Homo sapiens (human): 29881
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Entry
29881 CDS
T01001
Symbol
NPC1L1, LDLCQ7, NPC11L1, SLC65A2
Name
(RefSeq) NPC1 like intracellular cholesterol transporter 1
KO
K14461
Niemann-Pick C1-like protein 1
Organism
hsa
Homo sapiens (human)
Pathway
hsa04975
Fat digestion and absorption
Drug target
Ezetimibe:
D01966
<JP/US>
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09150 Organismal Systems
09154 Digestive system
04975 Fat digestion and absorption
29881 (NPC1L1)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
02000 Transporters [BR:
hsa02000
]
29881 (NPC1L1)
Transporters [BR:
hsa02000
]
Solute carrier family (SLC)
SLC65: NPC-type cholesterol transporter
29881 (NPC1L1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
NPC1_N
NPC1_MLD
Sterol-sensing
Patched
MMPL
Folate_rec
Motif
Other DBs
NCBI-GeneID:
29881
NCBI-ProteinID:
NP_037521
OMIM:
608010
HGNC:
7898
Ensembl:
ENSG00000015520
UniProt:
Q9UHC9
Structure
PDB
PDBj
LinkDB
All DBs
Position
7:complement(44512535..44541330)
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AA seq
1359 aa
AA seq
DB search
MAEAGLRGWLLWALLLRLAQSEPYTTIHQPGYCAFYDECGKNPELSGSLMTLSNVSCLSN
TPARKITGDHLILLQKICPRLYTGPNTQACCSAKQLVSLEASLSITKALLTRCPACSDNF
VNLHCHNTCSPNQSLFINVTRVAQLGAGQLPAVVAYEAFYQHSFAEQSYDSCSRVRVPAA
ATLAVGTMCGVYGSALCNAQRWLNFQGDTGNGLAPLDITFHLLEPGQAVGSGIQPLNEGV
ARCNESQGDDVATCSCQDCAASCPAIARPQALDSTFYLGQMPGSLVLIIILCSVFAVVTI
LLVGFRVAPARDKSKMVDPKKGTSLSDKLSFSTHTLLGQFFQGWGTWVASWPLTILVLSV
IPVVALAAGLVFTELTTDPVELWSAPNSQARSEKAFHDQHFGPFFRTNQVILTAPNRSSY
RYDSLLLGPKNFSGILDLDLLLELLELQERLRHLQVWSPEAQRNISLQDICYAPLNPDNT
SLYDCCINSLLQYFQNNRTLLLLTANQTLMGQTSQVDWKDHFLYCANAPLTFKDGTALAL
SCMADYGAPVFPFLAIGGYKGKDYSEAEALIMTFSLNNYPAGDPRLAQAKLWEEAFLEEM
RAFQRRMAGMFQVTFMAERSLEDEINRTTAEDLPIFATSYIVIFLYISLALGSYSSWSRV
MVDSKATLGLGGVAVVLGAVMAAMGFFSYLGIRSSLVILQVVPFLVLSVGADNIFIFVLE
YQRLPRRPGEPREVHIGRALGRVAPSMLLCSLSEAICFFLGALTPMPAVRTFALTSGLAV
ILDFLLQMSAFVALLSLDSKRQEASRLDVCCCVKPQELPPPGQGEGLLLGFFQKAYAPFL
LHWITRGVVLLLFLALFGVSLYSMCHISVGLDQELALPKDSYLLDYFLFLNRYFEVGAPV
YFVTTLGYNFSSEAGMNAICSSAGCNNFSFTQKIQYATEFPEQSYLAIPASSWVDDFIDW
LTPSSCCRLYISGPNKDKFCPSTVNSLNCLKNCMSITMGSVRPSVEQFHKYLPWFLNDRP
NIKCPKGGLAAYSTSVNLTSDGQVLDTVAILSPRLEYSGTISAHCNLYLLDSTSRFMAYH
KPLKNSQDYTEALRAARELAANITADLRKVPGTDPAFEVFPYTITNVFYEQYLTILPEGL
FMLSLCLVPTFAVSCLLLGLDLRSGLLNLLSIVMILVDTVGFMALWGISYNAVSLINLVS
AVGMSVEFVSHITRSFAISTKPTWLERAKEATISMGSAVFAGVAMTNLPGILVLGLAKAQ
LIQIFFFRLNLLITLLGLLHGLVFLPVILSYVGPDVNPALALEQKRAEEAVAAVMVASCP
NHPSRVSTADNIYVNHSFEGSIKGAGAISNFLPNNGRQF
NT seq
4080 nt
NT seq
+upstream
nt +downstream
nt
atggcggaggccggcctgaggggctggctgctgtgggccctgctcctgcgcttggcccag
agtgagccttacacaaccatccaccagcctggctactgcgccttctatgacgaatgtggg
aagaacccagagctgtctggaagcctcatgacactctccaacgtgtcctgcctgtccaac
acgccggcccgcaagatcacaggtgatcacctgatcctattacagaagatctgcccccgc
ctctacaccggccccaacacccaagcctgctgctccgccaagcagctggtatcactggaa
gcgagtctgtcgatcaccaaggccctcctcacccgctgcccagcctgctctgacaatttt
gtgaacctgcactgccacaacacgtgcagccccaatcagagcctcttcatcaatgtgacc
cgcgtggcccagctaggggctggacaactcccagctgtggtggcctatgaggccttctac
cagcatagctttgccgagcagagctatgactcctgcagccgtgtgcgcgtccctgcagct
gccacgctggctgtgggcaccatgtgtggcgtgtatggctctgccctttgcaatgcccag
cgctggctcaacttccagggagacacaggcaatggtctggccccactggacatcaccttc
cacctcttggagcctggccaggccgtggggagtgggattcagcctctgaatgagggggtt
gcacgttgcaatgagtcccaaggtgacgacgtggcgacctgctcctgccaagactgtgct
gcatcctgtcctgccatagcccgcccccaggccctcgactccaccttctacctgggccag
atgccgggcagtctggtcctcatcatcatcctctgctctgtcttcgctgtggtcaccatc
ctgcttgtgggattccgtgtggcccccgccagggacaaaagcaagatggtggaccccaag
aagggcaccagcctctctgacaagctcagcttctccacccacaccctccttggccagttc
ttccagggctggggcacgtgggtggcttcgtggcctctgaccatcttggtgctatctgtc
atcccggtggtggccttggcagcgggcctggtctttacagaactcactacggaccccgtg
gagctgtggtcggcccccaacagccaagcccggagtgagaaagctttccatgaccagcat
ttcggccccttcttccgaaccaaccaggtgatcctgacggctcctaaccggtccagctac
aggtatgactctctgctgctggggcccaagaacttcagcggaatcctggacctggacttg
ctgctggagctgctagagctgcaggagaggctgcggcacctccaggtatggtcgcccgaa
gcacagcgcaacatctccctgcaggacatctgctacgcccccctcaatccggacaatacc
agtctctacgactgctgcatcaacagcctcctgcagtatttccagaacaaccgcacgctc
ctgctgctcacagccaaccagacactgatggggcagacctcccaagtcgactggaaggac
cattttctgtactgtgccaatgccccgctcaccttcaaggatggcacagccctggccctg
agctgcatggctgactacggggcccctgtcttccccttccttgccattggggggtacaaa
ggaaaggactattctgaggcagaggccctgatcatgacgttctccctcaacaattaccct
gccggggacccccgtctggcccaggccaagctgtgggaggaggccttcttagaggaaatg
cgagccttccagcgtcggatggctggcatgttccaggtcacgttcatggctgagcgctct
ctggaagacgagatcaatcgcaccacagctgaagacctgcccatctttgccaccagctac
attgtcatattcctgtacatctctctggccctgggcagctattccagctggagccgagtg
atggtggactccaaggccacgctgggcctcggcggggtggccgtggtcctgggagcagtc
atggctgccatgggcttcttctcctacttgggtatccgctcctccctggtcatcctgcaa
gtggttcctttcctggtgctgtccgtgggggctgataacatcttcatctttgttctcgag
taccagaggctgccccggaggcctggggagccacgagaggtccacattgggcgagcccta
ggcagggtggctcccagcatgctgttgtgcagcctctctgaggccatctgcttcttccta
ggggccctgacccccatgccagctgtgcggacctttgccctgacctctggccttgcagtg
atccttgacttcctcctgcagatgtcagcctttgtggccctgctctccctggacagcaag
aggcaggaggcctcccggttggacgtctgctgctgtgtcaagccccaggagctgcccccg
cctggccagggagaggggctcctgcttggcttcttccaaaaggcttatgcccccttcctg
ctgcactggatcactcgaggtgttgtgctgctgctgtttctcgccctgttcggagtgagc
ctctactccatgtgccacatcagcgtgggactggaccaggagctggccctgcccaaggac
tcgtacctgcttgactatttcctctttctgaaccgctacttcgaggtgggggccccggtg
tactttgttaccaccttgggctacaacttctccagcgaggctgggatgaatgccatctgc
tccagtgcaggctgcaacaacttctccttcacccagaagatccagtatgccacagagttc
cctgagcagtcttacctggccatccctgcctcctcctgggtggatgacttcattgactgg
ctgaccccgtcctcctgctgccgcctttatatatctggccccaataaggacaagttctgc
ccctcgaccgtcaactctctgaactgcctaaagaactgcatgagcatcacgatgggctct
gtgaggccctcggtggagcagttccataagtatcttccctggttcctgaacgaccggccc
aacatcaaatgtcccaaaggcggcctggcagcatacagcacctctgtgaacttgacttca
gatggccaggttttagacacagttgccattctgtcacccaggctggagtacagtggcaca
atctcggctcactgcaacctctacctcctggattcaacctccaggttcatggcctatcac
aagcccctgaaaaactcacaggattacacagaagctctgcgggcagctcgagagctggca
gccaacatcactgctgacctgcggaaagtgcctggaacagacccggcttttgaggtcttc
ccctacacgatcaccaatgtgttttatgagcagtacctgaccatcctccctgaggggctc
ttcatgctcagcctctgccttgtgcccaccttcgctgtctcctgcctcctgctgggcctg
gacctgcgctccggcctcctcaacctgctctccattgtcatgatcctcgtggacactgtc
ggcttcatggccctgtggggcatcagttacaatgctgtgtccctcatcaacctggtctcg
gcggtgggcatgtctgtggagtttgtgtcccacattacccgctcctttgccatcagcacc
aagcccacctggctggagagggccaaagaggccaccatctctatgggaagtgcggtgttt
gcaggtgtggccatgaccaacctgcctggcatccttgtcctgggcctcgccaaggcccag
ctcattcagatcttcttcttccgcctcaacctcctgatcactctgctgggcctgctgcat
ggcttggtcttcctgcccgtcatcctcagctacgtggggcctgacgttaacccggctctg
gcactggagcagaagcgggctgaggaggcggtggcagcagtcatggtggcctcttgccca
aatcacccctcccgagtctccacagctgacaacatctatgtcaaccacagctttgaaggt
tctatcaaaggtgctggtgccatcagcaacttcttgcccaacaatgggcggcagttctga
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integrated database retrieval system
