KEGG   Homo sapiens (human): 29920
Entry
29920             CDS       T01001                                 
Symbol
PYCR2, HLD10, P5CR2
Name
(RefSeq) pyrroline-5-carboxylate reductase 2 isoform 1
  KO
K00286  pyrroline-5-carboxylate reductase [EC:1.5.1.2]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00330  Arginine and proline metabolism
hsa01100  Metabolic pathways
hsa01230  Biosynthesis of amino acids
Module
hsa_M00015  Proline biosynthesis, glutamate => proline
hsa_M00972  Proline metabolism
Network
nt06033  Glycine, serine and arginine metabolism
  Element
N01618  Proline biosynthesis, Orn to Pro
Disease
H00679  Hypomyelinating leukodystrophy
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00330 Arginine and proline metabolism
    29920 (PYCR2)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.2  pyrroline-5-carboxylate reductase
     29920 (PYCR2)
SSDB
Motif
Pfam: P5CR_dimer F420_oxidored NAD_Gly3P_dh_N Rossmann-like
Other DBs
NCBI-GeneID: 29920
NCBI-ProteinID: NP_037460
OMIM: 616406
HGNC: 30262
Ensembl: ENSP00000342502.6
UniProt: Q96C36 A0A0S2Z5U6
Structure
LinkDB
Position
1:complement(225919878..225924250)
AA seq 320 aa
MSVGFIGAGQLAYALARGFTAAGILSAHKIIASSPEMNLPTVSALRKMGVNLTRSNKETV
KHSDVLFLAVKPHIIPFILDEIGADVQARHIVVSCAAGVTISSVEKKLMAFQPAPKVIRC
MTNTPVVVQEGATVYATGTHALVEDGQLLEQLMSSVGFCTEVEEDLIDAVTGLSGSGPAY
AFMALDALADGGVKMGLPRRLAIQLGAQALLGAAKMLLDSEQHPCQLKDNVCSPGGATIH
ALHFLESGGFRSLLINAVEASCIRTRELQSMADQEKISPAALKKTLLDRVKLESPTVSTL
TPSSPGKLLTRSLALGGKKD
NT seq 963 nt   +upstreamnt  +downstreamnt
atgagcgtgggcttcatcggggccggccagctggcctatgctctggcgcggggcttcacg
gccgcaggcatcctgtcggctcacaagataatagccagctccccagaaatgaacctgccc
acggtgtccgcgctcaggaagatgggtgtgaacctgacacgcagcaacaaggagacggtg
aagcacagcgacgtcctgtttctggctgtgaagccacatatcatccccttcatcctggat
gagattggggccgacgtgcaagccagacacatcgtggtctcctgtgcggctggtgtcacc
atcagctctgtggagaagaagctgatggcattccagccagcccccaaagtgattcgctgc
atgaccaacacacctgtggtagtgcaggaaggcgctacagtgtacgccacgggcacccat
gccctggtggaggatgggcagctcctggagcagctcatgagcagcgtgggcttctgcact
gaggtggaagaggacctcatcgatgccgtcacggggctcagtggcagcgggcctgcctat
gcattcatggctctggacgcattggctgatggtggggtgaagatgggtttgccacggcgc
ctggcaatccaactcggggcccaggctttgctgggagctgccaagatgctgctggactcg
gagcagcatccatgccagcttaaggacaatgtctgctcccctgggggagccaccatccac
gccctgcactttctagagagtgggggcttccgctctctgctcatcaatgcagttgaggcc
tcctgtatccgaacacgagagctacagtccatggccgaccaagaaaagatctccccagct
gcccttaagaagaccctcttagacagagtgaagctggaatcccccacagtctccacactg
accccctccagcccagggaagctcctcacaagaagcctggccctgggaggcaagaaggac
taa

KEGG   Homo sapiens (human): 5831
Entry
5831              CDS       T01001                                 
Symbol
PYCR1, ARCL2B, ARCL3B, P5C, P5CR, PIG45, PP222, PRO3, PYCR
Name
(RefSeq) pyrroline-5-carboxylate reductase 1, mitochondrial isoform 1
  KO
K00286  pyrroline-5-carboxylate reductase [EC:1.5.1.2]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00330  Arginine and proline metabolism
hsa01100  Metabolic pathways
hsa01230  Biosynthesis of amino acids
Module
hsa_M00015  Proline biosynthesis, glutamate => proline
hsa_M00972  Proline metabolism
Network
nt06033  Glycine, serine and arginine metabolism
  Element
N01618  Proline biosynthesis, Orn to Pro
Disease
H00557  Cutis laxa
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00330 Arginine and proline metabolism
    5831 (PYCR1)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.2  pyrroline-5-carboxylate reductase
     5831 (PYCR1)
SSDB
Motif
Pfam: P5CR_dimer F420_oxidored NAD_Gly3P_dh_N Rossmann-like
Other DBs
NCBI-GeneID: 5831
NCBI-ProteinID: NP_001269209
OMIM: 179035
HGNC: 9721
UniProt: P32322
Structure
LinkDB
Position
17:complement(81932391..81937300)
AA seq 319 aa
MSVGFIGAGQLAFALAKGFTAAGVLAAHKIMASSPDMDLATVSALRKMGVKLTPHNKETV
QHSDVLFLAVKPHIIPFILDEIGADIEDRHIVVSCAAGVTISSIEKKLSAFRPAPRVIRC
MTNTPVVVREGATVYATGTHAQVEDGRLMEQLLSSVGFCTEVEEDLIDAVTGLSGSGPAY
AFTALDALADGGVKMGLPRRLAVRLGAQALLGAAKMLLHSEQHPGQLKDNVSSPGGATIH
ALHVLESGGFRSLLINAVEASCIRTRELQSMADQEQVSPAAIKKTILDKVKLDSPAGTAL
SPSGHTKLLPRSLAPAGKD
NT seq 960 nt   +upstreamnt  +downstreamnt
atgagcgtgggcttcatcggcgctggccagctggcttttgccctggccaagggcttcaca
gcagcaggcgtcttggctgcccacaagataatggctagctccccagacatggacctggcc
acagtttctgctctcaggaagatgggggtgaagttgacaccccacaacaaggagacggtg
cagcacagtgatgtgctcttcctggctgtgaagccacacatcatccccttcatcctggat
gaaataggcgccgacattgaggacagacacattgtggtgtcctgcgcggccggcgtcacc
atcagctccattgagaagaagctgtcagcgtttcggccagcccccagggtcatccgctgc
atgaccaacactccagtcgtggtgcgggagggggccaccgtgtatgccacaggcacgcac
gcccaggtggaggacgggaggctcatggagcagctgctgagcagcgtgggcttctgcacg
gaggtggaagaggacctgattgatgccgtcacggggctcagtggcagcggccccgcctac
gcattcacagccctggatgccctggctgatgggggtgtgaagatgggacttccaaggcgc
ctggcagtccgcctcggggcccaggccctcctgggggctgccaagatgctgctgcactca
gaacagcacccaggccagctcaaggacaacgtcagctctcctggtggggccaccatccat
gccttgcatgtgctggagagtgggggcttccgctccctgctcatcaacgctgtggaggcc
tcctgcatccgcacacgggagctgcagtccatggctgaccaggagcaggtgtcaccagcc
gccatcaagaagaccatcctggacaaggtgaagctggactcccctgcagggaccgctctg
tcaccttctggccacaccaagctgctcccccgcagcctggccccagcgggcaaggattga

KEGG   Homo sapiens (human): 65263
Entry
65263             CDS       T01001                                 
Symbol
PYCR3, PYCRL
Name
(RefSeq) pyrroline-5-carboxylate reductase 3 isoform 1
  KO
K00286  pyrroline-5-carboxylate reductase [EC:1.5.1.2]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00330  Arginine and proline metabolism
hsa01100  Metabolic pathways
hsa01230  Biosynthesis of amino acids
Module
hsa_M00015  Proline biosynthesis, glutamate => proline
hsa_M00972  Proline metabolism
Network
nt06033  Glycine, serine and arginine metabolism
  Element
N01618  Proline biosynthesis, Orn to Pro
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00330 Arginine and proline metabolism
    65263 (PYCR3)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.2  pyrroline-5-carboxylate reductase
     65263 (PYCR3)
SSDB
Motif
Pfam: P5CR_dimer F420_oxidored Rossmann-like DapB_N NAD_Gly3P_dh_N NAD_binding_2 NAD_binding_7 ApbA
Other DBs
NCBI-GeneID: 65263
NCBI-ProteinID: NP_075566
OMIM: 616408
HGNC: 25846
Ensembl: ENSP00000480945.1
UniProt: Q53H96 A0A0A0MQS1
LinkDB
Position
8:complement(143603210..143609575)
AA seq 274 aa
MAAAEPSPRRVGFVGAGRMAGAIAQGLIRAGKVEAQHILASAPTDRNLCHFQALGCRTTH
SNQEVLQSCLLVIFATKPHVLPAVLAEVAPVVTTEHILVSVAAGVSLSTLEELLPPNTRV
LRVLPNLPCVVQEGAIVMARGRHVGSSETKLLQHLLEACGRCEEVPEAYVDIHTGLSGSG
VAFVCAFSEALAEGAVKMGMPSSLAHRIAAQTLLGTAKMLLHEGQHPAQLRSDVCTPGGT
TIYGLHALEQGGLRAATMSAVEAATCRAKELSRK
NT seq 825 nt   +upstreamnt  +downstreamnt
atggcagctgcggagccgtctccgcggcgcgtgggcttcgtgggcgcgggccgcatggcg
ggggccatcgcgcagggcctcatcagagcaggaaaagtggaagctcagcacatactggcc
agtgcaccaacagacaggaacctatgtcactttcaagctctgggttgccggaccacgcac
tccaaccaggaggtgctgcagagctgcctgctcgtcatctttgccaccaagcctcatgtg
ctgccagctgtcctggcagaggtggctcctgtggtcaccactgaacacatcttggtgtcc
gtggctgctggggtgtctctgagcaccctggaggagctgctgcccccaaacacacgggtg
ctgcgggtcttgcccaacctgccctgtgtggtccaggaaggggccatagtgatggcgcgg
ggccgccacgtggggagcagcgagaccaagctcctgcagcatctgctggaggcctgtggg
cggtgtgaggaggtgcctgaagcctacgtcgacatccacactggcctcagtggcagtggc
gtggccttcgtgtgtgcattctccgaggccctggctgaaggagccgtcaagatgggcatg
cccagcagcctggcccaccgcatcgctgcccagaccctgctggggacggccaagatgctg
ctgcacgagggccaacacccagcccagctgcgctcagacgtgtgcaccccgggtggcacc
accatctatggactccacgccctggagcagggcgggctgcgagcagccaccatgagcgcc
gtggaggctgccacctgccgggccaaggagctcagcagaaagtag

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