Homo sapiens (human): 2990 Help Entry 2990              CDS       T01001                                  Symbol GUSB, BG, MPS7 Name (RefSeq) glucuronidase beta   KO K01195   beta-glucuronidase [EC:3.2.1.31] Organism hsa  Homo sapiens (human) Pathway hsa00040   Pentose and glucuronate interconversions hsa00053   Ascorbate and aldarate metabolism hsa00531   Glycosaminoglycan degradation hsa00860   Porphyrin metabolism hsa00983   Drug metabolism - other enzymes hsa01100   Metabolic pathways hsa01240   Biosynthesis of cofactors hsa04142   Lysosome Module hsa_M00014   Glucuronate pathway (uronate pathway) hsa_M00076   Dermatan sulfate degradation hsa_M00077   Chondroitin sulfate degradation hsa_M00078   Heparan sulfate degradation Network nt06012  Glycosaminoglycan degradation   Element N00615   Heparan sulfate degradation Disease H00132   Mucopolysaccharidosis type VII H00421   Mucopolysaccharidosis Drug target Aceglatone:  D01805 Vestronidase alfa:  D11004<JP/US> Brite KEGG Orthology (KO) [BR:hsa00001]  09100 Metabolism   09101 Carbohydrate metabolism    00040 Pentose and glucuronate interconversions     2990 (GUSB)    00053 Ascorbate and aldarate metabolism     2990 (GUSB)   09107 Glycan biosynthesis and metabolism    00531 Glycosaminoglycan degradation     2990 (GUSB)   09108 Metabolism of cofactors and vitamins    00860 Porphyrin metabolism     2990 (GUSB)   09111 Xenobiotics biodegradation and metabolism    00983 Drug metabolism - other enzymes     2990 (GUSB)  09140 Cellular Processes   09141 Transport and catabolism    04142 Lysosome     2990 (GUSB) Enzymes [BR:hsa01000]  3. Hydrolases   3.2  Glycosylases    3.2.1  Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds     3.2.1.31  beta-glucuronidase      2990 (GUSB) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Glyco_hydro_2_C Glyco_hydro_2_N Glyco_hydro_2 Glyco_hydro_2_N2 Glyco_hydro_42 Motif Other DBs NCBI-GeneID:  2990 NCBI-ProteinID:  NP_000172 OMIM:  611499 HGNC:  4696 Ensembl:  ENSG00000169919 UniProt:  P08236 Structure PDB LinkDB All DBs Position 7:complement(65960684..65982213) Genome browser AA seq 651 aa AA seqDB search MARGSAVAWAALGPLLWGCALGLQGGMLYPQESPSRECKELDGLWSFRADFSDNRRRGFE EQWYRRPLWESGPTVDMPVPSSFNDISQDWRLRHFVGWVWYEREVILPERWTQDLRTRVV LRIGSAHSYAIVWVNGVDTLEHEGGYLPFEADISNLVQVGPLPSRLRITIAINNTLTPTT LPPGTIQYLTDTSKYPKGYFVQNTYFDFFNYAGLQRSVLLYTTPTTYIDDITVTTSVEQD SGLVNYQISVKGSNLFKLEVRLLDAENKVVANGTGTQGQLKVPGVSLWWPYLMHERPAYL YSLEVQLTAQTSLGPVSDFYTLPVGIRTVAVTKSQFLINGKPFYFHGVNKHEDADIRGKG FDWPLLVKDFNLLRWLGANAFRTSHYPYAEEVMQMCDRYGIVVIDECPGVGLALPQFFNN VSLHHHMQVMEEVVRRDKNHPAVVMWSVANEPASHLESAGYYLKMVIAHTKSLDPSRPVT FVSNSNYAADKGAPYVDVICLNSYYSWYHDYGHLELIQLQLATQFENWYKKYQKPIIQSE YGAETIAGFHQDPPLMFTEEYQKSLLEQYHLGLDQKRRKYVVGELIWNFADFMTEQSPTR VLGNKKGIFTRQRQPKSAAFLLRERYWKIANETRYPHSVAKSQCLENSLFT NT seq 1956 nt NT seq  +upstreamnt  +downstreamnt atggcccgggggtcggcggttgcctgggcggcgctcgggccgttgttgtggggctgcgcg ctggggctgcagggcgggatgctgtacccccaggagagcccgtcgcgggagtgcaaggag ctggacggcctctggagcttccgcgccgacttctctgacaaccgacgccggggcttcgag gagcagtggtaccggcggccgctgtgggagtcaggccccaccgtggacatgccagttccc tccagcttcaatgacatcagccaggactggcgtctgcggcattttgtcggctgggtgtgg tacgaacgggaggtgatcctgccggagcgatggacccaggacctgcgcacaagagtggtg ctgaggattggcagtgcccattcctatgccatcgtgtgggtgaatggggtcgacacgcta gagcatgaggggggctacctccccttcgaggccgacatcagcaacctggtccaggtgggg cccctgccctcccggctccgaatcactatcgccatcaacaacacactcacccccaccacc ctgccaccagggaccatccaatacctgactgacacctccaagtatcccaagggttacttt gtccagaacacatattttgactttttcaactacgctggactgcagcggtctgtacttctg tacacgacacccaccacctacatcgatgacatcaccgtcaccaccagcgtggagcaagac agtgggctggtgaattaccagatctctgtcaagggcagtaacctgttcaagttggaagtg cgtcttttggatgcagaaaacaaagtcgtggcgaatgggactgggacccagggccaactt aaggtgccaggtgtcagcctctggtggccgtacctgatgcacgaacgccctgcctatctg tattcattggaggtgcagctgactgcacagacgtcactggggcctgtgtctgacttctac acactccctgtggggatccgcactgtggctgtcaccaagagccagttcctcatcaatggg aaacctttctatttccacggtgtcaacaagcatgaggatgcggacatccgagggaagggc ttcgactggccgctgctggtgaaggacttcaacctgcttcgctggcttggtgccaacgct ttccgtaccagccactacccctatgcagaggaagtgatgcagatgtgtgaccgctatggg attgtggtcatcgatgagtgtcccggcgtgggcctggcgctgccgcagttcttcaacaac gtttctctgcatcaccacatgcaggtgatggaagaagtggtgcgtagggacaagaaccac cccgcggtcgtgatgtggtctgtggccaacgagcctgcgtcccacctagaatctgctggc tactacttgaagatggtgatcgctcacaccaaatccttggacccctcccggcctgtgacc tttgtgagcaactctaactatgcagcagacaagggggctccgtatgtggatgtgatctgt ttgaacagctactactcttggtatcacgactacgggcacctggagttgattcagctgcag ctggccacccagtttgagaactggtataagaagtatcagaagcccattattcagagcgag tatggagcagaaacgattgcagggtttcaccaggatccacctctgatgttcactgaagag taccagaaaagtctgctagagcagtaccatctgggtctggatcaaaaacgcagaaaatac gtggttggagagctcatttggaattttgccgatttcatgactgaacagtcaccgacgaga gtgctggggaataaaaaggggatcttcactcggcagagacaaccaaaaagtgcagcgttc cttttgcgagagagatactggaagattgccaatgaaaccaggtatccccactcagtagcc aagtcacaatgtttggaaaacagcctgtttacttga

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