KEGG T01001: 3112

Homo sapiens (human): 3112

Entry

3112              CDS       T01001

Symbol

HLA-DOB, DOB, HLA_DOB

Name

(RefSeq) major histocompatibility complex, class II, DO beta

K06752

MHC class II antigen

Organism

hsa Homo sapiens (human)

Pathway

hsa04145

Phagosome

hsa04514

Cell adhesion molecules

hsa04612

Antigen processing and presentation

hsa04640

Hematopoietic cell lineage

hsa04658

Th1 and Th2 cell differentiation

hsa04659

Th17 cell differentiation

hsa04672

Intestinal immune network for IgA production

hsa04940

Type I diabetes mellitus

hsa05140

Leishmaniasis

hsa05145

Toxoplasmosis

hsa05150

Staphylococcus aureus infection

hsa05152

Tuberculosis

hsa05164

Influenza A

hsa05166

Human T-cell leukemia virus 1 infection

hsa05168

Herpes simplex virus 1 infection

hsa05169

Epstein-Barr virus infection

hsa05310

Asthma

hsa05320

Autoimmune thyroid disease

hsa05321

Inflammatory bowel disease

hsa05322

Systemic lupus erythematosus

hsa05323

Rheumatoid arthritis

hsa05330

Allograft rejection

hsa05332

Graft-versus-host disease

hsa05416

Viral myocarditis

Network

nt06160 Human T-cell leukemia virus 1 (HTLV-1)
nt06168 Herpes simplex virus 1 (HSV-1)

Element

N00508

HTLV-1 Tax to NFY-mediated transcription

N00590

Antigen processing and presentation by MHC class II molecules

Drug target

Glatiramer acetate:

D04318<JP/US>

Brite

KEGG Orthology (KO) [BR:hsa00001]
09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    3112 (HLA-DOB)
09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    3112 (HLA-DOB)
   04612 Antigen processing and presentation
    3112 (HLA-DOB)
   04658 Th1 and Th2 cell differentiation
    3112 (HLA-DOB)
   04659 Th17 cell differentiation
    3112 (HLA-DOB)
09160 Human Diseases
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    3112 (HLA-DOB)
   05164 Influenza A
    3112 (HLA-DOB)
   05169 Epstein-Barr virus infection
    3112 (HLA-DOB)
  09171 Infectious disease: bacterial
   05150 Staphylococcus aureus infection
    3112 (HLA-DOB)
   05152 Tuberculosis
    3112 (HLA-DOB)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    3112 (HLA-DOB)
   05140 Leishmaniasis
    3112 (HLA-DOB)
  09163 Immune disease
   05310 Asthma
    3112 (HLA-DOB)
   05322 Systemic lupus erythematosus
    3112 (HLA-DOB)
   05323 Rheumatoid arthritis
    3112 (HLA-DOB)
   05320 Autoimmune thyroid disease
    3112 (HLA-DOB)
   05321 Inflammatory bowel disease
    3112 (HLA-DOB)
   05330 Allograft rejection
    3112 (HLA-DOB)
   05332 Graft-versus-host disease
    3112 (HLA-DOB)
  09166 Cardiovascular disease
   05416 Viral myocarditis
    3112 (HLA-DOB)
  09167 Endocrine and metabolic disease
   04940 Type I diabetes mellitus
    3112 (HLA-DOB)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    3112 (HLA-DOB)
Exosome [BR:hsa04147]
Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   3112 (HLA-DOB)
  Exosomal proteins of epithelial cells
   3112 (HLA-DOB)
  Exosomal proteins of breast milk
   3112 (HLA-DOB)

SSDB

Motif

Pfam:

MHC_II_beta C1-set ig MHC_I C2-set_2 Sdh_cyt

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

LinkDB

Position

6:complement(32812763..32817002)

AA seq 273 aa
MGSGWVPWVVALLVNLTRLDSSMTQGTDSPEDFVIQAKADCYFTNGTEKVQFVVRFIFNL
EEYVRFDSDVGMFVALTKLGQPDAEQWNSRLDLLERSRQAVDGVCRHNYRLGAPFTVGRK
VQPEVTVYPERTPLLHQHNLLHCSVTGFYPGDIKIKWFLNGQEERAGVMSTGPIRNGDWT
FQTVVMLEMTPELGHVYTCLVDHSSLLSPVSVEWRAQSEYSWRKMLSGIAAFLLGLIFLL
VGIVIQLRAQKGYVRTQMSGNEVSRAVLLPQSC

NT seq 822 nt +upstreamnt +downstreamnt
atgggttctgggtgggtcccctgggtggtggctctgctagtgaatctgacccgactggat
tcctccatgactcaaggcacagactctccagaagattttgtgattcaggcaaaggctgac
tgttacttcaccaacgggacagaaaaggtgcagtttgtggtcagattcatctttaacttg
gaggagtatgtacgtttcgacagtgatgtggggatgtttgtggcattgaccaagctgggg
cagccagatgctgagcagtggaacagccggctggatctcttggagaggagcagacaggcc
gtggatggggtctgtagacacaactacaggctgggcgcacccttcactgtggggagaaaa
gtgcaaccagaggtgacagtgtacccagagaggaccccactcctgcaccagcataatctg
ctgcactgctctgtgacaggcttctatccaggggatatcaagatcaagtggttcctgaat
gggcaggaggagagagctggggtcatgtccactggccctatcaggaatggagactggacc
tttcagactgtggtgatgctagaaatgactcctgaacttggacatgtctacacctgcctt
gtcgatcactccagcctgctgagccctgtttctgtggagtggagagctcagtctgaatat
tcttggagaaagatgctgagtggcattgcagccttcctacttgggctaatcttccttctg
gtgggaatcgtcatccagctaagggctcagaaaggatatgtgaggacgcagatgtctggt
aatgaggtctcaagagctgttctgctccctcagtcatgctaa

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