Homo sapiens (human): 29920
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Entry
29920 CDS
T01001
Symbol
PYCR2, HLD10, P5CR2
Name
(RefSeq) pyrroline-5-carboxylate reductase 2
KO
K00286
pyrroline-5-carboxylate reductase [EC:
1.5.1.2
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00330
Arginine and proline metabolism
hsa01100
Metabolic pathways
hsa01230
Biosynthesis of amino acids
Module
hsa_M00015
Proline biosynthesis, glutamate => proline
hsa_M00972
Proline metabolism
Network
nt06033
Glycine, serine and arginine metabolism
Element
N01618
Proline biosynthesis, Orn to Pro
Disease
H00679
Hypomyelinating leukodystrophy
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09105 Amino acid metabolism
00330 Arginine and proline metabolism
29920 (PYCR2)
Enzymes [BR:
hsa01000
]
1. Oxidoreductases
1.5 Acting on the CH-NH group of donors
1.5.1 With NAD+ or NADP+ as acceptor
1.5.1.2 pyrroline-5-carboxylate reductase
29920 (PYCR2)
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Paralog
Gene cluster
GFIT
Motif
Pfam:
P5CR_dimer
F420_oxidored
NAD_Gly3P_dh_N
Rossmann-like
2-Hacid_dh_C
Motif
Other DBs
NCBI-GeneID:
29920
NCBI-ProteinID:
NP_037460
OMIM:
616406
HGNC:
30262
Ensembl:
ENSG00000143811
UniProt:
Q96C36
A0A0S2Z5U6
Structure
PDB
PDBj
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All DBs
Position
1:complement(225919878..225924250)
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AA seq
320 aa
AA seq
DB search
MSVGFIGAGQLAYALARGFTAAGILSAHKIIASSPEMNLPTVSALRKMGVNLTRSNKETV
KHSDVLFLAVKPHIIPFILDEIGADVQARHIVVSCAAGVTISSVEKKLMAFQPAPKVIRC
MTNTPVVVQEGATVYATGTHALVEDGQLLEQLMSSVGFCTEVEEDLIDAVTGLSGSGPAY
AFMALDALADGGVKMGLPRRLAIQLGAQALLGAAKMLLDSEQHPCQLKDNVCSPGGATIH
ALHFLESGGFRSLLINAVEASCIRTRELQSMADQEKISPAALKKTLLDRVKLESPTVSTL
TPSSPGKLLTRSLALGGKKD
NT seq
963 nt
NT seq
+upstream
nt +downstream
nt
atgagcgtgggcttcatcggggccggccagctggcctatgctctggcgcggggcttcacg
gccgcaggcatcctgtcggctcacaagataatagccagctccccagaaatgaacctgccc
acggtgtccgcgctcaggaagatgggtgtgaacctgacacgcagcaacaaggagacggtg
aagcacagcgacgtcctgtttctggctgtgaagccacatatcatccccttcatcctggat
gagattggggccgacgtgcaagccagacacatcgtggtctcctgtgcggctggtgtcacc
atcagctctgtggagaagaagctgatggcattccagccagcccccaaagtgattcgctgc
atgaccaacacacctgtggtagtgcaggaaggcgctacagtgtacgccacgggcacccat
gccctggtggaggatgggcagctcctggagcagctcatgagcagcgtgggcttctgcact
gaggtggaagaggacctcatcgatgccgtcacggggctcagtggcagcgggcctgcctat
gcattcatggctctggacgcattggctgatggtggggtgaagatgggtttgccacggcgc
ctggcaatccaactcggggcccaggctttgctgggagctgccaagatgctgctggactcg
gagcagcatccatgccagcttaaggacaatgtctgctcccctgggggagccaccatccac
gccctgcactttctagagagtgggggcttccgctctctgctcatcaatgcagttgaggcc
tcctgtatccgaacacgagagctacagtccatggccgaccaagaaaagatctccccagct
gcccttaagaagaccctcttagacagagtgaagctggaatcccccacagtctccacactg
accccctccagcccagggaagctcctcacaagaagcctggccctgggaggcaagaaggac
taa
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