSPFLTHQVFNSYHSETNIVRYMKK
LENKDISLVHSMIPLGSCTMKLNSSSELAPITWKEFANIHPFVPLDQAQGYQQLFRELEK
DLCELTGYDQVCFQPNSGAQGEYAGLATIRAYLNQKGEGHRTVCLIPKSAHGTNPASAHM
AGMKIQPVEVDKYGNIDAVHLKAMVDKHKENLAAIMITYPSTNGVFEENISDVCDLIHQH
GGQVYLDGANMNAQVGICRPGDFGSDVSHLNLHKTFCIPHGGGGPGMGPIGVKKHLAPFL
PNHPVISLKRNEDACPVGTVSAAPWGSSSILPISWAYIKMMGGKGLKQATETAILNANYM
AKRLETHYRILFRGARGYVGHEFILDTRPFKKSANIEAVDVAKRLQDYGFHAPTMSWPVA
GTLMVEPTESEDKAELDRFCDAMISIRQEIADIEEGRIDPRVNPLKMSPHSLTCVTSSHW
DRPYSREVAAFPLPFVKPENKFWPTIARIDDIYGDQHLVCTCPPMEVYESPFSEQKRASS
NT seq 3063 nt   +upstreamnt  +downstreamnt
atgcagtcctgtgccagggcgtgggggctgcgcctgggccgcggggtcgggggcggccgc
cgcctggctgggggatcggggccgtgctgggcgccgcggagccgggacagcagcagtggc
ggcggggacagcgccgcggctggggcctcgcgcctcctggagcgccttctgcccagacac
gacgacttcgctcggaggcacatcggccctggggacaaagaccagagagagatgctgcag
accttggggctggcgagcattgatgaattgatcgagaagacggtccctgccaacatccgt
ttgaaaagacccttgaaaatggaagaccctgtttgtgaaaatgaaatccttgcaactctg
catgccatttcaagcaaaaaccagatctggagatcgtatattggcatgggctattataac
tgctcagtgccacagacgattttgcggaacttactggagaactcaggatggatcacccag
tatactccataccagcctgaggtgtctcaggggaggctggagagtttactcaactaccag
accatggtgtgtgacatcacaggcctggacatggccaatgcatccctgctggatgagggg
actgcagccgcagaggcactgcagctgtgctacagacacaacaagaggaggaaatttctc
gttgatccccgttgccacccacagacaatagctgttgtccagactcgagccaaatatact
ggagtcctcactgagctgaagttaccctgtgaaatggacttcagtggaaaagatgtcagt
ggagtgttgttccagtacccagacacggaggggaaggtggaagactttacggaactcgtg
gagagagctcatcagagtgggagcctggcctgctgtgctactgaccttttagctttgtgc
atcttgaggccacctggagaatttggggtagacatcgccctgggcagctcccagagattt
ggagtgccactgggctatgggggaccccatgcagcattttttgctgtccgagaaagcttg
gtgagaatgatgcctggaagaatggtgggggtaacaagagatgccactgggaaagaagtg
tatcgtcttgctcttcaaaccagggagcaacacattcggagagacaaggctaccagcaac
atctgtacagctcaggccctcttggcgaatatggctgccatgtttgcaatctaccatggt
tcccatgggctggagcatattgctaggagggtacataatgccactttgattttgtcagaa
ggtctcaagcgagcagggcatcaactccagcatgacctgttctttgataccttgaagatt
cagtgtggctgctcagtgaaggaggtcttgggcagggccgctcagcggcagatcaatttt
cggctttttgaggatggcacacttggtatttctcttgatgaaacagtcaatgaaaaagat
ctggacgatttgttgtggatctttggttgtgagtcatctgcagaactggttgctgaaagc
atgggagaggagtgcagaggtattccagggtctgtgttcaagaggaccagcccgttcctc
acccatcaagtgttcaacagctaccactctgaaacaaacattgtccggtacatgaagaaa
ctggaaaataaagacatttcccttgttcacagcatgattccactgggatcctgcaccatg
aaactgaacagttcgtctgaactcgcacctatcacatggaaagaatttgcaaacatccac
ccctttgtgcctctggatcaagctcaaggatatcagcagcttttccgagagcttgagaag
gatttgtgtgaactcacaggttatgaccaggtctgtttccagccaaacagcggagcccag
ggagaatatgctggactggccactatccgagcctacttaaaccagaaaggagaggggcac
agaacggtttgcctcattccgaaatcagcacatgggaccaacccagcaagtgcccacatg
gcaggcatgaagattcagcctgtggaggtggataaatatgggaatatcgatgcagttcac
ctcaaggccatggtggataagcacaaggagaacctagcagctatcatgattacataccca
tccaccaatggggtgtttgaagagaacatcagtgacgtgtgtgacctcatccatcaacat
ggaggacaggtctacctagacggggcaaatatgaatgctcaggtgggaatctgtcgccct
ggagacttcgggtctgatgtctcgcacctaaatcttcacaagaccttctgcattccccac
ggaggaggtggtcctggcatggggcccatcggagtgaagaaacatctcgccccgtttttg
cccaatcatcccgtcatttcactaaagcggaatgaggatgcctgtcctgtgggaaccgtc
agtgcggccccatggggctccagttccatcttgcccatttcctgggcttatatcaagatg
atgggaggcaagggtcttaaacaagccacggaaactgcgatattaaatgccaactacatg
gccaagcgattagaaacacactacagaattcttttcaggggtgcaagaggttatgtgggt
catgaatttattttggacacgagacccttcaaaaagtctgcaaatattgaggctgtggat
gtggccaagagactccaggattatggatttcacgcccctaccatgtcctggcctgtggca
gggaccctcatggtggagcccactgagtcggaggacaaggcagagctggacagattctgt
gatgccatgatcagcattcggcaggaaattgctgacattgaggagggccgcatcgacccc
agggtcaatccgctgaagatgtctccacactccctgacctgcgttacatcttcccactgg
gaccggccttattccagagaggtggcagcattcccactccccttcgtgaaaccagagaac
aaattctggccaacgattgcccggattgatgacatatatggagatcagcacctggtttgt
acctgcccacccatggaagtttatgagtctccattttctgaacaaaagagggcgtcttct
tag

KEGG   Homo sapiens (human): 275
Entry
275               CDS       T01001                                 
Symbol
AMT, GCE, GCE2, GCST, GCVT, NKH
Name
(RefSeq) aminomethyltransferase
  KO
K00605  glycine cleavage system T protein (aminomethyltransferase) [EC:2.1.2.10]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00260  Glycine, serine and threonine metabolism
hsa00630  Glyoxylate and dicarboxylate metabolism
hsa00670  One carbon pool by folate
hsa00785  Lipoic acid metabolism
hsa01100  Metabolic pathways
hsa01200  Carbon metabolism
Module
hsa_M00621  Glycine cleavage system
Network
nt06032  Lipoic acid metabolism
nt06033  Glycine, serine and arginine metabolism
  Element
N01611  Glycine cleavage system
N01613  Glycine cleavage system, Gly to MTHF
Disease
H00191  Nonketotic hyperglycinemia
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00630 Glyoxylate and dicarboxylate metabolism
    275 (AMT)
  09105 Amino acid metabolism
   00260 Glycine, serine and threonine metabolism
    275 (AMT)
  09108 Metabolism of cofactors and vitamins
   00785 Lipoic acid metabolism
    275 (AMT)
   00670 One carbon pool by folate
    275 (AMT)
Enzymes [BR:hsa01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.2  Hydroxymethyl-, formyl- and related transferases
    2.1.2.10  aminomethyltransferase
     275 (AMT)
SSDB
Motif
Pfam: GCV_T GCV_T_C
Other DBs
NCBI-GeneID: 275
NCBI-ProteinID: NP_000472
OMIM: 238310
HGNC: 473
Ensembl: ENSG00000145020
UniProt: P48728
Structure
LinkDB
Position
3:complement(49416778..49422473)
AA seq 403 aa
MQRAVSVVARLGFRLQAFPPALCRPLSCAQEVLRRTPLYDFHLAHGGKMVAFAGWSLPVQ
YRDSHTDSHLHTRQHCSLFDVSHMLQTKILGSDRVKLMESLVVGDIAELRPNQGTLSLFT
NEAGGILDDLIVTNTSEGHLYVVSNAGCWEKDLALMQDKVRELQNQGRDVGLEVLDNALL
ALQGPTAAQVLQAGVADDLRKLPFMTSAVMEVFGVSGCRVTRCGYTGEDGVEISVPVAGA
VHLATAILKNPEVKLAGLAARDSLRLEAGLCLYGNDIDEHTTPVEGSLSWTLGKRRRAAM
DFPGAKVIVPQLKGRVQRRRVGLMCEGAPMRAHSPILNMEGTKIGTVTSGCPSPSLKKNV
AMGYVPCEYSRPGTMLLVEVRRKQQMAVVSKMPFVPTNYYTLK
NT seq 1212 nt   +upstreamnt  +downstreamnt
atgcagagggctgtaagtgtggtggcccgtctgggctttcgcctgcaggcattccccccg
gccttgtgtcgtccacttagttgcgcacaggaggtgctccgcaggacaccgctctatgac
ttccacctggcccacggcgggaaaatggtggcgtttgcgggttggagtctgccagtgcag
taccgggacagtcacactgactcgcacctgcacacacgccagcactgctcgctctttgac
gtgtctcatatgctgcagaccaagatacttggtagtgaccgggtgaagctgatggagagt
ctagtggttggagacattgcagagctaagaccaaaccaggggacactgtcgctgtttacc
aacgaggctggaggcatcttagatgacttgattgtaaccaatacttctgagggccacctg
tatgtggtgtccaacgctggctgctgggagaaagatttggccctcatgcaggacaaggtc
agggagcttcagaaccagggcagagatgtgggcctggaggtgttggataatgccctgcta
gctctgcaaggccccactgcagcccaggtactacaggccggcgtggcagatgacctgagg
aaactgcccttcatgaccagtgctgtgatggaggtgtttggcgtgtctggctgccgcgtg
acccgctgtggctacacaggagaggatggtgtggagatctcggtgccggtagcgggggca
gttcacctggcaacagctattctgaaaaacccagaggtgaagctggcagggctggcagcc
agggacagcctgcgcctggaggcaggcctctgcctgtatgggaatgacattgatgaacac
actacacctgtggagggcagcctcagttggacactggggaagcgccgccgagctgctatg
gacttccctggagccaaggtcattgttccccagctgaagggcagggtgcagcggaggcgt
gtggggttgatgtgtgagggggcccccatgcgggcacacagtcccatcctgaacatggag
ggtaccaagattggtactgtgactagtggctgcccctccccctctctgaagaagaatgtg
gcgatgggttatgtgccctgcgagtacagtcgtccagggacaatgctgctggtagaggtg
cggcggaagcagcagatggctgtagtcagcaagatgccctttgtgcccacaaactactat
accctcaagtga

KEGG   Homo sapiens (human): 1738
Entry
1738              CDS       T01001                                 
Symbol
DLD, DLDD, DLDH, E3, GCSL, LAD, OGDC-E3, PHE3
Name
(RefSeq) dihydrolipoamide dehydrogenase
  KO
K00382  dihydrolipoyl dehydrogenase [EC:1.8.1.4]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00010  Glycolysis / Gluconeogenesis
hsa00020  Citrate cycle (TCA cycle)
hsa00260  Glycine, serine and threonine metabolism
hsa00280  Valine, leucine and isoleucine degradation
hsa00310  Lysine degradation
hsa00380  Tryptophan metabolism
hsa00620  Pyruvate metabolism
hsa00630  Glyoxylate and dicarboxylate metabolism
hsa00640  Propanoate metabolism
hsa00670  One carbon pool by folate
hsa00785  Lipoic acid metabolism
hsa01100  Metabolic pathways
hsa01200  Carbon metabolism
hsa01210  2-Oxocarboxylic acid metabolism
hsa01240  Biosynthesis of cofactors
Module
hsa_M00009  Citrate cycle (TCA cycle, Krebs cycle)
hsa_M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
hsa_M00032  Lysine degradation, lysine => saccharopine => acetoacetyl-CoA
hsa_M00036  Leucine degradation, leucine => acetoacetate + acetyl-CoA
hsa_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA
hsa_M00621  Glycine cleavage system
Network
nt06024  Valine, leucine and isoleucine degradation
nt06031  Citrate cycle and pyruvate metabolism
nt06032  Lipoic acid metabolism
nt06033  Glycine, serine and arginine metabolism
  Element
N01610  Dihydrolipoamide dehydrogenase
N01611  Glycine cleavage system
N01616  Dihydrolipoamide dehydrogenase
Disease
H00072  Pyruvate dehydrogenase complex deficiency
H00172  Maple syrup urine disease
H02000  Dihydrolipoamide dehydrogenase deficiency
H02006  Alpha-ketoglutarate dehydrogenase complex deficiency
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00010 Glycolysis / Gluconeogenesis
    1738 (DLD)
   00020 Citrate cycle (TCA cycle)
    1738 (DLD)
   00620 Pyruvate metabolism
    1738 (DLD)
   00630 Glyoxylate and dicarboxylate metabolism
    1738 (DLD)
   00640 Propanoate metabolism
    1738 (DLD)
  09105 Amino acid metabolism
   00260 Glycine, serine and threonine metabolism
    1738 (DLD)
   00280 Valine, leucine and isoleucine degradation
    1738 (DLD)
   00310 Lysine degradation
    1738 (DLD)
   00380 Tryptophan metabolism
    1738 (DLD)
  09108 Metabolism of cofactors and vitamins
   00785 Lipoic acid metabolism
    1738 (DLD)
   00670 One carbon pool by folate
    1738 (DLD)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    1738 (DLD)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.8  Acting on a sulfur group of donors
   1.8.1  With NAD+ or NADP+ as acceptor
    1.8.1.4  dihydrolipoyl dehydrogenase
     1738 (DLD)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of breast cancer cells
   1738 (DLD)
SSDB
Motif
Pfam: Pyr_redox_2 Pyr_redox_dim Pyr_redox FAD_oxidored NAD_binding_8 Pyr_redox_3 FAD_binding_2 GIDA AlaDh_PNT_C HI0933_like FAD_binding_3 Thi4 Lys_Orn_oxgnase DAO
Other DBs
NCBI-GeneID: 1738
NCBI-ProteinID: NP_000099
OMIM: 238331
HGNC: 2898
Ensembl: ENSG00000091140
UniProt: P09622 A0A024R713
Structure
LinkDB
Position
7:107891107..107921198
AA seq 509 aa
MQSWSRVYCSLAKRGHFNRISHGLQGLSAVPLRTYADQPIDADVTVIGSGPGGYVAAIKA
AQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAHGKDFASRGIEMSEVRLNL
DKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVTATKADGGTQVIDTKNIL
IATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKMVVIGAGVIGVELGSVWQRLGADVT
AVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGK
AEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPVNTRFQTKIPNIYAIGDVVAGP
MLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIYTHPEVAWVGKSEEQLKEEGIEYKVGK
FPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPGAGEMVNEAALALEYGASCEDI
ARVCHAHPTLSEAFREANLAASFGKSINF
NT seq 1530 nt   +upstreamnt  +downstreamnt
atgcagagctggagtcgtgtgtactgctccttggccaagagaggccatttcaatcgaata
tctcatggcctacagggactttctgcagtgcctctgagaacttacgcagatcagccgatt
gatgctgatgtaacagttataggttctggtcctggaggatatgttgctgctattaaagct
gcccagttaggcttcaagacagtctgcattgagaaaaatgaaacacttggtggaacatgc
ttgaatgttggttgtattccttctaaggctttattgaacaactctcattattaccatatg
gcccatggaaaagattttgcatctagaggaattgaaatgtccgaagttcgcttgaattta
gacaagatgatggagcagaagagtactgcagtaaaagctttaacaggtggaattgcccac
ttattcaaacagaataaggttgttcatgtcaatggatatggaaagataactggcaaaaat
caagtcactgctacgaaagctgatggcggcactcaggttattgatacaaagaacattctt
atagccacgggttcagaagttactccttttcctggaatcacgatagatgaagatacaata
gtgtcatctacaggtgctttatctttaaaaaaagttccagaaaagatggttgttattggt
gcaggagtaataggtgtagaattgggttcagtttggcaaagacttggtgcagatgtgaca
gcagttgaatttttaggtcatgtaggtggagttggaattgatatggagatatctaaaaac
tttcaacgcatccttcaaaaacaggggtttaaatttaaattgaatacaaaggttactggt
gctaccaagaagtcagatggaaaaattgatgtttctattgaagctgcttctggtggtaaa
gctgaagttatcacttgtgatgtactcttggtttgcattggccgacgaccctttactaag
aatttgggactagaagagctgggaattgaactagatcccagaggtagaattccagtcaat
accagatttcaaactaaaattccaaatatctatgccattggtgatgtagttgctggtcca
atgctggctcacaaagcagaggatgaaggcattatctgtgttgaaggaatggctggtggt
gctgtgcacattgactacaattgtgtgccatcagtgatttacacacaccctgaagttgct
tgggttggcaaatcagaagagcagttgaaagaagagggtattgagtacaaagttgggaaa
ttcccatttgctgctaacagcagagctaagacaaatgctgacacagatggcatggtgaag
atccttgggcagaaatcgacagacagagtactgggagcacatattcttggaccaggtgct
ggagaaatggtaaatgaagctgctcttgctttggaatatggagcatcctgtgaagatata
gctagagtctgtcatgcacatccgaccttatcagaagcttttagagaagcaaatcttgct
gcgtcatttggcaaatcaatcaacttttga

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