KEGG   ORTHOLOGY: K06752
Entry
K06752                      KO                                     
Symbol
MHC2
Name
MHC class II antigen
Pathway
map04145  Phagosome
map04514  Cell adhesion molecules
map04612  Antigen processing and presentation
map04640  Hematopoietic cell lineage
map04658  Th1 and Th2 cell differentiation
map04659  Th17 cell differentiation
map04672  Intestinal immune network for IgA production
map04940  Type I diabetes mellitus
map05140  Leishmaniasis
map05145  Toxoplasmosis
map05150  Staphylococcus aureus infection
map05152  Tuberculosis
map05164  Influenza A
map05166  Human T-cell leukemia virus 1 infection
map05168  Herpes simplex virus 1 infection
map05169  Epstein-Barr virus infection
map05310  Asthma
map05320  Autoimmune thyroid disease
map05321  Inflammatory bowel disease
map05322  Systemic lupus erythematosus
map05323  Rheumatoid arthritis
map05330  Allograft rejection
map05332  Graft-versus-host disease
map05416  Viral myocarditis
Disease
H00079  Asthma
H00080  Systemic lupus erythematosus
H00083  Allograft rejection
H00294  Dilated cardiomyopathy
H00342  Tuberculosis
H00408  Type 1 diabetes mellitus
H00630  Rheumatoid arthritis
H01362  Dermatitis herpetiformis
H01490  Multiple sclerosis
H01504  Vogt-Koyanagi-Harada syndrome
H02123  Celiac disease
H02424  Primary central nervous system lymphoma
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04514 Cell adhesion molecules
    K06752  MHC2; MHC class II antigen
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    K06752  MHC2; MHC class II antigen
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    K06752  MHC2; MHC class II antigen
   04612 Antigen processing and presentation
    K06752  MHC2; MHC class II antigen
   04658 Th1 and Th2 cell differentiation
    K06752  MHC2; MHC class II antigen
   04659 Th17 cell differentiation
    K06752  MHC2; MHC class II antigen
   04672 Intestinal immune network for IgA production
    K06752  MHC2; MHC class II antigen
 09160 Human Diseases
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K06752  MHC2; MHC class II antigen
   05164 Influenza A
    K06752  MHC2; MHC class II antigen
   05168 Herpes simplex virus 1 infection
    K06752  MHC2; MHC class II antigen
   05169 Epstein-Barr virus infection
    K06752  MHC2; MHC class II antigen
  09171 Infectious disease: bacterial
   05150 Staphylococcus aureus infection
    K06752  MHC2; MHC class II antigen
   05152 Tuberculosis
    K06752  MHC2; MHC class II antigen
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    K06752  MHC2; MHC class II antigen
   05140 Leishmaniasis
    K06752  MHC2; MHC class II antigen
  09163 Immune disease
   05310 Asthma
    K06752  MHC2; MHC class II antigen
   05322 Systemic lupus erythematosus
    K06752  MHC2; MHC class II antigen
   05323 Rheumatoid arthritis
    K06752  MHC2; MHC class II antigen
   05320 Autoimmune thyroid disease
    K06752  MHC2; MHC class II antigen
   05321 Inflammatory bowel disease
    K06752  MHC2; MHC class II antigen
   05330 Allograft rejection
    K06752  MHC2; MHC class II antigen
   05332 Graft-versus-host disease
    K06752  MHC2; MHC class II antigen
  09166 Cardiovascular disease
   05416 Viral myocarditis
    K06752  MHC2; MHC class II antigen
  09167 Endocrine and metabolic disease
   04940 Type I diabetes mellitus
    K06752  MHC2; MHC class II antigen
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K06752  MHC2; MHC class II antigen
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K06752  MHC2; MHC class II antigen
  Exosomal proteins of epithelial cells
   K06752  MHC2; MHC class II antigen
  Exosomal proteins of breast milk
   K06752  MHC2; MHC class II antigen
Genes
HSA: 3108(HLA-DMA) 3109(HLA-DMB) 3111(HLA-DOA) 3112(HLA-DOB) 3113(HLA-DPA1) 3115(HLA-DPB1) 3117(HLA-DQA1) 3118(HLA-DQA2) 3119(HLA-DQB1) 3122(HLA-DRA) 3123(HLA-DRB1) 3125(HLA-DRB3) 3126(HLA-DRB4) 3127(HLA-DRB5)
PTR: 100608816(MAMU-DMA) 100610904 100616520 104006793 449592(PATR-DMB) 462591(PATR-DRA) 462592(PATR-DRB5) 462594(PATR-DQB1) 462598(PATR-DPA1) 462599(PATR-DPB1) 471974(PATR-DQA1) 471976(PATR-DQA2) 471977(PATR-DOB) 471979
PPS: 100967723 100968410(MHC-DMB) 100968989 100970847 100972641 100972994 100973583 100979649 100986750 100987081 100994561 100995226 100995577
GGO: 101128237 101131235 101132303 101133052 101133995 101134815 101137108 101139685 101140024(MHC-DMB) 101140641 101141025 101141395 109027175 115934980 115935014
PON: 100438181 100442225 100442586 100442956 100443317 100443682 100443747 100444477 100448112 100448477 100449199 100453254 100456477 100456830 100457574 100458290 100460187
NLE: 100579397 100581510 100584042 100601771 100602317 100602659 100602736 100602990 100603340 100603684 100606472 100606816 100607501 100607843
HMH: 116460144 116460248 116460249 116460315 116460316 116460317 116460318 116460319 116460327 116460328 116460329 116460331 116460420
MCC: 100187587(MAMU-DRA) 100428228(MAMU-DRB5) 100428435 100429857(MAMU-DMB) 106997902 114669810 114675357 692100(MAMU-DRB1) 716823(MAMU-DQB1) 717702(MAMU-DOB) 717870(MAMU-DMA) 717947(MAMU-DOA) 717969(MAMU-DPB) 717992(MAMU-DPA) 720582(MAMU-DQA1)
MCF: 102132662 102133044 102136468 102136862 102137481 102139994 102140649 102144039 102144414 102145413 123572852 123572854 123572909
MTHB: 126952222 126952695 126952697 126952698 126952699 126952700 126952701 126952702 126952777 126952785 126952790 126952792 126952793 126952833
CSAB: 103221682(MHC-DPB1) 103221683(MHC-DPA1) 103221684(MHC-DOA) 103221688(MHC-DMA) 103221689(MHC-DMB) 103221695(MHC-DOB) 103221696(MHC-DQB1) 103221698(MHC-DQA1) 103221700 103221702 103221704(MHC-DRA) 103247136 103247138 103247148
CJC: 100385427(CAJA-DRA) 100386155(CAJA-DRB1) 100386865 100387227 100397732 100405222 100407771(CAJA-DMA) 100408132(CAJA-DOA) 100408503(CAJA-DPB1) 100411388 100412691(CAJA-DMB) 100413648(CAJA-DPA1) 128931734
MMU: 100504404(H2-Ea) 14960(H2-Aa) 14961(H2-Ab1) 14969(H2-Eb1) 14998(H2-DMa) 14999(H2-DMb1) 15000(H2-DMb2) 15001(H2-Oa) 15002(H2-Ob) 381091(H2-Eb2)
RNO: 24981(RT1-Db2) 24984(RT1-DOa) 24986(RT1-Ha) 294269(RT1-Da) 294270(RT1-Db1) 294273(RT1-DMb) 294274(RT1-DMa) 309621(RT1-Ba) 309622(RT1-Bb) 365542(RT1-DOb)
CFA: 100856137 474860(HLA-DRB1) 474869(DLA-DOA) 481731(DLA-DRA) 481732(DLA-DMA) 607786(DLA-DOB) 607827(DLA-DMB)
BTA: 100848815 282490(BOLA-DMA) 282491(BOLA-DMB) 282493(BOLA-DOB) 282494(BOLA-DQA5) 282495(BOLA-DQB) 282497(BOLA-DYA) 282498(BOLA-DYB) 282530(BOLA-DRB3) 282535(BOLA-DQA2) 506214(BOLA-DRA) 525727(BOLA-DOA) 538700(BOLA-DRB2) 539241(BLA-DQB) 618722(DSB)
SSC: 100037921(SLA-DQB1) 100135040(SLA-DRA) 100135049(SLA-DOB) 100135050(SLA-DMB) 100153386(SLA-DRB1) 100153387(SLA-DQA1) 100157996(SLA-DOA) 106504372 445528(SLA-DMA)
GGA: 101747454(BLB2) 101748499(MHCBL2) 107057103 417050(MHCDMA) 417051(DMB2) 425256(BLB3) 430189(BLA) 693256(BLB1)
ACYG: 106049922
CCW: 120412174
ACHL: 103803394
FPG: 101911209(Fape-DAB) 101911566 101920105
HALD: 104323948
GCL: 127027075
CCRI: 104169148
CSTI: 104554940
GSTE: 104259360
LDI: 104354370
TEO: 104382030
BRHI: 104500978
CPOO: 109306820
GGN: 109303386
XLA: 100037177 108698550(XB5827395.L) 108698551 373671(eladab-a) 373678(hla-dqa2.L) 399001(mhc2a.S) 495464
XTR: 100127727(hla-dqa1) 100145508 100495183 100495336(mhc2a)
DRE: 103911540(mhc2dhb) 30762(mhc2dab) 30763(mhc2dcb) 30783(mhc2a) 368614(mhc2dga) 368615(mhc2dgb) 368816(si:busm1-194e12.8) 368877(si:busm1-266f07.1) 368878(mhc2daa) 571282 64691(mhc2a1) 795595(si:dkey-33b17.1)
MANU: 129414229 129414280 129414285 129448765(si:ch73-31d8.2)
PGEO: 117451690
LERI: 129694455
ATEN: 116305295
 » show all
Reference
  Authors
Handunnetthi L, Ramagopalan SV, Ebers GC, Knight JC
  Title
Regulation of major histocompatibility complex class II gene expression, genetic variation and disease.
  Journal
Genes Immun 11:99-112 (2010)
DOI:10.1038/gene.2009.83
Reference
PMID:8849454
  Authors
Weber DA, Evavold BD, Jensen PE
  Title
Enhanced dissociation of HLA-DR-bound peptides in the presence of HLA-DM.
  Journal
Science 274:618-20 (1996)
DOI:10.1126/science.274.5287.618
  Sequence
[hsa:3109]
Reference
PMID:1922365
  Authors
Kelly AP, Monaco JJ, Cho SG, Trowsdale J
  Title
A new human HLA class II-related locus, DM.
  Journal
Nature 353:571-3 (1991)
DOI:10.1038/353571a0
  Sequence
[hsa:3108]
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